著者

Kenji Nakahama Hiroyasu Kaneda Koichi Ogawa Yoshiya Matsumoto Yoko Tani Tomohiro Suzumura Shigeki Mitsuoka Tetsuya Watanabe Kazuhisa Asai Tomoya Kawaguchi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.7, pp.1039-1042, 2022-04-01 (Released:2022-04-01)

参考文献数

16

被引用文献数

3

---

A 68-year-old Japanese man was diagnosed with lung adenocarcinoma stage IVB. We introduced a first-line chemotherapy of four cycles of carboplatin and pemetrexed and pembrolizumab, followed by pemetrexed and pembrolizumab maintenance therapy. Approximately four months after anticancer therapy, a small nodule appeared in the right peripheral S3 lesion. After five months, the nodule was confirmed as a Mycobacterium tuberculosis (TB) nodule. We initiated anti-TB therapy without stopping pembrolizumab, and the right S3 nodule shrank immediately. This report supports the concurrent use of anti-TB treatment with an immune checkpoint inhibitor when the TB infection area is limited.

著者

小嶋 文博 刈谷 円 細川 知子 Fumihiro Ojima Madoka Kariya Tomoko Hosokawa

雑誌

盛岡大学短期大学部紀要 = Bulletin of Morioka Junior College (ISSN:09168079)

巻号頁・発行日

vol.14, pp.21-30, 2004-05-01

---

野菜・果実類の酸化還元電位を測定し,加熱したほうが食品の酸化還元電位が低下することが判った。これは(1)食品中のポリフェノラーゼなどが加熱により失活するため,抗酸化成分の酸化・分解が抑制されること,(2)加熱より細胞組織が柔軟化し,細胞内容物が細胞外に浸出しやすくなることなどが主な理由であると考えられた。また酸化還元電位の異なる食品の摂取試験から,人体の酸化還元電位よりも相対的に低い酸化還元電位を有する食品の摂取が人体(尿)の酸化還元電位を低くすることが示唆された。特に野菜・果実類を加熱して摂取することが,生で摂取するよりも,人体の酸化還元電位という指標から体内の酸化還元電位の改善に有効であることが示唆された。

著者

Shin-ichiro Ohmura Yoichiro Homma Takayuki Masui Toshiaki Miyamoto

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.7, pp.997-1006, 2022-04-01 (Released:2022-04-01)

参考文献数

52

被引用文献数

11

---

Objective To investigate the risk factors for the development of Pneumocystis jirovecii pneumonia (PCP) in patients with rheumatoid arthritis (RA) undergoing methotrexate (MTX) therapy. Methods This single-center retrospective cohort study included consecutive patients with RA who received MTX for at least one year. The study population was divided into PCP and non-PCP groups, depending on the development of PCP, and their characteristics were compared. We excluded patients who received biologic disease-modifying anti-rheumatic drugs (DMARDs), Janus kinase inhibitors, and anti-PCP drugs for prophylaxis. Results Thirteen patients developed PCP, and 333 did not develop PCP. At the initiation of MTX therapy, the PCP group had lower serum albumin levels, a higher frequency of pulmonary disease and administration of DMARDs, and received a higher dosage of prednisolone (PSL) than the non-PCP group. A multivariate Cox regression analysis revealed that the concomitant use of PSL [hazard ratio (HR) 5.50, p=0.003], other DMARDs (HR 5.98, p=0.002), and serum albumin <3.5 mg/dL (HR 4.30, p=0.01) were risk factors for the development of PCP during MTX therapy. Patients with these risk factors had a significantly higher cumulative probability of developing PCP than patients who lacked these risk factors. Conclusion Clinicians should pay close attention to patients with RA who possess risk factors for the development of PCP during MTX therapy.

著者

Tetsuaki Ban Shin-ichiro Fujiwara Rui Murahashi Hirotomo Nakajima Takashi Ikeda Sae Matsuoka Yumiko Toda Shin-ichiro Kawaguchi Shoko Ito Takashi Nagayama Kento Umino Daisuke Minakata Hirofumi Nakano Kaoru Morita Masahiro Ashizawa Chihiro Yamamoto Kaoru Hatano Kazuya Sato Ken Ohmine Yoshinobu Kanda

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.7, pp.989-995, 2022-04-01 (Released:2022-04-01)

