著者

原田 亜紀子 杉原 数美 渡部 容子 山路 誠一 北村 繁幸 太田 茂

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.10, pp.1185-1196, 2015 (Released:2015-10-01)

参考文献数

22

被引用文献数

8

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Aryl hydrocarbon receptor (AhR) ligand activity of the extracts of 62 herbal medicines was examined using yeast reporter assay. Fifty-eight herbal extracts exhibited AhR ligand activity. The highest activity was observed with Ogon (Scutellariae Radix), followed by Oren (Coptidis Rhizoma), Kujin (Sophorae Radix) and Shoma (Cimicifiigae Rhizoma). When these extracts were treated with hesperinase, a hydrolase for sugar conjugates, the aglycones showed higher activity than the parent extracts. Among the constituents of Ogon extract, baicalein and wogonin showed AhR ligand activity, while the sugar conjugate of baicalein, baicalin, was inactive. Among the flavonoid components of these herbal medicines, flavone and chrysin exhibited high ligand activity for AhR. Ethoxyresorufin O-dealkylase (EROD) activity due to CYP1A1 in HepG2 cells was enhanced by the addition of baicalein. Baicalein also decreased the 3-methylcholanthrene-induced increase of EROD activity, but this effect was not statistically significant. When wogonin or baicalein was orally administered at the dose of 100 mg/kg to mice, EROD activity in liver was only slightly changed. Furthermore, when Ogon extract was co-administered with 3-methylcholanthrene, the EROD and methoxyresorufin O-dealkylase activities were not significantly changed. These results indicate that many herbal extracts have AhR ligand activity, and their inducing effect on CYP1A1/2 can be evaluated in HepG2 cells.

著者

水田 栄之助

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.6, pp.789-792, 2015-06-01 (Released:2015-06-01)

参考文献数

12

被引用文献数

1 3

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Individual taste sensitivity affects one's eating habits, and could thus play a role in the development of lifestyle-related diseases, such as obesity, hypertension and dyslipidemia. However, only a handful of studies have been conducted to investigate these associations. Therefore, we performed taste sensitivity tests on approximately 250 patients with lifestyle-related diseases who were undergoing outpatient treatment at the Department of Internal Medicine, or received a health check-up in order to examine the associations of individual taste sensitivity with their eating habits and lifestyle-related diseases. Our findings showed that sensitivity to sweet or salt taste was significantly lower in patients with cardiovascular diseases, and sensitivity to umami taste was significantly lower in obese patients. These findings suggest that taste sensitivity disorders may be linked not only to eating habits and lifestyle-related diseases, but also to the onset of cardiovascular diseases. Many of the drugs used in the treatment of lifestyle-related diseases and cardiovascular diseases, including antihypertensive agents, statins, fibrates, and allopurinol, are known to form zinc chelates and thereby possibly cause drug-induced taste disorders. Focusing on individual taste sensitivity to improve or maintain intake levels may become a new target for drug development in the areas of lifestyle-related and cardiovascular diseases.

著者

松村 美奈 中山 拓人 寒水 孝司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.11, pp.1563-1571, 2016-11-01 (Released:2016-11-01)

参考文献数

7

被引用文献数

4 1

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A survey of introductory statistics courses at Japanese medical schools was published as a report in 2014. To obtain a complete understanding of the way in which statistics is taught at the university level in Japan, it is important to extend this survey to related fields, including pharmacy, dentistry, and nursing. The current study investigates the introductory statistics courses offered by faculties of pharmaceutical sciences (six-year programs) at Japanese universities, comparing the features of these courses with those studied in the survey of medical schools. We collected relevant data from the online syllabi of statistics courses published on the websites of 71 universities. The survey items included basic course information (for example, the course names, the targeted student grades, the number of credits, and course classification), textbooks, handouts, the doctoral subject and employment status of each lecturer, and course contents. The period surveyed was July-September 2015. We found that these 71 universities offered a total of 128 statistics courses. There were 67 course names, the most common of which was “biostatistics (iryou toukeigaku).” About half of the courses were designed for first- or second-year students. Students earned fewer than two credits. There were 62 different types of textbooks. The lecturers held doctoral degrees in 18 different subjects, the most common being a doctorate in pharmacy or science. Some course content differed, reflecting the lecturers' academic specialties. The content of introductory statistics courses taught in pharmaceutical science programs also differed slightly from the equivalent content taught in medical schools.

