著者

Satoshi MATSUYAMA Yuko NAKANO Mieko NAKAMURA Ryohei YAMAMOTO Terumasa SHIMADA Fumihito OHASHI Kihei KUBO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0239, (Released:2014-10-14)

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Prohibitin is an antiproliferative protein that is a product of a putative tumor suppressor gene. However, there is little information on prohibitins in companion animals. In this study, we cloned canine prohibitin mRNA using RT-PCR and 3′-RACE (Rapid Amplification of cDNA Ends). The sequence was well conserved compared with those of other mammals, including human. The deduced amino acid sequence translated from the open reading frame completely corresponded to the human sequence. Canine prohibitin mRNA was expressed in all normal mammary and tumor samples examined. These results suggest that this protein plays a vital role in cell growth mechanisms and may be related to the occurrence of canine mammary tumors.

著者

Akihiko SUGIYAMA Sayaka HATA Kengo SUZUKI Eriko YOSHIDA Ryohei NAKANO Sharbanee MITRA Ryo ARASHIDA Yuta ASAYAMA Yukinori YABUTA Takashi TAKEUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.72, no.6, pp.755-763, 2010 (Released:2010-07-04)

参考文献数

49

被引用文献数

54 89

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Paramylon is a β-1,3-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (TNCB) in sensitized NC/Nga mice. The effects of paramylon were assessed by measuring macroscopical and histopathological findings of skin, ear swelling, serum levels of total IgE, interleukin-4 (IL-4) and interferon-γ (IFN-γ) and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon inhibited the development of AD-like skin lesions as exemplified by a significant decrease in dermatitis scores for the back, ear swelling and hypertrophy of the skin, infiltration of inflammatory cells in the skin, and serum IgE levels. Oral administration of paramylon reduced serum levels of both IL-4 and IFN-γ and IL-18 and IL-12 contents in the skin lesions. Oral administration of paramylon did not cause weight loss, as was observed with prednisolone. These results suggest that paramylon inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing both the T-helper (Th) 1 and Th 2 cell responses. Our results indicate that paramylon treatment could provide an effective alternative therapy for the management of AD.

著者

Yuuichi Nakano Mitsuo Iwadate Hideaki Umeyama Y-h. Taguchi

出版者

一般社団法人 情報処理学会

雑誌

IPSJ Transactions on Bioinformatics (ISSN:18826679)

巻号頁・発行日

vol.7, pp.2-15, 2014 (Released:2014-01-17)

参考文献数

15

被引用文献数

1

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Type III secretion system (T3SS) effector protein is a part of bacterial secretion systems. T3SS exists in the pathogenic and symbiotic bacteria. How the T3SS effector proteins in these two classes differ from each other should be interesting. In this paper, we successfully discriminated T3SS effector proteins between plant pathogenic, animal pathogenic and plant symbiotic bacteria based on feature vectors inferred computationally by Yahara et al. only from amino acid sequences. This suggests that these three classes of bacteria employ distinct T3SS effector proteins. We also hypothesized that the feature vector proposed by Yahara et al. represents protein structure, possibly protein folds defined in Structural Classification of Proteins (SCOP) database.

著者

Kumiko NAKANO Haruka KUBO Shigenobu MATSUMURA Tsukasa SAITO Tohru FUSHIKI

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.77, no.6, pp.1166-1170, 2013-06-23 (Released:2013-06-23)

参考文献数

24

被引用文献数

6

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The present study explored the possibility that aroma components generated by the oxidation of olive oil may enhance the palatability of olive oil. Using a mouse behavioral model, we found that olive oil oxidized at room temperature for 3 weeks after opening the package, and heated olive oil were both significantly preferred over non-oxidized olive oil. Furthermore, this preference was enhanced with an additive of oxidized refined olive oil flavoring preparation at a certain concentration. These results suggest that the aroma of oxidized fat might be present in most fats, and might act as a signal that makes possible the detection of fats or fatty acid sources.

