著者

Britt S.R. Claes Emi Takeo Eiichiro Fukusaki Shuichi Shimma Ron M.A. Heeren

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

pp.A0078, (Released:2019-11-06)

参考文献数

119

被引用文献数

4

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Mass spectrometry imaging is an imaging technology that allows the localization and identification of molecules on (biological) sample surfaces. Obtaining the localization of a compound in tissue is of great value in biological research. Yet, the identification of compounds remains a challenge. Mass spectrometry alone, even with high-mass resolution, cannot always distinguish between the subtle structural differences of isomeric compounds. This review discusses recent advances in mass spectrometry imaging of lipids, steroid hormones, amino acids and proteins that allow imaging with isomeric resolution. These improvements in detailed identification can give new insights into the local biological activity of isomers.

著者

Jonny Wu John Suppe Renqu Lu Ravi V.S. Kanda

出版者

日本地球惑星科学連合

雑誌

JpGU-AGU Joint Meeting 2017

巻号頁・発行日

2017-03-10

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Seismic tomography has revealed enigmatic stagnant slab anomalies under Japan, Korea and NE China (i.e. the Japan slab). The stagnant slabs flatten near the mantle transition zone around ~410 to 660 km depths and extend >2000 km westward from the NW Pacific subduction zones. The location of the outboard stagnant slabs far inland under Eurasia cannot be explained by slab rollback alone and pose a challenge to our current understanding of subducted slab dynamics, in which slabs sink vertically over time with minimal lateral motion.In this study, we use new and recently published 3D slab mapping, slab unfolding and plate reconstruction constraints (Wu et al., 2016, JGR) from MITP08 and GAP_P4 global tomography (Li et al., 2008, G3; Fukao et al., 2013, JGR). We show that the Japan stagnant slabs are best reconstructed as Pacific slabs that subducted in the Cenozoic after Pacific-Izanagi ridge subduction between 60 to 50 Ma. Mantle flow forward models reproduce our Japan slab reconstruction results (Seton et al., 2015, GRL). Our reconstruction implies the Japan slabs moved laterally westwards within the upper mantle and transition zone after subduction at near-plate tectonic rates (~2 cm/yr over 50 Ma), indicating a greater lateral mobility of slabs within the upper mantle and transition zone than previously recognized.Using our Japan slab subduction model, we re-examine the enigmatic Vityaz deep earthquakes under the Fiji Basin, which are widely thought to be a globally-unique case of seismicity within a foundered and detached slab. Our Tonga slab mapping shows the Vityaz earthquakes are actually part of a >2500 km-long mega-Wadati-Benioff zone of the northern Tonga stagnant slab. Our slab reconstruction suggests the northern Tonga slab moved laterally westward in a similar fashion to the Japan slabs, but at a faster rate of >5 cm/yr over 15 Ma within the upper ~660 km. Our results suggest that earthquakes can be produced thousands of kilometers away from a subduction zone from lateral movements of still-attached but mobile stagnant slabs within the uppermost ~660 km mantle.

著者

So Nakagawa Toshiaki Katayama Lihua Jin Jiaqi Wu Kirill Kryukov Rise Oyachi Junko S Takeuchi Takatomo Fujisawa Satomi Asano Momoka Komatsu Jun-ichi Onami Takashi Abe Masanori Arita

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

pp.23-00085, (Released:2023-10-14)

参考文献数

53

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Since the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a number of research institutes have been sequencing and sharing high-quality severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes to trace the route of infection in Japan. To provide insight into the spread of COVID-19, we developed a web platform named SARS-CoV-2 HaploGraph to visualize the emergence timing and geographical transmission of SARS-CoV-2 haplotypes. Using data from the GISAID EpiCoV database as of June 4, 2022, we created a haplotype naming system by determining the ancestral haplotype for each epidemic wave and showed prefecture- or region-specific haplotypes in each of four waves in Japan. The SARS-CoV-2 HaploGraph allows for interactive tracking of virus evolution and of geographical prevalence of haplotypes, and aids in developing effective public health control strategies during the global pandemic. The code and the data used for this study are publicly available at: https://github.com/ktym/covid19/.

