著者

武藤 崇 ヘイズ スティーブン C.

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.15, no.3, pp.482-495, 2008 (Released:2010-02-15)

参考文献数

80

被引用文献数

3

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This commentary gave some additional findings and implications for “symmetrical bias (or bidirectional relation)” from a viewpoint of Contextual Behavioral Science, in particular, Relational Frame Theory and Acceptance and Commitment Therapy. The given findings were related with a) the transformation of stimulus function through bidirectional relation in persons with specific phobia or mental disorder, b) the emergence or non-emergence of bidirectional relation influenced by baseline-training reversals or protocols in matching-to-sample procedure, and c) the emergence or non-emergence of bidirectional relation in infants or nonhuman subjects. Furthermore, the given implications were related with d) necessity of balancing between abduction and induction, particularly identifying and cumulating the manipulable variables inductively, e) prevention of confusing explanation with cause through symmetrical biases, and f) clarification of own ”purpose and value”, in pursuing symmetry bias or bidirectional relation as one of most fundamental processes in human cognition.

著者

Naoto Suzue Tetsuya Matsuura Toshiyuki Iwame Kosaku Higashino Toshinori Sakai Daisuke Hamada Tomohiro Goto Yoichiro Takata Toshihiko Nishisho Yuichiro Goda Takahiko Tsutsui Ichiro Tonogai Ryo Miyagi Mitsunobu Abe Masatoshi Morimoto Kazuaki Mineta Tetsuya Kimura Akihiro Nitta Tadahiro Higuchi Shingo Hama Subash C. Jha Rui Takahashi Shoji Fukuta Koichi Sairyo

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.62, no.3.4, pp.109-113, 2015 (Released:2015-09-18)

参考文献数

39

被引用文献数

2 14

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Athletes sometimes experience overuse injuries. To diagnose these injuries, ultrasonography is often more useful than plain radiography, computed tomography (CT), or magnetic resonance imaging (MRI). Ultrasonography can show both bone and soft tissue from various angles as needed, providing great detail in many cases. In conditions such as osteochondrosis or enthesopathies such as Osgood-Schlatter disease, Sinding-Larsen-Johansson disease, bipartite patella, osteochondritis dissecans of the knee, painful accessory navicular,and jumper's knee, ultrasonography can reveal certain types of bony irregularities or neovascularization of the surrounding tissue. In patients of enthesopathy, ultrasonography can show the degenerative changes at the insertion of the tendon. Given its usefulness in treatment, ultrasonography is expected to become essential in the management of overuse injuries affecting the lower limb in athletes. J. Med. Invest. 62: 109-113, August, 2015

著者

Tsubasa Suzuki Yasuhiko Ono Hidenori Maeda Yoshiki Tsujimoto Yugo Shobugawa Clyde Dapat Mohd Rohaizat Hassan Chihiro Yokota Hiroki Kondo Isolde C. Dapat Kousuke Saito Reiko Saito

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.232, no.2, pp.97-104, 2014 (Released:2014-02-15)

参考文献数

31

被引用文献数

8 8

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Influenza vaccination is considered the single most important medical intervention for the prevention of influenza. The dose of trivalent influenza vaccine in children was increased almost double since 2011/12 season in Japan. We estimated the influenza vaccine effectiveness for children 1-11 years of age using rapid test kits in Isahaya City, involving 28,884 children-years, over two consecutive influenza seasons (2011/12 and 2012/13). Children were divided into two groups, vaccinated and unvaccinated, according to their vaccination record, which was obtained from an influenza registration program organized by the Isahaya Medical Association for all pediatric facilities in the city. There were 14,562 and 14,282 children aged from 1-11 years in the city in 2011 and 2012 respectively. In the 2011/12 season, the overall vaccine effectiveness in children from 1-11 years of age, against influenza A and B were 23% [95% confidence interval (CI): 14%-31%] and 20% [95% CI: 8%-31%], respectively. In the 2012/13 season, vaccine effectiveness against influenza A and B was 13% (95% CI: 4%-20%) and 9% (95% CI: −4%-21%), respectively. The vaccine effectiveness was estimated using the rapid diagnosis test kits. Age-stratified estimation showed that vaccine effectiveness was superior in younger children over both seasons and for both virus types. In conclusion, the trivalent influenza vaccine has a significant protective effect for children 1-11 years of age against influenza A and B infection in the 2011/12 season and against influenza A infection in the 2012/13 season in a community in Japan.