参考文献数

19

被引用文献数

3

---

Objective Peripherally inserted central catheters (PICCs) are widely used in patients with hematologic malignancies. However, the risks of PICC-related complications during chemotherapy for acute myeloid leukemia (AML) are not fully understood. Methods We conducted a retrospective review of 128 adult patients with AML who received induction therapy by way of PICC insertion between 2012 and 2019. Results The median duration of PICC insertion was 30 days. The incidence rate of catheter-related bloodstream infection (CRBSI) was 2.4% at 30 days, and women were more likely to suffer from CRBSI than men. Local reactions at the insertion site were observed in 56 patients; however, these events did not predict CRBSI. The incidence rates of catheter-related thrombosis (CRT) were 1.6% at 30 days. Obesity put patients at an increased risk for CRT. Unexpected PICC removal occurred in 59 patients, and women were at a higher risk of catheter removal than men. Conclusion Low PICC-related complication rates, possibly associated with high rates of catheter removal, were observed during intensive chemotherapy for AML. Women and obese patients require careful monitoring of their PICC. Procedures to achieve appropriate PICC removal without increasing the complication rate need to be considered.

著者

Yuto Yasuda

出版者

Japan Society of Physical Education, Health and Sport Sciences

雑誌

International Journal of Sport and Health Science (ISSN:13481509)

巻号頁・発行日

vol.20, pp.19-25, 2022 (Released:2022-04-02)

参考文献数

48

---

Different cultures have different societal structures and different communication style. Additionally, how sports are organized varies from country to country in terms of structure. These factors make athletes across the world demonstrate different psychological characteristics. Despite these differences, these cultural impacts have been paid little attention to, and psychological universality has been explored in the field of sport psychology even though the importance of cultural differences is remained. This review article explores the consideration of cultural psychology within the domain of sport psychology. Specifically, this article compares East Asian culture and North American culture from an achievement motivation perspective. Self-construal, regulatory focus theory, self-determination theory, and achievement goal theory are investigated in order to compare the two cultures. It is recommended that future researchers in the domain of sport psychology refer to both cultural differences as well as psychological universality to deepen insight into the sport psychology field. Practitioners in sport psychology such as mental performance consultants and coaches, are also suggested to consider cultural differences in order to effectively communicate with players and implement more effective interventions.

著者

Taro Noguchi Koh Shinohara Yasuhiro Tsuchido Satomi Yukawa Masaki Yamamoto Yasufumi Matsumura Michiko Hayashi Yutaka Yamada Akihiko Hayashi Tsunehiro Shimizu Miki Nagao

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.75, no.2, pp.205-208, 2022-03-31 (Released:2022-03-24)

参考文献数

12

---

Transitioning from intravenous to oral antibiotic therapy for Escherichia coli bacteremia could reduce the length of hospital stay and drug costs without compromising efficacy. Despite the expansion of extended-spectrum β-lactamase (ESBL)-producing E. coli, limited data are available regarding the effectiveness of switching to oral antibiotic therapy in patients with bacteremia caused by this organism. To compare clinical outcomes between oral transition therapy and intravenous therapy in patients with bacteremia due to ESBL-producing E. coli with a urinary source, we conducted a retrospective cohort study at 3 Japanese hospitals. The effects were estimated by Cox hazard analysis using propensity scores. Among 996 patients with bacteremia due to E. coli, 73 were included in the study. In the adjusted analysis weighted by propensity scores including 26 patients in the oral switch group and 47 in the intravenous group, oral transition did not increase the risk of treatment failure within 60 days (adjusted hazard ratio 0.86, 95% confidence interval 0.18–4.10), whereas the length of hospital stay was shorter in the oral switch group than in the intravenous group (median, 12 days vs. 19 days, P = 0.04). Intravenous-to-oral transition may be an effective treatment option that shortens the hospital stay.

著者

御手洗 明佳 松本 暢平 飯田 陸央

出版者

早稲田大学大学院教育学研究科

雑誌

早稲田大学大学院教育学研究科紀要 : 別冊 (ISSN:13402218)

巻号頁・発行日

vol.20, no.2, pp.117-128, 2013-03-30

著者

石塚 正英

出版者

特定非営利活動法人 頸城野郷土資料室

雑誌

頸城野郷土資料室学術研究部研究紀要 (ISSN:24321087)

巻号頁・発行日

vol.2020, no.62, pp.1-13, 2020 (Released:2020-03-14)

著者

重盛 大輔 山下 真人

出版者

日本理学療法士協会(現 一般社団法人日本理学療法学会連合)

