著者

Saisai Li Weibo Li Bo Sheng Xueqiong Zhu

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.68, no.2, pp.211-219, 2021 (Released:2021-02-28)

参考文献数

39

被引用文献数

1 2

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Uterine fibroids and thyroid nodules, both of which are crucially affected by estrogen, are common diseases among reproductive-age women. However, little attention has been paid to the association between the two diseases. This retrospective case-control study aimed to assess the relationships among thyroid nodules, thyroid function and uterine fibroids in China. We reviewed the electronic records of 853 reproductive-age women who attended health check-ups at the Second Affiliated Hospital of Wenzhou Medical University from July 1st, 2017, to June 30th, 2018. All subjects received transvaginal pelvic ultrasound, thyroid ultrasound, thyroid function, and other laboratory tests. We found that the prevalence of thyroid nodules in subjects with uterine fibroids was remarkably higher than that in subjects without fibroids. The proportion of thyroid nodules ≥1 cm in subjects with uterine fibroids was significantly higher than that in subjects without fibroids. Women with thyroid nodules had a higher proportion of multiple uterine fibroids than women without thyroid nodules. Among the parameters of thyroid function, the only statistically significant parameter was total triiodothyronine, i.e., women with uterine fibroids had lower total triiodothyronine levels than unaffected controls; however, the total triiodothyronine levels were within the normal ranges. Moreover, no significant difference was noted in thyroid hormone status between subjects with and without uterine fibroids. Our findings suggest that thyroid nodules are positively correlated with uterine fibroids among reproductive-age women in China. Further studies are needed to confirm this association and fully understand the common pathogenetic mechanism underlying the association between uterine fibroids and thyroid nodules.

著者

内藤 猛 京谷 博 横町 嘉之

出版者

公益社団法人 精密工学会

雑誌

精密機械 (ISSN:03743543)

巻号頁・発行日

vol.51, no.9, pp.1684-1688, 1985-09-05 (Released:2009-06-30)

参考文献数

5

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VHD方式ダイヤモンドセ/サの先端しゅう動面の精密ラッピング技術, ならびにこの技術を応用した多数本のスタイラスを同時に研磨するダイヤモンドセンサラッピングシステムについて述べてきた.このシステムの特徴として, (1) ダイヤモンドの特性に基づくラッピング方法 (2) ダイヤモンドセンサのラッピング特性に基づく加工時間制御による電極幅の管理<RB> (3) マイクロコンピュータを使用した, 多数本のダイヤモンドセンサの同時加工における個別制御方法の以上の3点が上げられる.

著者

ミッチェル・カメラ・コーポレーション 編

出版者

日本映画技術協会

巻号頁・発行日

1955

著者

高井 昌吏

出版者

日本メディア学会

雑誌

マス・コミュニケーション研究 (ISSN:13411306)

巻号頁・発行日

vol.88, pp.17-33, 2016-01-31 (Released:2017-10-06)

参考文献数

27

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This study focuses on popular songs concerning "the war and women" in post-war Japan. In particular, three songs were examined: Akiko Kikuchi's "Hoshi no Nagare ni" and "Ganpeki no Haha" released in 1947 and 1954, respectively, and Yuriko Futaba's popular remake of "Ganpeki no Haha" released in 1972. These songs were analyzed in connection with the societal background in which they gained popularity, including the influence of mainstream values as well as concepts of women and mothers that were held at the time. The results of this analysis suggested that directly after the war ended, many Japanese women were despondent and pushed into prostitution because of an impoverished society. The song "Hoshi no Nagare ni" conveys the sorrows of prostitution, and this theme is directly connected to its success. The 1954 hit "Ganpeki no Haha" has strong connections to the suspicion that Japanese citizens felt toward the Self Defense Force, which was established in the same year, as well as to the massive protests in 1960 concerning the US-Japan Defense Treaty. In particular, the general public tended to be influenced by stories about "mothers' sadness," particularly in terms of mothers and children being separated by war. This had powerful correlations with peace-oriented public opinion and anti-rearmament attitudes of the time. However, Yuriko Futaba's mid-1970s remake of "Ganpeki no Haha" gained mass popularity for several reasons. The 1970s witnessed the appearance of the "kyouiku-mama" (literally "education mama") -a type of mother who stressed on education for her children above everything else. The "kyouiku-mama" was considered to be a social problem during the time, and the completely different type of mother presented in "Ganpeki no Haha" produced feelings of longing for an "ideal mother" archetype that was perceived to be lost from the society. Therefore, "Ganpeki no Haha" was highly praised by the general public.

