著者

田之口 真理子 細野 江津子 北岡 真由子 有本 正生 山口 秀夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.7, pp.1873-1876, 1991-07-25 (Released:2008-03-31)

参考文献数

10

被引用文献数

8 11

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Two kinds of lignans were isolated from the seeds of Hernandia ovigera L. in addition to the nine lignans previously reported. One was confirmed as (-)-dimethylmatairesinol (11) and the other was identified as 5'-methoxypodorhizol (14) by comparison with the anthentic sample. An attempt at the cyclization of 14 afforded two compounds which were determined to be isohernandin (15) and an isomer of 15, 2-hydroxymethy 1-5, 6-methylenedioxy-7-methoxy-4-(3', 4', 5'-trimethoxyphenyl)-1, 2, 3, 4-tetrahydronaphthoic acid lactone (16).

著者

Kazuhiko KONDO Masaru OGURA Yuichiro MIDORIKAWA Mitsugi KOZAWA Hiroshi TSUJIBO Yoshihiko INMORI

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.52, no.10, pp.2673-2674, 1988 (Released:2006-04-05)

参考文献数

19

被引用文献数

4

著者

山口 秀夫 有本 正生 中島 淳二 田之口 眞理子 深田 能成

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.5, pp.2056-2060, 1986-05-25 (Released:2008-03-31)

参考文献数

16

被引用文献数

10 11

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Epipodophyllotoxin (EPT) and podophyllotoxin (PT) were prepared from desoxypodophyllotoxin (DPT), obtained from the seeds of Hernandia ovigera L. (Hernandiaceae) EPT was obtaind together with dehydrodesoxypodophyllotoxin (I) by a radical bromination of DPT with N-bromosuccinimide (NBS) followed by hydrolysis of the resultant 1-bromo-DPT, which was confirmed to be a mixture of 1α- and 1β-bromo compounds (7 : 3). EPT was oxidized with pyridinium chlorochromate to give podophyllotoxone (IV). The stereoselective reduction of IV to afford PT was examined with a variety of reagents, and borane-tert-butylamine complex was found to be effective.

著者

山口 秀夫 中島 淳二 有本 正生 田之口 真理子 石田 寿昌 井上 正敏

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.32, no.5, pp.1754-1760, 1984-05-25 (Released:2008-03-31)

参考文献数

18

被引用文献数

2 5

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Two kinds of 4-aryltetralin type lignans, β-peltatin-A methyl ether (I-A) and β-peltatin-B methyl ether (I-B), were synthesized from desoxypodophyllotoxin (DPT), which is available in large quantities from the seeds of Hernandia ovigera L. (Hernandiaceae). The syntheses were achieved via demethylene-DPT (IV), 8-bromo-demethylene-DPT (V) and 8-bromo-DPT (VI). Methylenation of V was carried out successfully by using cesium fluoride and methylene iodide in DMF. Compound I-B was readily obtained by the reaction of VI with cuprous iodide and sodium methoxide in the presence of pyridine. Synthesis of I-A was only achieved by the reaction of lithiated VI with nitrobenzene at-100°C in the presence of tetramethylethylene diamine, and I-A was obtained in low yield, together with I-B.

著者

山口 秀夫 有本 正生 田之口 眞理子 石田 寿昌 井上 正敏

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.30, no.9, pp.3212-3218, 1982-09-25 (Released:2008-03-31)

参考文献数

22

被引用文献数

12 21

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Two kinds of lignans were isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) besides the previously reported desoxypodophyllotoxin (DPT), desoxypicropodophyllin, bursehernin and podorhizol, and the structures of the lignans were clarified. One, C23H24O8, named hernandin, was identified as 5-methoxy-desoxypodophyllotoxin (I) by both chemical and X-ray crystallographic methods. The other, C22H18O7, was obtained by purification of a previously isolated impure substance, mp 270-275°C. This compound was identified as 1, 2, 3, 4-dehydrodesoxypodophyllotoxin (II). This is the first report of the natural occurrence of II in plants.