雑誌

理学療法学Supplement Vol.48 Suppl. No.1 (第55回日本理学療法学術大会 抄録集)

巻号頁・発行日

pp.B-145_2, 2021 (Released:2021-12-24)

著者

鶴田 大 豊島 裕樹

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第35回 (2021)

巻号頁・発行日

pp.2H3GS3b03, 2021 (Released:2021-06-14)

---

金融機関においてアパートローンの残高が中長期的に増加してきており、金融機関ではアパートの収益性を適切に把握し、リスク管理を行うことが課題となっている。収益評価においてはアパート賃料の予測が必要となる。本研究では、機械学習手法を用い、物件属性情報に加え、緯度経度や住所に紐づく情報を活用することで精度が改善することを示す。具体的には緯度経度情報や住所情報などを用い、周辺の同種物件の過去賃料を用いることで短期的な賃料の予測精度が向上することを示す。また、緯度経度情報を活用し各物件が属する災害情報などの地理空間情報(GIS)データを取り込み、周辺の過去賃料に災害情報を加えることでは、賃料予測の精度が改善しないことを示す。

著者

西口 美穂 楠見 孝

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

pp.93.21001, (Released:2022-03-31)

参考文献数

36

被引用文献数

1

---

Many recent studies, primarily about comprehension, have shown that perceptual simulation occurs in language processing. We conducted two studies to investigate how such perceptual simulation influences sentence production. In both studies, the participants were first repeatedly presented with pictures of an object with a specific shape (e.g., an unbroken egg or a broken egg). In Study 1, they produced a sentence using two words (e.g., egg, refrigerator) and the onset times for their speech were recorded. In Study 2, they were presented with three words and asked to produce a sentence from the target word (e.g., egg) and a word they freely chose from the others (e.g., refrigerator or skillet). Results indicated that visual information matching the sentences did not influence speech onset times (Study 1). However, more sentences implied that the shape matched the presented picture compared to the other picture (Study 2). This suggests perceptual simulation plays an important role in sentence production when spontaneously formulating the message to be conveyed.

著者

柴垣 克司 中出 文平

出版者

公益社団法人 日本都市計画学会

雑誌

都市計画論文集 (ISSN:09160647)

巻号頁・発行日

vol.28, pp.835-840, 1993-10-25 (Released:2019-09-01)

参考文献数

6

被引用文献数

1 3

---

THIS ARTICLE FOCUSES THE PROBLEM THAT FLOOR AREA RATIONS ARE NOT FILLED WELL IN THE COMMERCIAL ZONE AT THE CENTRAL AREA OF LOCAL CITY AND STUDIES THE CONDITIONS OF LOW FILLING AND THOSE FACTORS. WE ASSUME 1)THE DECREASE OF AVAILABLE FLOOR AREA RATIO BY REGULATIONS AND 2)THE EXCESSIVE DESIGNATION OF COMMERCIAL ZONE AND FLOOR AREA RATIO,AS THE FACTORS OF LOW FILLING DEGREE. FOR THE FIRST FACTOR, THERE ARE 3 REGULATIONS, ONE BY OBLIQUE LINE, ONE BY NARROW ROAD AND ONE BY CONDITION OF CONTACTING ROAD, AND AT EVERY LOT THE SECOND ONE EFFECTS VERY MUCH. FOR THE SECOND FACTOR, WE CONFIRM THE EXCESSIVE DESIGNATION COMPARING THE ECONOMIC ABILITY OF THE CITY.

著者

佐伯 真一

出版者

青山学院大学

雑誌

青山語文 (ISSN:03898393)

巻号頁・発行日

no.31, pp.93-101, 2001-03

出版者

学習研究社

巻号頁・発行日

2003

出版者

新人物往来社

巻号頁・発行日

1991

著者

外山操 森松俊夫編著

出版者

芙蓉書房 (発売)

巻号頁・発行日

1987

著者

河野 礼実

出版者

山梨学院大学グローバルラーニングセンター編集委員会

雑誌

国際共修・語学教育実践 = Journal of Intercultural Collaborative Learning & Language Education (ISSN:24368334)

巻号頁・発行日

vol.創刊号, pp.5-12, 2022-03-23

著者

KURODA,Nagamichi

出版者

日本動物学会

雑誌

日本動物学彙報

巻号頁・発行日

vol.24, no.1, 1950-12-25