著者

吉廣 尚大 冨田 隆志 橋本 佳浩

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.42, no.6, pp.445-452, 2016-06-10 (Released:2017-06-10)

参考文献数

13

被引用文献数

5 2

---

This study investigated whether the review of systems (ROS), an evaluation method that covers all organ systems, improves the quality of pharmaceutical care provided in intensive care units (ICUs). We retrospectively examined patients from the respiratory and emergency intensive care departments admitted to the ICU of our hospital in 2012 (before the introduction of ROS; non-ROS group, n = 93) and in 2014 (after the introduction of ROS; ROS group, n = 65). The number of pharmaceutical interventions and adverse drug events prevented by pharmacists per 1000 patient days were higher in the ROS group (265.7 and 57.8 for the ROS group and 190.8 and 39.9 for the non-ROS group). Pharmacists' proposals were accepted at a significantly higher rate in the ROS group than in the non-ROS group (89.5% vs 72.3%, P < 0.01), and the accepted proposals in the ROS group were implemented for a wider range of organ systems. These results indicate that the ROS was helpful in terms of identifying the patients' clinical manifestations and evaluating the adequacy and safety of medication administered in the ICU, which resulted in improved and precise proposals by pharmacists. Moreover, the ROS approach introduced in this study was considered to be suitable for pharmaceutical activities in the ICU and to contribute to improving the quality of pharmaceutical care.

著者

山神 彰 山田 武宏 北川 善政 大廣 洋一 佐藤 淳 石黒 信久 今井 俊吾 小林 正紀 井関 健

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.45, no.5, pp.254-261, 2019-05-10 (Released:2020-05-10)

参考文献数

20

被引用文献数

2 4

---

Third-generation oral cephalosporins are broad-spectrum antimicrobial agents and constitute one of the most used antibiotic classes in Japan. In the “National Action Plan on Antimicrobial Resistance (AMR),” the Japanese government declared implementation of efforts to reduce the use of oral cephalosporins by 50% by 2020, compared to 2013. Antimicrobial resistance generally occurs due to inappropriate use or low-dosage exposure to antibiotic agents. Therefore, the choice of appropriate antibiotics is essential for implementing antimicrobial stewardship. To evaluate the prophylactic effects of antibiotics in impacted mandibular third molar surgery, we compared the rate of surgical site infection (SSI) in patients who were administered cefcapene-pivoxil (CFPN-PI) orally with that in patients who received amoxicillin (AMPC) orally. We conducted a retrospective study by reviewing the medical charts of patients from Hokkaido University Hospital from April 2016 to March 2017. The patients evaluated were classified into two groups: the AMPC group (n = 164) and the CFPN-PI group (n = 129). The SSI ratio of the CFPN-PI group was significantly higher than that of the AMPC group (CFPN-PI group, 11.6% (15/129); AMPC group, 2.4% (4/164); P = 0.002). Multivariate logistic regression analysis demonstrated that “use of CFPN-PI for prophylactic treatment” and “hospitalization after surgery” were independent factors related to the onset of SSI following impacted mandibular third molar surgery. These results demonstrated that AMPC was more effective than CFPN-PI in the prevention of SSI after impacted mandibular third molar surgery, and its regulated dosage can effectively contribute to the optimal use of antimicrobial prophylactic treatment.

著者

堀内 正子 相良 篤信 吉田 梨紗 小林 百代 竹ノ谷 文子 琉子 友男 小林 哲郎 仲間 若菜 黄 仁官 里 史明 湯本 哲郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.12, pp.659-666, 2021-12-10 (Released:2022-12-10)

