著者
Satomi Ishihara Shinya Hiramitsu Koshiro Kanaoka Mizuri Taki Hitoshi Nakagawa Tomoya Ueda Ayako Seno Taku Nishida Kenji Onoue Tsunenari Soeda Tomohito Ohtani Makoto Watanabe Rika Kawakami Yasushi Sakata Kazuomi Kario Yoshihiko Saito
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-22-0032, (Released:2022-05-25)
参考文献数
33
被引用文献数
4

Background: Although B-type natriuretic peptide (BNP) and N-terminal (NT)-proBNP are commonly used markers of heart failure, a simple conversion formula between these peptides has not yet been developed for clinical use.Methods and Results: A total of 9,394 samples were obtained from Nara Medical University, Jichi Medical University, and Osaka University. We randomly selected 70% for a derivation set to investigate a conversion formula from BNP to NT-proBNP using estimated glomerular filtration rate (eGFR) and body mass index (BMI); the remaining 30% was used as the internal validation set and we used a cohort study from Nara Medical University as an external validation set. Multivariate linear regression analysis revealed a new conversion formula: log NT-proBNP = 1.21 + 1.03 × log BNP − 0.009 × BMI − 0.007 × eGFR (r2=0.900, P<0.0001). The correlation coefficients between the actual and converted values of log NT-proBNP in the internal and external validation sets were 0.942 (P<0.0001) and 0.891 (P<0.0001), respectively. We applied this formula to samples obtained from patients administered with sacubitril/valsartan. After treatment initiation, NT-proBNP levels decreased and actual BNP levels increased. However, the calculated BNP levels decreased roughly parallel to the NT-proBNP levels.Conclusions: This new and simple conversion formula of BNP and NT-proBNP with eGFR and BMI is potentially useful in clinical practice.
著者
Kaeko Hirai Rika Kawakami Maki Nogi Satomi Ishihara Yukihiro Hashimoto Yasuki Nakada Hitoshi Nakagawa Tomoya Ueda Taku Nishida Kenji Onoue Tsunenari Soeda Satoshi Okayama Makoto Watanabe Hiroyuki Okura Yoshihiko Saito
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.3, no.7, pp.388-395, 2021-07-09 (Released:2021-07-09)
参考文献数
28
被引用文献数
1

Background:Atrial fibrillation (AF) and mitral regurgitation (MR) are frequently combined in patients with heart failure (HF). However, the effect of AF on the prognosis of patients with HF and MR remains unknown.Methods and Results:We studied 867 patients (mean age 73 years; 42.7% female) with acute decompensated HF (ADHF) in the NARA-HF registry. Patients were divided into 4 groups based on the presence or absence of AF and MR at discharge. Patients with severe MR were excluded. The primary endpoint was the composite of cardiovascular (CV) death and HF-related readmission. During the median follow-up of 621 days, 398 patients (45.9%) reached the primary endpoint. In patients with MR, AF was associated with a higher incidence of the primary endpoint regardless of left ventricular function; however, in patients without MR, AF was not associated with CV events. Cox multivariate analyses showed that the incidence of CV events was significantly higher in patients with AF and MR than in patients with MR but without AF (hazard ratio 1.381, P=0.036). Similar findings were obtained in subgroup analysis of patients with AF and only mild MR.Conclusions:The present study demonstrated that AF is associated with poor prognosis in patients with ADHF with mild to moderate MR, but not in those without MR.
著者
Hisashi Yoshimoto Ayumi Takayashiki Ryohei Goto Go Saito Kyoko Kawaida Rika Hieda Yoshihiro Kataoka Maie Aramaki Naoto Sakamoto Tetsuhiro Maeno Yoshinao Kobayashi Yousuke C. Takemura
出版者
東北ジャーナル刊行会
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.242, no.2, pp.157-163, 2017 (Released:2017-06-22)
参考文献数
30
被引用文献数
18

