著者

山岸 明彦 矢野 創 奥平 恭子 小林 憲正 横堀 伸一 田端 誠 河合 秀幸

出版者

日本宇宙生物科学会

雑誌

Biological Sciences in Space (ISSN:09149201)

巻号頁・発行日

vol.21, no.3, pp.67-75, 2007 (Released:2007-12-26)

参考文献数

21

被引用文献数

15 13 2

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TANPOPO, dandelion, is the name of a grass whose seeds with floss are spread by the wind. We propose the analyses of interplanetary migration of microbes, organic compounds and meteoroids on ISS-JEM. Ultra low density aerogel will be used to capture micrometeoroid and debris. Particles captured by aerogel will be used for several analyses after the initial inspection of the gel and tracks. Careful analysis of the tracks in the aerogel will provide the size and velocity dependence of debris flux. The particles will be analyzed for mineralogical, organic and microbiological characteristics. To test the survival of microbes in space environment, microbial cells will be exposed. Organic compounds are also exposed to evaluate the possible denaturation under the conditions. Aerogels are ready for production in Japan. Aerogels and trays are space proven. All the analytical techniques are ready.

著者

清水 早苗 山本 和彦 王 彩華 佐藤 雄隆 棚橋 英樹 丹羽 義典

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.124, no.6, pp.1288-1295, 2004 (Released:2004-09-01)

参考文献数

27

被引用文献数

1 1

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Moving object detection with a mobile image sensor is an important task in robotics and computer vision, when considering the practical use of robots in human environments. In this paper, we propose a robust method that detects moving objects in the environment using the omni-directional depth information obtained by a mobile Stereo Omni-directional System (SOS). In order to detect only the moving objects within the depth image that are obtained by a sensor in motion, we first estimate the ego-motion of the sensor, and generate a predicted depth image for the current time from the depth obtained at the previous time by only considering the ego-motion of the sensor. Then the predicted depth image is compared with the actual one obtained at the current time, and the inconsistent regions are detected as moving objects. When the senor moves, occlusions will occur in the scene and they will cause false detections. However, these false detections can be suppressed by estimating the occlusion regions using the ego-motion parameters of the sensor and the jump edges in the depth image. The effectiveness of the method is shown with the experiment results on a real environment.

著者

白井 宏樹 小堀 正人

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.1, pp.103-112, 2007-01-01 (Released:2007-01-01)

参考文献数

7

被引用文献数

1 1

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We describe the prospects of bioinformatics for drug discovery and discuss the current status, problems, and future direction of the interface between bioinformatics and docking studies. We also describe our recent work on sequence and structure analysis using the guanidino-modifying enzymes superfamily as a good example.

著者

Atsuya Takagi Akihiko Hirose Tetsuji Nishimura Nobutaka Fukumori Akio Ogata Norio Ohashi Satoshi Kitajima Jun Kanno

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.33, no.1, pp.105-116, 2008 (Released:2008-02-26)

参考文献数

22

被引用文献数

428 655

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Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/ carcinogenic properties, especially of their long-term biodurability, are fully assessed.

著者

上田 宏

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.1, pp.71-80, 2007 (Released:2007-01-01)

参考文献数

18

被引用文献数

4 6

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Proteins having multiple epitopes can be usually measured with sandwich ELISA employing two kinds of antibodies, which permits high sensitivity as well as a wide working range of more than three orders of magnitude. On the other hand, so-called monovalent antigens with MW less than 1000 are not susceptible to sandwich assays due to their small size and have almost always been measured in competitive assays. However, while a competitive assay needs only one antibody due to the principle of ratiometric measurement, optimization of the reaction conditions is necessary to attain suitable sensitivity and working range, which are often inferior to those of sandwich assays. As an alternative immunoassay for small antigens, here we propose a noncompetitive “open sandwich” immunoassay, which is based on the principle of stabilization of the antibody variable region Fv upon binding with antigen. Using ELISA to detect labeled VH fragments bound to immobilized VL in the presence of sample in microplate wells, various small molecules with MW around 200—300 can be measured with a superior detection limit and working range compared with those achieved with the corresponding competitive assays. The results indicate a common antigen recognition mode of anti-hapten antibody and wide applicability of the assay to the sensitive and handy analysis of low molecular-weight substances in areas such as environmental analysis and clinical diagnostics.

