著者

GEN SUWA YONAS BEYENE HIDEO NAKAYA RAYMOND L. BERNOR JEAN-RENAUD BOISSERIE FAYSAL BIBI STANLEY H. AMBROSE KATSUHIRO SANO SHIGEHIRO KATOH BERHANE ASFAW

出版者

日本人類学会

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

pp.150206, (Released:2015-04-14)

被引用文献数

4 26

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The vertebrate fossil localities of the Chorora Formation, Ethiopia, comprise one of only a few sub-Saharan African paleontological research areas that illuminate Late Miocene African mammalian and primate evolution. Field work at Chorora since 2007 has resulted in the establishment of new vertebrate fossil localities and a revised chronostratigraphic framework. The new Chorora Formation fossils include the earliest known records of Cercopithecinae, Hippopotaminae, and Leporidae in Africa. Two lineages of hipparionins are recognized at Chorora, a larger and smaller morph, forming potential phyletic links between the earlier Samburu Hills hipparionins and later Eurygnathohippus turkanensis and E. feibeli from Lothagam, Kenya. The Chorora colobines are larger than the >9 Ma Microcolobus and morphologically conservative with only moderate molar cusp notches. The Chorora cercopithecines represent the earliest documented occurrence of the subfamily.

著者

Kohei HOSOI Jong-Eun HONG Takaaki SAKAI Shintaro IDA Tatsumi ISHIHARA

出版者

公益社団法人 日本セラミックス協会

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.123, no.1436, pp.182-186, 2015-04-01 (Released:2015-04-01)

参考文献数

24

被引用文献数

1 4

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Preparation of Microtubular cell using doped lanthanum gallate (LSGM) electrolyte with a dip coating and co-sintering process was studied. In order to suppress Ni diffusion from Ni-based anode substrate to LSGM electrolyte layer, Ti added La-doped ceria (Ti-LDC) was inserted as buffer layer. The amount of Ni diffused in LSGM electrolyte was investigated by EDX analysis as a function of sintering temperatures. It was found that sintering at 1350°C is suitable from the sintering density and the Ni diffusion. The cell sintered at 1350°C exhibited the higher power density than that of the conventional LSGM micro-tubular cell, even though a small amount of Ni diffusion was still observed at the Ti-LDC buffer layer/LSGM electrolyte interface. The micro-tubular cell with around 50 µm thickness showed the open circuit potential higher than 1.0 V and the maximum power density of 0.69, 0.31 and 0.12 W/cm2 at 700, 600 and 500°C, respectively, were achieved.

著者

Kazuhiko OCHIAI Toshina ISHIGURO-OONUMA Yasunaga YOSHIKAWA Chihiro UDAGAWA Yuiko KATO Masami WATANABE Makoto BONKOBARA Masami MORIMATSU Toshinori OMI

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.36, no.2, pp.155-158, 2015-04-01 (Released:2015-04-16)

参考文献数

21

被引用文献数

2 13

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Mutations in the breast cancer susceptibility gene BRCA2 leading to the failure of interactions with the recombinase RAD51 are associated with an increased risk of cancer in humans. This interaction depends on the eight BRC repeat (BRC1–8) sequences in BRCA2. We previously reported that canine BRC3 has two polymorphisms (T1425P and K1435R) influencing the interaction with RAD51, and 1435R was identified in mammary tumor dog samples. In this study, we investigated the sequence variations of BRC3 and 4 in 236 dogs of five breeds. Allele frequencies of 1425P and 1435R were 0.063 and 0.314, respectively, and there was no other polymorphism in the sequenced region. A mammalian two-hybrid assay using BRC3–4 sequences demonstrated that 1425P allele reduced the binding strength with RAD51 but 1435R had no effect. These results may provide an insight into the functions of not only individual but also multiple BRC repeats of BRCA2 in dogs.

