著者

板垣鷹穂 著

出版者

岩波書店

巻号頁・発行日

1929

著者

波多倉志 著

出版者

海士町観光協会

巻号頁・発行日

1981

出版者

日本考古学会

巻号頁・発行日

vol.17(4), no.330, 1927-04

出版者

神奈川文化研究会

巻号頁・発行日

vol.(3月號), 0000

著者

古戎 道典 石田 貴之

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.155, no.4, pp.269-276, 2020 (Released:2020-07-01)

参考文献数

31

被引用文献数

3 3

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パーキンソン病は,運動緩慢,無動,振戦などの運動症状を主症状とする神経変性疾患である.中脳黒質のドパミン作動性神経細胞の変性脱落することにより,脳内のドパミンが枯渇し,大脳基底核の運動制御機能が異常になると考えられている.サフィナミドは,選択的で可逆的な新たなモノアミン酸化酵素B(MAO-B)阻害薬であり,ドパミン代謝酵素であるMAO-Bを阻害することで,脳内のドパミン量を増やすと考えられている.さらに本剤は,ナトリウムチャネル阻害作用やグルタミン酸放出抑制作用などの非ドパミン作用を有していることが特徴である.非臨床試験では,ドパミン作動性神経を破壊したラットやカニクイザルにサフィナミドが投与され,進行期のパーキンソン病症状であるウェアリングオフ様症状を改善することが示された.また,カニクイザルを用いた実験では,サフィナミドがレボドパに対する応答時間を延長すると同時に,レボドパ誘発性のジスキネジアを抑制した.これらの結果から,本剤は,MAO-B阻害作用による脳内ドパミン量の増加に加え,非ドパミン作用の影響を介した治療効果が期待できる.臨床試験では,サフィナミドがウェアリングオフを有するパーキンソン病患者のオン時間を延長し,Unified Parkinson’s Disease Rating Scale(UPDRS)Part III(運動機能検査)を改善させることが明らかにされ,パーキンソン病患者の日常生活の活動性を高めることが示された.この結果を受けて,本剤は,ウェアリングオフを有するパーキンソン病に対するレボドパ併用薬として,2019年9月に本邦で承認された.パーキンソン病治療の新たな選択肢として期待される.

著者

堀田 千絵 加藤 久恵 多鹿 秀継 十一 元三 八田 武志

出版者

奈良教育大学

雑誌

基盤研究(C)

巻号頁・発行日

2018-04-01

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本研究の目的は、学習力を支える高次認知機能としてのメタ認知の早期育成が、定型発達児のみならず発達障害児の予後の適応に多大な影響を与えることに鑑み、発達障害児のメタ認知活性化を促すことのできる学習支援法を開発し、当該幼児の小学校入学後までを見据え、その適切性を吟味することであった。その中で、幼児期からのメタ認知育成を可能にする学習支援法の1つとして「検索学習」の有効性を明らかにし現場で活用できる学習支援システムの土台を構築した。特に、食物連鎖に基づく課題を考案する過程で幼児期からのメタ認知の活性化には検索学習の3規定因が重要であることを明らかにした。特に、3規定因としては、第1に初回学習の徹底、第2に検索スケジュールの時間的分散、第3にフィードバックが効果の要となる点を明確にし、これらを組み込んだ学習支援システムを構築した。その成果を堀田・多鹿・加藤・八田(2020)に要約した。加えて申請者らは、検索学習の導入の仕方によっては有効に機能しない一部の発達症児の存在することも特定し、自閉スペクトラム症等の発達症の障害の程度のみならず、それ以外の個人を特定する個人差が影響する可能性を突き止めた。

著者

新日本文学会 [編]

出版者

新日本文学会

巻号頁・発行日

vol.46(10), no.520, 1991-10

出版者

神奈川文化研究会

著者

Vouクラブ

出版者

Vouクラブ

巻号頁・発行日

1935

出版者

スイングジャーナル社

巻号頁・発行日

vol.6, 1949-11

著者

須賀 音吉 滑石 直幸

出版者

公益社団法人 日本セラミックス協会

雑誌

窯業協會誌 (ISSN:00090255)

巻号頁・発行日

vol.62, no.695, pp.335-339, 1954-05-01 (Released:2010-04-30)

参考文献数

15

出版者

戦旗社

著者

倉賀野 妙子

出版者

一般社団法人 日本調理科学会

雑誌

日本調理科学会誌 (ISSN:13411535)