著者

大久保 三郎

出版者

公益社団法人 日本植物学会

雑誌

植物学雑誌 (ISSN:0006808X)

巻号頁・発行日

vol.1, no.1, pp.14, 1887 (Released:2007-04-05)

被引用文献数

1 1

著者

大平 恵一

出版者

一般社団法人 照明学会

雑誌

照明学会雑誌 (ISSN:00192341)

巻号頁・発行日

vol.58, no.4, pp.134-139, 1974-04-25 (Released:2011-07-19)

参考文献数

10

著者

王 先哲

出版者

公益社団法人 日本語教育学会

雑誌

日本語教育 (ISSN:03894037)

巻号頁・発行日

vol.155, pp.142-158, 2013 (Released:2017-02-17)

参考文献数

23

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本稿は,親しい日本人女性同士の依頼会話のビデオを中国人日本語学習者(C)と日本語母語話者(J)に視聴してもらい,両者が被依頼者の行動をどのように予測するか,何を手がかりに予測するかを認知の視点から,比較,考察したものである。 分析の結果,依頼直後に被依頼者が内容の確認をしている段階から,CよりJの方が断られると早く予測し,一度断られると予測したら,その後も,引き受ける可能性があると予測を立てる者は少ないことが分かった。また,報告された予測の手がかりにも違いが見られた。CはJより被依頼者からの依頼内容に関する「情報要求」を受諾の兆候だと認識する者が多く,被依頼者の念押しの「確認要求」に対して,被依頼者の顔の表情や姿勢など「表象的手がかり」を合わせて,予測の根拠に挙げる者も多かった。一方,JはCより「依頼内容の負担度への言及」,「責任感の表明」を拒絶の前触れだと認識する傾向があり,特に「責任感の表明」に対する認識は日中の間で大きく異なることが分かった。

著者

池田 眞朗

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.19, no.8, pp.8_76-8_79, 2014-08-01 (Released:2014-12-05)

著者

山下 敏彦

出版者

日本腰痛学会

雑誌

日本腰痛学会雑誌 (ISSN:13459074)

巻号頁・発行日

vol.13, no.1, pp.24-30, 2007 (Released:2008-01-22)

参考文献数

11

被引用文献数

1

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椎間関節包やその周囲組織には,痛覚伝達に関与する細径神経線維や侵害受容器が豊富に存在する.椎間関節の炎症により,受容器は長時間にわたり興奮し,機械的閾値が低下する.また,椎間関節の炎症は,神経根に波及し,後根神経節内のサイトカインの発現を増加させるとの報告がある.椎間関節に対する機械的有害刺激や,椎間関節の炎症あるいは椎間板変性に伴い発生する化学的有害刺激は,椎間関節および周囲組織に存在する侵害受容器を興奮させ,急性あるいは慢性腰痛の発生に関与しているものと思われる.また,椎間関節の変性や炎症は,神経根性疼痛の発生にも関与していることが推測される.

著者

山下 淳一 堀本 ゆかり 千葉 淳弘

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.37, no.1, pp.101-105, 2022 (Released:2022-02-20)

参考文献数

14

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〔目的〕理学療法士の「働きがい」の構成要素と影響度を明らかにすることを目的とし調査を行った.〔対象と方法〕当院理学療法士61名を対象に5件法による全18項目のアンケート調査を実施し,重回帰分析およびパス解析を用い分析した. 〔結果〕「働きがい」の構成要素は,「評価」,「処遇」,「人間関係」,「能力向上」,「配置」,「達成感」で構成されていることが明らかとなった. そのうち「働きがい」と特に関係が強い要素は,「評価」,「処遇」,「人間関係」の順であることが明らかとなった.〔結語〕理学療法士に対する「働きがい」を向上させるための具体的取り組みとして,まずは「評価・処遇」の改善が必要であることが示唆された.