著者

Ho Yi-Hao Chang Yue-Cune Huang Wei-Cheng Chen Hsin-Yi Lin Che-Chen Sung Fung-Chang

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.25, no.1, pp.15-19, 2015

被引用文献数

5

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<b>Background: </b>To date, the relationship between zolpidem use and subsequent risk of glaucoma in a Taiwanese population has not been assessed.<BR><b>Methods: </b>We used data from the National Health Insurance system to investigate whether zolpidem use was related to glaucoma risk. A 1:4 matched case-control study was conducted. The cases were patients newly diagnosed with glaucoma from 2001 to 2010. The controls were randomly selected non-glaucoma subjects matched by sex and age (±5 years). Zolpidem exposure and/or the average dosage of zolpidem used (mg/year) were evaluated. Medical comorbidities were considered as confounding factors. Multiple logistic regression models were used to evaluate the potential risk of zolpidem exposure on glaucoma with/without adjustment for the effects of confounding variables.<BR><b>Results: </b>The exposure rate of zolpidem use in the glaucoma group was significantly higher than that of the control group (2.8% vs. 2.0%, <i>P</i> < 0.0001). The adjusted odds ratio (OR) of the risk of glaucoma for those with zolpidem use vs. those without was 1.19 (95% confidence interval [CI], 1.02–1.38). Compared to non-zolpidem users, zolpidem users with an average dose of more than 200 mg/year had significantly increased risk of glaucoma (OR 1.31, 95% CI 1.03–1.68).<BR><b>Conclusions: </b>This study suggests that the use of zolpidem might increase the risk of subsequent glaucoma. Further confirmatory studies are recommended to clarify this important issue.

著者

ムゼーウス ヨ-ハン・カール・アウグスト 鈴木 滿

出版者

武蔵大学人文学会

雑誌

武蔵大学人文学会雑誌 : The Journal of Human and Cultural Sciences (ISSN:02865696)

巻号頁・発行日

vol.38, no.4, pp.109-151, 2007-03-20

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訳・注・解題

著者

AKIKO MATSUMOTO-ODA

出版者

日本人類学会

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

pp.150223, (Released:2015-03-31)

被引用文献数

9

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Predation has been an evolutionary force in primates, driving changes in their behavior, cognition, and numerous morphological characteristics. There is little evidence regarding the counter- strategies of primates to predation, because previous studies on primates have focused on the animals eaten rather than the animals that survive. I report a case of predation in which an adult male baboon was preyed on by a leopard in the early morning in the wild and describe how the surviving baboons behaved. Based on this report, I consider the counter-strategies of baboons to leopard predation, such as staying at the sleeping site, producing alarm calls, and shifting the sleeping site. Further information from other predation events is needed to understand the evolution of anti-predation behaviors.

著者

河 宗根 Ha Chong-Kun

出版者

名古屋大学大学院法学研究科

雑誌

名古屋大學法政論集 (ISSN:04395905)

巻号頁・発行日

vol.167, pp.363-404, 1997-01-31 (Released:2006-02-14)

著者

遠山 裕子 池田 実 丹羽 信彰 大高 明史 Wang Hong-Zhu Yongde Cui 西野 麻知子

出版者

日本陸水学会

雑誌

日本陸水学会 講演要旨集 日本陸水学会第73回大会 札幌大会

巻号頁・発行日

pp.90, 2008 (Released:2008-11-13)

著者

Taketoshi Kodama Kazutaka Takahashi Ken-ichi Nakamura Shinji Shimode Takafumi Yamaguchi Tadafumi Ichikawa

出版者

日本プランクトン学会、日本ベントス学会

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.10, no.1, pp.75-79, 2015-03-25 (Released:2015-03-20)

参考文献数

25

被引用文献数

1 4

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Short-term variation in the ammonium excretion rate by Calanus sinicus during the post-capture period was evaluated in 1-h incubations. Incubation water volume (13 mL vs. 100 mL) did not significantly affect the excretion rate, and the overall mean excretion rate of C. sinicus was similar to reported values from congeneric species. However, the 24-h variations in the excretion rate denoted that acclimation stress decreased the excretion rates 1–2 h after introduction to a no-food condition. The effect of presence/absence of food was not significant up to 24 h after capture.