参考文献数

15

---

The number of people taking nutritional supplements has increased rapidly due to heightened health consciousness; however, cases of doping through supplement intake have also increased. Therefore, pharmacists need to share not only instructions related to medication, but also anti-doping (AD) directions for supplements with athletes. However, reports on the use of supplements in athletes are limited, and the actual situation is unknown. Then, we conducted a questionnaire survey on 1,249 physical education university students regarding the use of supplements and their awareness on doping. We also examined the steps that need to be taken by pharmacists to facilitate AD.We found that 60% of the respondents had taken supplements, 50% of whom (i.e., 30% of the total respondents) continued to do so. Furthermore, 40% took multiple supplements and were at risk of ‘inadvertent doping.’ Most of the respondents took supplements for improving muscle strength, fatigue recovery, and malnutrition. Furthermore, friends and seniors were often the triggers for supplement intake, suggesting that leaders and teams were also involved. Since many respondents purchased supplements at drug stores, it is important for pharmacists to educate athletes and their leaders about AD. Further, supplements, like pharmaceuticals, are constantly advancing and therefore pharmacists need to expand their knowledge and strive to expand their role.

著者

高井 靖 梶間 勇樹 西川 英郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.7, pp.388-393, 2017-07-10 (Released:2018-07-10)

参考文献数

11

被引用文献数

1 2

---

This study examined the effects of continuous outpatient intervention by pharmacists on medication adherence in patients with heart failure after discharge. Data in the intervention group (n = 25) and non-intervention group (n = 25) were compared on admission (baseline) and after 6 months. Medication adherence was evaluated using the Morisky Medication Adherence Scale (MMAS-4). The number of medications and the medication regimen complexity index (MRCI) were examined as factors influencing such adherence. For statistical processing, the paired t-test was used to clarify differences in the means of dependent variables between before and after intervention in both groups. The significance level was set at 0.05. MMAS-4 scores significantly decreased after intervention in the intervention group, while MRCI scores markedly increased after it in the non-intervention group. In conclusion, regular intervention by pharmacists for outpatients with heart failure may improve medication adherence.

著者

佐藤 弘希 丸山 徹 小田切 陽子 三村 絵美子 河上 恵子 池田 倫子 岡山 善郎 安楽 誠 小田切 優樹

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.9, pp.940-945, 2006-09-10 (Released:2007-11-09)

参考文献数

25

被引用文献数

2 3

---

The results of a population pharmacokinetic (PPK) analysis for Japanese suggest that smoking and gender difference are factors influencing the clearance of olanzapine, an atypical antipsychotic drug. However, no post-marketing verification has been conducted regarding how these factors affect the prescribing of this drug by practicing physicians. We therefore conducted a retrospective analysis on the effects of smoking and gender difference on olanzapine dosages. The results showed that smokers received significantly higher doses of olanzapine than non-smokers and that males tended to receive higher doses of olanzapine than females. The dosage for male smokers, the highest dose group, was 1.3 times that for female non-smokers, the lowest dose group. These results showed good correspondence with those of the PPK analysis given in the package insert and suggests that PPK data could be useful information for the community pharmacist.

著者

遠山 泰崇 佐藤 雄己 鈴木 陽介 田辺 三思 竹中 隆一 和田 伸介 石井 圭亮 伊東 弘樹

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.8, pp.594-599, 2015-08-10 (Released:2016-08-10)

参考文献数

18

---

We report the cases of 10 patients with acute lithium intoxication who were treated over the past 6 years. The range of lithium overdose was 600 mg to 9,600 mg and the lithium concentration of all cases was greater than the toxic concentration. Three of the 10 cases were treated with fluid therapy. Another 3 cases were treated with continuous hemodiafiltration (CHDF). The rest were treated with hemodialysis (HD). The serum lithium concentration of the 3 patients with fluid therapy gradually decreased. However, it took 24 hours after the treatment to reach the therapeutic level in Case 2 since the slope was comparatively loose. In the meantime, the high lithium concentration of patients with CHDF (Cases 4, 8, 10) and HD rapidly decreased and it finally reached the therapeutic level. But a post-dialysis rebound effect in the lithium concentration was detected in Case 9. This report shows that CHDF and HD is an effective and sufficient treatment for lowering the serum concentration of lithium in a short period in acute lithium toxicity. As the serum lithium concentration of a patient with HD often rebounds and repeated or prolonged treatment may be required, we reaffirmed the patient's condition. Thus, completion of HD should be judged based on not only serum lithium concentration but also sufficient observation of the clinical course.