著者

MARIKO TANOGUCHI MASAO ARIMOTO HIDEYUKI SAIKA HIDEO YAMAGUCHI

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.10, pp.4162-4168, 1987-10-25 (Released:2009-10-19)

参考文献数

21

被引用文献数

17 29

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Three kinds of lignans, including a new lignan, named hernolactone, were isolated from the seeds of Hernandia ovigera L. besides six previously reported lignans, desoxypodophyllotoxin (DPT), desoxypicropodophyllin, bursehernin, podorhizol, hernandin and dehydro-DPT. The structure of hernolactone was determined as (2R, 3R) -3- (4′-hydroxy-3′, 5′-dimethoxybenzyl) -2- (3″, 4″, 5″-trimethoxybenzyl) -γ-butyrolactone (IV) and the other two lignans were identified as (-) -yatein ((-) -deoxypodorhizon) (V) and dehydropodophyllotoxin (IX).

著者

井藤 千裕 松井 卓哉 呉 天賞 古川 宏

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.5, pp.1318-1321, 1992-05-25 (Released:2008-03-31)

参考文献数

12

被引用文献数

10 19

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6, 7-Demethylenedesoxypodophyllotoxin (1) was isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) collected in Taiwan, together with several known lignans. This is the first example of the occurrence of 1 in a natural source. The assignments of the 13C-nuclear magnetic resonance signals of several podophyllotoxin analogues isolated from this plant were also established by means of two-dimensional H-C correlation spectroscopy (COSY) and H-C long range COSY techniques.

著者

山口 秀夫 有本 正生 田之口 真理子 沼田 敦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.101, no.5, pp.485-488, 1981-05-25 (Released:2008-05-30)

参考文献数

12

被引用文献数

5 7

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Two kinds of reactions were carried out on the components of the seeds of Hernandia ovigera L. The reaction of lead tetraacetate on desoxypodophyllotoxin (I) and its analogous compounds caused the cleavage of methylenedioxyl group, affording the corresponding diphenols. In the case of 3, 4-methylenedioxypropylbenzene (XII), an intermediate acetoxyl compound (XIII) was isolated. The reactions of 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) on I and its analogous compounds afforded smoothly aromatized compounds. By the same reaction on bursehernin (III), cyclization and aromatization occurred simultaneously affording chinensin (XVIII) which was confirmed by direct comparison with authentic speciemen. The results of the cleavage reaction on I and XII by use of borontrichloride were also described.

著者

山口 秀夫 有本 正生 山本 起巳子 沼田 敦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.99, no.6, pp.674-677, 1979-06-25 (Released:2008-05-30)

参考文献数

15

被引用文献数

12 14

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Four kinds of lignans were isolated from the seeds of Hernandia ovigera L. collected in Okinawa besides the previously reported desoxypodophyllotoxin (I). Oily substance II, named bursehernin, C21H22O6, was confirmed to be lignan-2 isolated from Bursera schlechtendalii. III, mp 171-173°, and IV, mp 125-126°, were determined as desoxypicropodophyllin and podorhizol obtained from Podophyllum emodi WALL. respectively. V, mp 270-275°, could not be clarified due to its small amount.

著者

西村 吉雄 齋藤 仁 好川 博 近藤 信一 竹内 富雄

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集 30 (ISSN:24331856)

巻号頁・発行日

pp.508-515, 1988-09-26 (Released:2017-08-18)