Alcohol-related injuries in college students are a major public health problem worldwide. We clarified the association between excessive drinking and alcohol-related injuries in Japanese college students. This was a cross-sectional study with a self-administered questionnaire. From January to March 2013, we sampled all college students and graduate students aged 20 years or older during annual health examinations at three colleges in Mie Prefecture in Japan. The questionnaire assessed the frequency of alcohol drinking, amount of alcohol consumed per day, binge drinking during the past year, alcohol-related injuries during the past year, and demographic data. Logistic regression analysis was conducted on the association between excessive alcohol use and alcohol-related injuries. A total of 2,842 students underwent health examinations, of whom 2,177 (76.6%) completed the questionnaire. Subjects included 1,219 men (56.0%) and 958 women (44.0%). Eighty-eight men (7.2%) and 93 women (9.7%) were classified as excessive weekly drinkers, while 693 men (56.8%) and 458 women (47.8%) were determined to be binge drinkers. Eighty-one men (6.6%) and 26 women (2.7%) had experienced alcohol-related injuries during the past year. In the logistic regression analysis, binge drinkers (odds ratio 25.6 [8.05-81.4]) and excessive weekly drinkers (odds ratio 3.83 [2.41-6.09]) had a history of significantly more alcohol-related injuries, even after adjusting for age and sex. In conclusion, alcohol-related injuries in college students in Japan were strongly associated with excessive drinking. As a strategy for preventing such injuries in this population, an interventional study is required to identify effective methods for reducing excessive alcohol use.
著者
Jun Suzuki Tadashi Yamakawa Mari Oba Jo Nagakura Erina Shigematsu Haruka Tamura Kenichiro Takahashi Yoshihisa Okamoto Rika Sakamoto Minori Shinoda Tatsuro Takano Kazuaki Kadonosono Yasuo Terauchi
出版者
The Japan Endocrine Society
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.66, no.11, pp.971-982, 2019 (Released:2019-11-28)
参考文献数
43
被引用文献数
11

The short-term efficacy and safety of insulin degludec U100 (IDeg) in patients with type 2 diabetes have not been reported widely. We compared insulin IDeg and insulin glargine U100 (IGla) for glycemic control and glucose variability in hospitalized patients with type 2 diabetes. In an open-label, multicenter, randomized controlled trial, 74 patients were randomly assigned to either the IDeg (36 patients) or IGla (38 patients) group and were administered with basal-bolus therapy during hospitalization. Following the start of the treatment, on day 11, glucose variability was assessed by continuous glucose monitoring. A fasting blood glucose level of 110 mg/dL and 2-hour postprandial blood glucose level of 180 mg/dL throughout at least one day during the observation period were achieved in 31.3% (10/32) and 30.6% (11/36) of the patients in the IDeg and IGla groups, respectively. The 6-point self-monitoring of blood glucose profiles showed a significant difference between the two groups. On day 7, the intra-day variation was larger in the IDeg group than in the IGla group. The incidence of hypoglycemia or glucose variability was comparable in the two groups. This study suggests that short-term efficacy and safety of IDeg and IGla in patients with type 2 diabetes during the initial phase of basal-bolus therapy were comparable, and these results can help in deciding which treatment to opt for.
著者
Shiojiri Kaori Ozawa Rika Yamashita Ken-Ichi Uefune Masayoshi Matsui Kenji Tsukamoto Chigen Tokumaru Susumu Takabayashi Junji
出版者
Springer Nature
雑誌
Scientific Reports (ISSN:20452322)
巻号頁・発行日
vol.7, 2017-01-30
被引用文献数
11

草刈りの匂いで作物の防衛力を強化 --草刈り時の匂いを受容した大豆株では葉と豆の被害が減少し、豆中のイソフラボン量が増加する--. 京都大学プレスリリース. 2017-02-01.
著者
Koshiro Kanaoka Tsunenari Soeda Satoshi Terasaki Yuichi Nishioka Tomoya Myojin Shinichiro Kubo Katsuki Okada Tatsuya Noda Makoto Watanabe Rika Kawakami Yasushi Sakata Tomoaki Imamura Yoshihiko Saito
出版者
The Japanese Circulation Society
雑誌
Circulation Reports (ISSN:24340790)
巻号頁・発行日
vol.3, no.3, pp.122-130, 2021-03-10 (Released:2021-03-10)
参考文献数
25
被引用文献数
15