著者

Rie Hayashi Hiroyasu Iso Kazumasa Yamagishi Hiroshi Yatsuya Isao Saito Yoshihiro Kokubo Ehab S. Eshak Norie Sawada Shoichiro Tsugane for the Japan Public Health Center-Based (JPHC) Prospective Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.5, pp.1072-1079, 2019-04-25 (Released:2019-04-25)

参考文献数

43

被引用文献数

24 27

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Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40–59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01–2.63) for acute myocardial infarction and 0.83 (95% CI 0.60–1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03–4.35) and men aged 50–59 years (HR 2.60, 95% CI 1.42–4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

著者

Editorial team for the Special Issue on Oosawa’s Lectures

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.18, no.Supplemental, pp.S001-S002, 2021 (Released:2021-12-10)

参考文献数

3

被引用文献数

1

著者

S. Manabe

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.35, no.6, pp.311-326, 1957-12-25 (Released:2007-10-19)

参考文献数

20

被引用文献数

69 71

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Japan Sea is generally considered to be one of the places where the most rapid airmass transformation takes place in winter season.As it is surrounded by the dense network of radiosonde and surface observation stations, quantitative investigation about the modification of airmass is possible.Selecting the period of a typical continuous outburst of cold air from 20 Dec.'54 to 3 Jan.'55 during which the air-sea temperature difference exceeded 10°C, we computed the integrated netflux divergence of enthalpy and water vapor and the vertical transport of them at the standard levels in the lower half of the troposphere, and further estimated the amount of heating and cooling due to radiation and condensation.Then, based upon the balance requirement, the amount of heat or water vapor supplied from the sea to the atmosphere was obtained.According to the results of above computations, it is concluded that the amount of supplied heat is as much as 1000ly/day in such a typical unstable situation, and is 2.3 times as large as that of supplied latent heat in spite of the fact that mean Bowen's ratio expected from mixing length theory was nearly equal, to unity.Finally, for several periods when no remarkable cyclone passed over the Japan Sea, the amount of evaporation computed by the scheme above-mentioned are compared with the results obtained by use of climatological evaporation equation after Jacobs.

著者

Yoon C. Kang S.H. Yang J.O. Noh D.J. Indiragandhi P. Kim G.H.

出版者

日本農薬学会

巻号頁・発行日

vol.34, no.2, pp.77-88, 2009 (Released:2011-03-05)

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T型チューブの嗅覚計を用いて、精油17種類のチャバネゴキブリに対する忌避効果を調べた。柑橘類であるグレープフルーツ、レモン、ライムおよびオレンジより得たものを含む5種類の精油は、70.0から96.7%の範囲で良好な効果を示した。各精油はワモンゴキブリおよびクロゴキブリに対しても同等の活性を示した。ガスクロマトグラフィー(GC)およびGC-質量分析の解析から、柑橘油類のこの効果における主成分はリモネン、β-ピネンおよびγ-テルピネンであり、特にリモネンが主な成分であることがわかった。これらの化合物の忌避効果は用量とゴキブリの種によって異なった。オレンジ油を除く柑橘類の精油では、微量成分も忌避活性に寄与しているようであった。オレンジ油の場合には、活性の発現にはほとんどリモネンのみがかかわっていた。柑橘油および各テルペン類の活性において、3種類のゴキブリに対する忌避効果にはほとんど差がなかった。

著者

Britt S. R. Claes Emi Takeo Eiichiro Fukusaki Shuichi Shimma Ron M. A. Heeren

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.8, no.1, pp.A0078, 2019-12-27 (Released:2019-12-28)

参考文献数

119

被引用文献数

4

---

Mass spectrometry imaging is an imaging technology that allows the localization and identification of molecules on (biological) sample surfaces. Obtaining the localization of a compound in tissue is of great value in biological research. Yet, the identification of compounds remains a challenge. Mass spectrometry alone, even with high-mass resolution, cannot always distinguish between the subtle structural differences of isomeric compounds. This review discusses recent advances in mass spectrometry imaging of lipids, steroid hormones, amino acids and proteins that allow imaging with isomeric resolution. These improvements in detailed identification can give new insights into the local biological activity of isomers.

