著者

堤 浩之 平原 和朗 中田 高 杉戸 信彦 DELA CRUZ Laarni. S. RAMOS Noelynna T. PEREZ Jeffrey S.

出版者

京都大学

雑誌

基盤研究(B)

巻号頁・発行日

2008

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フィリピン断層の地形・歴史地震・古地震調査に基づき,この断層から発生する地震の規模や頻度が走向方向に大きく変化することを明らかにした.フィリピン断層のほぼ全域の縮尺5万分の1の活断層分布図を作成し,フィリピン火山地震研究所のホームページで公開した.完新世隆起サンゴ礁段丘の調査により,海岸部を数m隆起させるような巨大地震がフィリピン海溝やマニラ海溝で繰り返し発生してきたことをはじめて実証的に明らか

著者

T. Oguti

出版者

Society of Geomagnetism and Earth, Planetary and Space Sciences

雑誌

Journal of geomagnetism and geoelectricity (ISSN:00221392)

巻号頁・発行日

vol.45, no.3, pp.231-242, 1993-03-20 (Released:2007-04-03)

参考文献数

20

被引用文献数

6 6

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Variations in the location of the auroral zone over the past 1000 years is inferred from a model of secular variation in the geomagnetic field and its backward extrapolation. It is shown that the auroral zone was elongated and deviated towards the European sector 300 years ago, although it is deviated to the Canadian sector at present. The northern UK was located in or very close to the auroral zone, and large parts of the UK, Denmark and northern Germany were in the subauroral zone at that time. It cannot be accidental that the studies of aurorae were developed in France and the UK in the 17th and 18th centuries.

著者

Tonegawa S Kasahara S Fukuda T Sugimoto K Yasuda N Tsuruhara Y Watanabe D Mizukami Y Haga Y Matsuda T D Yamamoto E Onuki Y Ikeda H Matsuda Y Shibauchi T

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-06-19

被引用文献数

57

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直接観測された物質物理学の謎「隠れた秩序」. 京都大学プレスリリース. 2014-06-19.

著者

Kurniawan Muhammad T. A.

出版者

立命館大学国際関係学会

雑誌

立命館国際関係論集

巻号頁・発行日

no.11, pp.1-23, 2011-10

著者

Kumagai T. Shiotari A. Okuyama H. Hatta S. Aruga T. Hamada I. Frederiksen T. Ueba H.

出版者

Nature Publishing Group

雑誌

Nature Materials (ISSN:14761122)

巻号頁・発行日

2011-11-27

被引用文献数

107

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もっとも軽い元素である水素原子(プロトン)の連続リレー移動反応の直接観察と微視的機構を世界で初めて確立. 京都大学プレスリリース. 2011-11-28.

著者

VARGHESE T

雑誌

Ultrasound Med. Biol.

巻号頁・発行日

vol.26, pp.1525-1537, 2000

被引用文献数

4 94

著者

T・O

出版者

日本幼稚園協会

雑誌

幼児の教育

巻号頁・発行日

vol.84, no.4, pp.33-33, 1985-04-01

著者

Ishida T

出版者

IEEE COMPUTER SOC

雑誌

COMPUTER (ISSN:00189162)

巻号頁・発行日

vol.35, no.11, pp.42-47, 2002-11

被引用文献数

16 82

著者

Ryota Sakamoto Yusuke T. Maeda

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.20, no.3, pp.e200032, 2023 (Released:2023-09-01)

参考文献数

52

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Single-cell behaviors cover many biological functions, such as cell division during morphogenesis and tissue metastasis, and cell migration during cancer cell invasion and immune cell responses. Symmetry breaking of the positioning of organelles and the cell shape are often associated with these biological functions. One of the main players in symmetry breaking at the cellular scale is the actin cytoskeleton, comprising actin filaments and myosin motors that generate contractile forces. However, because the self-organization of the actomyosin network is regulated by the biochemical signaling in cells, how the mechanical contraction of the actin cytoskeleton induces diverse self-organized behaviors and drives the cell-scale symmetry breaking remains unclear. In recent times, to understand the physical underpinnings of the symmetry breaking exhibited in the actin cytoskeleton, artificial cell models encapsulating the cytoplasmic actomyosin networks covered with lipid monolayers have been developed. By decoupling the actomyosin mechanics from the complex biochemical signaling within living cells, this system allows one to study the self-organization of actomyosin networks confined in cell-sized spaces. We review the recent developments in the physics of confined actomyosin networks and provide future perspectives on the artificial cell-based approach. This review article is an extended version of the Japanese article, The Physical Principle of Cell Migration Under Confinement: Artificial Cell-based Bottom-up Approach, published in SEIBUTSU BUTSURI Vol. 63, p. 163–164 (2023).