Background:Although cardiac rehabilitation (CR) has been reported to be associated with better clinical outcomes in patients with cardiovascular diseases, there are few nationwide studies about CR participation by patients with coronary artery disease in Japan.Methods and Results:We performed a nationwide retrospective cohort study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan between April 2014 and March 2018. Patients were divided into 2 groups (acute coronary syndrome [ACS] and stable coronary artery disease [sCAD]), and the rates of participation in in- and outpatient CR after percutaneous coronary intervention (PCI) were investigated. Propensity score-matched analysis was performed and the association between outpatient CR participation and all-cause mortality 3 months after PCI was examined. Overall, 616,664 patients (ACS, n=202,853; sCAD, n=413,811) were analyzed. The participation rates of CR increased annually. The participation rate was higher for inpatient than outpatient CR in both the ACS (52% vs. 9%, respectively) and sCAD (15% vs. 3%, respectively) groups. Prognosis was better for patients with than without outpatient CR in both the ACS (hazard ratio [HR] 0.52; 95% confidence interval [CI] 0.47–0.59) and sCAD (HR 0.72; 95% CI 0.65–0.80) groups.Conclusions:Outpatient CR was associated with a better prognosis in patients with ACS or sCAD. The participation rates of outpatient CR following PCI were extremely low in Japan.
著者
Fumiaki Kato Nobuhiro Tanabe Keiichi Ishida Rika Suda Ayumi Sekine Rintaro Nishimura Takayuki Jujo Toshihiko Sugiura Seiichiro Sakao Koichiro Tatsumi
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-15-1208, (Released:2016-02-16)
参考文献数
21
被引用文献数
1 7

Background:The postoperative changes in the coagulation-fibrinolysis system and the association between the system and postoperative course of patients with chronic thromboembolic pulmonary hypertension (CTEPH) who have undergone pulmonary endarterectomy (PEA) remain unclear.Methods and Results:Between 1986 and 2013, 117 patients (55.1±11.2 years, preoperative mean pulmonary arterial pressure 46.5±10.5 mmHg) underwent PEA, and 15 patients died during the perioperative period. We studied the association between the preoperative coagulation-fibrinolysis markers and surgical outcomes of all patients, and the long-term outcomes of the 102 survivors from the date of PEA. We also investigated the postoperative changes in coagulation-fibrinolysis markers and their association with residual pulmonary hypertension (PH) in 20 consecutive patients. Only an elevated factor VIII level was associated with perioperative death. Thrombomodulin and plasminogen values were significantly increased after PEA. Univariate logistic regression analysis revealed that D-dimer positivity at follow-up was a risk factor for residual PH. Patients with both an elevated fibrinogen level (≥291 mg/dl [median]) and decreased plasminogen activity (<100% [median]) had significantly worse disease-specific survival than the other patients (5-year disease-specific survival: 84.0% vs. 100%, respectively; P=0.0041 [log-rank test]).Conclusions:Preoperatively high fibrinogen and low plasminogen values in patients with CTEPH are associated with poor long-term postoperative outcome. PEA benefited not only the pulmonary hemodynamics but also the coagulation-fibrinolysis system of patients.
著者
Jeong Hui Kim Ryosuke Kikuchi Atsuo Suzuki Rika Watarai Kaori Goto Yui Okumura Tadashi Matsushita
出版者
Japanese Society of Laboratory Medicine
雑誌
Laboratory Medicine International (ISSN:24368660)
巻号頁・発行日
vol.2, no.3, pp.60-66, 2023 (Released:2023-12-29)
参考文献数
24

The immune system produces antibodies following SARS-CoV-2 infection and vaccination. However, we lack comprehensive information about the humoral responses after infection and vaccination, which are similar but might differ in type or amount of produced antibodies. Therefore, we compared different types and amounts of antibodies produced by the immune system in response to infection versus those produced by BNT162b2 (Pfizer/BioNTech) vaccines. Our findings indicated that naturally infected individuals had 14-fold higher anti-SARS-CoV-2 spike protein (anti-S) and 41-fold higher anti-SARS-CoV-2 receptor-binding domain of the viral spike protein (anti-RBD) IgM titers than SARS-CoV-2-naïve vaccinees. Remarkably, naturally infected individuals maintained high levels of IgM antibody titers up to six weeks after symptom onset. A significantly rapid increase in anti-S IgG titers in primary infection was observed, eventually reaching a level similar to that in people who had third booster vaccination. This study revealed the characteristics of the target antigen and immunoglobulin isotypes after natural SARS-CoV-2 infection and COVID-19 vaccination.
著者
Shogo DOFUKU Daisuke SATO Rika NAKAMURA Shotaro OGAWA Seiei TORAZAWA Masayuki SATO Takahiro OTA
出版者
The Japan Neurosurgical Society
雑誌
Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日
pp.2022-0164, (Released:2022-10-13)
参考文献数
30
被引用文献数
7

