著者

前田 至剛 Noritaka Maeda

雑誌

先端社会研究

巻号頁・発行日

no.3, pp.299-306, 2005-12-20

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シリーズ「語りえぬものを問う」国際シンポジウム

著者

松裏 知彦 貞安 一廣 松倉 隆一 高尾 芳三

出版者

公益社団法人 日本水産学会

雑誌

日本水産学会誌 (ISSN:00215392)

巻号頁・発行日

vol.80, no.5, pp.702-712, 2014 (Released:2014-10-01)

参考文献数

18

被引用文献数

1

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エチゼンクラゲ分布調査を効率化するため,音響データからクラゲエコーを自動検出する手法,及び傘径を推定する手法を開発した。調査熟練者によるエコー検出過程を解析し,自動検出アルゴリズムを決定した。次に,クラゲエコー検出のための特徴量を検討し,サイズと形状に依存する特徴量が有効なことを確かめた。水中ビデオ映像から体形を解析し,エコーサイズと傘径の関係式を作成した。自動検出による個体数密度分布は熟練者の結果と時空間的に良く一致した。音響推定された傘径と中層トロール標本の傘径の最頻値も良い一致を見た。

著者

巨瀬 勝美

出版者

日本磁気共鳴医学会

雑誌

日本磁気共鳴医学会雑誌 (ISSN:09149457)

巻号頁・発行日

vol.41, no.3, pp.61-66, 2021-08-15 (Released:2021-09-06)

参考文献数

9

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Recent MRI technology and pulse sequences have become increasingly complex and difficult to understand. However, the Bloch equations, which are the basic principle of MRI, have remained unchanged since it was proposed in 1973. Here we have presented a method to numerically solve the Bloch equations to understand the principle of MRI. This method enables us to reproduce complex pulse sequences on a computer and to understand various phenomena related to pulse sequences.

著者

石井 正将

出版者

熊本大学

雑誌

若手研究

巻号頁・発行日

2019-04-01

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急性心筋梗塞に対する治療法の発展により、その予後は改善傾向であるものの、最近、閉塞血管のない心筋梗塞であるMINOCA(myocardial infarction with non-obstructive coronary arteries)の存在が認識され始めたが、日本においてはまだMINOCAに関する報告がほぼなく、MINOCAの実態は不明である。本研究ではビッグデータを用いて日本におけるMINOCAの診療実態を疫学的に明らかにするとともに、その診断に寄与する血液バイオマーカーの探索を行う。

著者

遠藤 芳信

出版者

北海道教育大学

雑誌

北海道教育大学紀要, 人文科学・社会科学編 (ISSN:13442562)

巻号頁・発行日

vol.58, no.2, pp.57-72, 2008-02

著者

遠藤 芳信

出版者

北海道教育大学

雑誌

北海道教育大学紀要, 人文科学・社会科学編 (ISSN:13442562)

巻号頁・発行日

vol.60, no.2, pp.25-40, 2010-02

著者

境 智洋 山内 斉 山内 崇

出版者

北海道教育大学釧路校

雑誌

釧路論集 : 北海道教育大学釧路校研究紀要 (ISSN:02878216)

巻号頁・発行日

vol.第48号, pp.1-7, 2016-12

著者

後藤 秋正

出版者

北海道教育大学国語国文学会・札幌

雑誌

札幌国語研究 (ISSN:13426869)

巻号頁・発行日

vol.22, pp.59-66, 2017

著者

Shinichiro Yamada Yuji Morine Satoru Imura Tetsuya Ikemoto Yu Saito Mayuko Shimizu Koichi Tsuneyama Mitsue Nishiyama Shiori Ishizawa Mitsuo Shimada

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.70, no.1.2, pp.66-73, 2023 (Released:2023-05-11)

参考文献数

51

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Background : Non-alcoholic steatohepatitis (NASH) is associated with a higher risk of hepatocellular carcinoma (HCC), and the importance of the gut?liver axis has been recognized in NASH-associated HCC. We investigated the effect of TU-100 on the intestinal microbiome and hepatocarcinogenesis in a NASH model. Methods : Seven-week-old Tsumura Suzuki obese diabetes mice, a model that shows the spontaneous onset of NASH and HCC, were used. They were divided into a TU-100 treated group and a control group. Mice were sacrificed at 24 and 48 weeks to evaluate hepatic steatosis, fibrosis, carcinogenesis, cytokine expression, and microbiome abundance. Results : At 24 weeks, the TU-100 group showed significantly lower expression of IL6, IL1B, and ACTA2 mRNA in the liver (P?<?0.05). At 48 weeks, the TU-100 group showed significantly lower levels of serum alanine aminotransferase. The TU-100 group also showed a lower rate of NASH than the control group (28% vs 72%?;?P?=?0.1). Tumor diameter was significantly smaller in the TU-100 group compared with that in the control group (P?<?0.05). Regarding the intestinal microbiome, the genera Blautia and Ruminococcus were increased in the TU-100 group (P?<?0.05), whereas Dorea and Erysipelotrichaceae were decreased in the TU-100 group (P?<?0.05). Conclusions : TU-100 regulates the intestinal microbiome and may suppress subsequent hepatocarcinogenesis in the NASH model. J. Med. Invest. 70 : 66-73, February, 2023

著者

Hiroyuki Hayashida Akiko Matsumoto Hinako Nanri Yuichiro Nishida Yusuke Takagi Megumi Hara