著者

Hiroki Shiomi Takeshi Morimoto Yutaka Furukawa Yoshihisa Nakagawa Ryuzo Sakata Hitoshi Okabayashi Michiya Hanyu Mitsuomi Shimamoto Noboru Nishiwaki Tatsuhiko Komiya Takeshi Kimura on behalf of the CREDO-Kyoto PCI/CABG registry cohort-2 investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-0034, (Released:2015-03-30)

参考文献数

23

被引用文献数

9 36

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Background:Studies evaluating long-term (≥5 years) outcome of percutaneous coronary intervention (PCI) compared with coronary artery bypass grafting (CABG) in patients with unprotected left main coronary artery disease (ULMCAD) are still limited, despite concerns for late adverse events after drug-eluting stents implantation.Methods and Results:We identified 1,004 patients with ULMCAD (PCI: n=364, CABG: n=640) among 15,939 patients with first coronary revascularization enrolled in the CREDO-Kyoto PCI/CABG registry cohort-2. The primary outcome measure in the current analysis was a composite of death, myocardial infarction, and stroke (death/MI/stroke). The cumulative 5-year incidence of and the adjusted risk for death/MI/stroke were significantly higher in the PCI group than in the CABG group (34.5% vs. 24.1%, log-rank P<0.001, adjusted hazard ratio (HR): 1.48 [95% confidence interval (CI): 1.07–2.05, P=0.02]). The adjusted risks for all-cause death was not significantly different between the 2 groups. Regarding the stratified analysis by the SYNTAX score, the adjusted risk for death/MI/stroke was not significantly different between the 2 groups in patients with low (<23) or intermediate (23–33) SYNTAX score, whereas it was significantly higher in the PCI group than in the CABG group in patients with high (≤33) SYNTAX score.Conclusions:CABG as compared with PCI was associated with better long-term outcome in patients with ULMCAD, especially those with high anatomical complexity.

著者

Siraj-Blatchford Iram 門田理世

出版者

一般社団法人 日本発達心理学会

雑誌

日本発達心理学会 第26回大会

巻号頁・発行日

2015-02-17

著者

川窪 広明 松富 謙一 井之上 節朗 Hiroaki KAWAKUBO Ken-ichi MATSUTOMI Setsuro INOUE

出版者

大手前大学

雑誌

大手前大学論集 = Otemae journal (ISSN:1882644X)

巻号頁・発行日

vol.10, pp.69-109, 2009-03-31

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本報告は、2009年度特別研究、「尾道空き屋再生プロジェクト参加による学生の社会体験教育と建築の学習に対するモティベーション向上」に関するものである。この特別研究は、尾道市の斜面地に数多く存在する空き屋再生活動に取り組んでいるNPO法人・尾道空き屋再生プロジェクトとの協働により、実際の住宅再生作業を通して学生に社会体験をさせることを主な目的としている。また9月に開催された「尾道建築塾夏合宿」には、本学の学生以外にも全国各地から学生や社会人が参加し、尾道市東土堂町の傾斜地に建つ築52年の木造住宅の改装工事や五右衛門風呂製作を行った。本報告では、この夏合宿を中心に学生が作業内容や取得した技能などを日報形式で詳細に報告する。

著者

Du Lei Li Zhao-Jie Xu Jie Wang Jing-Feng Xue Yong Xue Chang-Hu Takahashi Koretaro Wang Yu-Ming

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.61, no.6, pp.321-330, 2012 (Released:2012-05-23)

参考文献数

40

被引用文献数

17 35

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The present study was undertaken to examine the effect of cerebrosides derived from the sea cucumber Acaudina molpadioides and the starfish Asterias amurensis on the anti-tumor activity in vitro and in vivo. The results indicated that both Acaudina molpadioides cerebrosides (AMC) and Asterias amurensis cerebrosides (AAC) exhibited an inhibitory effect on cell proliferation through induction of apoptosis in S180 cells. Moreover, administration of AMC and AAC (50 mg/kg BW) on S180 tumor bearing mice reduced the tumor weight by 45.24 % and 35.71 %, respectively. In S180 ascites tumor model, AMC and AAC (50 mg/kg BW) treatment exhibited a significant ascites fluid growth inhibition of 31.23 % and 22.72 %. Furthermore, the ascites tumor cell viability ratio in AMC and AAC groups reduced to 50.89 % and 51.69 %, respectively. The life span of AMC and AAC administrated groups increased by 55.28 % and 35.77 % compared to control. Quantitative real-time PCR analysis demonstrated that the administration of AMC and AAC down-regulated the expression of Bcl-2, Bcl-xL, while on the other hand, up-regulated Bax, Cytochrome c, caspase-9 and caspase-3 mRNA level of the S180 ascites tumor cells. It was concluded that AMC and AAC should have potential anti-tumor activity both in vitro and in vivo by inducing apoptosis through the mitochondria-mediated apoptosis pathway. AAC seemed to be more effective than AMC in vitro but less potent in vivo. It may depend on the structural differences in their fatty acid groups and sphingoid bases.

