著者

中野 裕二 ナカノ ユウジ Nakano Yuji

出版者

駒澤大学法学部

雑誌

駒澤法学 (ISSN:13476599)

巻号頁・発行日

vol.15, no.3・4, pp.60[71]-39[92], 2016-03

著者

Hiroe Sato Junichiro James Kazama Akira Murasawa Hiroshi Otani Asami Abe Satoshi Ito Hajime Ishikawa Kiyoshi Nakazono Takeshi Kuroda Masaaki Nakano Ichiei Narita

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.2, pp.121-126, 2016 (Released:2016-01-15)

参考文献数

33

被引用文献数

3 34

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Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease accompanied by periarticular and systemic osteoporosis. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes, circulates to the kidneys and regulates bone metabolism. We herein assessed serum FGF23 and its relationship to inflammation and osteoporosis in patients with RA. Methods Sixty-one patients with RA were included. Serum concentrations of FGF23 were determined using a sandwich enzyme-linked immunosorbent assay. Results The mean (± standard deviation) serum FGF23 concentration was 34.9±9.2 (range, 21.0-61.0) pg/mL. The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261, p=0.044, r=0.280, p=0.029, r=0.409, p=0.001 and r=0.421, p=0.001, respectively). The serum matrix metalloproteinase-3 level was also significantly and positively correlated with the serum FGF23 level (r=0.331, p=0.015). Concentrations of type I collagen cross-linked N-telopeptide in the serum was significantly correlated with the serum FGF23 level (r=0.272, p=0.034). Neither the bone mineral density in the femoral neck nor lumbar was significantly correlated with the serum FGF23 level. Serum phosphate, calcium, 25-hydroxy vitamin D, and intact parathyroid hormone were not related to the serum FGF23 level. Conclusion In patients with RA, serum FGF23 is correlated with inflammation, the disease activity of RA, and bone absorption markers. Serum FGF23 may be associated with abnormal bone absorption related to RA inflammation. Further studies are necessary to clarify the mechanism underlying this association.

著者

Yuko NAKANO Tetsuya KOBAYASHI Fukiko OSHIMA Eri FUKAZAWA Tetsushi YAMAGAMI Yozo SHIRAISHI Masamine TAKANOSU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0156, (Released:2013-11-29)

被引用文献数

4 13

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In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation resulted in the substitution of valine by aspartic acid (p.Val559Asp) in the juxtamembrane domain of the protein. Imatinib mesylate, a therapeutic agent for canine mast cell tumors, was used to treat both tumors. Complete remission was achieved at 33 and 14 days after administration, respectively. However, in both cases, the therapeutic response subsequently tapered with the duration of remission lasting 66 and 255 days, respectively. Although these 2 novel c-KIT mutations in exon11 were not confirmed to be gain-of-function mutations, a further study may help clarify relevance between mutations identified in this report and responsiveness.

著者

Takuya Takahashi Hirofumi Saiki Akira Sato Seiko Kuwata Satoshi Nakano Yumi Sato Manami Akasaka Junichi Koizumi Hideaki Senzaki Kotaro Oyama

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0147, (Released:2023-09-28)

参考文献数

21

被引用文献数

1

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Background: Although right ventricular (RV) enlargement may affect RV diastolic dysfunction assessed by end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (TOF), EDFF may also be modified by left ventricular (LV) hemodynamics. We hypothesized that EDFF is affected by LV hemodynamics, not limited to RV diastolic stiffening.Methods and Results: Among 145 consecutive patients with repaired TOF who underwent catheterization, hemodynamic properties in 47 with consistent EDFF and 75 without EDFF were analyzed. Compared with patients without EDFF, those with EDFF had a large RV volume with a high regurgitant fraction. Although cardiac index and central venous pressure (CVP) were similar, contrast injection augmented CVP and LV end-diastolic pressure (EDP) in patients with vs. those without EDFF, suggesting compromised diastolic reserve. In patients with EDFF, the velocity–time integral (VTI) of EDFF was positively correlated with LVEDP and systemic vascular resistance, in addition to RV EDP. EDFF-VTI was correlated with hepatic venous wedge pressure and markers of hepatic dysfunction. Subanalysis of the older (≥6 years) half of the study cohort revealed that EDFF was associated with bi-atrial enlargement independent of RV volume, highlighting the pronounced role of EDFF on the diastolic property in the aged cohort.Conclusions: EDFF-VTI in patients with repaired TOF reflects RV diastolic dysfunction, affected by the left heart system. EDFF-VTI indicates blood stagnation, which may be attributed to end-organ damage.