著者

Peter M. VAUGHAN Jessie C. BUETTE Barry W. BROOK

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.21, no.1, pp.3-12, 2022 (Released:2022-01-31)

参考文献数

42

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Understanding the behavioural responses of bird species to their environments is important for effective conservation, especially in captive-management and resource-provisioning programs. Camera traps present a growing opportunity to research bird breeding and foraging behaviour in situ. Remotely triggered cameras are commonly deployed to study mammals and large terrestrial birds. They are rarely used to survey small or arboreal birds due to habitat constraints. However, a wealth of information about small or arboreal birds can be generated opportunistically from camera traps in the course of collecting data on other taxa. Here, we describe and quantify the types of behavioural information that can be so gleaned, based on over 1,700 small-bird images captured as "collateral" during a geographically extensive mammal-focused camera study in Tasmania, Australia in 2018–2020. Postural analysis of images revealed 10 distinct behaviours. Large- and medium-sized terrestrial bird species were most commonly observed (61.6% of behavioural images), but small and arboreal species were also photographed at high rates (18.4% and 29.5% of behavioural images respectively). Investigative activity was the most commonly observed behaviour in small and arboreal species (around half of all images), but feeding, mating and even very rare behaviours like fur plucking, were also captured photographically. This case study reveals the value of opportunistically analysing camera trap images for small or arboreal birds species, especially when they are of conservation interest, even for cases where deliberately targeting them would not be a cost-effective strategy.

著者

Yağız Anıl Çiçek David C. Luther Jessica A. Kretzmann Vincent M. Rotello

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.42, no.3, pp.304-311, 2019-03-01 (Released:2019-03-01)

参考文献数

83

被引用文献数

4

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Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized therapeutic gene editing by providing researchers with a new method to study and cure diseases previously considered untreatable. While the full range and power of CRISPR technology for therapeutics is being elucidated through in vitro studies, translation to in vivo studies is slow. To date there is no totally effective delivery strategy to carry CRISPR components to the target site in vivo. The complexity of in vivo delivery is furthered by the number of potential delivery methods, the different forms in which CRISPR can be delivered as a therapeutic, and the disease target and tissue type in question. There are major challenges and limitations to delivery strategies, and it is imperative that future directions are guided by well-conducted studies that consider the full effect these variables have on the eventual outcome. In this review we will discuss the advances of the latest in vivo CRISPR/Cas9 delivery strategies and highlight the challenges yet to be overcome.

著者

Tirza Springeling Sharon W. Kirschbaum Alexia Rossi Timo Baks Yusuf Karamermer Carl Schulz Mohammed Ouhlous Dirk J. Duncker Adriaan Moelker Gabriel P. Krestin Patrick W.J.C. Serruys Pim de Feyter Robert-Jan M. van Geuns

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.1, pp.81-88, 2013 (Released:2012-12-25)