著者

半田 智子 柳沢 侑子 南 藍子 竹ノ内 敏孝 坂田 穣 村山 純一郎 原 和夫 前田 正輝 加藤 裕久

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.1, pp.35-46, 2014-01-10 (Released:2015-01-10)

参考文献数

8

---

The continual development of mobile technology and spread of mobile devices have led to the use of personal digital assistants (PDAs) in medical fields. In this report, we describe the applications of PDAs, such as smartphones, in pharmaceutical practice.Participants included pharmacists in university hospitals (n = 121), community pharmacies (n = 100), and 6th-year pharmacy students (n = 166) who had already successfully completed their clinical rotations. We conducted questionnaires regarding PDA use frequency and interest in future PDA use, which were evaluated using 4-point scales. These two variables were compared statistically between the university hospital pharmacists and community pharmacists. The data from the pharmacy students were analyzed separately using descriptive statistics.For university hospital pharmacists, the top use for PDAs was as a personal scheduler; for community pharmacists, it was as a dispensing error prevention system. Most university hospital pharmacists reported high interest in future PDA use, mainly for obtaining practice guidelines and obtaining package insert information, while community pharmacists would use PDAs to obtain package insert information. For pharmacy students, PDAs were most often used to obtain package insert information; furthermore, pharmacy students showed high interest in future PDA use during hospital and pharmacy clinical rotations.As six interests regarding the use of PDAs in future pharmaceutical practice differed between the university hospital and community pharmacists (P < 0.05), PDA software applications should be tailored for each medical setting.

著者

鈴木 門之 岸本 桂子 中西 弘和 福島 紀子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.6, pp.373-387, 2015-06-10 (Released:2016-06-10)

参考文献数

23

被引用文献数

1 2

---

We conducted a survey on veterinarians regarding the use of anticancer drugs in veterinary medicine and instructions to owners. Two-hundred veterinary hospitals were randomly selected from 438 hospitals, in Yokohama and Kawasaki City, Kanagawa, using a questionnaire, by visit distribution, and by mail recovery. The recovery rate was 62.5% (n = 125). In total, 103 veterinarians (82.4%) had anticancer drug use experience, 99 (96.1%) had injectable drug administration experience, and 81 (78.6%) had oral administration experience. In total, 97.0% of veterinarians used cyclophosphamide and vincristine, 90.9% used doxorubicin. As a precaution for oral drug administration and excrement disposal of anticancer drugs after administration, approximately 50% of veterinarians instructed the owners to “wash your hands well” and “wear gloves.” With regard to injections (n = 99), 86.7% of veterinarians answered it was under an “open environment,” 8.1% used “Luer Lock” syringe, and 67.7% prepared the vial product with “negative pressure.” With regard to protective equipment used during preparations, “single latex gloves,” “mask” was more than 50% respectively. With regard to the first learning experience about anticancer drugs, 24.8% learned when they were in university and, 70.4% learned after graduation. With regard to experience after graduation, 53.4% answered that they “took a workshop” ; the “Veterinary System Society” was the main workshop organizer and the “veterinarian” was the main instructor. In total, 66.9% wished to attend a workshop on anticancer drugs. Considering the results of this study, human medicine and veterinary medicine need coordination, and it is important to provide training and education.

著者

金田 達也 大谷 誠司 高根 浩 椎木 芳和 林原 正和 大坪 健司

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.3, pp.187-193, 2011 (Released:2012-04-25)

参考文献数

9

被引用文献数

2 2

---

To ensure the proper use of drugs,pharmacists must pay attention to drug incompatibility information.However,drug incompatibilityinformation relating to tablets or capsules in one-dose packages (DII) is not well understood.Therefore,weactively collected DII and shared it with Tottori West District pharmacists and investigated how they currently dispensedone-dose packages as well as their degree of understanding of DII.For sharing,we selected 3 combinations of one-dosepackage including the olmesartan medoxomil(OM)-metformin hydrochloride (MET) combination for which incompatibilityhad actually been reported in our area.Before sharing DII,hardly any of the pharmacists knew about such information inthe package inserts,suggesting that it was not widely available to them.Our sharing of DII enhanced understanding of itfor all combinations.Also,the dispensing of one-dose packages was improved in many hospitals and community pharmacies.This suggestedthat the active collection of DII and its sharing by pharmacists helped ensure proper drug use.However,we should shareDII continuously to achieve a thorough understanding of it and additional methods may be required (for example,makingpresentations at meetings) for this purpose.We should also actively collect DII because the DII in package inserts is insufficientto ensure proper drug use.