著者

Haruka Sato Eri Eguchi Narumi Funakubo Hironori Nakano Hironori Imano Tetsuya Ohira

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.12, pp.607-617, 2023-12-05 (Released:2023-12-05)

参考文献数

46

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Background: The 2011 Great East Japan Earthquake has resulted in a nuclear accident, forcing residents of the surrounding areas to evacuate. To determine any association between excessive drinking and hypertension in the setting of disaster, we assessed whether the proportion of excessive drinkers increased and if post-disaster excessive drinking was a risk factor for hypertension.Methods: This retrospective study assessed data from the Japanese National Database. Cumulative population data for Fukushima Prefecture (3,497,576 people) were analyzed by categorizing residents into four areas—evacuation, coastal, central, and mountainous—to calculate the proportion of excessive, heavy (equivalent to binge drinking), and at-risk drinkers for 2008–2017. The hazard ratios (HRs) for the incidence of hypertension for 2012–2017 were examined in association with changes in drinking status pre- and post-disaster, which included 136,404 people who received specific health checkups pre-disaster (2008–2010) and post-disaster (2011–2012).Results: The proportion of excessive drinkers among women increased after the disaster in all areas examined. The association between excessive drinking and the incidence of hypertension was determined among men and women in all areas; it was stronger among women in the evacuation areas, with the sex- and age-adjusted HRs for the incidence of hypertension of 1.41 for pre-disaster excessive drinking, 2.34 for post-disaster excessive drinking, and 3.98 for pre- and post-disaster excessive drinking, compared with not excessive drinking pre- and post-disaster.Conclusion: Excessive drinking post-disaster may be associated with an increased risk of hypertension among men and women, especially among women in the evacuation areas.

著者

Yoshimi Nakano Maki Kawai Moeca Arai Sumire Fujiwara

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

vol.40, no.4, pp.337-344, 2023-12-25 (Released:2023-12-25)

参考文献数

26

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Correct flower organ formation at the right timing is one of the most important strategies for plants to achieve reproductive success. Ectopic overexpression of LATE FLOWERING (LATE) is known to induce late flowering, partly through suppressing expression of the florigen-encoding gene FLOWERING LOCUS T (FT) in Arabidopsis. LATE is one of the C2H2 zinc finger transcription factors, and it has a canonical transcriptional repression domain called the ethylene-responsive element-binding factor-associated amphiphilic repression (EAR) motif at the end of its C terminus. Therefore, LATE is considered a transcriptional repressor, but its molecular function remains unclear. Our genome-edited late mutants exhibited no distinct phenotype, even in flowering, indicating the presence of redundancy from other factors. To reveal the molecular function of LATE and factors working with it, we investigated its transcriptional activity and interactions with other proteins. Transactivation activity assay showed that LATE possesses transcriptional repression ability, which appears to be attributable to both the EAR motif and other sequences. Yeast two-hybrid assay showed the EAR motif-mediated interaction of LATE with TOPLESS, a transcriptional corepressor. Moreover, LATE could also interact with CRABS CLAW (CRC), one of the most important regulators of floral meristem determinacy, through sequences in LATE other than the EAR motif. Our findings demonstrated the possibility that LATE can form a transcriptional repression complex with CRC for floral meristem determinacy.

著者

Tomoko Sakai Chisato Hoshino Masanobu Hirao Megumi Nakano Yusuke Takashina Atsushi Okawa

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.8, pp.20230017, 2023 (Released:2023-06-14)

