著者
江石 義信
出版者
公益財団法人 日本ビフィズス菌センター
雑誌
腸内細菌学雑誌 (ISSN:13430882)
巻号頁・発行日
vol.23, no.1, pp.23-29, 2009 (Released:2009-02-10)
参考文献数
14
被引用文献数
1

常在性細菌と疾患との関連性があちこちで話題になりつつある.なかでもサルコイドーシスとアクネ菌についてわが国では長年の研究蓄積を有しており,最近では本症の奇異な病態を説明しうるようなアクネ菌の興味ある生体内特性や内因性感染症としての新しい疾病発生機構が徐々に見えつつある.既によく知られている「帯状疱疹ウイルスのストレスによる活性化」や「結核の内因性再燃」などの現象と同様に,初期感染(不顕性感染)後に宿主の細胞内で冬眠状態にある細胞壁欠失型アクネ菌が内因性に活性化することが,サルコイドーシスという全身性肉芽腫疾患の発症をトリガーしている可能性がある.疾病素因として本菌に対するアレルギー素因を有する個体では,内因性に本菌が活性化するたびごとに増菌局所で肉芽腫反応が生じてくるものと想定され,細胞内細菌に感受性のある抗生剤の投与は,新たな細胞内増菌を防止する観点から肉芽腫形成の予防に有効である可能性が高い.また,本症からの完全寛解を目指すためには,代謝活性を低下させて生き残りを図る冬眠状態の菌も含めて排除する必要があり,近年では米国患者団体が主体となり通常の感染症とは異なる除菌プロトコール(マーシャルプロトコール)が検討されつつある.
著者
矢吹 康夫
出版者
日本オーラル・ヒストリー学会
雑誌
日本オーラル・ヒストリー研究 (ISSN:18823033)
巻号頁・発行日
vol.6, pp.169-189, 2010-09-12 (Released:2018-12-28)

Albinism is a rare genetic condition, resulting in the malfunction of producing the melanin pigment in the eyes, skin, and hair. A person with albinism has visual impairment, extreme sun sensitivity, and distinctive physical appearance. The symptom is very stable and will not become serious, so this condition cannot be considered a matter of life and death. In addition, there are bare minimum supports in order to avoid institutional and structural disadvantages. People with albinism have not been able to refer to any model stories and have been forced on bearing or coping with their troubles alone. Though their coping strategies are various and optional, they are ranked by whether they can contribute toward the members of the community or they have had to conform to the expectations of the society. This article will analyze interviews with an albino woman in order to focus on her coping strategies. She looks on her efforts made without exposing and explaining her identity, and then regards these strategies as norms. Therefore, she has lived in comfort by maintaining silence and liberated herself from the terms of ranking the coping strategies through her "going my way" strategy of caring for herself first of all.
著者
Peipei Song Takashi Karako
出版者
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌
BioScience Trends (ISSN:18817815)
巻号頁・発行日
pp.2020.01056, (Released:2020-02-25)
参考文献数
9
被引用文献数
116

Rapidly sharing scientific information is an effective way to reduce public panic about COVID-19, and doing so is the key to providing real-time guidance to epidemiologists working to contain the outbreak, clinicians managing patients, and modelers helping to understand future developments and the possible effectiveness of various interventions. This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. As an academic journal, we will continue to quickly and transparently share data with frontline healthcare workers who need to know the epidemiological and clinical features of COVID-19.
著者
佐藤 諒 西村 夏夫 保木 邦仁
出版者
一般社団法人情報処理学会
雑誌
研究報告ゲーム情報学(GI) (ISSN:09196072)
巻号頁・発行日
vol.2014, no.11, pp.1-6, 2014-03-10

本研究では,シャンテン数が下がるような牌を有効牌とし,数手先の有効牌を数え上げることによって牌効率を向上させた麻雀 AI の性能を評価することを目的とした.簡単のために副露や降りをしない面前全ツッパに麻雀AIの戦略を制限した.性能評価は,インターネット雀荘 「東風荘」 で人間のプレイヤーと対局させ,安定レートや他の統計情報を利用して行った.In this work, we analyze the performance of Mahjong AI programs that count the number of effective legal moves. Here, an effective legal move decreases Shanten numbers (the number of tiles away from tempai). For the sake of simplicity, we limit the strategy of AI programs to Menzen-Zentsupa strategy (no open melds by calling and no defense by discarding safe tiles). The performance is measured in the internet Mahjong server, Tonpu-So, with human players and it is analyzed in terms of rating and other statistic information.
著者
堀江 重郎
出版者
一般社団法人 日本内科学会
雑誌
日本内科学会雑誌 (ISSN:00215384)
巻号頁・発行日
vol.102, no.4, pp.914-921, 2013 (Released:2014-04-10)
参考文献数
56