著者

加藤里路 著

出版者

村上書店

巻号頁・発行日

1896

著者

山下 幸太郎

出版者

鹿児島国際大学国際文化学部

雑誌

国際文化学部論集 (ISSN:13459929)

巻号頁・発行日

vol.12, no.3, pp.231-247, 2011-12

著者

高野 幸路

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.103, no.4, pp.841-848, 2014-04-10 (Released:2015-04-10)

参考文献数

13

被引用文献数

1

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プロラクチン産生腫瘍は,性周期のある女性の場合は無月経,乳汁漏で,男性の場合はリビドーの低下や下垂体機能低下症の症状,視機能障害をきっかけに診断に至る場合が多い.プロラクチン産生腫瘍をふくむ多くの間脳,下垂体疾患において女性では月経周期の異常や無月経が起こるので,月経についての問診は重要である.高プロラクチン血症の原因として最も多いのは薬剤性高プロラクチン血症である.また,妊娠による高プロラクチン血症など,鑑別診断は重要である.鑑別診断をよく理解するためには,生理的なプロラクチン分泌の調節機構の知識が必須である.本稿ではこれを略述したのちに高プロラクチン血症の鑑別診断を述べ,最後にプロラクチン産生腫瘍の治療について解説する.

著者

池口 徹 合原 一幸

出版者

一般社団法人 日本応用数理学会

雑誌

応用数理 (ISSN:24321982)

巻号頁・発行日

vol.7, no.4, pp.260-270, 1997-12-15 (Released:2017-04-08)

参考文献数

25

被引用文献数

1

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This paper reviews such embedding theorems of dynamical systems as Takens' embedding theory and the extended theory by Sauer et al. and practical methods to reconstruct possible attractors only from observed time series data. These are bases for time series analysis from the view point of nonlinear dynamical systems theory. The reconstruction method by filtered delay coordinates is also discussed.

著者

Jia GUAN Shiro TANAKA Shuhei YAMADA Izumi SATO Koji KAWAKAMI

出版者

Japanese Society for Pharmacoepidemiology

雑誌

薬剤疫学 (ISSN:13420445)

巻号頁・発行日

pp.25.e2, (Released:2020-07-15)

参考文献数

32

被引用文献数

1 1

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Objective: To describe the treatment patterns and time to next treatment (TTNT) in newly diagnosed multiple myeloma patients (MM) using a large-scale claims database in Japan.Design: Cohort studyMethods: The patients with newly diagnosed MM from 2008 to 2015 were classified into two groups: age <65 years, and age ≥65 years. Specific regimens and general regimens were identified with a complex algorithm considering interval of no therapy, additional and discontinued agents. Correspondingly, TTNT between the first- and second-line were measured among non-transplant patients with Kaplan-Meier method.Results: A total of 425 patients were eligible to participate in the analysis. The most common regimen for the treatment of MM was bortezomib-based regimens (52.9% in the first-line, 28.2% in later lines), followed by melphalan-prednisolone (27.1% in the first-line, 12.9% in later lines) and lenalidomide-based regimens (4.7% in the first-line, 26.1% in later lines). TTNT between the first- and second-line was 11.4 months and was seen to vary greatly with each regimen. A statistically longer TTNT was observed in subgroups of patients aged 65 years or over compared with patients aged younger than 65 years, but no statistical difference was found between conventional therapy and novel therapy.Conclusion: Based on the data from the study, patients with MM were commonly treated with novel agent-based regimens, especially bortezomib-based regimens. Between the first- and second-line therapies a relatively short TTNT was observed, indicating that therapies in clinical practice poorly complied with treatment guidelines.