参考文献数

39

被引用文献数

1

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Objectives : We aimed to review the most recent articles on the rehabilitation of patients after coronavirus disease 2019 (COVID-19) and to identify the methods and effects of rehabilitation on such patients.Methods : A literature search was conducted using PubMed and Web of Science from study inception to October 2022 using the following search terms to identify meta-analyses and randomized controlled studies with abstracts written in English: [“COVID-19” or “COVID 19” or “2019-nCoV” or “SARS-CoV” or “novel coronavirus” or “SARS-CoV-2”] and [“rehabilitation”]. Publications investigating the effects of pulmonary and physical rehabilitation on patients with COVID-19 were extracted.Results: The extraction process selected four meta-analyses, two systematic reviews, two literature reviews, and two randomized controlled trials. Pulmonary rehabilitation recovered forced vital capacity (FVC), 6-min walk distance (6MWD), health-related quality of life (HRQOL), and dyspnea. Pulmonary rehabilitation increased predicted FVC, distance in the 6MWD test, and HRQOL score compared with baseline values. Physical rehabilitation, comprising aerobic exercises and resistance training, effectively improved fatigue, functional capacity, and quality of life with no adverse events. Telerehabilitation was an effective tool to provide rehabilitation for patients with COVID-19.Conclusions: Our study suggests that rehabilitation after COVID-19 should be considered an effective therapeutic strategy to improve the functional capacity and quality of life of patients with COVID-19.

著者

Yoshiharu Kawaguchi Masato Nakano Taketoshi Yasuda Shoji Seki Kayo Suzuki Yasuhito Yahara Hiroto Makino Masahiko Kanamori Tomoatsu Kimura

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

vol.1, no.4, pp.174-178, 2017-10-20 (Released:2017-11-27)

参考文献数

13

被引用文献数

1 1

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Introduction: In more than 20 years' follow-up after cervical laminoplasty, some patients died at an early stage, within 5 years postoperatively. The details remain unclear. This study was conducted to elucidate the clinical features in patients who died at an early stage after cervical laminoplasty to determine possible preventive measures against early death after surgery.Methods: A total of 74 patients who died with the follow-up period were included. The patients were divided into two groups: patients with a short survival period (S group, died ≤5 years after surgery) and patients with a long survival period (L group, died >5 years after surgery). Diseases, gender, age, causes of the death, general complications before surgery, and the pre- and postoperative JOA scores were compared between the two groups.Results: Eleven patients (15%) died within 5 years after laminoplasty. The average age at death in the S group was 68.7 years which was considerably younger than that in the L group (80.2 years). The ratio of pneumonia was higher in the S group, compared to that in the L group. Postoperative JOA score in the S group was lower than that in the L group.Conclusions: 11 patients out of 74 patients (15%) died within 5 years after laminoplasty. The average age at the death in the S group was much younger than that in the L group. The postoperative JOA score in the S group was lower than that in the L group. As pneumonia was more prevalent in the S group, it might be reasonable to give the information for the protection of pneumonia after cervical laminoplasty.

著者

Koji Tamai Hidetomi Terai Akinobu Suzuki Hiroaki Nakamura Masaomi Yamashita Yawara Eguchi Shiro Imagama Kei Ando Kazuyoshi Kobayashi Morio Matsumoto Ken Ishii Tomohiro Hikata Shoji Seki Masaaki Aramomi Tetsuhiro Ishikawa Atsushi Kimura Hirokazu Inoue Gen Inoue Masayuki Miyagi Wataru Saito Kei Yamada Michio Hongo Kenji Endo Hidekazu Suzuki Atsushi Nakano Kazuyuki Watanabe Junichi Ohya Hirotaka Chikuda Yasuchika Aoki Masayuki Shimizu Toshimasa Futatsugi Keijiro Mukaiyama Masaichi Hasegawa Katsuhito Kiyasu Haku Iizuka Kotaro Nishida Kenichiro Kakutani Hideaki Nakajima Hideki Murakami Satoru Demura Satoshi Kato Katsuhito Yoshioka Takashi Namikawa Kei Watanabe Kazuyoshi Nakanishi Yukihiro Nakagawa Mitsunori Yoshimoto Hiroyasu Fujiwara Norihiro Nishida Masataka Sakane Masashi Yamazaki Takashi Kaito Takeo Furuya Sumihisa Orita Seiji Ohtori