著者

齋藤 充生

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.2, pp.245-249, 2016-02-01 (Released:2016-02-01)

参考文献数

5

被引用文献数

7

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According to the “Japan Revitalization Strategy” established in June 2013, “the government will promote better contributions of local pharmacies and pharmacists in encouraging self-medication of citizens by making pharmacies the community-based hub for providing information, giving advice on the proper use of non-prescription drugs, etc. and offering consultation and information service concerning health”. In addition, the “Demanded Function and Ideal Form of Pharmacy,” published in January 2014, requested a change, from pharmacies that specialized in dispensing medicines to pharmacies that serve as whole healthcare stations, providing pharmaceutical care based on patients' medical history, including the intake of dietary supplements. The medication fee was revised in April 2014 to enhance family pharmacy services and the management of pharmaceutical care. At that time, blood testing at a registered pharmacy was officially allowed under strict regulation. Revision of the “Pharmacist Law” in June 2014 included a request to pharmacists to provide pharmaceutical advice in addition to information. For the mitigation of drug-induced tragedies, the “Pharmaceutical Affairs Law” was amended to the “Pharmaceutical and Medical Device Act (PMD Act)” in November 2014, and proper use of medicines was imposed on healthcare professionals and other stakeholders. Patients were also requested to learn and understand the safety and harmful effects of medicines, and were requested to use medicines appropriately. As mentioned above, the status of pharmacies and pharmacists has dramatically changed in the past 2 years, and such changes over time are required.

著者

村山 義温 篠崎 好三

出版者

公益社団法人 日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.51, no.5, pp.379-384, 1931-05-26 (Released:2009-11-13)

被引用文献数

2

著者

辻 敏和 永田 健一郎 川尻 雄大 山田 孝明 入佐 俊弘 村上 裕子 金谷 朗子 江頭 伸昭 増田 智先

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.11, pp.1573-1584, 2016 (Released:2016-11-01)

参考文献数

20

被引用文献数

3

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There are many reports regarding various medical institutions' attempts at the prevention of dispensing errors. However, the relationship between occurrence timing of dispensing errors and subsequent danger to patients has not been studied under the situation according to the classification of drugs by efficacy. Therefore, we analyzed the relationship between position and time regarding the occurrence of dispensing errors. Furthermore, we investigated the relationship between occurrence timing of them and danger to patients. In this study, dispensing errors and incidents in three categories (drug name errors, drug strength errors, drug count errors) were classified into two groups in terms of its drug efficacy (efficacy similarity (−) group, efficacy similarity (+) group), into three classes in terms of the occurrence timing of dispensing errors (initial phase errors, middle phase errors, final phase errors). Then, the rates of damage shifting from “dispensing errors” to “damage to patients” were compared as an index of danger between two groups and among three classes. Consequently, the rate of damage in “efficacy similarity (−) group” was significantly higher than that in “efficacy similarity (+) group”. Furthermore, the rate of damage is the highest in “initial phase errors”, the lowest in “final phase errors” among three classes. From the results of this study, it became clear that the earlier the timing of dispensing errors occurs, the more severe the damage to patients becomes.

著者

小野 秀樹

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.5, pp.767-781, 2019-05-01 (Released:2019-05-01)

参考文献数

67

被引用文献数

2 2

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Although the anti-influenza virus drug oseltamivir ameliorates the fever of influenza, adverse events related to its hypothermic effect have been reported. We found that oseltamivir causes dose-dependent hypothermia in normal mice, and have been studying the pharmacological mechanisms responsible for 12 years. Oseltamivir blocks nicotinic cholinergic transmission at sympathetic ganglia and reduces sympathetic modulation of brown adipose tissue (BAT), a heat generator. Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells expressing the human α3β4 nicotinic receptor. Metabolized oseltamivir carboxylate, which inhibits the influenza virus neuraminidase, did not elicit hypothermia and ion channel suppression. Body temperature was decreased by intracerebroventricular administration of oseltamivir. Because this hypothermic effect was inhibited by dopamine D2 receptor blockade, it was suggested that oseltamivir centrally stimulates the D2 receptor. In Japan, the package inserts for oseltamivir and amantadine indicate very similar adverse neuropsychiatric reactions for the two drugs (abnormal behavior, consciousness disturbance, convulsion, delirium, delusion, hallucination). A literature search revealed that in some previous studies, oseltamivir and amantadine were shown to block the ion channel systems and activate the dopaminergic nervous system via several mechanisms. Therefore the similarity of the adverse reactions elicited by oseltamivir and amantadine was considered attributable to their similar pharmacological effects.

