著者

石川 覚

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.51, no.4, pp.203-204, 2013-04-01 (Released:2014-04-01)

参考文献数

4

被引用文献数

2

著者

小川 高 岩田 涼子 小川 ひとみ

出版者

公益社団法人 日本獣医師会

雑誌

日本獣医師会雑誌 (ISSN:04466454)

巻号頁・発行日

vol.76, no.1, pp.e1-e4, 2023 (Released:2023-01-11)

参考文献数

10

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猫の口腔内悪性神経鞘腫に対してカルボプラチン混和リドカインゼリーの局所注射とオルソボルテージ照射の併用療法を実施した.局所注射に起因する有害症状は認められず,腫瘍は顕著に縮小した.治療開始時からPEGチューブ栄養管理を行い,全身状態の改善を行った.今回用いた併用療法はオルソボルテージ照射単独治療と比較して効果的である可能性があるが,症例の集積による検討が必要である.

著者

遠藤 美紀 重黒木 恵子 大町 哲夫 山田 武喜

出版者

一般社団法人日本獣医がん学会

雑誌

日本獣医がん学会雑誌 (ISSN:18843344)

巻号頁・発行日

vol.11, no.4, pp.33-37, 2022-12-27 (Released:2022-12-27)

参考文献数

20

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A 10-year-old 4.7-kg spayed female mix breed dog presented with mucoid vaginal discharge despite treatment for cystitis for a month. A malignant neoplasm was suspected based on atypical cells found on vaginal mucus cytology. A cystoscopy biopsy was performed, and the histopathologic diagnosis was consistent with transitional cell carcinoma (TCC). A subtotal urethrectomy and urethral-vaginal anastomosis were performed. Treatment with piroxicam (0.3mg/kg eod for 1278 days) and carboplatin (150~250mg/m2/3~4 weeks, nine times) was initiated 2 weeks postoperatively. Other than recurrent cystitis that started 3 weeks postoperatively, the patient maintained a good quality of life with neither recurrence nor metastasis. The patient died of renal failure 3 years and 9 months (1395 days) after the initial visit. While TCC is generally considered to have poor prognosis, it was suggested from the management of this case that early diagnosis and radical surgery could achieve good long-term survival.

著者

Hiyori SHOJI Yuma TSUKASA Koichi KITAO Takayuki MIYAZAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0526, (Released:2023-01-19)

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Feline leukemia virus (FeLV) is a retrovirus that causes immune suppression and immunodeficiency, leading to opportunistic infections and leukemia/lymphoma in cats. Today, a variety of domestic mammals are kept in houses, and it is important to evaluate the possibility of interspecies transmission of FeLV. In this study, we assessed the infectivity of FeLV-B in ferrets that belong to Mustelidae. By pseudotype virus infection assay, we revealed that a ferret cell line, Mpf cells, is resistant to FeLV-B infection. The mRNA expression level of the FeLV-B receptor, Pit-1, was approximately half that of cat FEA cells in ferret Mpf cells. There was no significant difference in receptor usage between ferret’s and cat’s Pit1. These data may indicate the presence of the post-transcriptional modification and/or the restriction factor(s) against the FeLV-B infection in ferrets.

著者

本田 洋

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.27, no.11, pp.702-711, 1989-11-25 (Released:2009-05-25)

参考文献数

54

著者

上野 雄史

出版者

一般社団法人 日本リスク学会

雑誌

リスク学研究 (ISSN:24358428)

巻号頁・発行日

vol.32, no.4, pp.253-258, 2023-05-15 (Released:2023-05-16)

参考文献数

18

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The purpose of this paper is to examine the current status and challenges to the final disposal of radiocesium-contaminated soil and to explore a theoretical framework for building shared knowledge and collaboration among a wide range of stakeholders. It is difficult to make effective solutions about the issues only by accountability from stakeholders. It is necessary to build common goals for cooperation among stakeholders.

著者

Leni MAYLINA Satoshi KAMBAYASHI Kenji BABA Masaya IGASE Takuya MIZUNO Masaru OKUDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.85, no.1, pp.99-104, 2023 (Released:2023-01-20)

参考文献数

29

被引用文献数

1

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Canine lymphoma/leukemia cell lines with p16 protein expressions: high (17–71 and GL-1) and low (CLBL-1, CLC, Nody-1, and UL-1) were treated in vitro with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, palbociclib or abemaciclib. Cell proliferation decreased as a result, with higher IC50 levels observed in the high p16 (17–71 and GL-1) and one low p16 (UL-1) cell lines compared with the low p16 cells (CLBL-1, CLC, and Nody-1). As expected, palbociclib and abemaciclib treatment reduced pRb phosphorylation in a dose-dependent manner, especially in cells with low p16. These results suggest that CDK4/6 inhibitors have potential as new chemotherapeutic agents for canine lymphoma and high p16 protein expression may be used as a biomarker for resistance to CDK4/6 inhibitor therapy.