著者

Tatsuya SUZUKI Yuriko MUNAKATA Kazuki MORITA Tatsuya SHINODA Hiroshi UEDA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.23, no.1, pp.65-70, 2007 (Released:2007-01-10)

参考文献数

29

被引用文献数

23 41

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Zearalenone (ZEA) is an estrogenic mycotoxin produced by Fusarium sp., and its production on corn and small grains during storage has been of considerable concern. For sensitive ZEA detection, we applied an open sandwich (OS) immunoassay that can noncompetitively detect monovalent antigens utilizing an antigen-induced enhancement of the VH/VL interaction. We cloned the VH and VL cDNAs of anti-ZEA mAb to a split-Fv phagemid pKST2, and firstly both VH and VL fragments were displayed on M13 phage p9 and p7, respectively, using an amber suppressor, TG-1, as a host. The split-Fv phage showed specific binding to immobilized ZEA, which was well inhibited by free ZEA. Then, the VH/VL interaction and its antigen-dependency were analyzed using a non-suppressor HB2151 as a host to produce VH-displaying phage and his/myc-tagged soluble VL in the culture supernatant. By capturing VL with an anti-myc or -his antibody and probing bound VH-phage, ZEA was successfully detected with a superior detection limit as well as a wider working range than those of a competitive assay. Also, essentially the same results were reproduced with purified VH-alkaline phosphatase and MBP-VL fusion proteins.

著者

Midori YOSHIDA Takasumi SHIMOMOTO Sayumi KATASHIMA Gen WATANABE Kazuyoshi TAYA Akihiko MAEKAWA

出版者

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

vol.50, no.3, pp.349-360, 2004 (Released:2004-06-24)

参考文献数

56

被引用文献数

23 32

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Effects of maternal exposure to low doses of bisphenol A (BPA), including those comparable with human exposure levels, on growth and development of the female reproductive system and uterine carcinogenesis in Donryu rats were investigated. Dams were administered BPA (0, 0.006 and 6 mg/kg/day) daily by gavage from gestation day 2 up to the day before weaning (postnatal day 21 at offspring). The serum levels of BPA were significantly elevated in the dams receiving 6 mg/kg/day, however, BPA levels in the milk of dams, and those in the serum and liver of offspring were similar between control and treated groups. The treatment did not exert any influences on uterine development including weight, gland genesis and estrogen receptor α expression, vaginal opening and gonadotropin secretion in the female offspring up to puberty. After maturation, no effects were evident with regard to estrous cyclicity in female offspring treated with BPA. In addition, the treatment had no effects on age-related morphological changes of the reproductive and endocrine organs and uterine carcinogenesis until 15 months of age. The results demonstrate that maternal exposure to BPA at levels comparable to human exposure did not have any effects on the female reproductive system of offspring in rats. In addition, BPA was also found in the serum, milk and liver of control dams and pups, and low levels of BPA were detected in drinking water and pellet diet. The present study showed that the experimental animals were also exposed to environmental BPA in the animal room.

著者

加納 尚之 佐久間 研司 中島 健二

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.127, no.11, pp.1949-1950, 2007-11-01 (Released:2007-11-01)

参考文献数

2

被引用文献数

1

---

For communication of ALS patients, the authors put emphasis on ERP. This paper described that ALS patient could get high rate of correct judgment on the target word-specific experiment by detecting ERP. For practical use, it is very important that ALS patients can communicate with surrounding person smoothly. The authors discussed how to shorten the time to specify the target word, and discussed the prevention of misjudgment.