男性更年期障害の低テストステロンによる症候であるLOH(late onset hypogonadism syndrome)症候群は2型糖尿病に高頻度に見られる.テストステロンは糖代謝,脂質代謝に関与し,またテストステロン低値は,糖尿病,メタボリック症候群のリスク因子である.テストステロン補充療法は筋肉量を増やし,また耐糖能を改善する.LOH症候群は,男性糖尿病患者の生活の質や健康増進を高める上で重要な疾患である.
著者
小笠原 信実
出版者
日本医療福祉政策学会
雑誌
医療福祉政策研究 (ISSN:24336858)
巻号頁・発行日
vol.2, no.1, pp.113-136, 2019 (Released:2019-04-02)

世界的な新自由主義化の影響をうけながら、韓国では2004年に廬武鉉政権により、日本では2001年に小泉政権により、新自由主義的医療改革が開始され、両国の産業界とアメリカの要求を受けながら類似した内容の改革が試みられた。しかし韓国では公的医療保険の給付水準が低かったこととサムソン財閥が医療産業の拡大と参入を強力に進めたために新自由主義的医療改革が急速に進んだのに対し、日本では漸進的にしか進まなかった。
著者
Kaoru Umehara Naoko Mukai Jun Hata Yoichiro Hirakawa Tomoyuki Ohara Daigo Yoshida Hiro Kishimoto Takanari Kitazono Sumio Hoka Yutaka Kiyohara Toshiharu Ninomiya
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.81, no.9, pp.1315-1321, 2017-08-25 (Released:2017-08-25)
参考文献数
36
被引用文献数
13

Background:Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations.Methods and Results:We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002–2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95% confidence interval, 1.18–2.01] for the lowest quartile, 1.31 [0.99–1.73] for the 2nd quartile, 0.94 [0.70–1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04).Conclusions:The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.
著者
西谷 真人 杉野 友啓 門脇 孝徳 﨑川 伸基 西川 和男 梶本 修身
出版者
日本補完代替医療学会
雑誌
日本補完代替医療学会誌 (ISSN:13487922)
巻号頁・発行日
vol.7, no.2, pp.113-116, 2010 (Released:2010-10-15)
参考文献数
4
被引用文献数
2 2

プラズマクラスターイオン®の肌保湿効果および快適性向上作用について検討するため,肌の乾燥を感じやすい健常女性 32 名を対象とした単盲検ランダム化 2 試験区クロスオーバー試験を実施した.対照と比較して,プラズマクラスターイオン濃度 2.5 万個/cm3 では,有意な肌水分量の増加がみられ,イオン濃度 7 千個/cm3 では,有意な快適感の上昇がみられた.プラズマクラスターイオンが肌保湿効果や快適感向上作用を有することが示唆された.
著者
岡部 明日香
出版者
国文学研究資料館
雑誌
国際日本文学研究集会会議録 = PROCEEDINGS OF INTERNATIONAL CONFERENCE ON JAPANESE LITERATURE (ISSN:03877280)
巻号頁・発行日
no.28, pp.97-111, 2005-03-01

Genji Monogatari was written in the middle of the Heian period, but from the Kamakura period on, Chinese poetry (kanshi) based on the story and attempts to translate it into Chinese (kanbun) were made. HikaruGenji Monogatari Wo Fusuru Shi (Shouou 4) features kanshi composed for each chapter, a style that was carried on through to the late Edo period with Shi Shi Ginpyou (Tenpou 9, by Narushima Chikuzan). In the Meiji era, prose kanbun interpretations appear, such as “Wakamurasaki”, “Nakagawa Suisou Bikou (Hahakigi)”, and “Utsusemi” from Yakujun Kigo (Meiji 18, by Kikuchi Sankei) and Shi Shi (Meiji 26, Kawai Jirou).This presentation will look at such “kanyaku Genji” works, focusing on the Meiji era. The Edo period work Shi Shi Ginpyou continued to exert an influence into the Meiji era, and will therefore be looked at as well.Shi Shi Ginpyou was published in Kagetsu Sinshi (Meiji 12), a magazine run by Chikuzan’s son Narushima Ryuuhoku. In Showa 15, Chinese scholar Taniguchi Kairan of Shimane published a commentary as well as composed “Ji-in” (Chinese poems on the Genji Monogatari).Yakujun Kigo features kanyaku reneditions of a variety of works of Japanese literature, and includes partial translations of the Genji Monogatari. The Chinese scholar Adachi Keitei of Nagasaki published the work in Meiji 44 after Sankei's death, but “Nakagawa Suisou Bikou (Hahakigi)” and “Utsusemi” were excluded by Keitei based on his personal ethics. Kikuchi Sankei was also involved in editing Kagetsu Shinshi, and had an interesting connection to Shi Shi Ginpyou.Only the Utsusemi chapter remains from Shi Shi.This presentation will examine the characteristics of each interpretation, as well as the influences seen in and exerted by the works. Modern Chinese studies around the time of the Mejii Restoration carried over the literary traditions of Japan through to the Edo period while including the products of the new era. We will also try and examine what the Chinese scholars of such a time thought of the Genji Monogatari.