著者

SHOSUKE OKAMOTO UTAKO OKAMOTO

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

vol.11, no.3, pp.105-115, 1962 (Released:2009-03-27)

参考文献数

32

被引用文献数

122 143

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1) A new potent inhibitor of the fibrinolytic system was found. Its chemical name was 1-(aminomethyl)-cyclohexane-4-carboxylic acid and abbrevi-ated as AMCHA in our laboratories.2) The inhibitory effect of AMCHA in vitro was far more potent than that of EACA when examined by the fibrinolytic system.3) The inhibitory effect of AMCHA given to rabbits intravenously or orally was also more potent than that of EACA when the effect was examined by the streptokinase activation test of blood samples taken at various intervals.4) Reversal by AMCHA of the accelerated fibrinolysis in circulatory blood produced in rabbits by streptokinase was demonstrated.

著者

髙橋 直美

出版者

東洋大学ライフデザイン学部

雑誌

ライフデザイン学研究 = Journal of Human Life Design (ISSN:18810276)

巻号頁・発行日

no.12, pp.59-73, 2017-03

著者

斎藤 洋典

出版者

心理学評論刊行会

雑誌

心理学評論 (ISSN:03861058)

巻号頁・発行日

vol.23, no.1, pp.89-105, 1980 (Released:2019-08-07)

著者

堀川 玲子

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.101, no.4, pp.965-974, 2012 (Released:2013-05-10)

参考文献数

10

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ヒトを含む多くの動物が雌雄異体で,各々特徴的な身体構造を有し,生殖において役割分担している.このような性腺と身体構造の分化を性分化といい,この過程に異常があり,性腺・内性器・外性器の分化が非典型的であるものを性分化疾患という.近年分子生物学の進歩により,多くの性分化疾患の原因が同定されてきた.性分化疾患では,生化学的・分子生物学的アプローチによる的確な診断と共に,社会的性や性自認の問題など,社会医学的側面も重要である.

著者

小川 さつき

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.56, no.9, pp.1182-1199, 1980-09-20 (Released:2012-09-24)

参考文献数

21

被引用文献数

4 5

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In order to elucidate the diurnal and circadian rhythms of oxytocin secretion, and the relation of estrogen, progesterone, testosterone and LH-RH to oxytocin secretion, plasma oxytocin levels were determined before and after the administration of these hormones in normal and hypogonadal subjects. The results were as follows.(1) In females with normal menstrual cycle, plasma oxytocin levels in the morning after overnight fasting were significantly higher (4.5 ± 2.6 pg/ml (mean ± SE)) in the follicular phase than they were (2.1 ± 1.3 pg/ml) in the luteal phase (p<0.01). Plasma oxytocin levels were higher in the follicular and ovulatory phases than they were in the luteal phase. In the luteal phase, the mean oxytocin concentration was higher during sleeping than during waking; however, in the follicular phase a variation of plasma oxytocin level was higher during waking than during sleeping.(2) In healthy males, plasma oxytocin level in the morning after overnight fasting was 3.5 ± 1.7 pg/ml, which was higher during sleeping than during waking. But the variation of plasma oxytocin levels during waking was larger than that during sleeping. Plasma oxytocin levels did not show cyclic changes in a year, but they were higher in summer than in winter.(3) Plasma oxytocin levels rose significantly after estradiol administration in normal females and males and did not change significantly after progesterone, and estradiol and progesterone administrations. A significant positive correlation was observed between plasma oxytocin level and the ratio of estradiol to progesterone concentrations in plasma in females and males.Plasma oxytocin levels rose significantly after testosterone administration in normal males. A significant positive correlation was observed between oxytocin and testosterone levels in plasma after the administration of testosterone.In the male subjects with hypogonadism, plasma oxytocin levels were elevated markedly 15 minutes after LH-RH administration.From these findings, it is suspected that in females with normal menstrual cycle, estrogen or LH-RH stimulates oxytocin secretion which is inhibited by progesterone, and that testosterone or LH-RH stimulates oxytocin secretion in normal males. On the other hand, a transient elevation of oxytocin secretion during waking in both females and males may be attributed to stimuli other than the sex hormones.The results also suggest that oxytocin secretion is affected by mechanism related to the hypothalamus-pituitary-gonadal system, and by mechanisms other than the system.