著者

岩槻 健

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.50, no.9, pp.885-887, 2014 (Released:2016-09-17)

参考文献数

14

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最近,日本が誇る伝統文化の1つである和食がユネスコの無形文化遺産に登録された.その理由は,自然食材の利用やそれを用いた表現,栄養バランス,年中行事とのかかわりなどが認められたということである.しかしながら,和食の神髄は食材のうまみを引き出す“出汁(ダシ)”を使うことにある.和食では出汁を昆布,削り節,干し椎茸などからとるが,昆布からはグルタミン酸が,削り節や椎茸などからは核酸が主な成分となっている.これらはいずれも,味覚受容体の1つであるうま味受容体に結合し,うま味シグナルを味神経に伝える.これまでの研究から,うま味受容体は甘味,苦味と同様にGタンパク質共役型受容体(GPCR)で構成されており,T1R1+T1R3のヘテロ2量体,代謝型グルタミン酸受容体(mGluR)1,mGluR4と報告されている.

著者

石田 祐

出版者

公益社団法人 日本薬学会

雑誌

MEDCHEM NEWS (ISSN:24328618)

巻号頁・発行日

vol.33, no.4, pp.165-169, 2023-11-01 (Released:2023-11-01)

参考文献数

1

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英国スコットランドのダンディー大学に2019年から3年ほど滞在した経験とそこから感じたことを、米国に以前駐在した経験との比較を踏まえ紹介したい。また滞在中にはCOVID-19パンデミックや英国のEU離脱、ウクライナ危機などの大きな変動を経験したので、現地がどのような状況であったかも併せて紹介したい。本稿が海外での研究に挑戦しようか悩んでいる方の背中を押す一助になれば幸いである。

著者

小林 正義 山元 正昭

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.95, no.8, pp.959-965, 1975-08-25 (Released:2008-05-30)

参考文献数

9

被引用文献数

3 3

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Acceleration of gelation reaction of limulus lysate was observed by the addition of a concentration higher than 10-3M of alkaline earth metals, such as Mg2+, Ca2+, B2+, or Sr2+. The limulus lysate containing Mg2+ or Ca2+ in a concentration of 10-1M as an additive showed the highest sensitivity which was 500 times that of original lysate. The sensitivity of the limulus lysates with Sr2+ or Ba2+ as an additive was lower than that of the limulus lysates with Mg2+ or Ca2+ as an additive. Acceleration of gelation reaction was interrupted by the use of any of alkaline earth metals in 1M concentration, and especially by the addition of Ca2+ in 1M concentration, approximately complete inhibition of gelation reaction being observed. Addition of a chelating agent such as ethylenediaminetetraacetic acid (EDTA) or diethylenetriamine-N, N, N', N", N"-pentaacetic acid (DTPA) reduced the sensitivity of limulus lysates to one-tenth of the sensitivity of the original limulus lysate in 10-2M concentration of such a chelating agent. The lowering of pH resulting from chelating streng-thens the lowering of the sensitivity of the limulus lysates. Complete inhibition of the gelation reaction was observed with marked lowering of the pH by the addition of EDTA to the limulus lysate containing a higher concentration of Mg2+. Correlation between the sensitivity of the limulus lysates and concentration of Mg2+ or Ca2+ was not observed. Reexamination of the optimum pH for the gelation readion necessitated the correction of pH to 6.75-7.25 from the previously reported pH range of 6, 50-6.75.

著者

寺崎 展幸

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.8, pp.1125-1128, 2016-08-01 (Released:2016-08-01)

参考文献数

4

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Hyogo Prefectural Amagasaki General Medical Center has formed a heart failure team. Here, I report on the role of the pharmacist in this heart failure team at this hospital. Patient education is one of the roles of the pharmacist. It is the pharmacist's responsibility to improve medication adherence among patients. For this purpose, the pharmacist uses a brochure created by the heart failure team. The brochure outlines drug information in an easy-to-understand manner. The roles of a pharmacist were addressed in a lecture presented to the heart failure team. These lectures helped improve the pharmaceutical knowledge of the team, allowing the team to prescribe medicines more safely and appropriately. Maintaining co-operation between hospital and community pharmacies is another important role of a hospital pharmacist. This allows patients to be properly educated by pharmacists even after discharge from the hospital.