Middle meningeal artery embolization (MMAE) for chronic subdural hematoma (CSDH) is a novel, minimally invasive treatment. The indications and treatment practices for MMAE are variable and remain controversial. This study aimed to evaluate a strategy involving sequential MMAE after burr hole surgery for treating recurrent CSDH. We performed a retrospective analysis of data from consecutive patients who had undergone MMAE using liquid embolic agents within approximately 2 weeks after burr hole surgery for recurrent CSDH from September 2020 to March 2022. We analyzed patient characteristics, procedural details, CSDH recurrence after MMAE, surgical rescue, and complications. Six of the nine patients who underwent MMAE for CSDH recurrence were male, and the median age was 85 (range, 70-94) years. Five of the nine patients were being administered antithrombotic agents. The median duration between the burr hole surgery and MMAE procedure was 10 (range, 3-25) days. Anterior and posterior convexity branches were targeted for embolization using low-concentration N-butyl cyanoacrylate (NBCA), and the abnormal vascular networks with a cotton wool appearance disappeared after embolization in all cases. The NBCA distribution was observed by high-resolution computed tomography during the procedure; in three of nine cases, the NBCA penetrated not only the MMA but also the inner membrane. No recurrence, surgical rescue, or complications were observed in any patient during the median follow-up period of 3 months. As a minimally invasive treatment for recurrent CSDH, sequential MMAE after burr hole surgery may be a safe and effective option for preventing recurrence.
著者
Goichi Beck Rika Yamashita Chizu Saeki Takuya Ogawa Mikito Shimizu Hideki Mochizuki
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.4601-20, (Released:2020-05-26)
参考文献数
23
被引用文献数
1

We herein report a 56-year-old Japanese woman who had been diagnosed with hereditary angioedema. She experienced progressing muscle weakness and pain in the upper and lower extremities. Blood tests revealed a marked increase in creatine kinase levels; however, myositis-specific autoantibodies were not detected. Serum C1-inhibitor activity and C4 levels were low. A muscle biopsy showed mild muscle fiber necrosis and C5b-9 deposition in the endomysial capillary vessel walls and sarcolemma, mimicking necrotizing myopathy. These results suggest that C1-inhibitor deficiency induces myositis-like symptoms through the activation of the complement pathway and deposition of the membrane attack complex in the muscles.
著者
Koji WADA Mikako ARAKIDA Rika WATANABE Motomi NEGISHI Jun SATO Akizumi TSUTSUMI
出版者
National Institute of Occupational Safety and Health
雑誌
Industrial Health (ISSN:00198366)
巻号頁・発行日
pp.2013-0016, (Released:2013-07-26)
被引用文献数
49 48

We aimed to determine the economic impact of absenteeism and presenteeism from five conditions potentially comorbid with depressive symptoms—back or neck disorders, depression, anxiety, or emotional disorders, chronic headaches, stomach or bowel disorders, and insomnia—among Japanese workers aged 18–59 yr. Participants from 19 workplaces anonymously completed Stanford Presenteeism Scale questionnaires. Participants identified one primary health condition and determined the resultant performance loss (0–100%) over the previous 4-wk period. We estimated the wage loss by gender, using 10-yr age bands. A total of 6,777 participants undertook the study. Of these, we extracted the data for those in the 18–59 yr age band who chose targeted primary health conditions (males 2,535; females 2,465). The primary health condition identified was back or neck disorders. We found that wage loss due to presenteeism and absenteeism per 100 workers across all 10-yr age bands was high for back or neck disorders. Wage loss per person was relatively high among those identifying depression, anxiety, or emotional disorders. These findings offer insight into developing strategies for workplace interventions on increasing work performance.
著者
Risa Tamura Mari Kuinose Rika Kurahashi Mari Furuya Masatoshi Amako
出版者
The Japanese Association of Rehabilitation Medicine
雑誌
Progress in Rehabilitation Medicine (ISSN:24321354)
巻号頁・発行日
vol.8, pp.20230043, 2023 (Released:2023-12-01)
参考文献数
21

Background: Functional neurological disorder (FND) is a clinical syndrome characterized by abnormal involuntary movements and specific clinical features that are incongruent with known neurologic diseases. Clinical information is lacking on outpatient rehabilitation for patients with FND.Case: A 28-year-old woman visited our hospital for gait disturbance. She had experienced an occupational accident 20 months earlier. Her injuries were relatively minor, but subsequently, she was unable to move her ankle voluntarily and began receiving workers’ compensation benefits. The patient had persistent gait disturbance and preferred to walk with an ankle–foot orthosis. However, at her first visit, her ankle could move while walking without her ankle brace. Nerve conduction studies showed no abnormalities. Shortly after receiving an explanation regarding the diagnosis of FND, the patient was able to move her ankle voluntarily; however, her gait disturbance was partially persistent. After outpatient rehabilitation, she was able to walk in different types of footwear without an ankle brace. Satisfied with the result, she agreed to end rehabilitation and her access to workers’ compensation.Discussion: After diagnosis and rehabilitation for FND following an occupational injury, our patient was eventually able to walk without an ankle brace. In this case, providing the patient with information regarding a diagnosis of FND and obtaining her informed consent for subsequent rehabilitation may have helped to improve the symptoms of FND.
著者
Kazuki Yamazaki Rika Kitamura Tomohiro Suzuki Takeshi Kurokura Kenji Yamane
出版者
The Japanese Society for Horticultural Science
雑誌
The Horticulture Journal (ISSN:21890102)
巻号頁・発行日
pp.QH-079, (Released:2023-10-14)