著者

Naoki UMEDA Hinako YAMAZOE Atsuhito WADA Katuyuki NAGATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.22-0400, (Released:2023-01-24)

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A 12-year-old French bulldog presented with a mass on the right lower jaw. Computed tomography revealed that the mass originated from the salivary gland and was not continuous with the right mandible. The mass was surgically removed and subsequently diagnosed as extraskeletal osteosarcoma of the salivary gland following histopathological and immunohistochemical examinations. Although the surgical margin was clear, postoperative adjuvant therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) was initiated. Lung metastasis was observed 249 days after the initial examination; therefore, toceranib was initiated with NSAIDs. The dog died 496 days after the initial examination of this disease progression but had good long-term management with a combination of surgery, NSAIDs, and toceranib.

著者

筒井 義郎

出版者

心理学評論刊行会

雑誌

心理学評論 (ISSN:03861058)

巻号頁・発行日

vol.55, no.1, pp.22-25, 2012 (Released:2018-08-18)

著者

長野 真紀

出版者

一般社団法人 芸術工学会

雑誌

芸術工学会誌 (ISSN:13423061)

巻号頁・発行日

vol.86, pp.22-29, 2023 (Released:2023-03-31)

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本研究は、台湾金門島に現存する伝統的集落の移住経緯と空間特性を明らかにすることを目的とする。これまで個別に捉えられてきた全143の伝統的集落の立地環境、歴史的建築物の種類と残存数、集落規模、建物棟数、方位軸、抱護の種類と空間範囲、居住者の主要姓氏、移住前後の居住地をまとめ、集落空間を類型化した。その結果、立地環境を平地から山裾、斜面地までの10類型、自然地形と植生による抱護の種類を9つに分類した。さらに集落を構成する建物棟数から空間規模を小・中・大に設定し、歴史的建築物の残存数と合わせて、各集落の現状を明らかにした。また、居住者の主要姓氏から単姓村76、複姓村67が確認された。文献資料とヒアリング調査に基づいて長期間にわたる移動前後の居住地とその変遷を追い、現地調査により居住地の環境を理解することで、集落の移住形態を5つの型(移住群:拠点型Ⅰ、Ⅱ、転移型、定住群:発展型、安定型)に分類した。これらの結果から、周囲を海に囲まれた島嶼の環境と歴史的な居住地の移動によって構築された集落の空間特性を明らかにした。

著者

池田 宗讓

出版者

Japanese Association of Indian and Buddhist Studies

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.28, no.2, pp.666-667, 1980-03-31 (Released:2010-03-09)

著者

米村 みゆき

出版者

昭和文学会

雑誌

昭和文学研究 (ISSN:03883884)

巻号頁・発行日

vol.68, pp.52-63, 2014 (Released:2022-11-19)

著者

大橋 崇行

出版者

昭和文学会

雑誌

昭和文学研究 (ISSN:03883884)

巻号頁・発行日

vol.60, pp.66-78, 2010 (Released:2022-11-19)

著者

神瀬 昭 金田 実

出版者

一般社団法人 映像情報メディア学会

雑誌

テレビジョン (ISSN:18849644)

巻号頁・発行日

vol.26, no.3, pp.209-228, 1972-03-01 (Released:2011-03-14)

参考文献数

23

著者

加藤 大生

出版者

昭和文学会

雑誌

昭和文学研究 (ISSN:03883884)

巻号頁・発行日

vol.76, pp.75-88, 2018 (Released:2021-07-01)

著者

富塚 清

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会誌 (ISSN:24242675)

巻号頁・発行日

vol.70, no.576, pp.23-25, 1967-01-05 (Released:2017-06-21)

著者

Takashi Oshio Satoshi Shimizutani

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.1, pp.15-22, 2023-01-05 (Released:2023-01-05)