参考文献数

26

被引用文献数

20 30

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Background: Primary percutaneous coronary intervention (PPCI) preserves function and improves survival. The late effects of PPCI on left ventricular remodeling, however, have not yet been investigated on cardiac magnetic resonance imaging (CMRI). Methods and Results: Twenty-five patients with acute myocardial infarction (AMI) treated with PPCI underwent CMRI within 10 days, at 4 months and at 5 years. Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume were quantified on cine images. Infarct mass and transmural extent of infarction were quantified on contrast-enhanced imaging. In all patients EDV increased significantly in the early phase (192±40ml to 211±49ml, P≤0.01) and LVEF improved significantly (42±9% to 46±9%, P=0.02). In the late phase (>4 months) no significant changes were observed (LVEF 44±9%, P=0.07; EDV 216±68ml, P=0.38). Three different groups could be identified. One-third (32%) had no dilatation at all; one-third (32%) had limited dilatation at 4 months without progression later; and 36% had progressive dilatation both at 4 months and at late follow-up. This third group had an average increase in EDV of 20% in the acute phase followed by an additional 13%. The strongest predictor for progressive dilatation was infarct mass. Conclusions: Even in the era of PPCI for AMI followed by optimal medical therapy, one-third of patients had progressive dilatation, which was best predicted by infarct mass.  (Circ J 2013; 77: 81–88)

著者

Iara Katrynne F OLIVEIRA Vanessa C CARVALHO Gabriela S SANTOS Nayara V N MONTEIRO Margarete A F AZEVEDO Carlos Henrique R LIMA Emídio M M NETO Maria do Carmo C MARTINS Liania A LUZIA Patrícia H C RONDÓ Adriana A PAIVA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.69, no.6, pp.395-401, 2023-12-31 (Released:2023-12-31)

参考文献数

33

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The role of vitamin A in the pathophysiological context of coronavirus disease 2019 (COVID-19) represents a current challenge, given the major impact of COVID-19 on morbidity and mortality and the importance of retinol in pulmonary and immunomodulatory functions. The aim of this review is to assess the relationship between vitamin A nutritional status and clinical outcomes in people with COVID-19. The PubMed, Web of Science, Scopus and ScienceDirect databases were used to search for observational studies that assessed retinol levels in hospitalized individuals with COVID-19, following the PRISMA recommendations. A total of 1,912 articles were identified and seven met the inclusion criteria. Four studies showed borderline or deficient retinol blood levels (retinol <0.20 mg/L or <0.70 mol/L) in people with COVID-19, associated with worsened clinical outcomes. In the other three studies lower mean values of this vitamin were identified in COVID-19 symptomatic groups compared to asymptomatic or convalescent groups that showed worse clinical outcomes. The results suggest a possible association between retinol and COVID-19 outcomes. However, there is a clear need to develop clinical trials to elucidate the role of vitamin A in the pathophysiological process of COVID-19.

著者

竹村 英二 伊東 貴之 江藤 裕之 Kornicki Peter Francis Elman Benjamin A. Tortarolo Edoardo Domanska Ewa Guthenke Constanze Grafton Anthony Pollock Sheldon Collcutt Martin C. Tankha Brij Mohan 佐藤 正幸 大川 真 尾崎 順一郎

出版者

国士舘大学

雑誌

基盤研究(C)

巻号頁・発行日

2013-04-01

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本科研研究では、(1) 18~19世紀日本の儒学世界において発展した実証主義的学問の解明、(2) その清代考証学との比較検討と日中間の学問特性の相違点の考察、(3) 日本考証学と西欧のフィロロギーとの比較研究が目指され、これらを、分野の異なる研究者との共同研究、海外の研究者との国際研究連携をもってすすめ、下記「研究成果」に列挙したごとくの成果が産出された。またその過程では、ヨーロッパ日本研究協会(EAJS、欧州最大の日本研究学会)を含めた主要な国際学会での研究発表、英ケンブリッジ大学に於ける国際研究集会の開催も実施され、これらを通じ、高い水準の日本思想史研究の海外への発信にも寄与した。

著者

C.L.ストング 編

出版者

白揚社

巻号頁・発行日

1963

著者

Ariadne Nóbrega Marinho Furtado Ornella Comandini Marco Leonardi Andrea C. Rinaldi Maria Alice Neves

出版者

The Mycological Society of Japan

雑誌

Mycoscience (ISSN:13403540)

巻号頁・発行日

vol.63, no.2, pp.73-78, 2022-03-20 (Released:2022-03-31)