Gladiolus (Gladiolus spp.) florets exhibit low ethylene sensitivity. Accordingly, the wilting of their tepals is an ethylene-independent process. Both trehalose and cycloheximide can extend the vase life of gladiolus florets. Floral senescence is probably regulated by programmed cell death. However, senescence-related genes have not been thoroughly investigated, except in ethylene-sensitive species. In this study, we analyzed the expression of senescence-associated genes by conducting transcriptome (RNA-seq) analysis. First, we examined the effects of 0.1 M trehalose (Tre), 300 μM cycloheximide (CHI), and 50 μM chloramphenicol (CAP) treatments on postharvest quality and senescence-related gene expression in gladiolus ‘Fujinoyuki’ cut florets. The Tre and CHI treatments extended the vase life of gladiolus florets by about 1 day, i.e., 30% of Cont. Tepals were sampled at 0 days (0d) and 2 days (2d) post-treatment. The RNA-seq analysis of floret tissues generated 81,136 unique sequences. Moreover, 2,892, 4,670, and 57 differentially expressed genes were identified from the 0d_Control (Cont) vs 2d_Cont, 2d_Cont vs 2d_CHI, and 2d_Cont vs 2d_Tre comparisons, respectively. Gene Ontology (GO) analysis suggested that cysteine-type endopeptidase activity was significantly higher for 2d_Cont than for 0d. Additionally, the 0d vs 2d_Cont comparison showed the cell wall-related GO terms were more enriched for 2d_Cont. The Kyoto Encyclopedia of Genes and Genomes analysis revealed an increase in the expression of sucrose synthesis-related genes in the 2d_Cont samples. Among the genes involved in starch and sucrose metabolism, the genes mediating cell wall degradation were more actively expressed in the 2d_Cont samples than in the 2d_CHI samples. The fragments per kilobase per million reads (FPKM) values were used to select candidate senescence-related gene families, including the cysteine protease, invertase, peroxidase, pectinesterase, and transcription factor (NAC [no apical meristem (NAM), Arabidopsis transcription activation factor (ATAF), and cup-shaped cotyledon (CUC)] and WRKY) families. The expression levels of transcription factor genes, including NAC 048, 68, 073 and WRKY 6, 11, 24, were validated by qPCR. The expression of these NAC and WRKY transcription factor genes was upregulated by CHI, suggesting their involvement in senescence or side reactions in gladiolus tepals. This study revealed several candidate genes and associated GO terms for senescence of cut florets, but further study is needed, especially on key genes, including transcription factors.
著者
Akito Kato-Kataoka Masashi Sakai Rika Ebina Chiaki Nonaka Tsuguyoshi Asano Takashi Miyamori
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌
Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日
vol.47, no.3, pp.246-255, 2010 (Released:2010-10-29)
参考文献数
39
被引用文献数
52 72

Soybean-derived phosphatidylserine (Soy-PS) is a phosphatidylserine made from soybean lecithin by enzymatic reaction with L-serine. A double-blind, randomized controlled study was conducted to investigate the effects of Soy-PS on the cognitive functions of the elderly Japanese subjects with memory complaints. Seventy-eight elderly people with mild cognitive impairment (50–69 years old) were randomly allocated to take Soy-PS (100 mg, 300 mg/day) or placebo for 6 months. As a result, there was no difference in blood markers and vital signs during Soy-PS treatment and any side effect caused by Soy-PS treatment was not observed. Neuropsychological test scores were similarly increased in all groups including placebo group. However, in the subjects with relatively low score at baseline, the memory scores in PS treated groups were significantly increased against the baseline, while those of placebo group remained unchanged. And the memory improvements in Soy-PS-treated groups were mostly attributed to the increase in delayed verbal recall, a memory ability attenuated in the earliest stage of dementia. In conclusion, Soy-PS used in this study is considered as safety food ingredient and 6 months of Soy-PS supplementation could improve the memory functions of the elderly with memory complaints.