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

vol.1, no.4, pp.179-184, 2017-10-20 (Released:2017-11-27)

参考文献数

26

被引用文献数

3 3

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Introduction: With an aging population, the proportion of patients aged ≥80 years requiring cervical surgery is increasing. Surgeons are concerned with the high incidence of complications in this population, because "age" itself has been reported as a strong risk factor for complications. However, it is still unknown which factors represent higher risk among these elderly patients. Therefore, this study was conducted to identify the risk factors related to surgical complications specific to elderly patients by analyzing the registry data of patients aged ≥80 years who underwent cervical surgery.Methods: We retrospectively studied multicenter collected registry data using multivariate analysis. Sixty-six patients aged ≥80 years who underwent cervical surgery and were followed up for more than one year were included in this study. Preoperative patient demographic data, including comorbidities and postoperative complications, were collected from multicenter registry data. Complications were considered as major if they required invasive intervention, caused prolonged morbidity, or resulted in prolongation of hospital stay. Logistic regression analysis was performed to analyze the risk factors for complications. A p-value of <0.05 was considered as statistically significant.Results: The total number of patients with complications was 21 (31.8%), with seven major (10.6%) and 14 minor (21.2%) complications. Multivariate logistic regression analysis, after adjusting for age, revealed two significant risk factors: preoperative cerebrovascular disorders (OR, 6.337; p=0.043) for overall complications and cancer history (OR, 8.168; p=0.021) for major complications. Age, presence of diabetes mellitus, and diagnosis were not significant predictive factors for complications in this study.Conclusions: Preoperative cerebrovascular disorders and cancer history were risk factors for complications after cervical surgery in patients over 80 years old. Surgeons should pay attention to these specific risk factors before performing cervical surgery in elderly patients.

著者

Tatsuya Maruhashi Masahiko Ogawa Yasuo Fukunaga Daisaku Kitaura Masato Kajikawa Shinji Kishimoto Yuji Takaeko Takayuki Yamaji Takahiro Harada Yu Hashimoto Yiming Han Aya Mizobuchi Farina Mohamad Yusoff Kazuaki Chayama Ayumu Nakashima Chikara Goto Kenichi Yoshimura Yukiko Nakano Yukihito Higashi

出版者

Japan Society for Vascular Failure

雑誌

Vascular Failure (ISSN:24324477)

巻号頁・発行日

vol.6, no.1, pp.14-19, 2022-12-25 (Released:2023-02-14)

参考文献数

15

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Background: Sleep apnea is an independent risk factor for motor vehicle accidents. We investigated the prevalence of sleep-disordered breathing (SDB) among commercial motor vehicle drivers in a transport company. Methods: Among 355 drivers in a transport company, 345 commercial motor vehicle drivers (mean age: 47.0±8.8 years, range: 21-71 years) underwent unattended out-of-center sleep testing using a type IV portable sleep monitor between September 2019 and November 2019.Results: The prevalence of oxygen desaturation index 3% (ODI3) score ≥15 was 17.7%. The prevalence of moderate-to-severe SDB, defined as respiratory event index (REI) score ≥15, was 31.9%. The prevalence of Epworth Sleepiness Scale (ESS) score ≥11 was 15.3%. There was no significant correlation between the ESS score and ODI3 (ρ=−0.05, P=0.40) or REI (ρ=−0.03, P=0.65) score. Multivariate analysis revealed that age (odds ratio [OR]: 1.05, 95% confidence interval [CI]: 1.02-1.09, P=0.002), body mass index (OR: 1.14, 95% CI: 1.05-1.23, P<0.001), and daily alcohol intake (OR: 1.98, 95% CI: 1.10-3.55, P=0.02) were significantly associated with moderate-to-severe SDB in drivers. The ESS score was not significantly associated with moderate-to-severe SDB (OR: 0.98, 95% CI: 0.93-1.05, P=0.70).Conclusions: Objective screening tests for sleep apnea such as unattended out-of-center sleep testing may be necessary to improve the health and safety of commercial motor vehicle drivers, especially middle-aged obese male drivers having daily alcohol intake.