著者

向井 淳治 面谷 幸子 初田 泰敏 名德 倫明

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.45, no.8, pp.433-440, 2019-08-10 (Released:2020-08-10)

参考文献数

13

---

When press-through-package (PTP) sheets of similar appearance are divided into smaller sizes, their similarity increases. This in turn increases the probability of recognition errors. We created images of units of 10-, 6-, and 2-tablet PTP sheets of different colors and designs using a personal computer and then reduced their sizes in five steps. These images of different sizes were then arranged horizontally and presented to the study participants. Differences in recognizability were determined based on the percentages of correct recognition of the size differences. A logistic regression analysis showed that there were no interactions between the packaging units and the image reduction ratio to the original sizes of the PTP sheets. However, with respect to the main effect of the packaging units themselves, significant differences were observed based on the color or design of the PTP sheet, and recognizability deteriorated as the PTP sheets were further divided. As for the percentage of correct answers, right-left differences were observed in the identification of the presented images; this suggests the effect of ocular dominance.

著者

名徳 倫明 仲下 知佐子 北出 尚子 岡 隆志 中村 紗矢香 梅谷 亮介 瀬名波 宏昌 岩本 千晶 田河 みゆき 浦嶋 庸子 廣谷 芳彦

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.6, pp.334-343, 2014-06-10 (Released:2015-06-10)

参考文献数

18

被引用文献数

4 3

---

Pharmacists need to check prescriptions of parenteral lipid emulsions from various aspects due to the many difficulties that occur when administering them. Thus, we performed a questionnaire survey on the usage of and current involvement of pharmacists in administering parenteral lipid emulsions. Pharmaceutical departments of 381 institutions in Osaka Prefecture participated in this survey between June 1 and July 31, 2012. The questionnaire contained items including the characteristics of the hospital, usage of parenteral lipid emulsions, and current prescription-checking by pharmacists. A hundred and twelve institutions (29.4%) responded to the survey; parenteral lipid emulsions were used in 96 institutions. Some institutions appropriately used them but others did not. Additionally, in some institutions, pharmacists did not check the prescriptions for detailed items, such as the dosing rate and administration route. Furthermore, we observed a trend toward more items indicating the inappropriate use of these emulsions and less involvement of pharmacists in institutions without compared to with a nutrition support team (NST). These current situations were considered to largely relate to the number of pharmacists and whether NST therapists (pharmacists) are available. In the future, pharmacists should significantly contribute to nutritional and risk management in in-hospital team medicine.

著者

小森 由美子 赤澤 知美 森部 初美 荻野 賀子 劉 秀娥 二改 俊章

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.478-483, 2002-10-10 (Released:2011-03-04)

参考文献数

16

---

Medical workers are continually faced with determining the appropriate usage of disinfectants in the areas of hospital nursing and home health care. The present study has been designed to provide answers to such questions as “what kind of technique is best for intra-airway and oral aspiration ?” and “what is the most effective use of disinfectants during aspiration procedures to prevent infectious diseases ?” First, the microbial contamination of suction catheters and disinfectant solutions, which have been in use for 24 hours, were investigated. The results indicated contaminations in 50% of catheters and one of the disinfectant solutions, which were presumably caused by the different aspiration techniques of nurses.Experiments were designed to improve the manual, and the results presented to nurses and pharmacists. Additional items to the manual are : (1) The necessity of removing saliva and sputum from the catheter prior to rinsing with the disinfectant solution; (2) The appropriate volume of rinse water and disinfectant solution necessary to achieve a complete de-contamination of the catheter; (3) Preventive techniques used to avoid microbial contamination of disinfectant; (4) Disinfectant soaking techniques for the catheter; (5) Advice for hospital/home health care personnel regarding the proper bedside use of a catheter and disinfectant bottle to maintain appropriate hygienic conditions.The results and subsequent improvement of the instruction manual had a pronounced effect on both the aspiration techniques of nurses, and upon the attitude of pharmacists in our hospital. The pharmacists now realize their leading role in the effective and proper usage of disinfectants.