著者

Takanori Ohata Nozomi Niimi Yasuyuki Shiraishi Fumiko Nakatsu Ichiro Umemura Takashi Kohno Yuji Nagatomo Makoto Takei Tomohiko Ono Munehisa Sakamoto Shintaro Nakano Keiichi Fukuda Shun Kohsaka Tsutomu Yoshikawa

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0356, (Released:2023-10-31)

参考文献数

43

被引用文献数

1

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Background: Despite recommendations from clinical practice guidelines to initiate and titrate guideline-directed medical therapy (GDMT) during their hospitalization, patients with acute heart failure (AHF) are frequently undertreated. In this study we aimed to clarify GDMT implementation and titration rates, as well as the long-term outcomes, in hospitalized AHF patients.Methods and Results: Among 3,164 consecutive hospitalized AHF patients included in a Japanese multicenter registry, 1,400 (44.2%) with ejection fraction ≤40% were analyzed. We assessed GDMT dosage (β-blockers, renin-angiotensin inhibitors, and mineralocorticoid-receptor antagonists) at admission and discharge, examined the contributing factors for up-titration, and evaluated associations between drug initiation/up-titration and 1-year post-discharge all-cause death and rehospitalization for HF via propensity score matching. The mean age of the patients was 71.5 years and 30.7% were female. Overall, 1,051 patients (75.0%) were deemed eligible for GDMT, based on their baseline vital signs, renal function, and electrolyte values. At discharge, only 180 patients (17.1%) received GDMT agents up-titrated to >50% of the maximum titrated dose. Up-titration was associated with a lower risk of 1-year clinical outcomes (adjusted hazard ratio: 0.58, 95% confidence interval: 0.35–0.96). Younger age and higher body mass index were significant predictors of drug up-titration.Conclusions: Significant evidence-practice gaps in the use and dose of GDMT remain. Considering the associated favorable outcomes, further efforts to improve its implementation seem crucial.

著者

Hiroki Ikenaga Shinya Takahashi Yukiko Nakano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0866, (Released:2023-12-13)

参考文献数

14

著者

Takato Hara Reina Kumagai Tohru Tanaka Tsuyoshi Nakano Tomoya Fujie Yasuyuki Fujiwara Chika Yamamoto Toshiyuki Kaji

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.48, no.12, pp.655-663, 2023 (Released:2023-12-01)

参考文献数

39

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Vascular endothelial cell growth is essential for the repair of intimal injury. Perlecan, a large heparan sulfate proteoglycan, intensifies fibroblast growth factor-2 (FGF-2) signaling as a co-receptor for FGF-2 and its receptor, and promotes the proliferation of vascular endothelial cells. Previously, we reported that 2 µM of lead, a toxic heavy metal, downregulated perlecan core protein expression and then suppressed the growth of vascular endothelial cells. However, since the mechanisms involved in the repression of perlecan by lead remains unclear, we analyzed its detailed signaling pathway using cultured bovine aortic endothelial cells. Our findings indicate that 2 µM of lead inhibited protein tyrosine phosphatase (PTP) activity and induced cyclooxygenase-2 (COX-2) via phosphorylation of the epidermal growth factor receptor (EGFR) and its downstream extracellular signal-regulated kinases (ERK1/2). In addition, among the prostanoids regulated by COX-2, prostaglandin I2 (PGI2) specifically contributes to the downregulation of perlecan expression by lead. This study revealed an intracellular pathway—the EGFR-ERK1/2-COX-2-PGI2 pathway activated by inhibition of PTP by lead—as a pathway that downregulates endothelial perlecan synthesis. The pathway is suggested to serve as a mechanism for the repression of perlecan expression, which leads to a delay in cell proliferation by lead.

