著者

ダニエル・S.ハマーメッシュ著 望月衛訳

出版者

東洋経済新報社

巻号頁・発行日

2015

著者

岩井建樹著

出版者

朝日新聞出版

巻号頁・発行日

2019

著者

谷本奈穂著

出版者

新曜社

巻号頁・発行日

2019

著者

藤井輝明著

出版者

講談社

巻号頁・発行日

2008

著者

金森 耀平 村上 賢 松井 徹 舟場 正幸

出版者

日本微量栄養素学会

雑誌

微量栄養素研究 (ISSN:13462334)

巻号頁・発行日

vol.31, pp.88-98, 2014-12-15 (Released:2022-12-28)

参考文献数

76

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The liver-derived peptide hormone hepcidin is a master regulator of systemic iron homeostatis. Hepcidin binds to an iron exporter ferroportin expressing on the basolateral membrane of enterocytes and induces the internalization and degradation of ferroportin, leading to a decrease in intestinal iron absorption. Various stimuli such as body iron stores, inflammation, erythropoiesis, and hypoxia affect hepcidin expression through the transcriptional regulation. This mini-review summarizes current understandings on the factors affecting hepcidin expression.

出版者

商業界

巻号頁・発行日

1962

著者

日本経済新聞社編

出版者

日本経済新聞社

巻号頁・発行日

1975

著者

通商産業大臣官房調査統計部編

出版者

通商産業調査会

巻号頁・発行日

1972

著者

通商産業大臣官房調査統計部編

出版者

通商産業調査会

巻号頁・発行日

1997

著者

日本経済新聞社編

出版者

日本経済新聞社

巻号頁・発行日

2004

著者

橋山 富樹

出版者

公益社団法人 日本化学会

雑誌

化学と教育 (ISSN:03862151)

巻号頁・発行日

vol.47, no.11, pp.736-738, 1999-11-20 (Released:2017-07-11)

参考文献数

1

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国内外で高い評価を得ているカルシウム拮抗薬, ジルチアゼム(ヘルベッサー[○!R])の開発研究の動機と経緯について概説する。さらに, 1, 5-ベンゾチアゼピン誘導体と冠血管拡張作用との構造活性相関について説明する。つぎに, ジルチアゼムの従来の工業的合成法とその問題点について論ずる。問題解決のためには, エポキシドの開裂様式に関して, いままでの常識を打破した反応を開発しなければならなかった。鋭意努力の結果, スズ触媒反応を見いだし, 問題を解決することができ, その反応機構も明らかにすることができた。

著者

小森 貞男

出版者

岩手大学

雑誌

基盤研究(C)

巻号頁・発行日

2020-04-01

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リンゴ品種の遺伝子組成を変えずに目的遺伝子のみの改変を行うため、一過的な遺伝子発現によるゲノム編集を可能にする培養技術を開発する。「高頻度にシュートを形成する組織・細胞塊」を用いる方法として①DH個体の葯培養による胚様体の形成、②珠心細胞由来の胚様体の作出、③成長点に由来するカルスからのシュート形成に係る培養技術を開発し、「1細胞からのシュート再分化系」を用いる方法として④プロトプラストからの再分化系を確立し、パーティクルガン法等でRNPを細胞に導入する。①、②、③で得られたキメラ化したシュートは⑤キメラ解除の過程の体系化の実験で対応し、リンゴにおけるゲノム編集個体の獲得方法を確立する。

著者

大野 清隆 西尾 伸太郎

出版者

公益社団法人 日本薬学会

雑誌

MEDCHEM NEWS (ISSN:24328618)

巻号頁・発行日

vol.3, no.2, pp.37-42, 1993-04-15 (Released:2021-10-13)

参考文献数

9

著者

清水 俊夫

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.40, no.4, pp.580-584, 2023 (Released:2023-11-27)

参考文献数

52

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Weight loss is frequently observed in early–stage amyotrophic lateral sclerosis (ALS) and is considered an independent predictor of survival. Weight loss observed in ALS is associated with multifactorial etiology, including muscle wasting and dysphagia. Recent studies have implicated disease–specific hypermetabolism as one of causes of weight loss in ALS. Involvement of the hypothalamus in ALS has been the other topic in metabolic dysfunction in ALS. TDP–43 protein aggregates detected in the hypothalamic subnuclei may be associated with weight loss or abnormalities of eating behavior in patients with ALS. Nutritional intervention to maintain body weight could become one of disease–modifying therapies, and recent studies have reported that slowing of weight reduction rate after diagnosis was associated with better survival and that a high–calorie fat diet improved survival in patients with rapidly progressive disease. Nutritional education regarding a high–calorie diet, weight control, and early gastric tube placement is required at the time of diagnosis. Formulas to estimate the recommended daily energy intake for patients with early–stage ALS were reported from USA, Europe and Japan. Multidisciplinary team approach and rehabilitation is necessary to support patients with swallowing disturbance. Surgical intervention to prevent aspiration is often needed for patients who frequently develop aspiration pneumonia.