著者

黒田 明平 木下 歩美 椎 崇 社本 典子 三巻 祥浩

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.11, pp.619-629, 2017-11-10 (Released:2018-11-10)

参考文献数

17

被引用文献数

3 3

---

Pseudohyperaldosteronism and associated hypokalemia are serious adverse effects caused by glycyrrhizinic acid (GA) present in Kampo medicines containing Glycyrrhizae Radix (GR); GA is the major component of GR. To obtain knowledge about the effective and safe use of Kampo medicines, we analyzed the quantities of GA in Kampo medicines by HPLC. The quantities of GA in 13 Kampo decoctions containing GR (2-6 g/day) were found to be almost 2-3.5 fold higher than those of the corresponding Kampo extract products. Among the Kampo extract products containing GR (3 g/day), the GA quantity in Shoseiryuto was significantly lower compared with that in the others, and Pinelliae Tuber as well as Schisandrae Fructus were found to contribute to the decrease in GA quantity. The GA quantity in the Yokukansakachinpihange decoction was found to be lower than that in the Yokukansan decoction; this was caused by the presence of Pinelliae Tuber and Citri Unshiu Pericarpium. Analysis of inter-product variations in GA quantities among the Kampo extract products revealed a maximum 2.6-fold difference in the quantities in the Shoseiryuto extract products from different companies. Our analyses show that GA quantities in Kampo medicines are influenced by the presence of concomitant crude drug constituents. This results in differences in GA quantities between decoctions and extract products having the same Kampo formula, and also among the Kampo extract products from different companies. It is recommended that GA quantities in Kampo extract products should be presented to prevent the adverse effects caused by GA.

著者

出雲 信夫 重山 昌人 田口 真穂 長嶋 大地 長野 将大 菊池 絵里 橋口 宏司 藤澤 順 村田 実希郎 礒部 隆史 梶原 康宏 五十鈴川 和人 埴岡 伸光 渡邉 泰雄 寺町 ひとみ

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.42, no.4, pp.246-254, 2016-04-10 (Released:2017-04-10)

参考文献数

10

被引用文献数

4 3

---

Massive bleeding induced by disintegration of breast cancer tumors for 4 yrs (88 yrs-old lady) was treated by applying Mohs' paste (75g/45mL of Zinc complex). This huge site healed quickly and the healing effects were sustained for 48 days. Based on this clinical evidence, the hemostatic mechanism of Mohs' paste was evaluated using the hind limb ischemia model in mice. Unilateral hind limb ischemia was induced in 6 week-old male C57BL/6JJmsSlc mice by resecting the right femoral and saphenous arteries. Mice were painted once a day with Mohs' paste containing 0, 37.5, 50 and 62.5g/45mL of zinc after the surgery. Hind limb blood perfusion was measured by using a laser Doppler perfusion imaging system (moorLDI2-Ⅱλ : S/N 5489). To identify capillaries, the thigh muscles were harvested on Day 1 to make a tissue section and immunostained for CD31. One day after painting of Mohs' paste, blood flow suppression to the ischemic leg was significantly enhanced in a dose dependent manner. Furthermore, anti-CD31 immunostaining revealed that Mohs' paste decreased capillary density in the ischemic muscle. The results of both the clinical and animal studies suggest that Mohs' paste suppressed angiogenesis due to the acute effects of aggregated protein and the sustained effects of decreases of CD31.