著者

菅井 清美

出版者

社団法人 繊維学会

雑誌

繊維学会誌 (ISSN:00379875)

巻号頁・発行日

vol.62, no.3, pp.P_66-P_71, 2006 (Released:2006-05-01)

著者

石原 研治

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.125, no.9, pp.717-723, 2005-09-01 (Released:2005-09-01)

参考文献数

36

被引用文献数

2 2

---

Eosinophils are one of the cells that play a critical role in the pathogenesis of allergic diseases. The increase in the number of eosinophils in such diseases is regulated by interleukin-5 (IL-5). The author have prepared recombinant rat IL-5 using a baculovirus expression system and examined its biological activities in rat eosinophils. It was demonstrated that recombinant rat IL-5 prolongs the survival of mature eosinophils and differentiates immature eosinophils into mature eosinophils, suggesting that rat IL-5 is a factor for eosinophilia in rats. Recombinant rat eosinophil-associated ribonuclease (Ear)-1 and Ear-2 were also prepared. Eosinophil granule proteins are thought to cause tissue damage due to their cytotoxic activity, but using recombinant rat Ear-1 and Ear-2, it was found that rat Ear-1 and Ear-2 have strong RNase A activity and bactericidal activity, suggesting that these proteins play critical roles in host defense. Finally, the important role of acetylation of histones was clarified in the differentiation of HL-60 clone 15 cells into eosinophils using the histone deacetylase inhibitors sodium n-butyrate, apicidin, and trichostatin A. These findings would be useful for further investigations of the role of eosinophils in allergic inflammation.

著者

安川 毅 藤井 智子

出版者

日本臨床麻酔学会

雑誌

日本臨床麻酔学会誌 (ISSN:02854945)

巻号頁・発行日

vol.25, no.1, pp.42-50, 2005 (Released:2005-03-25)

参考文献数

17

被引用文献数

2 2

---

手術中や集中治療領域において脳虚血の監視は近年, ますます重要となっている. 頸動脈内膜剥離術や上行・弓部大動脈人工血管置換術は, 術中に一時的に脳血流を遮断あるいは脳灌流を行うので, 脳虚血を監視するために術中モニタリングの工夫が試みられている. そのモニタリングの一つである近赤外分光法 (NIRS) は手技的に計測が簡単であり, 内頸動脈領域など局所脳動脈領域のモニタリングとして有用で, 他のモニターとの組み合わせにより信頼性を増す. しかし椎骨動脈領域を含む全脳のモニタリングには限界があり, 今後の検討が必要である.

著者

新保 史生

出版者

情報メディア学会

雑誌

情報メディア研究 (ISSN:13485857)

巻号頁・発行日

vol.4, no.1, pp.55-76, 2005 (Released:2006-03-27)

参考文献数

23

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人の身体的・行動的特徴を用いて特定の個人を認証する仕組みであるバイオメトリクスは,社会の様々な局面において情報セキュリティの確保等の目的で利用される場面が増えつつある.しかし,バイオメトリクスは,鍵やパスワードなどを用いることなく身体そのものが「鍵」になるという利便性がある一方で,生体情報は変更することができない情報であり,それが不正に利用されると鍵の紛失やパスワードの不正利用とは異なる問題が生ずる可能性がある.とりわけ,生体情報は,個人に「唯一」備わっている特徴(情報)であり,本人が生存している限り「不変」かつ「永続的」に存在する情報であることから,その取扱いは極めて慎重に行うことが求められている.そこで,本稿では,バイオメトリクスの適正な利用にあたって必要な生体情報の保護の問題について,個人情報保護法に基づく個人情報の適正な取扱いを中心に考察する.

著者

新保 史生

出版者

情報メディア学会

雑誌

情報メディア研究 (ISSN:13485857)

巻号頁・発行日

vol.2, no.1, pp.29-43, 2003 (Released:2004-04-27)

参考文献数

14

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ネットワークにおいて個人情報を取得して利用する機会が増えるにつれ,情報システムの脆弱性を原因とする個人情報漏えい事件や不正利用が頻繁に発生している.また,我が国においても個人情報保護法が制定されたことから,個人情報の適正な取扱いと保護への関心と社会的要求が高まっている.その要請に応ずるための具体的な「指針」や「方針」を示したものとして「プライバシーポリシー」と呼ばれるものがあり,民間の事業者の多くは,これを掲載するところが増えてきている.行政機関においても日常的に行政事務やそれ以外の場面における個人情報の取扱量が増加している現状からすると,民間の事業者における取組同様に,行政機関におけるプライバシーポリシー掲載の必要性は高まっているといえる.そこで,主に米国の連邦政府機関の取組を中心に,プライバシーポリシーの掲載意義と現状を概観する.