著者

仙石 錬平

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.40, no.4, pp.463-466, 2023 (Released:2023-11-27)

参考文献数

14

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One of the clinical characteristics of elderly Parkinson disease (PD) is an increased incidence of postural reflex impairment, falls, and freezing of gait compared to other age groups with PD. Aging is considered a risk factor for PD, in addition to genetic and environmental factors. Abnormal protein accumulation associated with aging has been observed in several proteins, including tau, amyloid beta, argyrophilic grains, and TDP–43, all of which show an increased incidence with age. However, the presence of Lewy pathology, a hallmark of PD, is reported to decrease after the age of 80, and may be absent in cases over 100 years old. Thus, it may be said that the pathological feature of PD in the elderly is characterized by the absence of Lewy pathology in cases over 100 years old.

著者

上野 真一 波田野 琢 服部 信孝

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.40, no.4, pp.455-457, 2023 (Released:2023-11-27)

参考文献数

15

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Parkinson disease (PD) is a neurodegenerative disease with various motor and non–motor symptoms such as bradykinesia, rigidity, tremor, constipation, sleep disturbance, cognitive dysfunction, and depression. Although multiple risk factors including aging, genetic predisposition, and environmental factors are involved in the pathogenesis of PD, the number of patients with PD has been increasing in recent years in the world. Previous reports have shown that the severity of PD is high in elderly patients from the early stage of the disease and that a particularly high percentage of them have symptoms such as impaired postural instability, freezing of gait, hallucination, and cognitive dysfunction that reduce their quality of life (QOL). In addition, it is necessary to take into account factors that may reduce motor function, such as frailty, cerebrovascular disease, and spinal disease, as well as the effects of multiple medications for comorbid diseases and the environment surrounding the patient, such as elderly caregivers. In this section, we discuss future issues, focusing on the epidemiology of PD.

著者

齊藤 勇二

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.40, no.4, pp.458-462, 2023 (Released:2023-11-27)

参考文献数

14

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The average life expectancy of Japanese people in 2021 is 81.47 years for men and 87.57 years for women. Because of recent improvements in nutrition and sanitation, as well as the advances in medical care, it is predicted that the average life expectancy will reach 100 years, so–called the era of 100–year–life. Although the lifespan is getting longer, very few people will be free from disorder throughout their lives, and the majority will live with various diseases, especially chronic diseases.Parkinson disease (PD) is the second most common, progressive neurodegenerative disorder, and its global incidence is on the rise, due to the aging of the world's population. “Elderly PD patients” are divided into two groups : patients with PD those who have been living with PD for a long time and those who develop PD at an old age. In the clinical practice for the elderly with PD, it is indispensable for clinicians to keep complex physical conditions, such as pharmacokinetics, comorbidities, and polypharmacy in “the elderly” in mind, as well as “PD” itself. In addition, reduced physical activity in the elderly could make it difficult to attend distant medical facilities; therefore, clinicians should provide PD care in their lives locally. In other words, the essence of clinical practice for the elderly with PD is not only to provide specialized “PD” treatment but also to treat and care for “the elderly”.In general, it is difficult to establish evidence in the medical field for the elderly, because each elderly has a wide variety of background factors, including comorbidities or polypharmacy, which could be biases in the clinical research. Japan is one of the first countries in the world to face a super–aging society, and we are in a position to establish evidence about the clinical practice for “the elderly patients with PD”. We need to discuss what we can and should do for the elderly patients with PD and to provide evidence, preparing for the world's PD pandemic.

著者

大野 佳美 原 一郎

出版者

Japan Oil Chemists' Society

雑誌

油化学 (ISSN:18842003)

巻号頁・発行日

vol.31, no.4, pp.238-242, 1982-04-20 (Released:2009-11-10)

参考文献数

23

著者

松永 一彦

出版者

公益社団法人 日本食品科学工学会

雑誌

日本食品科学工学会誌 (ISSN:1341027X)

巻号頁・発行日

vol.64, no.7, pp.385-388, 2017-07-15 (Released:2017-08-18)

参考文献数

9

被引用文献数

1

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Kagoshima no Tsubozukuri Kurozu was registered with the Japan Geographical Identification (GI) system on December 22, 2015. Kagoshima no Tsubozukuri Kurozu is a type of rice vinegar from Kagoshima Prefecture in southern Japan that is produced using a traditional method that has been handed down from one generation to the next. Tsubo and Kurozu are translated as earthen pots and black vinegar, respectively. The origin, history, and quality of GI-certified Kagoshima no Tsubozukuri Kurozu are reviewed herein.

著者

林 節男

出版者

美味技術学会

雑誌

美味技術学会誌 (ISSN:21867224)

巻号頁・発行日

vol.11, no.1, pp.64-69, 2012-04-30 (Released:2018-10-15)

参考文献数

8