著者

Akira Yamazaki Ao Takezawa Kazusa Nishimura Ko Motoki Kyoka Nagasaka Ryohei Nakano Tetsuya Nakazaki Munetaka Hosokawa

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.QH-094, (Released:2023-10-17)

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Chili pepper is cultivated in the absence of fruit-promoting treatments or insect pollinators. The fertilization ability of both males and females, as well as natural self-pollination ability under high temperatures, are necessary for autonomous set fruit under high temperatures. The reproductive traits related to autonomous self-pollination ability and fertilization ability of both males and females after pollination under control (CK) and high temperature (HT) treatments were investigated in this study. ‘Takanotsume’ (TK) showed a significantly higher percentage of autonomous fruit set than ‘Peruvian Purple’ (PP) in both CK and HT treatments, suggesting that TK has a strong autonomous fruit set regardless of temperature. On the other hand, the percentage of autonomous fruit set of PP was 0% in the HT treatment, while autonomous fruit set was observed in the CK treatment. Therefore, TK had autonomous fruit set ability even at high temperatures when PP did not have any. TK had more pollen on the stigma than PP, suggesting that TK has a higher ability for autonomous self-pollination. Flower morphology was not considered a factor in the autonomous self-pollination of TK. In contrast, TK tended to release more pollen than PP. One factor that can support autonomous self-pollination is pollen dispersion. A significant difference was observed in the fruit set rate during artificial pollination between the treatments (CK and HT) of the pollen parent and the cultivars (TK and PP) of the seed parent. In fact, female fertility in TK was higher than that in PP, regardless of the temperature condition. Almost no fruit set of PP was observed via autonomous self-pollination in the HT treatment, but fruits were set by artificial pollination using both the pollen and pistil of PP in the HT treatment. This result is consistent with the finding that PP exhibits decreased autonomous self-pollination at high temperatures. The higher autonomous fruit-set ability of TK than PP under high temperatures may be attributed not only to superior female fertility, but also to its autonomous self-pollination ability under high temperatures. Therefore, pollen dispersal ability under high temperatures was considered a key factor for autonomous fruit-set.

著者

中野 円佳 Madoka NAKANO

出版者

国立社会保障・人口問題研究所

雑誌

人口問題研究 = Journal of Population Problems (ISSN:03872793)

巻号頁・発行日

vol.79, no.2, pp.133-156, 2023-06

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特集Ⅰ

著者

中野 毅 Tsuyoshi NAKANO

出版者

創価大学比較文化研究所

雑誌

創価大学比較文化研究 (ISSN:02895706)

巻号頁・発行日

no.7, pp.100-135, 1990-01-01

著者

Shinichiro MORISHITA Katsuyoshi SUZUKI Taro OKAYAMA Junichiro INOUE Takashi TANAKA Jiro NAKANO Takuya FUKUSHIMA

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

pp.R0023, (Released:2023-03-22)

参考文献数

54

被引用文献数

1

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In recent years, the number of cancer survivors has been increasing each year due to advances in the early diagnosis and treatment of cancer. Cancer survivors present a variety of physical and psychological complications due to cancer and its treatment. Physical exercise is an effective nonpharmacological treatment for complications in cancer survivors. Furthermore, recent evidence has shown that physical exercise improves the prognosis of cancer survivors. The benefits of physical exercise have been widely reported, and guidelines for physical exercise for cancer survivors have been published. These guidelines recommend that cancer survivors engage in moderate- or vigorous-intensity aerobic exercises and/or resistance training. However, many cancer survivors have a poor commitment to physical exercise. In the future, it is necessary to promote physical exercise among cancer survivors through outpatient rehabilitation and community support.