著者

青木 悠 杉山 昌秀 依田 一美 星野 明子 跡部 治

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.6, pp.371-376, 2011 (Released:2012-08-25)

参考文献数

14

被引用文献数

1 1

---

When lansoprazole orally dispersing tablets (30 mg) are administered through a tube, a residue often remains in the syringe and tube because the tablets contain fine enteric granules which are nearly insoluble in water. As a solution, we added thickening agents and examined their effectiveness in reducing the residue in syringes.The amount of lansoprazole residue in syringes was 11.4±1.3 mg when the agents were not added (Group A) and 1.3±0.6 mg when the agents were added (Group B). For Group A, the residue from a single injection was approximately 30-40% of the total amount of lansoprazole, while there was almost no lansoprazole residue for Group B. Performed by nurses, tube administration took slightly longer for Group B - 51.4±5.5 sec for Group A and 70.8±6.1 sec for Group B.Our solution of just adding thickening agents improved the dispersivity of the drug in the suspension as well as the mobility of the drug suspension, by getting the particles and solvent traveling at the same speed. It enabled injection to be performed smoothly and decreased the amount of residue in the syringe. The addition of thickening agents is therefore useful in tube administration because avoiding any lansoprazole loss would help ensure that the expected efficacy is achieved, since this is dosedependent.

著者

荻田 義明 高橋 由里 本多 伴絵 吉川 循江 町田 良治 須藤 秀夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.7, pp.613-618, 2007 (Released:2009-09-04)

参考文献数

14

被引用文献数

2 1

---

White petrolatum is widely used as an ointment base.In this study,we examined the quality characteristics of pharmaceutical petrolatums and a cosmetic petrolatum.There are 6 brands of pharmaceutical white petrolatum which are Perfecta and White 1S made by Sonneborn Co.and Ultima,Snow,Snow V and Regent made by Penreco Co.<br>We measured the melting point and viscosity of the white petrolatums.Perfecta had the highest melting point and Ulitima had the lowest.Snow had the highest viscosity and Perfecta the lowest.These results show that the characteristics of white petolatums vary among brands.Spectrophotometry was used to evaluate potential allergenicity.For extracts of Ultima,Regent and a cosmetic petrolatum,absorption was not observed in the 260 to 270 nm range suggesting that Ultima,Regent and the cosmetic petrolatum have a low content of polycyclic aromatic hydrocarbons which cause skin irritation.Upon investigating the brands of white petrolatum used in the base of commercial ointments,we found that the brand of petrolatum varied among the ointments.In order to ensure the proper use of ointments,suitable ointments should therefore be selected in consideration of patient needs.

著者

高井 靖 梶間 勇樹

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.46, no.8, pp.446-451, 2020-08-10 (Released:2021-08-10)

参考文献数

7

被引用文献数

1

---

This study aims to evaluate the usefulness of the Medication Management Summary, which is a tool of information sharing between hospital pharmacists and pharmacists at insurance pharmacies, based on patient-centered outcomes. Patients whose hospital pharmacists provided the Medication Management Summary to the pharmacists at the insurance pharmacy were assigned to the Medication Management Summary group (Group A), and patients before the introduction of the Medication Management Summary were assigned to the control group (Group B). Each group consisted of 90 patients, among which 30 were cardiac arrest patients, 30 were ischemia heart disease patients, and 30 were arrhythmia patients. The primary endpoint was the number of events, and the secondary endpoints were the presence or absence of readmission, evaluation of medication adherence, and changes in the number of medications in 6 months. The information on the Medication Management Summary in Group A was as follows: medication changes: 20; start of medication: 43; adverse effects: 4; medication management: 29; adjustment of leftover medication: 8; monitoring: 6 (including duplicates). The number of events was significantly lower (P = 0.032) in Group A (2 events) compared to that in Group B (9 events). The number of patients who were readmitted to the hospital was not significantly different between Group A and Group B. The medication adherence was unchanged in Group A but significantly worsened in Group B (P = 0.001). The number of medications did not change significantly in both groups. In conclusion, the provision of the Medication Management Summary by hospital pharmacists to insurance pharmacy pharmacists can help control patient events.