著者

渡辺 俊明 田中 正彦 渡邉 和俊 高松 康雄 戸部 昭広

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.124, no.3, pp.99-111, 2004-03-01 (Released:2004-02-25)

参考文献数

51

被引用文献数

84 86

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Increasing data suggest that oxygen free radical species play detrimental roles in ischemic diseases. A free radical scavenger capable of inhibiting oxidative injury is expected to become a new drug for the treatment of ischemic diseases such as cerebral ischemia. Edaravon (3-methyl-1-phenyl-2-pyrazolin-5-one), which has been developed as an neuroprotective agent for more than 15 years since its discovery, is approved for the treatment of acute cerebral infarction. In this paper, the pharmacologic characteristics and clinical effects of edaravone are reviewed. In early stage of investigation, edaravone was found to have promising activities as an antioxidative radical scavenger, quenching hydroxyl radical (•OH) and inhibiting both •OH-dependent and •OH-independent lipid peroxidation. Edaravone showed inhibitory effects on both water-soluble and lipid-soluble peroxyl radical-induced peroxidation systems, which are different from the inhibitory effects of vitamins C and E in each system, respectively. Oxidative injury to cultured endothelial cells caused by arachidonate (AA) peroxides is prevented in the existence of edaravone. To clarify the characteristics of this free radical scavenger, further investigation was carried out. Edaravone ameliorated exacerbation of cortical edema induced by a focal ischemia-reperfusion model in rats, suggesting inhibitory effects on oxidative injury to the blood-brain barrier (BBB). Additionally, edaravone also prevented rat cortical edema caused by intracortical AA infusion in which free radical production and subsequent oxidative injury to the BBB are involved. With advances in in vivo measurement technology of oxygen radicals, edaravone was shown to inhibit postischemic increases in •OH production and tissue injury in the penumbral or recirculated area in rat cerebral ischemia models. In clinical studies, edaravone improved the core neurologic deficits, activities of daily living, and functional outcome of stroke patients. Furthermore, a study using proton magnetic resonance spectroscopic techniques showed that edaravone preserved N-acetyl-aspartate in stroke patients, a promising neuronal marker in the brain. Further investigation is essential for a better understanding of free radical-mediated cerebral injury during ischemia followed by recirculation. We hope that edaravone represents a promising neuroprotectant for drug therapy in acute cerebral ischemia.

著者

佐藤 洋美 上野 光一

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.47, no.3, pp.218-222, 2011-03-01 (Released:2017-02-24)

被引用文献数

1

著者

大友 千絵子

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.52, no.9, pp.863-865, 2016 (Released:2016-09-02)

参考文献数

12

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全米の医療大麻人口はおよそ260万人と推計されている。50州から構成される連邦国家であるアメリカ合衆国で、医療大麻(医療マリファナ)が合法とされている州はそのうち24州と連邦政府直轄地区であるワシントンD.C地区である。その先陣を切り、最も早く医療大麻が合法化されたのがカリフォルニア州(加州)だ。規制薬物法で最も規制の厳しいスケジュールIに分類されている医療大麻の現状を紹介する。

著者

菅 敏幸 友岡 克彦

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.38, no.4, pp.301-303, 2002-04-01 (Released:2018-08-26)

参考文献数

4

被引用文献数

1

著者

近藤 あゆみ

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.1, pp.89-94, 2016

被引用文献数

1

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The increasing number of law-evading drug users in Japan is becoming a serious social problem. Previous studies have shown that law-evading drug users are younger, more educated, and less antisocial than methamphetamine users. They also tend to have some type of psychiatric disorder before starting drug use; therefore one of the reasons that they start using drugs may be to alleviate certain psychiatric symptoms. Furthermore, if drug users are successful in avoiding arrest, they often lack the motivation to stop, which makes treatment difficult. Therapists are required to be non-confrontational, to keep pace with their patients, and to take their patients' other existing disorders into account. Recently, the Matrix Model has shown promise as a new treatment strategy for drug abusers in Japan. The Matrix Model, which was originally developed in response to the 1980s cocaine epidemic in the USA, is an intensive outpatient treatment approach for drug abuse and dependence. The Matrix Model integrates cognitive-behavioral therapy, contingency management, motivational interviewing, 12-step facilitation, family involvement, and so on, with a directive, non-confrontational approach, and this style of therapy seems to fit with law-evading drug users. A Matrix Model-based treatment program was first established in Japan in 2006. The aim of this report is to introduce and assess the benefits of the TAMA Mental Health and Welfare Center Relapse Prevention Program, a Matrix Model-based treatment program established at the Tama Mental Health and Welfare Center in 2007.<br>

著者

及川 弘崇

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.53, no.3, pp.264, 2017 (Released:2017-03-01)