著者

Yusuke Sugawara Naoki Koike Takafumi Nakano

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.71, no.1, pp.27-31, 2022-06-30 (Released:2022-07-02)

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Spiders of the genus Cybaeus are diverse in Japan and exhibit extensive morphological variation of their genitalia among species. Among Japanese Cybaeus, several species possess an elongated embolus in males and elongated spermathecae in females. Here, we describe Cybaeus iharai sp. nov. from Nagano Prefecture, central Honshu, Japan, which possesses a short embolus in males and short copulatory ducts in females. In addition, DNA sequences of the new species were obtained for future phylogenetic analyses.

著者

金澤 貴之 二神 麗子 中野 聡子 KANAZAWA Takayuki FUTAGAMI Reiko NAKANO Satoko

出版者

群馬大学共同教育学部附属教育実践センター

雑誌

群馬大学教育実践研究 (ISSN:09123911)

巻号頁・発行日

vol.40, pp.165-174,

著者

Hiroto Nakano Kazuyoshi Yamaguchi Naoyuki Hama Yasuko Matsumoto Moeko Shinohara Hisashi Ide

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.6, pp.923-928, 2023-03-15 (Released:2023-03-15)

参考文献数

14

被引用文献数

5

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Anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that mainly occurs post-infection or post-vaccination. MOGAD after inoculation with coronavirus disease 2019 (COVID-19) vaccines is rare, and we herein report a rare case of a patient with MOGAD after vaccination using the Pfizer-BioNTech COVID-19 vaccine (BNT162b2, Pfizer Japan, Tokyo). Our report highlights the fact that MOGAD following inoculation with COVID-19 vaccine may show clinical relapse during reduction of the oral steroid dose, and continuous treatments with immunological agents is needed to prevent disease recurrence.

著者

鶴園 裕 笠井 純一 中野 節子 片倉 穣 Tsuruzono Yutaka Kasai Junichi Nakano Setsuko Katakura Minoru