著者

Ashraf Ramadan Hafez Ahmed H. Al-Johani Abdul Rahim Zakaria Abdulaziz Al-Ahaideb Syamala Buragadda Ganeswara Rao Melam Shaji J. Kachanathu

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.11, pp.1401-1405, 2013 (Released:2013-12-11)

参考文献数

58

被引用文献数

8 33

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[Purpose] To assess the effect of hamstring and quadriceps strengthening exercises on pain intensity, gait velocity, maximum isometric strength, and activities of daily living of patients with knee osteoarthritis (OA). [Subjects and Methods] A total of 20 patients with knee OA, 50 to 65 years of age (57.65 ± 4.78 years), received hot packs, strengthening exercises for the quadriceps and the hamstring muscles and stretching exercises for hamstring muscles. Outcome measures included: the Western Ontario and McMaster Universities OA index questionnaire (WOMAC) scores for assessing health status and health outcomes of knee OA; self-reported pain intensity scores, measured using a visual analogue scale; the 50 ft walk test (a measure of gait velocity and function); and handheld dynamometry (a tool used to measure maximum isometric strength of knee extension and flexion). [Results] There was a significant difference between pre- and post-intervention measures of pain intensity, 50 ft walk times, hamstring strength, and quadriceps strength. Significant differences in WOMAC measures were also observed in the subscales of pain, stiffness and physical function, as well as WOMAC total scores. [Conclusion] Strengthening the hamstring muscles in addition to strengthening the quadriceps muscles proved to be beneficial for perceived knee pain, range of motion, and decreasing the limitation of functional performance of patients with knee OA.

著者

Ahmed H Al-Johani Shaji John Kachanathu Ashraf Ramadan Hafez Abdulaziz Al-Ahaideb Abdulrahman D Algarni Abdulmohsen Meshari Alroumi Aqeel M. Alenazi

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.6, pp.817-820, 2014 (Released:2014-06-30)

参考文献数

47

被引用文献数

4 25

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[Purpose] Osteoarthritis (OA) of the knee is the most common form of joint disease. It is one of the major causes of impaired function that reduces quality of life (QOL) worldwide. The purpose of this study was to compare exercise treatments for hamstring and quadriceps strength in the management of knee osteoarthritis. [Subjects and Methods] Forty patients with OA knee, aged 50–65 years were divided into 2 groups. The first group (57.65±4.78 years) received hot packs and performed strengthening exercises for the quadriceps and hamstring, and stretching exercises for the hamstring. The second group (58.15±5.11 years) received hot packs and performed strengthening exercises for only the quadriceps, and stretching exercise for the hamstring. Outcome measures were the WOMAC (Western Ontario and McMaster Universities OA index questionnaire), Visual Analogue Scale (VAS) assessment of pain, the Fifty-Foot Walk Test (FWS), and Handheld dynamometry. [Results] There was a significant difference between the groups. The first group showed a more significant result than the second group. [Conclusion] Strengthening of the hamstrings in addition to strengthening of the quadriceps was shown to be beneficial for improving subjective knee pain, range of motion and decreasing the limitation of functional performance of patients with knee osteoarthritis.

著者

Takashi Watanabe Yuki Hayashi Akiko Aoki Shin Ishiguro Mikito Ueda Kazufumi Akiyama Kazuko Kato Yoshimasa Inoue Shoko Tsuchimine Norio Yasui-Furukori Kazutaka Shimoda

出版者

日本臨床精神神経薬理学会

雑誌

Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)

巻号頁・発行日

vol.6, pp.5-15, 2015 (Released:2015-03-13)