著者

天沼 香 Kaoru AMANUMA 東海女子大学 TOKAI WOMEN'S UNIVERSITY

雑誌

東海女子大学紀要 = Bulletin of Tokai Women's University (ISSN:02870525)

巻号頁・発行日

vol.24, pp.1-13, 2005-03-31

著者

佐々木 隆一郎 SUKUMURAN M. GAJALAKSHMI シー.ケイ CHANDRASEKAR アルナ KRISHNAMURTH エス SHANTA V. 岡本 和士 小川 浩 伊藤 宜則 横井 豊治 松山 睦司 M S Sukumura R Swaminatha ARUNA Chandr S Krishnamur V Shanta

出版者

愛知医科大学

雑誌

国際学術研究

巻号頁・発行日

1992

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南インド(マドラス)には、宗教上の理由から肉を食しない菜食主義者が多い。癌登録資料からみたこの地域における乳癌の年齢調整罹患率は人口10万対20.8と、日本と同程度(大阪19.7)である。これは、乳癌の発生要因のひとつとして肉食が考えられているが、肉食以外の乳がんの発生要因を追究するには格好の地といえる。また、研究対象地域のマドラスでの癌研究は、WHOの技術援助を得て完成した癌登録を有するCancer Instituteが中心に行っており、疫学的な研究を行う基盤が整っていた。以上の理由により、1992年7月から、南インド・マドラスにおいて、菜食主義者での乳癌の患者対照研究を行った。患者は、1992年7月以降Cancer Instituteで新たに診断された乳癌患者である。対照は健康対照として病院に入院している患者の家族の中からから性、年齢を一致させた者1人、病院対照としてCancer Instituteを受診した他の部位のがん患者から性、年齢を一致させた者1人を選び、患者対照200セット(600人)を集め、検討した。検討した項目は、問診項目(社会経済状態、生殖歴、栄養素摂取量、心理要因など)、体格(身長、体重)、血清情報(ホルモンレベル、脂質類、ビタミン類など)などの項目である。1993年12月24日現在までに、面接によっての情報収集、体格情報の収集が終了したのは、乳癌患者200人、病院対照200人(乳癌、子宮癌、卵巣癌、甲状腺癌以外の癌)、健康対照200人についてである。個人についての栄養素摂取量の算出、全ての情報の計算機への入力を行った。現在までに心理面の解析から、健康対照に比べ、乳癌患者と病院対照(癌患者)は、ストレスの多いLife event、抑欝的な状態におかれていることなどが伺われた。さらに、病院対照に比べ、乳癌患者はよりこれらの傾向が強いことが示唆された。本研究では、ホルモンレベルの測定のために黄体期に採血を行っているが、上記の対象者の内採血が終了した者は、乳癌患者200人、病院対照200人、健康対照75人であった。初期の予想に反し、健康対照についての採血が困難を極めたので、今回は血液成分のうち、健康対照のホルモンレベルについての検討を断念することとした。血清についての解析からは、健康対照75人についての検討では、マドラスでのβカロテンのレベルは日本よりは低い傾向があること、レチノールのレベルはやや低いがほぼ同程度であることが示唆されている。また、乳癌患者と病院対照のホルモンレベルを比較すると、前者ではエストロゲンE1 75.7pg/ml、エストロゲンE2 42.3pg/ml、エストロゲンE3 2.1pg/ml、後者ではエストロゲンE1 59.4pg/ml、エストロゲンE2 13.3pg/ml、エストロゲンE3 1.2pg/mlであった。また、乳癌患者(197人)についてEIAキット(Trion Diagnostics Inc.)を用いてc-erbB-2蛋白陽性率を測定したが、20U/ml以上を陽性とすると、陽性率は約28%であった。現在、上記の成果をもとに、各研究担当者が業績のまとめを行っている。

著者

Junya Hasegawa Bethany S. Strunk Lois S. Weisman

出版者

日本細胞生物学会

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.17003, (Released:2017-03-07)

被引用文献数

109

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In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial for the endocytic pathway, intracellular signaling, and adaptation to stress. Mutations that causes defects in the biosynthesis of PI5P and PI(3,5)P2 are linked to human diseases including neurodegenerative disorders. Here, we review recent findings on cellular roles of PI5P and PI(3,5)P2, as well as the pathophysiological importance of these lipids.

著者

Einas S. Al-Eisa Hind Al-Hoqail Asma S. Al-Rushud Azhar Al-Harthi Banan Al-Mass Bashayer M. Al-Harbi Sara Al-Azzaz Ahmad H. Alghadir Zaheen A. Iqbal

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.12, pp.3435-3439, 2016 (Released:2016-12-27)