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The semi-synthetic podophyllotoxin glycosides, VP-16-213 (1) and VM-26 (2) showing a marked clinical efficacy and the intriguing mechanisms of action have stimulated interest in the synthesis of new active analogues of the podophyllotoxin glycoside. The systematic chemical modification of podophyllotoxins was studied. 1) Aminoglycosidic lignan variants (6, 7, etc.) of 4'-O-demethy1-1-epipodophyllotoxin were synthesized by a stereoselective BF_3-catalyzed coupling of 5 with the corresponding aminosugar derivatives. N-Alkylaminoglycosyl analogues (8, etc.) of 1 were also derived from 6. 2) Syntheses of all possible diastereomers (1, 6, 8, and 15-23) of 1, 6 and 8 were achieved via optical resolution of (±)-podophyllotoxin by glycosidation with D- and L-sugars. 3) Glycosidic variants of 1-β-hydroxy-α-peltatin and 1-β-hydroxy-8-O-methyl-a-peltatin (24-26) were synthesized by glycosidation of 28 and 29 with the corresponding sugar derivatives. 4) The syntheses of carbocyclic lignan variants (34-37) of 4'-O-demethyl-1-epipodophyllotoxin were achieved by coupling of 5 with chiral aminocyclitols. 5) 1-O-(2-Aminoethyl) ethers of 4'-O-demethyl-1-epipodophyllotoxin (38-42, etc.) were synthesized by coupling of 5 with the corresponding 2-aminoethanol derivatives, and with ethylene glycol followed by reductive amination of its aldehyde. Among all derivatives synthesized, 6 and 8 were found to have superior antitumor activity to 1.

著者

藤林 宏一 村崎 憲雄 松井 満

出版者

The Institute of Electrical Engineers of Japan

雑誌

電気学会論文誌. B (ISSN:03854213)

巻号頁・発行日

vol.105, no.10, pp.867-872, 1985-10-20 (Released:2008-12-19)

参考文献数

6

著者

馬場 始三 宇夫陽次朗 山口 英 篠田 陽一

出版者

一般社団法人情報処理学会

雑誌

情報処理学会研究報告マルチメディア通信と分散処理(DPS) (ISSN:09196072)

巻号頁・発行日

vol.1996, no.63, pp.79-84, 1996-07-12

参考文献数

3

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本稿では、ネットワーク中を移動するユーザの利便性や電子メールの到達性を向上させることを目的としてユービキタスな電子メールサービスを提案する。ネットワークを通じてメールサービス自体を移動する技術及び電子メールに限定したネットワークへのアクセス手段の導入によって、移動ユーザに適応した電子メールサービスを提供可能である。そのための要素技術として、メールリダイレクション機構とWWMB (orld Wide Mail Bo)を提案する。メールリダイレクション機構は、電子メールの経路の動的変更により効率的な配送を目的とする。WWMBは、ネットワーク分散型の仮想メールボックスで、ネットワークをリージョンという管理領域に分け、その内部のメールストレージ同士の協調と、リージョン同士の協調でユーザの移動に対応する。This paper describes the concept of new ubiquitous E-mail service and the technologies for realizing it. Ubiquitous E-mail service can support users to read their E-mail through any acccss point on Internet, and improvement reachability of E-mail service. This service is realized by introducing two technologies. One make it possible to transfer E-mail service its own somewhere through the network. Another technology present the special access method restricted to make use of E-mail service. The former is called "Mail redirection mechanism", which dynamically translate a distribution path of a E-mail. The latter is called "World Wide Mail Box". This consists of pseudo mail boxes distributed to the network. We introduce the concept of regions to manage the distributed mail boxes. There are some mail strages in one region. The mail storages exchange information with each other, and regions too. By doing so, WWMB provide the functions mentioned above.

著者

林 毅陸

出版者

三田学会

雑誌

三田学会雑誌 (ISSN:00266760)

巻号頁・発行日

vol.3, no.3, pp.286(64)-303(81), 1910-03

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論説

著者

三宅 雄彦

出版者

早稲田大学法学会

雑誌

早稲田法学 = The Waseda law review (ISSN:03890546)

巻号頁・発行日

vol.91, no.3, pp.103-135, 2016

著者

向井 陽祐 黒柳 ふみ 村林 学 渡部 博之 北井 則行

雑誌

岐阜歯科学会雑誌 = The Journal of Gifu Dental Society (ISSN:03850072)