参考文献数

46

被引用文献数

2

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In this work, we characterize naturally occurring mycorrhizae formed by Amanita viscidolutea on Guapira opposita in the Atlantic Forest in Brazil. We sequenced the rDNA ITS region from the mycorrhizae and basidiomata to identify both symbionts. Amanita viscidolutea mycorrhizae were up to 43 mm long, mostly simple, and unbranched to irregularly pinnate. The fungal mantle surface was velvety to slightly cottony and white to yellowish with silver patches. Hyphal strands were infrequently present. Although the fungal mantle consisted of clampless hyphae, emanating hyphae and hyphal strands had sparsely distributed clamp connections. A unique character of the mycorrhizae was the absence of a Hartig net.

著者

Shamay S.M. Ng Shirley S.M. Fong Wayne L.S. Chan Ben K.Y. Hung Ricci K.S. Chung Tina H.T. Chim Patrick W.H. Kwong Tai-Wa Liu Mimi M.Y. Tse Raymond C.K. Chung

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.6, pp.1701-1708, 2016 (Released:2016-06-24)

参考文献数

32

被引用文献数

1 8

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[Purpose] To investigate the inter-rater and test-retest reliability of the sitting-rising test (SRT), the correlations of sitting-rising test scores with measures of strength, balance, community integration and quality of life, as well as the cut-off score which best discriminates people with chronic stroke from healthy older adults were investigated. [Subjects and Methods] Subjects with chronic stroke (n=30) and healthy older adults (n=30) were recruited. The study had a cross-sectional design, and was carried out in a university rehabilitation laboratory. Sitting-rising test performance was scored on two occasions. Other measurements included ankle dorsiflexor and plantarflexor strength, the Fugl-Meyer assessment, the Berg Balance Scale, the timed up and go test, the five times sit-to-stand test, the limits of stability test, and measures of quality of health and community integration. [Results] Sitting-rising test scores demonstrated good to excellent inter-rater and test-retest reliabilities (ICC=0.679 to 0.967). Sitting-rising test scores correlated significantly with ankle strength, but not with other test results. The sitting-rising test showed good sensitivity and specificity. A cut-off score of 7.8 best distinguished healthy older adults from stroke subjects. [Conclusions] The sitting-rising test is a reliable and sensitive test for assessing the quality of sitting and rising movements. Further studies with a larger sample are required to investigate the test’s validity.

著者

Anthony C. Keech Kazuma Oyama Peter S. Sever Minao Tang Sabina A. Murphy Atsushi Hirayama Chen Lu Leslie Tay Prakash C. Deedwania Chung-Wah Siu Armando Lira Pineda Donghoon Choi Min-Ji Charng John Amerena Wan Azman Wan Ahmad Vijay K. Chopra Terje R. Pedersen Robert P. Giugliano Marc S. Sabatine on behalf of the FOURIER Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-1051, (Released:2021-05-12)

参考文献数

19

被引用文献数

13

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Background:There are concerns that Asian patients respond differently to some medications. This study evaluated the efficacy and safety of evolocumab among Asian vs. other subjects in the FOURIER trial, which randomized stable atherosclerosis patients to receive either evolocumab or placebo.Methods and Results:Effects of adding evolocumab vs. placebo to background statin therapy on low-density lipoprotein cholesterol (LDL-C) reductions, cardiovascular outcomes, and adverse events were compared among 27,564 participants with atherosclerotic disease, according to self-reported Asian (n=2,723) vs. other (n=24,841) races followed for a median of 2.2 years in the FOURIER trial. The primary endpoint was a composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. At randomization, Asians had slightly lower LDL-C (median 89 [IQR 78–104] mg/dL vs. 92 [80–109] mg/dL; P<0.001) and were much less likely to be on a high-intensity statin (33.3% vs. 73.3%; P<0.001). Evolocumab lowered LDL-C more in Asians than in others (66% vs. 58%; P<0.001). The effect of evolocumab on the primary endpoint was similar in Asians (HR, 0.79; 95% CI, 0.61–1.03) and others (HR, 0.86; 95% CI, 0.79–0.93; P interaction=0.55). There was no excess of serious adverse events with evolocumab among Asians over others.Conclusions:Use of evolocumab robustly lowers LDL-C and is equally efficacious in lowering the risk of cardiovascular events and safe in Asians as it is in others.