著者

浅野 美帆 桑原 雅夫

出版者

東京大学生産技術研究所

雑誌

生産研究 (ISSN:0037105X)

巻号頁・発行日

vol.59, no.3, pp.184-187, 2007 (Released:2007-06-29)

参考文献数

6

著者

笹木 圭子 小林 弘幸 恒川 昌美

出版者

一般社団法人 資源・素材学会

雑誌

資源と素材 (ISSN:09161740)

巻号頁・発行日

vol.117, no.9, pp.747-752, 2001 (Released:2006-01-08)

参考文献数

10

被引用文献数

3 4

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Aragonite-type of light calcium carbonate was synthesized by the successive reaction using calcined-hydrous scallop shells and calcined lime stones in the aqueous system with Mg2+ ions under the CO2 bubbling. In order to obtain the high aspect ratios of aragonite, the reaction temperature and concentrations of Ca2+ ions in the 2nd step were important. The aspect ratio of aragonite increased when the reaction temperature was higher in the 2nd step than in the 1st step of the successive reaction. When the smaller amounts of calcium source were added in the 2nd step than in the 1st step, and the reaction temperature was lower in the 2nd step than in the 1st step, large particles of aragonite were produced with no smooth surfaces. The successive reaction was useful to extend the variety of morphologies in aragonite.

著者

中村 三春

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.51, no.1, pp.55-65, 2008 (Released:2008-04-01)

参考文献数

4

---

2004年に発足した大学コンソーシアムやまがた(愛称・ゆうキャンパス)は,現在,山形県内すべての大学等11の高等教育機関と山形県とから成り,広報・高大連携・教職員交流・合同入試説明会・単位互換・学生活動・委託事業などを展開している。「ゆうキャンパスリポジトリ」は,山形県内高等教育機関が発行する紀要等の電子化とデータベースの構築・公開を行うプロジェクトである。国立情報学研究所から山形大学への委託事業として整備されたこのプロジェクトを,本コンソーシアムでは,地域大学間連携の重要な契機として位置づけ,参加機関の協力のもとに強力に推進している。

著者

名和 小太郎

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.51, no.1, pp.74-76, 2008 (Released:2008-04-01)

著者

土井 晃一郎 山下 哲矢 田中 孝侑 山本 章博

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会論文誌 (ISSN:13460714)

巻号頁・発行日

vol.23, no.3, pp.185-192, 2008 (Released:2008-03-11)

参考文献数

20

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We present the intentional kernel as a new class of kernel functions for structured data. The class is highly contrasted to the convolution kernel, that is a typical class of kernel functions. That is, the convolution kernel is defined with sub-structures, while the intentional kernel is based on derivations constracting structures. We show instances of the intentional kernel for boolean functions, first-order terms, context sensitive languages, and RNA sequences. We also show some properties of the intentional kernel, and discuss the difference between the intentional kernel and the convolution kernel.

著者

上原 宏 佐藤 忠彦 吉田 健一

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会論文誌 (ISSN:13460714)

巻号頁・発行日

vol.23, no.3, pp.205-216, 2008 (Released:2008-03-11)

参考文献数

20

被引用文献数

1

---

This paper proposes a method to measure the effects of TV advertisements on the Internet bulletin boards. It aims to clarify how the viewes' interests on TV advertisements are reflected on their images on the promoted products. Two kinds of time series data are generated based on the proposed method. First one represents the time series fluctuation of the interests on the TV advertisements. Another one represents the time series fluctuation of the images on the products. By analysing the correlations between these two time series data, we try to clarify the implicit relationship between the viewer's interests on the TV advertisement and their images on the promoted products. By applying the proposed method to an Internet bulletin board that deals with certain cosmetic brand, we show that the images on the products vary depending on the difference of the interests on each TV advertisement.