参考文献数

24

被引用文献数

14

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[Purpose] Over the years physiotherapy has been recognized as a popular mode of treatment that decreases the disability and dependency rate of patients. However, there is still a need for its recognition in multidisciplinary health care structures. If a physician were well aware of how a physical therapist could help with treatment if patients and prevent complications, hospital patient load could be decreased to a greater extent. The aim of this study was to study the awareness, perception and beliefs of physicians working in Saudi Arabia about physiotherapy. [Subjects and Methods] Three hundred fifteen members of the Saudi Commission for Health Specialties (SCFHS) with different specialties, nationalities, designation, and work experience, working in various hospitals in 5 regions of Saudi Arabia were invited to participate in this study. A 22-item questionnaire was used for data collection including sections on physicians’ demographics, educational levels and knowledge about physiotherapy. [Results] After applying the inclusion and exclusion criteria, data from 280 respondents was used for analysis. Seventy-five percent of respondents reported to having some knowledge of physiotherapy, and 11% of them referred patients to physiotherapy departments regularly, while 14% referred patients occasionally. To the best of our knowledge, this is first study performed in Saudi Arabia to evaluate awareness of physicians about the physiotherapy profession. [Conclusion] The results of this study highlight the need to organize various workshops and lectures about the effectiveness of physiotherapy in various diseases for physicians, on a regular basis, to update them with evidence-based treatment. It is the responsibility of physical therapists to raise the perceptions of other healthcare professionals about their profession.

著者

Jonathan J. Sullivan Kean S. Goh

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.33, no.4, pp.339-350, 2008-11-25 (Released:2008-11-25)

参考文献数

47

被引用文献数

13 82 23

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Pyriproxyfen is a broad-spectrum insect growth regulator (IGR) with insecticidal activity against public health insect pests such as houseflies, mosquitoes and cockroaches. In agriculture and horticulture, pyriproxyfen has registered uses for the control of scale, whitefly, aphids and fire ants. It is used extensively worldwide, particularly in developing countries, although it has no significant uses in California. Pyriproxyfen acts on the endocrine system of insects by mimicking the juvenile hormone, thereby hindering molting and subsequently inhibiting reproduction. IGRs are unique in that they are specific for insects and have very low mammalian toxicity. As such, pyriproxyfen has received U.S. EPA status as a Reduced Risk insecticide and an organophosphate alternative and is the only pesticide approved by the World Health Organization (WHO) for treatment of potable water against mosquito. However, concerns about its environmental persistence and latent toxicity to nontarget organisms have been recently raised and discussed. In this context, a detailed review of the environmental fate and physicochemical properties of pyriproxyfen from the available scientific literature and from data gathered in its development and testing is needed. This paper gathers, combines, and abridges important environmental fate and property data on pyriproxyfen for academics, environmental scientists and agricultural professionals needing ready access to this information.

著者

Raul D. Santos Thiago S. Frauches Ana P.M. Chacra

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.31237, (Released:2015-07-21)

参考文献数

103

被引用文献数

3 16

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Familial hypercholesterolemia is a genetic disorder associated with elevated LDL-cholesterol and high lifetime cardiovascular risk. Both clinical and molecular cascade screening programs have been implemented to increase early definition and treatment. In this systematic review, we discuss the main issues found in 65 different articles related to cascade screening and familial hypercholesterolemia, covering a range of topics including different types/strategies, considerations both positive and negative regarding cascade screening in general and associated with the different strategies, cost and coverage consideration, direct and indirect contact with patients, public policy around life insurance and doctor–patient confidentiality, the “right to know,” and public health concerns regarding familial hypercholesterolemia.

著者

ハワード・S・ベッカー[著] 後藤 将之 海老田 大五朗(訳)

出版者

成城大学

雑誌

コミュニケーション紀要 (ISSN:02887843)

巻号頁・発行日

vol.13, pp.23-50, 2000-03

著者

D.A. Hodgson P. Convey E. Verleyen W. Vyverman S.J. McInnes C.J. Sands R. Fernandez-Carazo A. Wilmotte A. De Wever K. Peeters I. Tavernier A. Willems

出版者

国立極地研究所

雑誌

Polar science (ISSN:18739652)

巻号頁・発行日

vol.4, no.2, pp.197-214, 2010-08

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南極大陸の高緯度内陸部に位置するDufek Massifの湖沼と、そこに見られる生物を調査した。ここには二つのドライバレーがあり、地球上最南端の生物生息地となっている。優占する生物はラン藻で、その多様性は観察されてきた南極湖沼のどこよりも低い。緑藻、ケルコゾア類、バクテリアは存在するが、珪藻は風で飛ばされてきたと思われる一枚の殻が見つかっただけであった。コケ類を欠き、地衣類は一種類のみが見つかった。三種類のクマムシ、ワムシを含む後生動物は見いだされたが、節足動物と線虫は見つからなかった。これらの単純な動植物群集は、この地域のきわめて厳しい環境のために、低緯度南極に通常存在する要素のほとんどを欠く。