著者

牧野 利明 中村 峰夫 野田 敏宏 高市 和之 井関 健

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.7, pp.505-510, 2005-07-10 (Released:2011-03-04)

参考文献数

3

被引用文献数

3 2

---

Dietary supplements are gaining wide popularity in Japan and are used by a large number of patients as self-medication. Though dietary supplements cannot be considered as drugs, patients expect pharmacological benefits from them since they usually have very little knowledge of their effects. Thus, pharmacists have the responsibility to expand their knowledge of dietary supplements so that they can give better advice to patients who are using them. However, only a limited amount of information on dietary supplements is available to pharmacists.In the present study, we evaluated the content and solubility of coenzyme Q10 (ubidecarenone, CoQ10) in dietary supplements. CoQ10 is not only used as a dietary supplement, it is also prescribed as a drug by physicians. CoQ10 preparations were ground up and various techniques were used to extract the active ingredient, among them extraction using solvents, ultrasonication and heat. We found that the prescription drug preparations containing CoQ10, both original and generic products, had exactly the same content as stated on the label and had good solubility. Though dietary supplements containing CoQ10 also had the exact content stated on their labels, they showed poor solubility. Such poor solubility would give rise to major differences in elution and bioavailability between dietary supplements and prescription drugs containing CoQ10.

著者

浦上 勇也 木村 功二 河田 由紀子 枯木 始 須﨑 晶子 河﨑 光彦 山本 和幸 飯原 なおみ

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.43, no.6, pp.344-350, 2017-06-10 (Released:2018-06-10)

参考文献数

12

被引用文献数

3 4

---

Pharmacists are expected to help reduce increasing healthcare costs. This study assessed the effects of pharmacists at community pharmacies checking for unused prescribed medications using a bag in which patients put medications (Setsuyaku Bag). We examined whether this check improved medication adherence and also measured the costs of the unused medications.Patients aged ≥ 20 years who brought the bag to community pharmacies were followed-up for 6 months. They took the bag to pharmacies if they had unused medications including those recently prescribed. Medication adherence scores at the first visit and after 6 months were assessed by patients (good 0–bad 4) and by pharmacists (good 1–bad 4). Changes in scores were analyzed using paired t-tests. Costs of unused medications were calculated, grouped as reused, saved, or discarded.The patient adherence score for 73 patients (mean age 71.3 years) decreased from a mean of 1.8, SE 0.1 at the first visit to 0.8, 0.1 at the 6-month visit (P < 0.001). The pharmacist adherence score also decreased over this period from a mean of 2.4, SE 0.1 to 1.5, 0.8 (P < 0.001). The mean cost of total unused medications during the 6-month per person was 9,962 yen: reused 6,523 yen (65.5%), saved 1,506 yen (15.1%), and discarded 1,933 yen (19.4%).Pharmacists' checkup for unused medications using a Setsuyaku Bag was likely to be effective for improving medication adherence, indicating that pharmacists can contribute indirectly to reducing healthcare costs through medication adherence and directly by lowering medication costs.

著者

腰山 節子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.39, no.8, pp.482-490, 2013-08-10 (Released:2014-08-10)

参考文献数

15

被引用文献数

1

---

For patients receiving prescriptions of inhaled steroids, gargling after completing inhalation is necessary to prevent adverse drug reactions, including oral problems (stomatitis caused by oral candidiasis, hoarseness, and pharyngolaryngeal irritation). However, it has been reported that many patients experience oral problems despite gargling considered to be appropriate after inhalation. A possible cause of these problems is dry mouth, which is one of the adverse drug reactions to anti-allergic drugs and leukotriene receptor antagonists frequently administered concomitantly. This study evaluated the relationship between the onset of oral problems and salivary secretion. In 531 patients receiving treatment for asthma, we conducted a questionnaire survey, measured salivary secretion, and examined prognostic factors for the onset of oral problems using simple and multiple regression analyses. The results revealed significant prognostic factors before adjustment to be the number of concomitant drugs other than anti-asthma drugs and decreased salivary secretion. Furthermore, independent significant prognostic factors after adjustment were age and decreased salivary secretion.These results suggested that oral care focusing on improvement of dry mouth and thorough instructions to younger patients would be effective for the prevention of oral problems. Based on the verification results obtained in this study, re-establishment of the current instructions for inhalation is considered to be necessary to support better treatment for asthma in the future.