巻号頁・発行日

vol.40, no.3, pp.283-288, 2014-02-20

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下顎左側側切歯の先天性欠如を伴う骨格性1級症例と診断された15歳9ヵ月の女子に対して上顎歯のストリッピングを併用した矯正歯科治療を行った。その結果、良好なオーバージェット、オーバーバイト、I級の犬歯・大臼歯関係および緊密な咬頭嵌合を得ることができた。保定開始から2年5ヵ月を経過し、現在も、安定した咬合関係を保っており、患者の十分な満足が得られた。

著者

閻 錫山

出版者

改造社

雑誌

改造

巻号頁・発行日

vol.32, no.6, pp.56-64, 1951-05

出版者

日経BP社

雑誌

日経情報ストラテジ- (ISSN:09175342)

巻号頁・発行日

no.73, pp.108-111, 1998-05

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社内に電子メールが普及し,いろいろな弊害が出てきた。大量のゴミメールに悩まされる。メール・ストーカーは現れる。あまり頼りすぎると,病気になってしまうこともある上司の名前は覚えておかないとA代:近頃,メールの数が増えてきたのよね。嬉しいんだけど,メールのアドレスだけでは,誰だか思い出せない人もいて。B美:メールは気軽だからね。

著者

長崎 二三夫

出版者

日本鱗翅学会

雑誌

やどりが (ISSN:0513417X)

巻号頁・発行日

vol.2013, no.236, pp.32-35, 2013-04-10 (Released:2017-08-19)

参考文献数

2

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Sasakia charonda is single brooded in nature. Very rarely second brood has been recorded under breeding condition in netted environment in extremely hot summer or in times when bright overnight garden light was nearby. In the fall of 2008, two males and four females of second brood emerged from successively breeding materials since 2006. After coupling one pair of these second broods, about 60 eggs were obtained which hatched in late October to early November. These larvae grew steadily but could only reach to second instar by December when natural defoliation of food plant Celtis sinensis began. For diapause to occur, growth to at least fourth instar is required (?). In breeding in the room, potted Celtis boninensis was used, which had renewed foliation under artificial condition in green house. Larvae grew slowly during winter without hibernation. In May, they pupated. Six males and three females emerged in mid May to early June. Sizes of emerged adults were intermediate between first and second brood. They were fertile and numerous additional second broods appeared in the following autumn which might suggest hereditary factor as a cause of second brood emergence.

著者

Fukushima Masayoshi

出版者

新潟大学大学院現代社会文化研究科

雑誌

現代社会文化研究 (ISSN:13458485)

巻号頁・発行日

no.60, pp.161-168, 2015-03

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本研究は、何故新興企業がライバル企業より利益率を早くそして高くあげることができるのかについて実証するため仮説と検証方法を提案することを目的とする。二つの対立的な概念を用いる。一つ目はレッドクイーン効果(RQE -攻めの競争行動)、二つ目はメールストローム効果(MSE-守りの戦略)である。RQE下でのDCと、MSE下でのDCでは、企業が得られる成果が全く異なることを論じる。DCは、急激な環境変化に対処するために内部と外部のコンピタスを統合、構築、再構成することができる企業の能力(Teece, 2009)をいう。ハイパー・コンペティション下の市場では積極的に攻めることがますます重要になってきている。しかしRQE下での行動は競争圧力を向上させ、競争者の数を増やし、行動のスピードも増すことになり、次第に企業業績に悪影響を及ぼす。利益率を上げるには攻めと守りの両立が解であることを分析し実証を次回の論文で明らかにする。

著者

佐々木 英哲

出版者

桃山学院大学

雑誌

人間文化研究 (ISSN:21889031)