巻号頁・発行日

vol.28, no.4, pp.297-302, 1995-11-20 (Released:2013-04-26)

参考文献数

8

著者

Nanaka Yamaguchi Tatsuo Mano Ryo Ohtomo Hiroyuki Ishiura M. Asem Almansour Harushi Mori Junko Kanda Yuichiro Shirota Kenichiro Taira Teppei Morikawa Masako Ikemura Yasuo Yanagi Shigeo Murayama Jun Shimizu Yasuhisa Sakurai Shoji Tsuji Atsushi Iwata

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.23, pp.3459-3462, 2018-12-01 (Released:2018-12-01)

参考文献数

10

被引用文献数

6 20

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Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease with marked variety in its clinical manifestations. While characteristic neuroimaging and skin biopsy findings are important clues to the diagnosis, autopsy studies are still important for confirming the exact disease features. We herein report the case of a patient who received an antemortem diagnosis of familial NIID with dementia-dominant phenotype that was later confirmed by an autopsy. Our report is the first to document a case of autopsy-confirmed NIID involving both cognitive impairment and sensorimotor neuropathy.

著者

小宮山昌秀

出版者

写

巻号頁・発行日

vol.[8],

著者

佐藤 智美 佐藤 俊明 川瀬 博 植竹 富一

出版者

日本建築学会

雑誌

日本建築学会構造系論文集 (ISSN:13404202)

巻号頁・発行日

vol.63, no.506, pp.83-92, 1998-04-30 (Released:2017-02-02)

参考文献数

32

被引用文献数

2 2

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Using more than two hundred JMA-87 type strong-motion records we show that pseudo-velocity response spectra are noticeably different from Fourier acceleration spectra in several occasions because response spectra are sensitive to other frequency components or attenuation due to dispersion but insensitive to duration. Therefore, regression coefficients such as magnitude coefficients, attenuation coefficient, and site amplification factors for response spectra and Fourier spectra show clear differences. We conclude that physical characteristics of strong motion cannot always be represented by the regression coefficients for response spectra.

著者

武田 真一 中田 慎二 田里 伊佐雄

出版者

The Ceramic Society of Japan

雑誌

Journal of the Ceramic Society of Japan (日本セラミックス協会学術論文誌) (ISSN:09145400)

巻号頁・発行日

vol.99, no.1146, pp.141-145, 1991-02-01 (Released:2010-08-06)

参考文献数

31

被引用文献数

1 1

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Post-indentation slow crack growth in soda-lime-silica glass in various aqueous RNO3 (R+; Li+, Na+, K+, Rb+) solutions was investigated in order to understand the mechanism of stress corrosion of glass. The crack growth was found to depend on both the concentration and the nature of the supporting electrolytes. The crack growth was enhanced by the change in the concentration of alkali metal ions from 10-4-1M, and also by the nature of alkali metal ions in the order of Hofmeister series Li+<Na+<K+<Rb+ at the ion concentration of 10-2M. These behaviors showed that the results obtained can be interpreted in terms of the molecular structure of the glass/electrolyte interface based on the charged states.

著者

濱田幸弘 [著]

巻号頁・発行日

1997

著者

牟田 聡子 八藤後 猛

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.82, no.742, pp.3051-3060, 2017 (Released:2017-12-30)