著者

Hironori SAHARA Satoshi HOSODA Yoshiki SUGAWARA Masakatsu NAKANO Shinichi NAKASUKA

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.8, no.ists27, pp.Tu_1-Tu_4, 2010 (Released:2011-06-14)

参考文献数

1

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This paper proposes to hold “Ig Satellite Design Contest,” in order to expand our space utilization by means of content-based satellites in the stream of recent microsatellite development. Going back to the history of the recent microsatellite, such a content-based satellite is positioned as the third-generation one. Ig Satellite Design Contest stands on the position of the two policies, that is, the satellite is chip in porridge for practical effect, but is to bring pleasure or happiness to people, or to stimulate access to the space and our future space activities.

著者

Hironori SAHARA Satoshi HOSODA Yoshiki SUGAWARA Masakatsu NAKANO Shinichi NAKASUKA

出版者

THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES

雑誌

TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)

巻号頁・発行日

vol.10, no.ists28, pp.Tf_1-Tf_4, 2012 (Released:2012-03-29)

参考文献数

1

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We organize Ig Satellite Design Contest to collect the NEEDS and to establishment of NEEDS database for microsatellite. It will be polestar for the satellite developers. This paper shows an example of NEEDS collection and derivation of the key technologies from the NEEDS, which should offer a strategic direction to the SEEDS, the satellite developers for example.

著者

TAKEO OHNISHI KEN OHNISHI AKIHISA TAKAHASHI YOSHITAKA TANIGUCHI MASARU SATO TAMOTSU NAKANO SHUNJI NAGAOKA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.43, no.S, pp.S133-S136, 2002 (Released:2003-05-02)

参考文献数

7

被引用文献数

20

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Although physical monitoring of space radiation has been accomplished, we aim to measure exact DNA damage as caused by space radiation. If DNA damage is caused by space radiation, we can detect DNA damage dependent on the length of the space flight periods by using post-labeling methods. To detect DNA damage caused by space radiation, we placed fixed human cervical carcinoma (HeLa) cells in the Russian Mir space station for 40 days and in an American space shuttle for 9 days. After landing, we labeled space-radiation-induced DNA strand breaks by enzymatic incorporation of [3H]-dATP with terminal deoxyribo-nucleotidyl transferase (TdT). We detected DNA damage as many grains on fixed silver emulsion resulting from β-rays emitted from 3H-atoms in the nuclei of the cells placed in the Mir-station (J/Mir mission, STS-89), but detected hardly any in the ground control sample. In the space shuttle samples (S/MM-8), the number of cells having many grains was lower than that in the J/Mir mission samples. These results suggest that DNA damage is caused by space radiation and that it is dependent on the length of the space flight.

著者

Hiroaki MURAYAMA Kazuya KANEMARU Hideyuki YOSHIOKA Akira FUKAMACHI Tsuneo SHIMIZU Tomohiro OMATA Isao FUKASAWA Mitsuyasu NAGASAKA Shin NAKANO Yasuhiro ASARI Hiroyuki KINOUCHI

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2023-0004, (Released:2023-08-23)