著者

Rocío de la Vega Irina A. Heinisuo Alicia E. López-Martínez Elena R. Serrano-Ibáñez Gema T. Ruíz-Párraga Carmen Ramírez-Maestre Rosa Esteve

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.35, no.12, pp.768-776, 2023 (Released:2023-12-01)

参考文献数

26

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[Purpose] Non-invasive and drug-free interventions for pain are being developed. One of them is ANF (which stands for “Amino Neuro Frequency”) Therapy®, which consists in the application of carbonized metal devices on a patient’s skin. We aimed to: 1) test perceived changes in pain intensity after ANF application, 2) record frequency and severity of side effects, 3) assess clinician and patient satisfaction, 4) explore effects on swelling and range of motion (ROM). [Participants and Methods] In this real-world multisite observational study, N=113 physical therapists in 45 countries, applied ANF to N=1,054 patients (Mage=45.2, 56.2% female) with pain complaints. Demographic data, pain intensity (NRS-11), effects of ANF on swelling and ROM, clinician and patient satisfaction and side effects were collected. [Results] Main pain locations were: low back (14.9%), knee (12.4%), neck (10%), and shoulder (9.6%). Pre-treatment pain intensity was high (Mean=7.6, SD=1.9). It significantly decreased post-treatment (Mean=3.1, SD=2.0), t(1053)=7.25, with a large effect size (Cohen’s d=2.2). Swelling decreased and ROM increased. Average satisfaction with ANF was 92/100. Patients often experienced mild side effects (42.3%): dry mouth, headache and fatigue. [Conclusion] Results show large effect sizes, high satisfaction, and mild and short-term side effects. This is very promising but should be interpreted with caution considering the study limitations.

著者

原田 佑規 原田 悦子 須藤 智 HARADA Yuki HARADA Etsuko T. SUTO Satoru

出版者

Division of Physhology, Faculty of Human Sciences, University of Tsukuba

雑誌

筑波大学心理学研究 = Tsukuba Psychological Research (ISSN:09158952)

巻号頁・発行日

vol.56, pp.27-34, 2018-08-31

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The Cognitive Reflection Test (CRT: Frederick, 2005) is a test designed to measure individual differences in intuitive-reflective thinking styles, and consists of three questions in a fixed order. Although Toplak, West, & Stanovich (2014) have proposed four additional questions, their validity as substitutes was not fully examined. This study investigated (1) the equivalences of the original and new questions, (2) order effects for the three original questions, and (3) the dependency of the CRT across instruction conditions (i.e., standard, under time pressures or stressing accuracy). More specifically, we administered a paper-and-pencil version of the CRT to 128 undergraduate students and analyzed both task performances and confirmation ratings. The results indicated (a) that three of the new questions are not suitable substitutes for the original CRT questions, (b) that order effects in terms of independent item-specific characteristics were observed only for the confirmation ratings, and (c) that the instructions had no effect on either performance or confirmation ratings. Finally, we discussed the importance of investigating both the CRT’s methodology and the cognitive processes underlying the CRT.

著者

ペンペル T.J.

出版者

日本比較政治学会

雑誌

日本比較政治学会年報 (ISSN:21852626)

巻号頁・発行日

vol.7, pp.44-63, 2005-06-30 (Released:2010-09-09)

参考文献数

52

著者

Silvano Gallus Alessandra Lugo Chiara Stival Sonia Cerrai Luke Clancy Filippos T. Filippidis Giuseppe Gorini Maria José Lopez Ángel López-Nicolás Sabrina Molinaro Anna Odone Joan B. Soriano Olena Tigova Piet A. van den Brandt Constantine I. Vardavas Esteve Fernandez the TackSHS Project Investigators

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.6, pp.276-284, 2023-06-05 (Released:2023-06-05)

