著者

釜谷 昌幸

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集 (ISSN:21879761)

巻号頁・発行日

vol.84, no.858, pp.17-00457-17-00457, 2018 (Released:2018-02-25)

参考文献数

8

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Structural integrity of cracked pipes is assessed by predicting crack growth. In the fitness-for-service code of the Japan Society of Mechanical Engineers (JSME), the crack growth is predicted using stress intensity factor at the deepest and surface points. A semi-elliptical crack is assumed not to become deeper than a semi-circular crack. However, in reality, the stress corrosion cracking initiated at nickel alloy welds stops growing at the fusion line and becomes deeper than a semi-circular crack. Furthermore, crack shape is close to a rectangular shape rather than a semi-elliptical shape. In this study, validity of the JSME code procedure was discussed for predicting the growth of stress corrosion cracking at nickel alloy welds. Crack growth was simulated by finite element analysis together with an auto meshing technique. Various residual stress distributions and retardation of the crack growth at the fusion line were considered in the simulation. It was demonstrated that the growth prediction procedure prescribed in the JSME code brought about a conservative prediction even if the crack became deeper than the depth of a semi-circular shape crack. It was revealed that, when the growth to the surface direction was retarded at the fusion line, the change in crack size in the depth direction could be predicted conservatively by the current JSME procedure. It was suggested that, when the retardation at the fusion line is assumed in the growth prediction, the crack shape should be modelled by a rectangular shape.

著者

渡部 岳陽 後藤 真由美 須知 成光 廣田 千明 板垣 直行 金澤 伸浩

出版者

秋田県立大学(地域連携・研究推進センター)

雑誌

秋田県立大学ウェブジャーナルA(地域貢献部門) = Akita Prefectural University Web Journal A (Regional Contribution Activities)

巻号頁・発行日

vol.1, pp.128-137, 2014-03-31

出版者

写

出版者

日経BP社

雑誌

日経マネー (ISSN:09119361)

巻号頁・発行日

no.353, pp.82-88, 2012-04

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欧州の信用不安を抜本的に解決するには、金融機関に対する大規模な資本注入が必要だ。不安が緩和されれば、日本株も金融株をはじめ水準訂正に向けて動き出す。 こうした戻り高値の局面では、本来の企業価値から見て割安に放置されているバリュー株の水準訂正の期待が大きくなる。

著者

前田 満和

出版者

東京大学

巻号頁・発行日

1975

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博士論文

著者

池田 大四郎 味戸 慶一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.49, no.11, pp.1002-1012, 1991-11-01 (Released:2009-11-16)

参考文献数

46

被引用文献数

2 3

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Anthracycline antibiotics, adriamycin, daunomycin and aclacinomycin A, have been widely used in the clinical treatment of various tumor diseases. Recently, semisynthetic anthracyclines, pirarubicin and epirubicin having improved antitumor effects and reduced adverse reactions in comparison with the parent compound, have been launched into clinical chemotherapy. Furthermore, several semisynthetic agents are under the clinical trials (phase I or phase II stage). In our search for useful and orally absorbable analogs, we synthesized a new barminomycin analog and a number of pirarubicin analogs. Barminomycins I and II have the unique eight-membered acetal-azomethine ring structure and show the strong activity in vitro. A new barminomycin analog (1) has been synthesized through the hypothetical biogenic intermediate, 4'-O-glycosyldaunomycin (22). The activity of 1 in vitro is stronger than that of the parent daunomycin. The quantitative structure-activity relationships of orally absorbable pirarubicin analogs are also discussed. The gastrointestinal absorption of salicylidene analogs of pirarubicin depends on the van der Waals volume of the substituent (s) on the salicylidene moiety and the polarity of the molecule.

著者

上野 義仁 松田 彰

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.61, no.9, pp.890-899, 2003-09-01 (Released:2009-11-13)

参考文献数

59

被引用文献数

2 4

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最後に, 筆者らが合成したアナログを含むオリゴヌクレオチドの性質を図11 (+は二本鎖の熱的安定性あるいはヌクレアーゼ耐性が未修飾のオリゴヌクレオチドと比較して高いことを, 一は低いことを示す) にまとめて示した。糖部4ノα位にアミノエチル側鎖を導入したヌクレオシドを含むオリゴヌクレオチドは, 相補鎖RNAとの二本鎖の熱的安定性を若干低下させるものの, エンドおよびエキソの両ヌクレアーゼに対して高い耐性を示すこと, またRNase H活性を誘導することから現在リン酸ジエステル結合型アンチセンス分子として最も有望であると考えている。

著者

梅澤 一夫

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.49, no.11, pp.1062-1069, 1991-11-01 (Released:2009-11-16)

参考文献数

31

被引用文献数

1 2

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Streptomyces and other microorganisms produce antibiotics, anticancer agents and enzyme inhibitors as secondary metabolites. Microorganisms are a treasury of organic compounds which have various structures and biological activities. Therefore, isolation of the specific bioactive products in culture broths is dependent upon the testing method. Since oncogene theory has been extensively developed, we have screened oncogene function inhibitors as a new group of microbial secondary metabolites. Oncogene functions include acting as a modified growth factor receptor (erb B, erb B 2 fms), acting as a growth factor itself (sis, hst), the tyrosine kinase activity (src oncogene group), and acting as a G protein to activate phosphatidylinositol turnover (ras).Erbstatin is an inhibitor of erb B, erb B 2 and src products-associated tyrosine kinase. In cell culture it inhibited EGF receptor internalization, delayed the onset of EGF-induced DNA synthesis in quiescent cells, and induced normal phenotypes in src oncogene expressing cells. It inhibited the growth of human breast and esophageal carcinomas in nude mice. Lavendustin A was isolated from Streptomyces as a potent inhibitor of tyrosine kinase. It is a novel compound and about 50 times stronger than erbstatin in in vitro inhibition of tyrosine kinase. Many oncogenes including ras, src, sis, fms, and fes are considered to activate cellular phosphatidylinositol turnover. We have isolated psi-tectorigenin, inostamycin and piericidin B1 N-oxide as inhibitors of inositol incorporation into phospholipids. Thus, various inhibitors of oncogene functions including novel structures have been discovered in microbial secondary metabolites. They are useful for the dynamic study of oncogenes.