参考文献数

43

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Aneurysmal subarachnoid hemorrhage (SAH) treatment has progressed, and patients are rapidly aging in Japan. Consequently, dynamic changes must have emerged in the clinical practice of SAH. This study aimed to elucidate chronological changes of aneurysmal SAH and the prognostic factors in the previous quarter century in Japan. We conducted a retrospective survey regarding aneurysmal SAH in eight institutions in Japan. The study included 848, 863, and 781 patients in the first (1989-1993), second (1999-2003), and third (2009-2013) periods, respectively. The chronological changes of factors that influenced the poor outcomes and differences between the nonelderly (<75 years) and elderly patients were investigated. Mean age was significantly higher in patients in the third period (61.4 years) than in those in the other two periods (first, 57.8 years; second, 59.5 years). During these periods, the proportion of good outcomes did not change; however, the mortality rate significantly decreased from 19% in the first period to 11% and 9.2% in the second and third periods, respectively. The poor outcome was mainly caused by the significantly higher incidence of systemic complication and procedural complication in the first period and the significantly lower incidence of delayed ischemic neurological deficit in the third period. The elderly patients had significantly poorer clinical outcomes than the nonelderly ones. During the last 25 years, the age of patients with aneurysmal SAH has rapidly increased. The study results may contribute to the improvement of the treatment strategy of SAH in advanced countries with a rapidly aging population.

著者

Kinuko Kimura Yoshio Nakano Kouji Matsuoka

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.105, no.1, pp.84-87, 1989-01-01 (Released:2008-11-18)

参考文献数

12

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The nucleotide ligation site of adenylylated glutamine synthetase, which contains a unique tyrosyl residue linked through a phosphodiester bond to 5'-AMP, was studied by digestion with three hydrolytic enzymes. The products on micrococcal nuclease digestion were adenosine and o-phosphotyrosyl glutamine synthetase. The Km for this macromolecular substrate with the nuclease was 40 μM, at pH 8.9. The glutamine synthetase activity was not affected by deadenosylation with the nuclease, in contrast to SVPDE digestion, with which the glutamine synthetase activity was markedly increased. The Km for the native adenylylated glutamine synthetase with the SVPDE was 36 μM, i. e., similar to that for the nuclease. When the isolated o-phosphotyrosyl enzyme was incubated with alkaline phosphatase at pH 7.2, the glutamine synthetase activity rapidly increased to the same level as that of the SVPDE treated enzyme. Furthermore, kinetic properties of the o-phosphotyrosyl glutamine synthetase were compared with those of the adenylylated enzyme. The optimum pH, apparent Km for each of three substrates, glutamate, ATP, and NH3, and Vmax were in good agreement, as to either Mg2+- or Mn2+-dependent biosynthetic activity. From these results we can conclude that the regulation of glutamine synthetase activitysimply requires the piosphorylation of the tyrosyl residue in each subunit, without recourse to adenylylation.

著者

Md. SHAHIDUZZAMAN Masahiro NAKANO Shinjiro UMEZU Makoto KARAKAWA Jean-Michel NUNZI Tetsuya TAIMA

出版者

The Imaging Society of Japan

雑誌

日本画像学会誌 (ISSN:13444425)

巻号頁・発行日

vol.62, no.3, pp.239-456, 2023-06-10 (Released:2023-06-10)

参考文献数

27

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The structure of the perovskite photoabsorber is one of the utmost key aspects to influence the performance of perovskite solar cells. However, it is quite challenging to attain perovskite films meeting of the essential properties scuh as, large grain sizes with few grain boundaries, high crystallinity and homogeneous morphology, by the present preparation methods. In this mini review, we report on the recent progress of perovskite nanostructured solar cells fabricated by simple, low-cost techniques, and their physical properties. We discuss challenges and future research direction for the fabrication of nanostructured perovskite solar cells.

著者

Nitaro Maekawa Ryo Sugawara Ryo Nakano Ryotaro Shino Kozue Sotome Akira Nakagiri Yuichi Oba

出版者

The Mycological Society of Japan

雑誌

Mycoscience (ISSN:13403540)

巻号頁・発行日

vol.64, no.4, pp.109-115, 2023-07-31 (Released:2023-07-31)

参考文献数

36

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Aleurodiscus sagittisporus sp. nov. is described and illustrated. This species is characterized by producing basidiomata with a monomitic hyphal system, clampless-septate hyphae, arrowhead-shaped, amyloid, finely verrucose basidiospores, gloeocystidia, dendrohyphidium-like branched paraphysoid hyphae, and variously shaped swelling cells in the hymenium. Phylogenetic analyses based on nuclear rDNA LSU and ITS sequences revealed that the species is distinct from the lineage of Aleurodiscus s. str. and related genera in the Aleurodiscus s. lat. clade. Basidiomata of A. sagittisporus have been collected only from dead petioles attached to living trees of Livistona chinensis var. subglobosa on Hachijo Island, Japan.