出版者

金沢大学教養部

雑誌

平成2(1990)年度 科学研究費補助金 一般研究(B) 研究成果報告書 = 1990 Fiscal Year Final Research Report

巻号頁・発行日

1991-03-01

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1.研究状況の把握 加賀藩はじめ諸藩における「渡来朝鮮人」の研究状況、史料の残存状況を調査・検討し、「日本近世初期渡来朝鮮人一覧稿」を作成した(研究成果報告書に収録)。 2.史料の調査・翻刻 (1)「家伝」の研究及び翻刻を行なった(報告書に収録)。(2)如鉄に関する(1)以外の史料の翻刻を行なった(報告書に収録)。(3)加賀藩における渡来朝鮮人の研究をすすめ、その成果を「加賀藩における渡来朝鮮人」としてまとめた(報告書に収録)。(4)九州地域他の「渡来朝鮮人」関係史料の調査を続行したが、目下整理中である。 3.加賀藩初期『侍塚』の分析 『加賀藩初期の侍帳』(石川県図書館協会)に収録された藩士の石高・役職等を全てパソコンに入力し、家臣団中における「渡来朝鮮人」如鉄の位置づけを明らかにした(報告書に収録)。 4.比較史的研究 東南アジアにおける「渡来朝鮮人」の研究を行ない、その存在形態を明らかにした(報告書に収録)。 5.研究会を月一回のペ-スで開き、研究成果の報告と問題点の整理を行なって、課題の追究に努めた。 6.総括と報告書の作成 上記の研究諸成に立脚し、総論「近世初期渡来朝鮮人冶究序説」をまとめ、諸成果とともに、研究成果報告書『日本近世初期における渡来朝鮮人の研究ー加賀藩を中心にー』に載録して刊行した。 5. Discussion Meeting were held once a month and members of the study team reported on their progress and problems. This helped to facilitate the individual research of team members. 6. Summary and Publication of the Research We summarized the findings of all the members of the study team and this is reported under the heading "Introduction to the Research on the Koreans brought to Japan in the Early Pre-Modern Period". The publication of this research also included the various reports mentioned above. 1. Literature Review Related to This Area of Research We reviewed and examined existing research and documents relating to these Koreans in the Kaga and the other clans and compiled a name list. This name list included such variables as could be determined, example age, rank etc. (Included in this report) 2. The Review and Rewriting of Documents (1) We reviewed and rewrote "Autobiography of Kim Jotetsu". (Included in this report) (2) We rewrote documents related directly to Jotetsu besides 2 (1) above. (Included in this report) (3) We reviewed and researched the history of these koreans in the Kaga clan and the result of this research is reported under the heading "The Koreans in the Kaga Clan". (Included in this report) (4) We expanded this study and included the Koreans brought to the Kyusyu area and other areas and are at the moment finalizing the details. 3. Analysis of the "Soldier's List" of the Early Kaga Clan With the help a personal computer, we analyzed the "Soldier's List" and was able to trace Jotetsu's movement and rise in rank in the Kaga clan. (Included in this report) 4. Comparative Study We also did a comparative study by researching this area in some South-Asian countries and endeavored to clarify the situation of the Koreans at that time. (Included in this report) 5. Discussion Meeting were held once a month and members of the study team reported on their progress and problems. This helped to facilitate the individual research of team members. 6. Summary and Publication of the Research We summarized the findings of all the members of the study team and this is reported under the heading "Introduction to the Research on the Koreans brought to Japan in the Early Pre-Modern Period". The publication of this research also included the various reports mentioned above.

著者

中野 伸彦 Nobuhiko Nakano

巻号頁・発行日

no.12, pp.25-40,

著者

NAKANO Masuo CHEN Ying-Wen SATOH Masaki

出版者

公益社団法人 日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2023-013, (Released:2023-02-24)

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Typhoon Krosa (2019) formed in the eastern part of the Philippine Sea and ∼ 1400 km east of another typhoon Lekima on 6 August and made landfall in the western part of Japan's mainland on 15 August. The operational global model forecasts, which were initialized just after Krosa's formation, showed a very large uncertainty and totally failed to predict the actual track of Krosa. In this study, we investigated the causes of this large uncertainty through 101-member ensemble forecast experiments by using a 28-km mesh global nonhydrostatic model. The experiments initialized at 1200 UTC 6 August, showed a large uncertainty. An ensemble-based lagged correlation analysis indicated that the western North Pacific Subtropical High (WNPSH) retreated further east in the members with large track forecast errors than in the members with small errors. For the members with a large track forecast error for Krosa, Krosa and Lekima approached each other by 250 km and Krosa moved northward faster than the observation in 36 hours from the initialization time. For the members with a small track forecast error for Krosa, two typhoons approached each other by only 50 km, and the northward moving speed was comparable with that of the observation. The typhoon-center relative composite analysis exhibited that at the initialization time, the members with a large Krosa track forecast error had a larger horizontal size of Krosa and the difference in Krosa's size was kept during the forecast period. This difference in size led to a stronger interaction between the two typhoons and retreatment of the WNPSH, thus resulting in a fast northward moving speed for the members with a large Krosa track error.