著者

Haga Kazuko Kruse Andrew C. Asada Hidetsugu Yurugi-Kobayashi Takami Shiroishi Mitsunori Zhang Cheng Weis William I. Okada Tetsuji Kobilka Brian K. Haga Tatsuya Kobayashi Takuya

出版者

Nature Publishing Group

雑誌

Nature (ISSN:00280836)

巻号頁・発行日

2012-01-25

被引用文献数

663

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認知症や心機能の抑制に関係する受容体の立体構造を世界で初めて解明-より効果的で副作用のない治療薬の探索・設計が可能に-. 京都大学プレスリリース.2012-01-26.

著者

Noriko Kojimahara Yong-Han Lee Ae-Kyoung Lee Sanghyuk Bae Ho-Jang Kwon Mina Ha Yasuto Sato Masao Taki J Wiart C.E. Langer Elisabeth Cardis

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230005, (Released:2023-06-17)

参考文献数

29

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Background: This study aimed to examine the association between risk of brain tumors and radiofrequency (RF) exposure from mobile phones among young people in Korea and Japan.Methods: This case-control study of brain tumors in young people was conducted in Korea and Japan under the framework of the international MOBI-Kids study. We included 118 patients diagnosed with brain tumors between 2011 and 2015 and 236 matched appendicitis controls aged 10–24 years. Information on mobile phone use was collected through face-to-face interviews. A detailed RF exposure algorithm, based on the MOBI-Kids algorithm and modified to account for the specificities of Japanese and Korean phones and networks, was used to calculate the odds ratios (ORs) for total cumulative specific energy using conditional logistic regression.Results: The adjusted ORs in the highest tertile of cumulative call time at 1 year before the reference date were 1.61 (95% confidence interval [CI], 0.72-3.60) for all brain tumors and 0.70 (95% CI, 0.16-3.03) for gliomas, with no indication of a trend with exposure. The ORs for glioma specifically, were below 1 in the lowest exposure category.Conclusions: This study provided no evidence of a causal association between mobile phone use and risk of brain tumors as a whole or glioma specifically. Further research will be required to evaluate the impact of newer technologies of communication in the future.

著者

Keiichi Kojima Hiroshi C. Watanabe Satoko Doi Natsuki Miyoshi Misaki Kato Hiroshi Ishikita Yuki Sudo

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.15, pp.179-188, 2018 (Released:2018-09-07)

参考文献数

42

被引用文献数

7 9

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Anion channelrhodopsin-2 (ACR2), a light-gated channel recently identified from the cryptophyte alga Guillardia theta, exhibits anion channel activity with exclusive selectivity. In addition to its novel function, ACR2 has become a focus of interest as a powerful tool for optogenetics. Here we combined experimental and computational approaches to investigate the roles of conserved carboxylates on the anion transport activity of ACR2 in Escherichia coli membrane. First, we replaced six conserved carboxylates with a neutral residue (i.e. E9Q, E56Q, E64Q, E159Q, E219Q and D230N), and measured anion transport activity using E. coli expression system. E159Q and D230N exhibited significantly lower anion transport activity compared with wild-type ACR2 (1/12~1/3.4), which suggests that E159 and D230 play important roles in the anion transport. Second, to explain its molecular aspects, we constructed a homology model of ACR2 based on the crystal structure of a cation channelrhodopsin (ChR). The model structure showed a cavity formed by four transmembrane helices (TM1, TM2, TM3 and TM7) similar to ChRs, as a putative anion conducting pathway. Although E159 is not located in the putative pathway, the model structure showed hydrogen bonds between E159 and R129 with a water molecule. D230 is located in the pathway near the protonated Schiff base (PSB) of the chromophore retinal, which suggests that there is an interaction between D230 and the PSB. Thus, we demonstrated the functional importance and the hypothetical roles of two conserved carboxylates, E159 and D230, in the anion transport activity of ACR2 in E. coli membrane.