巻号頁・発行日

no.1, pp.29-81, 2014-11-28

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Melville acquired the knowledge of Gnosticism in 1849, when he bought Dictionnaire historique et critique [The Historical and Critical Dictionary] by Pierre Bayle. Gnosticismmay have helped Melville unlock the door to a realm beyond the wall or the realm hidden behind the mask, the hidden knowledge. According to Foucault, knowledge in the ages from enlightenment to (post-) modernism was not so much truth or untruth as control and possession, in short, hegemonic power. Melville's attraction to Gnosticism is unsurprising if we recall that he possessed and was possessed with knowledge, but dispossessed of power (unpopular in literary circles) and destitute as a consequence. Curiously, however, the author allowed Pierre to nearly become a member of the mysterious mock-commune presided over by Plinlimmon, the man who happens to have the same given name as the third century anti-Gnostic, Plotinus. This paper tries to clarify (1) what factor(s) impel(s) Pierre to accept Isabel's /Plinlimmon's (anti-)Gnostic influence, (2) the direction in which Pierre finally goes, and (3) the pessimistic message, or oracle if you like, that Melville tries to transmit through Pierre's abrupt suicide, the nullification of his progress towards possible liberation for himself and his half-sister. Pierre is snugly bathed in "the brilliant chandeliers of the mansion of Saddle Meadow" as an inheritor-to-be. Pierre unknowingly follows the mode a white male (is forced to) make[s], the mode that perpetually (de)stabilizes his subject position, with recourse to false reality/ identity perception and / or reality/ identity fabrication. Pierre is too embarrassed to stay calm after hearing Isabel recount her life story. He tries to regain his subject position by stealing and lying beneath the "Terror Stone" or the "Memnon Stone" of the Delphi Omphalos (the "navel," or center of the world, in Greek). From there, Pierre says to Isabel, "[T]ell me every thing and any thing. I desire to know all." His burning desire for knowledge about Isabel's identity has a great deal to do with Foucauldian power-compared knowledge. As the intimacy with Isabel deepens, Pierre loses his subjective authority and veers towards Isabel, the representation of Gnosticism. Isabel appears in the occult atmosphere and misuses esotericism/ Gnosticism as an alternative to orthodox Christianity, leaving Pierre with an impression of epiphany, and thus prompting him to lean toward Gnosticism. Under her influence, he debunks his deceased father's genteel middle-class image, dethroning him to the equivalent of Demiurge. Moreover, Pierre is a symbolic look-alike of Simon Magus, the founder of Gnostic heresy, in gleaning inspiration from a suspicious (licentious) woman, Isabel (as Simon does from Helen(a)/Sophia). Imitating the Gnostic and dethroning his Demiurgeous father, Pierre flagrantly compares himself to "the heavenbegotten Christ" and falls into the fallacy of becoming the Demiurge or anti- God. Pierre happens to read a lecture pamphlet allegedly written by Plinlimmon and relapses again into the Anglo-European-centric mentality. This retreat is incited by Plinlimmon, the mysterious man whose surname sounds like Memnon (recalling the Memnon Stone that lies, according the Greek, in the center of the earth) and who shares the same given name as the anti-Gnostic Plotinus. Thus, Plinlimmon, the blue-eyed anti-Gnostic, is a stark opposite to Isabel, the "dark, olive cheek[ed]" (46) pro-Gnostic. Seen from another angle, this implies that Pierre, the nineteen-year-old preparing for initiation into mature adult life, desperately needs knowledge and mock-Messiahs to prop him up. The opposite two, the pro-Gnostic Isabel and the anti-Gnostic Plinlimmon, merge in Pierre's psyche. This is not necessarily to say that Pierre retreats to his starting point. Pierre holds himself so as not to entirely commit himself to the community provided over by Plinlimmon, the mock-utopia of sorts with its potential to change into a radically violent group. Pierre breaks this apparent vicious circle by taking poison from the bosom of Isabel. Thus, it turns out that unlike Foucault, Pierre exposes the inefficiency of Western knowledge, and that unlike Derrida and Levinas, Pierre exposes his pessimistic view about the futility of seeking (a) Messiah(s) in other being(s). He finally realizes that he is heading for a postmodern nowhere where one cannot or should not expect epiphany of a Messiah. In Pierre, Melville warned of the futility of Messiah-seeking. Melville could textually allow Pierre to solve his Messiah problem, but the author could not solve his own Messiah problem, the problem attributed to his traumatic experience of being virtually deserted by Hawthorne, the object of his love and worship.