著者

Hiroki Ikenaga Yukiko Nakano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0014, (Released:2023-02-08)

参考文献数

14

著者

Kazuki Shiina Takamichi Takahashi Hiroki Nakano Masatsune Fujii Yoichi Iwasaki Chisa Matsumoto Akira Yamashina Taishiro Chikamori Hirofumi Tomiyama

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.30, no.2, pp.192-202, 2023-02-01 (Released:2023-02-01)

参考文献数

33

被引用文献数

2

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Aims: This prospective observational study, which utilized repeated annual measurements performed over a 9-year period, applied mixed model analyses to examine age-related differences in longitudinal associations between alcohol intake and arterial stiffness, pressure wave reflection, and inflammation.Methods: In 4016 middle-aged (43±9 years) healthy Japanese male employees, alcohol intake, brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), and serum C-reactive protein (CRP) levels were measured annually during a 9-year study period.Results: The estimated marginal mean baPWV (non-drinkers=1306 cm/s, mild–moderate drinkers=1311 cm/s, and heavy drinkers=1337 cm/s, P<0.01) and that of rAI showed significant stepped increases in an alcohol dose-dependent manner in the entire cohort, but an increase in rAI was not observed in subjects aged ≥ 50 years. The estimated slope of the annual increase in baPWV, but not rAI, was higher for heavy drinkers than for non-drinkers (slope difference, 1.84; P<0.05), especially for subjects aged <50 years (slope difference, 2.84; P<0.05).Conclusion: In middle-aged male Japanese employees, alcohol intake may attenuate inflammatory activity. While alcohol intake may exacerbate the progression of arterial stiffening in a dose-dependent manner without mediating inflammation, especially in subjects under 50 years of age, it may promote pressure wave reflection abnormalities with aging at earlier ages without further exacerbation at older ages.

著者

Yasuhiro Nakano Mitsutaka Yamamoto Tetsuya Matoba Shunsuke Katsuki Soichi Nakashiro Susumu Takase Yusuke Akiyama Takuya Nagata Yasushi Mukai Shujiro Inoue Keiji Oi Taiki Higo Masao Takemoto Nobuhiro Suematsu Kenichi Eshima Kenji Miyata Makoto Usui Kenji Sadamatsu Toshiaki Kadokami Kiyoshi Hironaga Ikuyo Ichi Koji Todaka Junji Kishimoto Hiroyuki Tsutsui for the QcVIC Investigators

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.63507, (Released:2022-12-01)

参考文献数

18

被引用文献数

4

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Aim: Several clinical trials using intravascular ultrasound (IVUS) evaluation have demonstrated that intensive lipid-lowering therapy by statin or a combination therapy with statin and ezetimibe results in significant regression of coronary plaque volume. However, it remains unclear whether adding ezetimibe to statin therapy affects coronary plaque composition and the molecular mechanisms of plaque regression. We conducted this prospective IVUS analysis in a subgroup from the CuVIC trial. Methods: The CuVIC trial was a prospective randomized, open, blinded-endpoint trial conducted among 11 cardiovascular centers, where 260 patients with coronary artery disease who received coronary stenting were randomly allocated into either the statin group (S) or the combined statin and ezetimibe group (S+E). We enrolled 79 patients (S group, 39 patients; S+E group, 40 patients) in this substudy, for whom serial IVUS images of nonculprit lesion were available at both baseline and after 6-8 months of follow-up. Results: After the treatment period, the S+E group had significantly lower level of low-density lipoprotein cholesterol (LDL-C; 80.9±3.7 vs. 67.7±3.8 mg/dL, p=0.0143). Campesterol, a marker of cholesterol absorption, and oxysterols (β-epoxycholesterol, 4β-hydroxycholesterol, and 27-hydroxycholesterol) were also lower in the S +E group. IVUS analyses revealed greater plaque regression in the S+E group than in the S group (−6.14% vs. −1.18% for each group, p=0.042). It was noteworthy that the lowering of campesterol and 27-hydroxycholesterol, but not LDL-C, had a significant positive correlation with plaque regression. Conclusions: Compared with statin monotherapy, ezetimibe in combination with statin achieved significantly lower LDL-C, campesterol, and 27-hydroxycholesterol, which resulted in greater coronary plaque regression.