参考文献数

44

被引用文献数

3

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Background: Limited data on electronic cigarette prevalence, patterns, and settings of use are available from several European countries.Methods: Within the TackSHS project, a face-to-face survey was conducted in 2017–2018 in 12 European countries (Bulgaria, England, France, Germany, Greece, Ireland, Italy, Latvia, Poland, Portugal, Romania and Spain). Overall, 11,876 participants, representative of the population aged ⩾15 years in each country, provided information on electronic cigarette.Results: 2.4% (95% confidence interval [CI], 2.2–2.7%) of the subjects (2.5% among men and 2.4% among women; 0.4% among never, 4.4% among current- and 6.5% among ex-smokers) reported current use of electronic cigarette, ranging from 0.6% in Spain to 7.2% in England. Of the 272 electronic cigarette users, 52.6% were dual users (ie, users of both electronic and conventional cigarettes) and 58.8% used liquids with nicotine. In all, 65.1% reported using electronic cigarette in at least one indoor setting where smoking is forbidden; in particular, at workplaces (34.9%) and bars and restaurants (41.5%). Multivariable logistic regression analysis showed that electronic cigarette use was lower among older individuals (P for trend <0.001) and higher among individuals with high level of education (P for trend = 0.040). Participants from countries with higher tobacco cigarette prices more frequently reported electronic cigarette use (odds ratio 3.62; 95% CI, 1.80–7.30).Conclusion: Considering the whole adult population of these 12 European countries, more than 8.3 million people use electronic cigarettes. The majority of users also smoked conventional cigarettes, used electronic cigarettes with nicotine, and consumed electronic cigarettes in smoke-free indoor areas.

著者

Hiroyuki Imamura Yoshitaka Yoshimura Kazuhiro Uchida Seiji Nishimura Anthony T. Nakazawa

出版者

Japan Society of Physiological Anthropology

雑誌

Applied Human Science (ISSN:13413473)

巻号頁・発行日

vol.17, no.5, pp.215-218, 1998 (Released:2001-08-31)

参考文献数

15

被引用文献数

23 26

著者

Shinji C. Nagasaki Tomonori D. Fukuda Mayumi Yamada Yusuke III Suzuki Ryo Kakutani Adam T. Guy Itaru Imayoshi

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.22074, (Released:2022-12-16)

被引用文献数

1

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The Gal4/UAS system is a versatile tool to manipulate exogenous gene expression of cells spatially and temporally in many model organisms. Many variations of light-controllable Gal4/UAS system are now available, following the development of photo-activatable (PA) molecular switches and integration of these tools. However, many PA-Gal4 transcription factors have undesired background transcription activities even in dark conditions, and this severely attenuates reliable light-controlled gene expression. Therefore, it is important to develop reliable PA-Gal4 transcription factors with robust light-induced gene expression and limited background activity. By optimization of synthetic PA-Gal4 transcription factors, we have validated configurations of Gal4 DNA biding domain, transcription activation domain and blue light-dependent dimer formation molecule Vivid (VVD), and applied types of transcription activation domains to develop a new PA-Gal4 transcription factor we have named eGAV (enhanced Gal4-VVD transcription factor). Background activity of eGAV in dark conditions was significantly lower than that of hGAVPO, a commonly used PA-Gal4 transcription factor, and maximum light-induced gene expression levels were also improved. Light-controlled gene expression was verified in cultured HEK293T cells with plasmid-transient transfections, and in mouse EpH4 cells with lentivirus vector-mediated transduction. Furthermore, light-controlled eGAV-mediated transcription was confirmed in transfected neural stem cells and progenitors in developing and adult mouse brain and chick spinal cord, and in adult mouse hepatocytes, demonstrating that eGAV can be applied to a wide range of experimental systems and model organisms.Key words: optogenetics, Gal4/UAS system, transcription, gene expression, Vivid

著者

Sawada A. Koga T.