出版者

The Japanese Society for Hygiene

雑誌

Environmental Health and Preventive Medicine (ISSN:1342078X)

巻号頁・発行日

vol.28, pp.29, 2023 (Released:2023-05-11)

参考文献数

62

被引用文献数

3

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Background: According to recent reports, individuals with reduced aldehyde dehydrogenase activity may require more energy for the detoxification of aldehydes. Aldehyde dehydrogenase 2 (ALDH2), an ALDH isozyme, is responsible for detoxifying acetaldehyde, an intermediate metabolite of ethanol. Because the variant allele of the rs671 polymorphism of ALDH2 results in a substantial reduction in enzymatic activity, carriers of this variant allele may have a higher energy demand when consuming alcohol than non-carriers. However, no studies have evaluated this phenomenon to date.Method: To test the hypothesis, we statistically examined the interactive effects between the rs671 and ethanol consumption on energy intake using cross-sectional data from a population-based cohort study, the Japan Multi-Institutional Collaborative Cohort Study, which was conducted in Saga city between 2005–2007 (N = 12,068).Results: General linear regression models adjusted for age, sex, ethanol consumption, current smoking status, years of education, dietary restriction, medical history, and physical activity level revealed that energy intake was higher in variant allele carriers than in non-carriers among individuals with alcohol drinking habits, whereas no such correlation was observed among those without drinking habits (≤2 g ethanol/day) (p = 0.03 for interaction between rs671 and ethanol consumption). Energy intake excluding energy from alcoholic beverages, carbohydrate intake, protein intake, and fat intake, showed similar tendencies (p for interaction = 0.01, 0.01, 0.04, and 0.07, respectively).Conclusions: These findings support the hypothesis that increased energy intake is required for the detoxification of aldehydes in individuals with low ALDH activity. This epidemiological evidence provides a possible scientific basis for understanding aldehyde detoxification mechanisms and suggests a novel phenotype of the ALDH2 rs671 polymorphism.

著者

吉見 孝夫

出版者

北海道教育大学国語国文学会・札幌

雑誌

札幌国語研究 (ISSN:13426869)

巻号頁・発行日

vol.8, pp.1-12, 2003

著者

吉原 英夫

出版者

北海道教育大学札幌校国語国文学科

雑誌

札幌国語研究 (ISSN:13426869)

巻号頁・発行日

vol.2, pp.1-19, 1997

著者

木崎和広編著

出版者

第一法規出版

巻号頁・発行日

1976

著者

田代町編

出版者

田代町

著者

鳥谷部陽之助著

出版者

彩流社

巻号頁・発行日

1983

著者

義江彰夫 入間田宣夫 斉藤利男編著

出版者

校倉書房

巻号頁・発行日

2006

著者

木村 健智 上山 泰史 久保田 明人 藤森 雅博 高原 美規 秋山 征夫

出版者

日本草地学会

雑誌

日本草地学会誌 (ISSN:04475933)

巻号頁・発行日

vol.60, no.1, pp.55-58, 2014-04-15 (Released:2014-10-06)

参考文献数

20

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Reed canarygrass (Phalaris arundinacea L.) has been recognized as a major invasive plant in the US in recent years. In Japan, the differences between the native and invasive genotypes are unclear. To identify these differences, chromosomal analysis using fluorescence in situ hybridization (FISH) with 5S/45S rDNA probes was carried out on 7 populations of putative native Japanese P. arundinacea and 3 exotic P. arundinacea. The results showed that all populations were tetraploids (2n=4x=28). The 45S rDNA were mapped on 4 sites corresponding with the ploidy level in all populations. On the other hand, the numbers of 5S rDNA sites differed among the populations. Moreover, the 5S rDNA sites differed among individuals even within the same populations. Thus, the chromosomal characteristics could not ensure that the putative native Japanese P. arundinacea are the native.

著者

Mako Nagayoshi Kenji Takeuchi Yudai Tamada Yasufumi Kato Yoko Kubo Rieko Okada Takashi Tamura Asahi Hishida Jun Otonari Hiroaki Ikezaki Yuichiro Nishida Chisato Shimanoe Yuriko N. Koyanagi Keitaro Matsuo Haruo Mikami Miho Kusakabe Daisaku Nishimoto Keiichi Shibuya Sadao Suzuki Takeshi Nishiyama Etsuko Ozaki Isao Watanabe Kiyonori Kuriki Naoyuki Takashima Aya Kadota Kokichi Arisawa Sakurako Katsuura-Kamano Kenji Wakai

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.5, pp.236-245, 2023-05-05 (Released:2023-05-05)

参考文献数

50

被引用文献数

2

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Background: Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults.Methods: A total of 79,580 individuals aged 35–69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy (“sometimes,” and “often/very often” use versus “very few” use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated.Results: During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs for “sometimes” were 0.81 (95% confidence interval [CI], 0.67–0.97) for emotional expression, 0.79 (95% CI, 0.66–0.95) for emotional support-seeking, and 0.80 (95% CI, 0.66–0.98) for disengagement. Men who “sometimes” used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15–41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (P for interaction = 0.03).Conclusion: In a large Japanese sample, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.

著者

小沢 和光 Kazumitsu Ozawa

出版者

学習院大学英文学会

雑誌

学習院大学英文学会誌

巻号頁・発行日

vol.2011, pp.14-15, 2012-03-20