参考文献数

39

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Purpose: This study evaluated the impact of CYP2D6 polymorphism, and particularly CYP2D6*10 alleles, on the steady-state plasma concentrations of mirtazapine (MIR) and its metabolite N-desmethylmirtazapine (DMIR) in Japanese psychiatric patients.Patients and Methods: The subjects were 75 Japanese patients treated with racemic MIR. The steady-state plasma concentrations of MIR and DMIR were measured using liquid chromatography. The CYP2D6 genotypes were determined by polymerase chain reaction. Three subjects whose plasma levels of MIR and DMIR were below the limit of detection were regarded as non-adherent and excluded, and 4 subjects having the CYP2D6*5 allele (CYP2D6*1/CYP2D6*5 and CYP2D6*2/CYP2D6*5 (n = 3) and CYP2D6*5/CYP2D6*10 (n = 1)) were excluded from the analysis in order to eliminate the effect of the CYP2D6*5 allele. Accordingly, data from 68 subjects were subjected to analysis.Results: There were no significant differences in the plasma concentrations of MIR or DMIR (all corrected for dose and body weight) among different CYP2D6 genotypes. Multiple regression analysis also revealed that age affects MIR (corrected for dose and body weight) (p=0.079). Also, multiple regression analysis revealed that age correlated significantly to the plasma concentration of DMIR (corrected for dose and body weight) (p=0.026). Neither sex nor the number of CYP2D6*10 alleles were significant factors for either the plasma concentration of MIR (corrected for dose and body weight) or the plasma concentration of DMIR (corrected for dose and body weight).Conclusion: CYP2D6*10 polymorphism did not significantly affect the steady-state plasma levels of MIR and DMIR in Japanese patients, but age had a significant effect on the plasma levels of DMIR.

著者

笹川 寿之 浜 祐子 GIGA-HAMA Yuko

出版者

金沢大学

雑誌

基盤研究(C)

巻号頁・発行日

2003

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高リスク型ヒトパピローマウイルス(HPV)のHPV16が子宮頚癌の発生を誘発することが明らかになっている。したがって、HPV16に対して有効な免疫を誘導することが感染防止や将来の癌発生防止に有効であると考えられている。米国のグループがHPV16型L1蛋白を酵母で発現させて作成したウイルス様粒子(VLP)をワクチンとして人に免疫したところ、100%その感染は抑えられたと報じられた。このワクチンは注射ワクチンで、精製したウイルス様粒子を計3回の注射を行っている。効果はみとめられたが、このワクチンは単価が高く、また、低開発国など医療設備が充実していない地域において、このワクチンの保存や注射そのものが難しいなどの問題点がある。そこで、安価で経口投与出来るワクチンの開発が期待されている。最近、我々はHPV16型様粒子を産生する酵母を経口投与した後にごく少量のVLPを鼻粘膜に投与することで、HPV16型特異的な抗体が誘導されることを発見した。本研究では、この研究を発展させ、HPV16型感染の防御のみならず、HPV16型特異的なキラーT細胞を誘導し、治療を目的としたワクチンの作成を試みた。S.pombeの発現ベクターにHPV16L1-E7(L1を短くしたC-末に全長のE7を導入したもの)を組み込んで発現させたところ、57kD,63kD,67kDの蛋白発現に成功した。このHPV16L1-E7を発現する酵母を凍結乾燥させ、マウスに食べさせたところ、HPV16様粒子(VLP)に反応することを確認した。このことから、この融合蛋白がL1だけで構成される粒子と同じような粒子を形成し、それによって抗体産生が誘導されることが示唆された。E7に対するキラーT細胞が誘導されているかどうかについて今後検討する予定であり、もしこれが誘導されれば、予防的かつ治療的ワクチンとして有望となる可能性がある。

著者

ガルシ-ア・ロルカ フェデリコ 小海 永二

出版者

青土社

雑誌

ユリイカ (ISSN:13425641)

巻号頁・発行日

vol.25, no.6, pp.p30-41, 1993-06

著者

カソリーノ マルコ 戎崎 俊一 羽場 宏光 ピオトロブスキ- ビクター レフ 東出 一洋 後藤 昌幸 久永 勇 Marco Casolino Toshikazu Ebisuzaki Hiromitsu Haba Piotrowski Wiktor Lech Kazuhiro Higashide Masayuki Goto Isao Hisanaga

雑誌

【B】電力・エネルギー部門 原子力研究会

巻号頁・発行日

2013-09-02

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食品の放射線量の測定器LANFOSの開発を行っている。K40のバックグラウンドから、Cs137の存在を検出するために、検出器はサンプルの全周を覆っている。食品サンプルは測定のために加工をする必要はなく、測定後は、調理などに利用できる。ガンマ線測定などの専門家だけでなく、一般人の利用も念頭にデザインしており、簡単にセシウムからの放射線量やサンプルの安全性を測ることができる。

著者

Jun Ho-Kyung

出版者

開拓社

雑誌

音韻研究

巻号頁・発行日

no.9, pp.25-32, 2006