著者

Yujiro Nakano Chikara Komiya Hitomi Shimizu Hiroyuki Mishima Kumiko Shiba Kazutaka Tsujimoto Kenji Ikeda Kenichi Kashimada Sumito Dateki Koh-ichiro Yoshiura Yoshihiro Ogawa Tetsuya Yamada

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.67, no.11, pp.1099-1105, 2020 (Released:2020-11-28)

参考文献数

27

被引用文献数

3 3

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Sitosterolemia is caused by homozygous or compound heterozygous gene mutations in either ATP-binding cassette subfamily G member 5 (ABCG5) or 8 (ABCG8). Since ABCG5 and ABCG8 play pivotal roles in the excretion of neutral sterols into feces and bile, patients with sitosterolemia present elevated levels of serum plant sterols and in some cases also hypercholesterolemia. A 48-year-old woman was referred to our hospital for hypercholesterolemia. She had been misdiagnosed with familial hypercholesterolemia at the age of 20 and her serum low-density lipoprotein cholesterol (LDL-C) levels had remained about 200–300 mg/dL at the former clinic. Although the treatment of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors was ineffective, her serum LDL-C levels were normalized by ezetimibe, a cholesterol transporter inhibitor. We noticed that her serum sitosterol and campesterol levels were relatively high. Targeted analysis sequencing identified a novel heterozygous ABCG5 variant (c.203A>T; p.Ile68Asn) in the patient, whereas no mutations were found in low-density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 (PCSK9), or Niemann-Pick C1-like intracellular cholesterol transporter 1 (NPC1L1). While sitosterolemia is a rare disease, a recent study has reported that the incidence of loss-of-function mutation in the ABCG5 or ABCG8 gene is higher than we thought at 1 in 220 individuals. The present case suggests that serum plant sterol levels should be examined and ezetimibe treatment should be considered in patients with hypercholesterolemia who are resistant to HMG-CoA reductase inhibitors.

著者

Yoshiaki Nakano Yasuichi Nakayama

出版者

The International Academic Forum

雑誌

The IAFOR International Conference on Education – Hawaii 2019 (ISSN:21891036)

巻号頁・発行日

2019-01

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Japan played a major economic growth after the World War II, which could be realized with high industrial skill because of engineering education such as mechanical engineering and electrical engineering. However, in recent years, everyone agrees that the importance of information technology is rapidly increasing, while the industrial technology is also inevitable. Currently in Japan, IT education is responsible for the subject "Technology" in junior high schools and the subject "Informatics" in senior high schools. It is self-evident that excellent education relies heavily on excellent teachers. The recruitment of teachers in Japan is conducted for each prefectural board of education. The authors asked all the boards of education throughout the country to disclose information and investigated the present situation of hiring teachers. As a result, despite the fact that the number of faculty members in "Technology" in junior high schools and "Informatics" in senior high schools is much less than the required number, almost no faculty recruitment has been conducted, and as a result, It is clear that teachers of unrelated subjects doing classes or letting people without teacher's license temporarily take charge of classes. Because such an environment, class content is far from computer science in many cases, education is almost not done such as programming. Fulfilling the teacher recruitment and in-service teacher training and improving Japan's information technology capabilities, the authors are very worried about the future of Japan.

著者

Mahoko NAKANO

出版者

フェリス女学院大学

雑誌

フェリス女学院大学音楽学部紀要 (ISSN:13410601)

巻号頁・発行日

vol.23, pp.35-55, 2023-03