著者

Charlotte C. GUPTA Michelle DOMINIAK Katya KOVAC Amy C. REYNOLDS Sally A. FERGUSON Cassie J. HILDITCH Madeline SPRAJCER Grace E. VINCENT

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2021-0124, (Released:2021-10-25)

被引用文献数

3

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Due to the unpredictable nature of working time arrangements, on-call workers experience regular disruption to sleep, particularly if woken by calls. Sleep disruption can impact long term physical and mental health, next day performance, and importantly, performance immediately after waking. To reduce the impact of performance impairments upon waking (i.e., reducing sleep inertia), research has investigated strategies to promote alertness (e.g., bright light, caffeine, and exercise). This review puts forth on-call workers who are likely to return to sleep after a call, it is also important to consider the impact of these sleep inertia countermeasures on subsequent sleep. Future research should build on the preliminary evidence base for sleep inertia countermeasures by examining the impact on subsequent sleep. This research is key for both supporting alertness and performance during a call (“switching on”) and for allowing the on-call worker to return to sleep after a call (“switching off”).

著者

J.C.ブラウン著 永井三明 松本典昭 松本香訳

出版者

ミネルヴァ書房

巻号頁・発行日

1988

著者

Yoon C. Kang S.H. Yang J.O. Noh D.J. Indiragandhi P. Kim G.H.

出版者

日本農薬学会

巻号頁・発行日

vol.34, no.2, pp.77-88, 2009 (Released:2011-03-05)

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T型チューブの嗅覚計を用いて、精油17種類のチャバネゴキブリに対する忌避効果を調べた。柑橘類であるグレープフルーツ、レモン、ライムおよびオレンジより得たものを含む5種類の精油は、70.0から96.7%の範囲で良好な効果を示した。各精油はワモンゴキブリおよびクロゴキブリに対しても同等の活性を示した。ガスクロマトグラフィー(GC)およびGC-質量分析の解析から、柑橘油類のこの効果における主成分はリモネン、β-ピネンおよびγ-テルピネンであり、特にリモネンが主な成分であることがわかった。これらの化合物の忌避効果は用量とゴキブリの種によって異なった。オレンジ油を除く柑橘類の精油では、微量成分も忌避活性に寄与しているようであった。オレンジ油の場合には、活性の発現にはほとんどリモネンのみがかかわっていた。柑橘油および各テルペン類の活性において、3種類のゴキブリに対する忌避効果にはほとんど差がなかった。

著者

Tadahisa Sugiura Chitaru Kurihara Masashi Kawabori Andre C. Critsinelis Andrew B. Civitello Jeffrey A. Morgan O. H. Frazier

出版者

The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery

雑誌

Annals of Thoracic and Cardiovascular Surgery (ISSN:13411098)

巻号頁・発行日

vol.27, no.1, pp.64-67, 2021 (Released:2021-02-20)

参考文献数

5

被引用文献数

1 3

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An increasing number of children with congenital heart disease are surviving into adulthood and subsequently developing end-stage heart failure. Two example populations are adults who have been previously operated on for congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA). Implantation of a continuous flow left ventricular assist device (CF-LVAD) in these patients can present unusual anatomical and physiologic challenges. In this report, we describe outcomes of CF-LVAD implantation in three such patients. These cases demonstrate the feasibility of implanting a CF-LVAD in patients who have undergone surgery for CCTGA and/or TGA.

著者

A.C.ベンヂャミン著 篠原雄訳

出版者

開発社

巻号頁・発行日

1944