参考文献数

10

被引用文献数

1 1

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Past studies, including “Ken Yokoi: Fundamental Investigation of Evaluating Method of Safety in Building During Childcare” (2011), and “Mai Kanto: A fundamental study on living environment preparation for the life difficulty of a pregnant woman” (2004), have reported regarding accidents that occur during pregnancy and the difficulty in performing activities of daily living (ADL) but have not examined the causes of accidents. We first identified the types of accidents that occur during pregnancy and then examined the difficulties in performing ADL. Furthermore, to identify physical changes in pregnant women, we examined abdominal circumference (AC) and body weight. We also evaluated the relationship between physical changes and domestic accidents, as well as ADL, to clarify where accidents occur inside and outside of the home and how accidents can be attributed to physical changes. The survey included 490 women aged 20-44 years who were at 12 to 39 weeks' gestation. The women were categorized in seven groups at 4-week increments of pregnancy, with 70 women per group. Accidents experienced within 1 month of the survey date were considered. The main survey items were subject attributes (age, week of pregnancy, body weight, and AC). Thirty items were regarding difficulty in performing ADL (21 items for ADL performed at home and 9 for ADL performed outside of the home) and 50 items were regarding accidents (37 items for accidents occurring at home and 13 for those occurring out-side of the home). Our survey results revealed the following five findings. 1. The relationship among body weight changes, difficulty in performing ADL, and accidents experienced Women who gained more weight compared with their pre-pregnancy weight experienced a higher number of accidents or events predictive of accidents. However, no relationship was observed between difficulty in performing ADL and accidents experienced. 2. The relationship among AC change, difficulty in performing ADL, and accidents experienced As AC increased with the duration of pregnancy, the difficulty in performing ADL increased. However, although the rates of accidents and events predictive of accidents were high when AC was 80-89 cm (20-32 weeks' gestation), the rate of accident somewhat decreased as AC further increased. 3. Accident correlations For pregnant women who experienced accidents while “open and close the entrance door,” and “ascending/descending the front step,” as well as events predictive of accidents, other accidents could be predicted based on the details of such experiences owing to a marked correlation found with other accidents within the home. 4. Correlations with accidents according to changes in body weight and AC Again, women who gained more weight during pregnancy compared with their pre-pregnancy weight experienced a higher number of accidents or events predictive of accidents. As AC increased from 70-79 cm to 80-89 cm with the progression of pregnancy, the number of accidents increased, showing a strong correlation. However, as AC increased from 80-89 cm to 90- cm, the number of accidents decreased. 5. Locations of accidents according to changes in body weight and AC Accidents that tend to occur as AC increases include “<Collide> Kitchen: Cook” and “<Collide> Outside: Walk in a crowd.” Therefore, accidents commonly occur in places where the abdomen is more likely to bump into objects. Furthermore, the fact that a large number of women experienced events predictive of accidents indicates that accidents tend to occur when performing ADL while standing, such as “<Trip and fall down/Fall on the rear> Bathroom: Wash hair and body (while standing).”

著者

牟田 聡子 八藤後 猛

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.85, no.769, pp.473-483, 2020 (Released:2020-03-30)

参考文献数

11

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The authors previously reported results of a survey aimed at learning the background and causes of accidents or near accidents experienced by pregnant women. They found that accidents or near accidents among pregnant women were likely to occur from the 20th through 32th weeks of pregnancy or when there was substantial weight gain. This study investigated further details about environments at time of accidents or near accidents occurred based on the findings reported in the previous paper. We conducted a survey about pregnant women’s change in the body and their awareness of physiological changes due to pregnancy to determine reasons for accidents or near accidents. And the purpose was to explore cause of accidents or near accidents. First, Body Mass Index (BMI) was analyzed to assess the pregnant women’s pre-pregnant habitus. The results (N = 116) found that 72.4% of the women had normal body weights (BMI between 18.5 and 25.0) and 22.8% of the women had low body weights (lean type) (BMI less than 18.5). Then, the relationships between pre-pregnant habitus and post-pregnant body weight and abdominal circumference (AC) were investigated by pregnant period. We found that no significant relationship was found between weight gain, weight loss, or AC with the habitus. It was found that pregnant women tended to become aware of physiological changes as their pregnancies progressed, particularly in the lower part of the abdomen, and the extent of that awareness increased as the pregnancy progressed. Next, we learned the specific locations of accidents or near accidents in the house. We found that the extent of awareness of physiological changes was related as the cause of the events. The pregnant women who experienced accidents or near accidents tended to believe that these events had occurred because they lacked awareness of their physiological changes. The most frequent type of accident or near accident in the pregnant women’s houses was a fall down, which comprised 55.9% (N = 127) of all the accidents or near accidents. Falls most frequently occurred while descending stairs (26.0%, N = 127). In addition, the physical damage caused by falls was greater than the extent of damage caused by other types of accidents. The living room was the second most common place that accidents occurred (17.3%, N = 127). We assumed the living room was a frequent place where accidents or near accidents occurred because it often is used for multiple purposes, such as a child's playroom, the family’s common leisure place, and an indoor laundry area. In sum, pregnant women's accidents or near accidents were related to their physiological changes, particularly their habitus change and the rate of change. Regarding this finding, the period from the 6th to the 7th month of pregnancy was previously found to be the period when the habitus most significantly changed compared to pre-pregnancy (data from a retrospective study). When we examined the relationship between that finding and the numbers of accidents or near accidents in our study, a similar tendency was observed. In other words, the pregnant women were likely to experience accidents or near accidents between the 6th and 7th month when they were not fully aware of habitus changes. After the 7th month, the numbers of accidents or near accidents decreased as the women gradually became aware of their physiological changes.