著者

Yuki KOBAYASHI Nana INOUE Go SATO Takuya ITOU Hamilton P. SANTOS Cristina J. C. BRITO Albério A. B. GOMES Marli F. C. SANTOS Marlon V. SILVA Carla S. MOTA Fumio H. ITO Takeo SAKAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.69, no.7, pp.691-696, 2007 (Released:2007-08-05)

参考文献数

25

被引用文献数

13 15

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The incidence of canine rabies has been widely reported in Brazil, and new rabies virus (RV) variants, genetically similar to canine RV, have recently been isolated from foxes. In order to derive the epidemiological characteristics of Brazilian Carnivora RV, Brazilian RVs isolated from dogs, cats, and foxes were genetically analyzed. Brazilian Carnivora RV isolates were divided into 2 main lineages. The predominant lineage was found in dogs and cats, which included the Argentinean and Bolivian Carnivora RV isolates, and was extensively distributed throughout Brazil and surrounding countries. The other lineage consisted of three sublineages containing Brazilian dog and fox RV isolates, with the dog sublineages located on an internal branch of 2 fox sublineages, suggesting that RV transmission events might have occurred between foxes and dogs in the past. These results suggest that contact between dogs and wildlife has the potential to generate new rabies variants and that it is important to control RV infection cycles in both dogs and wildlife to prevent spread of rabies infection.

著者

C. Upendra PRASAD S. M. BOSE

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.20, no.2, pp.97-102, 1974 (Released:2009-04-28)

参考文献数

41

被引用文献数

3 4

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Young weanling albino rats were pair fed with control and thiamine deficient diets for five weeks. The analyses of skins and granulomas showed that, compared with the control, the thiamine deficient group had a decrease in the neutral salt soluble, insoluble, and total collagen contents. The incorporation of glycine-1-14C into the skin collagen and the free glycine content of skins were also decreased. There was no change in the RNA and DNA contents of skins and granulomas. The urinary excretion of hydroxyproline or plasma hydroxyproline was not affected. The results suggest that there is a reduction of collagen synthesis in thiamine deficiency.

著者

Jadson J. S. Oliveira Tiara S. Cabral Ruby Vargas-Isla José F. B. Silva Doriane P. Rodrigues Nelson Menolli Jr. Mariana P. Drewinski Noemia K. Ishikawa

出版者

The Mycological Society of Japan

雑誌

Mycoscience (ISSN:13403540)

巻号頁・発行日

vol.63, no.6, pp.254-266, 2022-09-20 (Released:2022-11-20)

参考文献数

51

被引用文献数

1

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In the search for new strains of edible mushrooms in the Brazilian Amazon Forest, we found Lentinula specimens different from Lentinula raphanica. These were described morphologically and evaluated phylogenetically within the Lentinula clade. The mating system was determined, and interbreeding compatibility with L. raphanica was verified. The basidiomata have a cinnamon or deep orange to fulvous brown, moist to dry pileus, occasionally with whitish scales; crowded whitish cream lamellae; and an eccentric to lateral stipe. The typical, predominant basidiospores are 4.4-7.2 µm in length. Endogenous, elongate (7.8-14 µm) basidiospores were also found in some specimens. The long spores seem rare and occasional, but nonetheless a novelty for the group. Basidia are homogeneous in size, cheilocystidia are pyriform or bulboid, and caulocystidia are long and spheropedunculate. The hyphae of the pileipellis are pigment-encrusted. The characteristics match those of Agaricus ixodes originally described from Guyana, currently a synonym of Lentinula boryana. In the phylogenetic trees, such taxon appears distinct from L. boryana and sister to L. raphanica with strong support. This unique lineage was confirmed to be reproductively isolated from sympatric L. raphanica strains. Lentinula ixodes comb. nov. is the second species of the genus reported in the Amazon Forest.

著者

吉村 譲 吉村 美由紀 Yuzuru Yoshimura Miyuki Yoshimura 岡崎女子大学 名古屋芸術大学 Okazaki Women's University Nagoya University Of Arts

雑誌

研究紀要 = Bulletin of Okazaki Women's University, Okazaki Women's Junior College (ISSN:21882770)

巻号頁・発行日

vol.49, pp.89-98, 2016-03-25