著者

向澤 彩 上木 耕一郎 諸井 明徳 岡部 克彦 高塚 茂行 中川 清昌 山本 悦秀

雑誌

日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine (ISSN:09149694)

巻号頁・発行日

vol.24, no.1, pp.71-77, 2011-02-20

参考文献数

10

出版者

写

巻号頁・発行日

vol.[124] (百七十六) (曹洞宗),

著者

仲上 健一 吉岡 泰亮 留野 僚也

出版者

立命館大学政策科学会

雑誌

政策科学 (ISSN:09194851)

巻号頁・発行日

vol.25, no.3, pp.273-290, 2018-03

著者

森 啓 MORI Kei

出版者

北海学園大学開発研究所

雑誌

開発論集 = The journal of development policy studies (ISSN:0288089X)

巻号頁・発行日

no.101, pp.53-77, 2018-03

出版者

近江屋九兵衛

巻号頁・発行日

1713

著者

水田 哲生

出版者

立命館大学政策科学会

雑誌

政策科学 (ISSN:09194851)

巻号頁・発行日

vol.25, no.3, pp.151-167, 2018-03

著者

金子 正勝 清水 文治

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.37, no.1, pp.40-56, 1979-01-01 (Released:2009-11-13)

参考文献数

120

被引用文献数

1 3

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Synthetic procedures of arabinofuranosyl nucleosides, especially, of arabinofuranosyl purine nucleosides are reviewed from the following points of view; i) methods which include nucleoside epoxide as an intermediate ii) direct condensation methods of arabinose derivatives and various purine bases iii) methods which include purine-8-cyclonucleosides as an intermediate and iv) other methods. Biological activities of arabinofuranosyl purine nucleosides are also summarized briefly.

著者

松田 彰

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.48, no.10, pp.907-920, 1990 (Released:2009-11-13)

参考文献数

135

被引用文献数

11 12

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Recent development in synthetic chemistry of the sugar moiety of nucleosides as potential anti-HIV agents has been reviwed. These include the chemical transformation of the sugar moiety of naturally-occurring nucleosides and the synthesis of carbocyclic nucleosides. Total syntheses of (-) -oxetanocin and its derivatives are also discussed.

著者

池原 森男 福井 寿一

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.37, no.11, pp.948-959, 1979-11-01 (Released:2009-11-13)

参考文献数

82

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Application of nucleic acid chemistry to drugs is discussed. The article contained 1) a survey of nucleobase and nucleoside analogs, which are used to anticancer and antiviral diseases ; 2) Application of oligo- and polynucleotides to medical purpose ; and 3) Use of gene recombinant technique for producing hormones etc.

著者

MASAO MIYAUCHI OSAMU KANNO ISAO KAWAMOTO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.50, no.9, pp.794-796, 1997-09-25 (Released:2006-11-25)

参考文献数

19

被引用文献数

7 8

著者

MASAO MIYAUCHI ROKURO ENDO MASAFUMI HISAOKA HIROSHI YASUDA ISAO KAWAMOTO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.50, no.5, pp.429-439, 1997-05-25 (Released:2006-11-25)

参考文献数

23

被引用文献数

16 25

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We have studied an ester prodrug of a carbapenem to develop a potent orally active β-lactam antibiotic. A variety of 1β-methylcarbapenem derivatives have been synthesized. We have found that some derivatives having an amide group in the C-2 side chain show potent and well balanced antibacterial activities as well as high stability against dehydropeptidase-I. Oral absorption of derivatives has been optimized by modifying the C-3 ester promoiety. Pivaloyloxymethyl (1R, 5S, 6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(R)-5-oxopyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylate, CS-834, has been selected as the most promising compound for further evaluation.

著者

宮内 正雄 笹原 邦宏 藤本 光一 川本 勲 井手 純也 中尾 英雄

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.37, no.9, pp.2369-2374, 1989-09-25 (Released:2008-03-31)

参考文献数

21

被引用文献数

10 9

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The degradation kinetics of pivaloyloxymethyl (POM) esters of cephalosporins in phosphate buffer solution (pH6-8) were investigated. The degradation of the starting Δ3 cephalosporin ester proceeded mainly via isomerization to the Δ2 ester and subsequent hydrolysis to the Δ2 acid. Hydrolysis to the Δ3 acid (the parent acid) was very slow. Analysis of the rate constants indicated that the isomerization rate k12 was approximately equal to the apparent degradation rate of the Δ3 ester kdeg, and slower than the hydrolysis rate of the Δ2 ester k24. The isomerization process to the Δ2 ester was found to be the rate-determining step in the degradation of cephalosporin esters. The substituent at the C-3 position of the cephalosporins affected the degradation kinetics. The degradation was accelerated by increase of pH, buffer concentartion and added protein.