出版者

American Physical Society (APS)

雑誌

Physical review e (ISSN:24700045)

巻号頁・発行日

vol.95, no.2, pp.23309, 2017-02-21

被引用文献数

10

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We have developed a method to calculate the weak localization and antilocalization corrections based on the real-space simulation, where we provide 147 885 predetermined return orbitals of quasi-two-dimensional electrons with up to 5000 scattering events that are repeatedly used. Our model subsumes that of Golub [L. E. Golub, Phys. Rev. B 71, 235310 (2005)] when the Rashba spin-orbit interaction (SOI) is assumed. Our computation is very simple, fast, and versatile, where the numerical results, obtained all at once, cover wide ranges of the magnetic field under various one-electron interactions H' exactly. Thus, it has straightforward extensibility to incorporate interactions other than the Rashba SOI, such as the linear and cubic Dresselhaus SOIs, Zeeman effect, and even interactions relevant to the valley and pseudo spin degrees of freedom, which should provide a unique tool to study new classes of materials like emerging 2D materials. Using our computation, we also demonstrate the robustness of a persistent spin helix state against the cubic Dresselhaus SOI.

著者

サーリネン T.F. 中村 和郎

出版者

空間の理論研究会

雑誌

理論地理学ノート (ISSN:09120459)

巻号頁・発行日

vol.3, pp.4-13, 1983-03

著者

Yu Ishima Toru Maruyama Masaki Otagiri Victor T. G. Chuang Tatsuhiro Ishida

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.70, no.5, pp.330-333, 2022-05-01 (Released:2022-05-01)

参考文献数

48

被引用文献数

21

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Albumin, the most abundant protein in human serum, is applied to various diseases as a drug delivery carrier because of its superior blood retention, high biocompatibility, and a wide variety of drug binding abilities. Albumin is known to distribute widely in the blood and various interstitial fluids and organs. Different albumin receptors skillfully regulate the distribution characteristics of albumin in the body. Albumin receptors are a group of diverse proteins, such as FcRn, gp60, gp18, megalin, cubilin, SPARC, and CD36. Their tissue distributions in vivo are unique, with different albumin’s recognition sites. Therefore, the distribution of albumin in vivo is ingeniously controlled by these multiple albumin receptors. Reevaluation of these albumin receptors opens up new possibilities for applying albumin as a drug delivery carrier. If the tissue distributions of albumin receptors were known and the albumin recognition site of the receptor was identified, organ-specific active targeting would be possible. In this review, we would like to scrutinize what is currently known and share information to develop next-generation albumin carriers that focus on interactions with albumin receptors.

著者

小田 静夫 Keally Charles T.

出版者

日本人類学会

雑誌

人類學雜誌 (ISSN:00035505)

巻号頁・発行日

vol.94, no.3, pp.325-361, 1986

被引用文献数

4

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日本の旧石器時代の研究において,一つの関心事は日本列島に最初に渡来した人類の問題であろう.現在多数の研究者は1万-3万年前頃の旧石器時代人類の存在は認めているが,3万年以前に遡るとされる所謂「前期旧石器時代」になると,その存在に賛否両論があり現在未解決の問題として残されている.日本の前期旧石器時代については,1969年頃から芹沢長介により本格的に研究され始め,全国に遺跡,遺物の発見があった.しかし,ここ数年,岡村道雄&bull;鎌田俊昭らが宮城県内で推進している「新たな前期旧石器時代」の提唱は,芹沢により研究されてきた本来の「前期旧石器問題」を解決させることなく,これこそ真の石器であり,遺跡も完壁なものであると力説する.現在宮城県内で33ヵ所の前期旧石器時代遺跡が発見されており,その中でも座散乱木,馬場壇A,志引,中峯C,北前,山田上ノ台遺跡等が有名である.

著者

本山 智洋 Ali Baratov Rui Shan Low 浦野 駿 中村 有水 葛原 正明 Joel T. Asubar 谷田部 然治

出版者

公益社団法人 日本表面真空学会

雑誌

日本表面真空学会学術講演会要旨集 2021年日本表面真空学会学術講演会 (ISSN:24348589)

巻号頁・発行日

pp.2Ca10S, 2021 (Released:2021-12-24)

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GaN系パワー・高周波デバイスのゲート絶縁膜として有望なAl2O3薄膜を低コストな酸化物薄膜形成手法であるミストCVD法により作製し評価した。ミストCVD法で作製したAl2O3薄膜は禁制帯幅など、ALD法で作製したAl2O3薄膜と同等の物性値を示した。またAl2O3/AlGaN/GaNキャパシタの容量-電圧特性から、良好なAl2O3/AlGaN界面が形成されていることが示唆された。