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2 0 0 0 OA 低エネルギー電子による生体損傷機構の分子論的理解の深化

著者: 高柳敏幸
出版者: 埼玉大学
雑誌: 基盤研究(C)
巻号頁・発行日: 2012-04-01

放射線照射によって生成する低いエネルギーを有する2次電子が生体損傷を引き起こすことが指摘されているが、その動力学機構はほとんどわかっていない。本研究課題では、低エネルギー電子による生体分子損傷の反応動力学について、理論的な立場から研究を行った。塩基ペア等への余剰電子の束縛機構を量子化学計算によって明らかにし、さらに分子系の全自由度を量子力学的に取扱う動力学シミュレーションも行った。これにより、損傷ダイナミクスを実時間で追跡できるようになった

2020-01-10 18:35:15
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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24550008/

2 0 0 0 OA バイオクリーンルームでの歩行動作による塵埃飛散

著者: 小関弘展尾﨑誠
出版者: 日本関節病学会
雑誌: 日本関節病学会誌 (ISSN:18832873)
巻号頁・発行日: vol.37, no.2, pp.105-109, 2018 (Released:2019-07-31)
参考文献数: 17

Objective: The present study aimed to determine the generation and behavior of airborne particles that could carry microorganisms around the area of the feet while walking in a bio-clean operating room.Methods: Four surgical staff members performed four walking patterns comprising combinations of the following: independently or as a group, and entering or exiting the operating room.Results: Fine particle visualization and laser particle counts revealed large numbers of airborne particles on shoes, the hems of gowns, and the floor regardless of the walking pattern. Numerous airborne particles were generated by followers who walked in groups and even more particles were brought to the level of the operating table by groups compared to solitary walkers.Conclusion: Surgical staff should be aware of transferring airborne particles from non-sterile areas to reduce the incidence of contamination by airborne bacteria in bio-clean rooms.

2020-01-10 18:19:14
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2 0 0 0 OA 財政政策への視点 : 財政再建策の回顧と模索

著者: 尾崎護
出版者: 大蔵財務協会
巻号頁・発行日: 2001-02

制度:新 ; 文部省報告番号:乙1669号 ; 学位の種類:博士(法学) ; 授与年月日:2002-02-12 ; 早大学位記番号:新3285 概要書あり

2020-01-10 14:07:56
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http://hdl.handle.net/2065/49627

2 0 0 0 石川県の小学生と中学生の携帯電話についての意識調査

著者: 村井万寿夫
出版者: 金沢星稜大学人間科学会
雑誌: 金沢星稜大学人間科学研究 (ISSN:18824668)
巻号頁・発行日: vol.4, no.2, pp.45-48, 2011-03

2020-01-10 14:01:37
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https://ci.nii.ac.jp/naid/40018879887

2 0 0 0 OA 劣化油の生体免疫毒性

著者: 大荒田素子宮沢陽夫
出版者: Japan Oil Chemists' Society
雑誌: 油化学 (ISSN:18842003)
巻号頁・発行日: vol.39, no.6, pp.373-379, 1990-06-20 (Released:2009-10-16)
参考文献数: 40
被引用文献数: 4 6

Among the oxidation products of edible fats and oils, lipid hydroperoxides and the low-molecular-weight compounds containing short-chain aldehydes such as 4-hydroxynonenal are absorbed from the intestinal wall and carried into the internal organs with oral administration to rodents. Oral intake of lipid hydroperoxides or the low-molecular-weight compounds causes significant cytotoxic damage to the lymphoid tissues. The DNA synthesis of thymocytes is remarkably depressed and lymphocyte necrosis is observed in the thymus and intestinal Peyer's patches. In these cases, the mitogenic response to concanavalin A of splenocytes is increased. With long-term (90 d) feeding of slightly autoxidized soybean oil (peroxide value ; 150 meq/kg) in mice, the same symptoms as those mentioned above are observed. These findings indicate that oral intake of rancid oils give significant effects on immunocompetent cells and causes depression of the DNA synthesis of thymocytes, which would be one of the major cause for impairing immunocompetent systems in animals.

2020-01-10 12:41:11
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2 0 0 0 IR 梁実秋と人文主義

著者: 小島久代
出版者: お茶の水女子大学中国文学会
雑誌: お茶の水女子大学中国文学会報 (ISSN:02866889)
巻号頁・発行日: no.1, pp.81-104, 1982-04-29

2020-01-10 12:16:57
1 知恵袋
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https://ci.nii.ac.jp/naid/110005858932

2 0 0 0 OA N-Terminal Pro-B-Type Natriuretic Peptide Is a Predictor of Chronic Kidney Disease in an Asian General Population ― The Ohasama Study ―

著者: Shingo Nakayama Michihiro Satoh Hirohito Metoki Takahisa Murakami Kei Asayama Azusa Hara Takuo Hirose Ryusuke Inoue Megumi Tsubota-Utsugi Masahiro Kikuya Takefumi Mori Atsushi Hozawa Koichi Node Yutaka Imai Takayoshi Ohkubo
出版者: The Japanese Circulation Society
雑誌: Circulation Reports (ISSN:24340790)
巻号頁・発行日: vol.2, no.1, pp.24-32, 2020-01-10 (Released:2020-01-10)
参考文献数: 41
被引用文献数: 6

Background:N-terminal pro-B-type natriuretic peptide (NT-proBNP) is known to increase in heart failure patients. Given that no reports have described the association between NT-proBNP and chronic kidney disease (CKD) incidence in Asian populations, we investigated this association in the Japanese population.Methods and Results:We followed up 867 participants without CKD from the general population of Ohasama, Japan. We defined CKD as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2and/or proteinuria. In accordance with previous studies, the participants were classified into 4 groups according to NT-proBNP level (<30.0, 30.0–54.9, 55.0–124.9, and ≥125.0 pg/mL). The Cox model was applied to assess adjusted hazard ratios (HR) for CKD incidence after full adjustment including baseline eGFR. Participant mean age was 59.1 years, and 587 (67.7%) were women. During the mean follow-up period of 9.7 years, 177 participants developed CKD. When the group with NT-proBNP <30.0 pg/mL was used as the reference, adjusted HR for CKD incidence in the 30.0–54.9, 55.0–124.9, and ≥125.0 pg/mL groups were 1.34 (95% CI: 0.90–2.01), 1.25 (95% CI: 0.81–1.92), and 1.83 (95% CI: 1.05–3.18), respectively.Conclusions:NT-proBNP can be significantly predictive for CKD incidence in Asian populations.