参考文献数

3

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成人期に形成された記憶は長期保持されるが,幼児期に形成された記憶は簡単に失われる.この現象は,「幼児期健忘」と呼ばれ,人ではおおむね3歳以前の幼児期の記憶を喪失することが知られている.長年,幼児期健忘の機構は明らかではなかったが,2014年にAkersらは,神経新生の多い幼若期海馬歯状回において,神経新生による回路再編が神経回路に蓄えられた記憶の忘却を促進し,神経新生の少ない成人期には記憶の忘却が起こりにくいということを明らかにした.その一方で,忘却したはずの早期記憶が,後の人生の脳機能と生理に深く影響していることも実証されている.例えば,育児放棄や虐待を幼児期に経験すると,成人期でのストレス脆弱性が増加し,心的外傷後ストレス障害などの発症素因となる.しかしながら,早期記憶を忘却するにもかかわらず,早期の経験が成人の行動に影響を及ぼす機構は明らかではなかった.今回Travagliaらは,幼児期健忘期に体験学習したことが潜在的な記憶として保管されることと,それが脳の発達過程の臨界期(神経回路網の再編成が一過的に高まり,記憶・学習に効果的とされる生後の限られた時期)に起こる機構の刺激により惹起されることを報告したので紹介したい.なお,本稿は下記の文献に基づいて,その研究成果を紹介するものである.1) Akers K. G. et al., Science., 344, 598–602(2014).2) Travaglia A. et al., Nat. Neurosci., 19, 1225–1233(2016).3) Matta J. A. et al., Neuron., 70, 339–351(2011).

著者

高根 浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.11, pp.1589-1594, 2011-11-01 (Released:2011-11-01)

参考文献数

30

被引用文献数

4 8

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Various drug transporters are selectively expressed in single or multiple tissues, such as the intestine, liver and kidney, where these transporters play various roles in drug absorption, distribution and excretion. Genetic polymorphisms in drug transporters as well as drug-metabolizing enzymes are associated with interindividual differences in drug disposition, efficacy and toxicity. Organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) is expressed on the basolateral membrane of hepatocytes and can facilitate hepatic uptake of certain clinically relevant drugs such as statins except for fluvastatin, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists, antidiabetic drug (repaglinide) and anticancer drugs (SN-38 and methotrexate). Some single nucleotide polymorphisms or haplotypes of the SLCO1B1 gene have been identified and demonstrated to have functional significance for transporter activity. For examples, the SLCO1B1*15 haplotype (or 521T>C genotype) results in decreased uptake activity of SN-38 from systemic circulation, leading to increased plasma concentration of SN-38 and an enhanced risk of neutropenia. This review focuses on the impact of genetic polymorphisms of the SLCO1B1 gene on transport activity, and implications for the clinical efficacy and toxicity of clinically useful drugs.

著者

黒澤 努

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.128, no.5, pp.741-746, 2008-05-01 (Released:2008-05-01)

参考文献数

7

被引用文献数

1 2 2

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Systematic modern animal experimentation was established by Bernard Claude who wrote “An Introduction to the Study of Experimental Medicine” in 1865. At this point, the public was already asking that the pain and distress of experimental animals be reduced. For this, scientists, William Russell and Rex Burch in 1959 proposed the principles of alternatives to animal experimentation, the “3Rs”. Since that time, animal welfare advocates have promoted the 3Rs concept in biomedical research communities. However, cruel animal experiments have continued and there are reports of radical extremists showing their opposition by invasion, arson, theft and even bombing of institutions involved, resulting in killing of the animals. SHAC, one extremist group believed to be animal welfare activitists was recognized as a terrorist group after the 9.11 tragedy in USA and the government viewed their activities very seriously. In 2001, British animal extremists invaded Japanese universities and stole laboratory resources; one individual was arrested and sentenced to prison for three years; Japanese who assisted in the incident were arrested and one was sentenced for one year. In 2006, SHAC USA members were prosecuted and sentenced for up to 6 years for their terrorism activities including arson. We need to consider the background of these activities which are financially supported by animal welfare advocates. The way we, as scientists who conduct such experiments can respond is by promoting alternatives to this experimentation. In Japan, the animal welfare law was revised in 2005 stressing the importance of 3Rs in scientific activities with animals. The promotion of 3Rs should be strengthened in the pharmaceutical community.

著者

秋山 遼太 中安 大 水谷 正治

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.57, no.8, pp.726-730, 2021 (Released:2021-08-01)

参考文献数

18

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ジャガイモはステロイドグリコアルカロイド(SGA)と呼ばれる有毒なα-ソラニンを含有している。SGAは少量であれば不快なえぐみを示す程度だが,多量に摂取した場合は食中毒を引き起こす。トマトにも有毒なSGAであるα-トマチン が葉や花、未熟果実に蓄積しているが、赤く熟した果実には有毒SGAは蓄積しておらず、食中毒を引き起こすことはない。本稿では、SGA生合成遺伝子同定に関する最近の研究の進展を解説するとともに,それらの知見を生かした有毒SGAを生産しないジャガイモの作出について紹介する.