参考文献数

34

被引用文献数

3

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Background: Encouraging older adults to continue working longer would be a realistic solution to the shrinking labor force, which is a result of the aging population. This study examined whether working longer improves the health of older adults.Methods: We used repeated cross-sectional data from 1,483,591 individuals aged 55–69 years collected from 11 waves of a nationwide population-based survey conducted in Japan from 1986 to 2016. We estimated pooled regression models to explain health outcomes by work status, controlling for potential endogeneity biases. Based on the estimation results, we conducted simulations to predict the health impact of policy measures that encourage older adults to participate in the labor force.Results: The regression analysis showed that work status had a mixed health impact. For example, work reduced the probability of poor self-rated health by 6.7 (95% confidence interval [CI], 6.2–7.2) percentage points and increased that of psychological distress by 12.2 (95% CI, 11.3–13.1) percentage points. The simulation results showed that raising both the mandatory retirement age and eligibility age for claiming public pension benefits to 70 years would increase the employment rate by 27.8 (standard deviation [SD], 4.2) percentage points among those aged 65–69 years, which would reduce their probability of poor self-rated health by 1.8 (SD, 0.4) percentage points and raise that of psychological distress by 4.1 (SD, 0.8) percentage points for that age group.Conclusion: The results suggest the need to pay attention to the health outcomes of policy measures that encourage older adults to work longer.

著者

内井 惣七

出版者

日本科学哲学会

雑誌

科学哲学 (ISSN:02893428)

巻号頁・発行日

vol.39, no.2, pp.1-15, 2006-12-25 (Released:2009-12-07)

参考文献数

27

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Einstein began the relativistic cosmology by his 1917 paper. But what is his most important contribution to the cosmology? I will argue that the answer is that he changed the notion of gravity so as to imply both the attractive and the repulsive force. Beginning with the elements of the general relativity, I will briefly review de Sitter's objection against Einstein's spherical universe, Lemaitre's and Eddington's works, the classic version of the expanding universe, the big-bang cosmology, and the inflationary cosmology. The seminal ideas emerged from the Einstein-de Sitter controversy culminated in the fruitful results of the inflationary cosmology, and the key idea was the gravity as a repulsive force.

著者

林 倫子 濱田 美知瑠

出版者

公益社団法人 日本造園学会

雑誌

ランドスケープ研究 (ISSN:13408984)

巻号頁・発行日

vol.86, no.5, pp.409-412, 2023-03-31 (Released:2023-05-12)

参考文献数

22

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This study focuses on the "Jingu Forest Management Plan" of Ise Jingu Shrine formulated in 1923, and clarifies the zoning method of shrine forests in the plan and the origin of the landscape conservation philosophy on which the plan was based, especially the values that emphasize the view of the shrine forest from the outside of the shrine area. As a result, it was found that the shrine forest zoning method of the plan was very similar to the management method of Shintairin (sacred shrine forest), which was discussed in the "Shaji Fuchirin Ron (Management Theory of Shrine and Temple Forest)" by Honda Seiroku, and was considered to be the origin of the zoning method. The landscape conservation philosophy as the basis for shrine forest zoning of the plan was different from the forest management concept of the 1912 shrine forest survey report. Rather, it is thought to have been created under the influence of the shrine city planning that was underway at the same time, and it is possible that the zoning of the Jingu Shrine forest was a milestone in protection of the view from the city area to the Jingu Shrine, with a view toward the future designation of the adjacent mountainous area as scenic districts.

著者

Kazumasa SUEYOSHI Manami KITAMURA Xinglin LEI Ikuo KATAYAMA

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.118, no.1, pp.221014, 2023 (Released:2023-04-13)

参考文献数

32

被引用文献数

1

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The frequency characteristics of acoustic emission (AE) during triaxial compression of thermally cracked and unheated (‘fresh’) granite samples were investigated with the aim of understanding the influence of pre-existing cracks on precursor information regarding macroscopic failure. The peak frequency during the damage process was the same for thermally cracked and fresh granites. Analysis of AE signals showed that signals with low peak frequency appeared before failure of the sample, implying the initiation of macrocracks with progressive growth of cracks. The peak amplitude of the frequency spectrum recorded in the thermally cracked samples was much lower than that in the fresh samples. This result suggests two reasons for the difference in peak amplitude: reduction in shear modulus and the attenuation filtering phenomenon caused by thermal cracks (i.e., the differences in overall bulk properties). In particular, the maximum value of peak amplitude in the low-frequency band for the thermally cracked samples was smaller than that for fresh samples. This characteristic can be related to the properties of source of AE signals, such as the stress drop and crack size. Assuming that pre-existing thermal cracks grow during the pre-failure stage, the events with low peak frequency and low peak amplitude in the heat-treated samples are interpreted as exhibiting a low stress drop for individual events. Therefore, although AE signals with low frequency can be considered as precursors to rock failure, cracking behavior suggested by events with low frequency depends on the initial damage condition of the rock sample.