著者

Makiko OZAWA James K. CHAMBERS Kazuyuki UCHIDA Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0624, (Released:2016-02-27)

被引用文献数

35

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Canine cognitive dysfunction (CCD) is a syndrome that manifests itself in abnormal behaviors, such as disorientation and wandering. β-amyloid deposition in the brain, including the senile plaque (SP) and cerebral amyloid angiopathy (CAA), has been suggested as a major cause of the syndrome. However, the pathological significance of β-amyloid deposition in CCD dogs remains unclear. The present study was conducted using 16 dogs aged 10 years or older to clarify the relationship between the age-related histopathological lesions, such as β-amyloid deposition, in the brain and the clinical symptoms of CCD as evaluated in a questionnaire previously established in a large survey. In addition, age-related brain lesions were assessed in 37 dogs. The pathological lesions were evaluated by the severity of β-amyloid deposition (SP and CAA), the amount of ubiquitin-positive granules (UBQ), GFAP-positive astrocytes, Iba-1-positive microglia and Nissle stain-positive nerve cells. The results revealed that there was no significant correlation between the severities of canine SP and CCD. The SP increased until 14 years old, but decreased thereafter, although the incidence of CCD is high at these ages. The CAA consistently increased with age, but did not correlate greatly with the CCD score. In contrast, the increases of UBQ, astrocytes and microglia were significantly correlated with CCD. Thus, the impairment in the synapse and/or myelin suggested by increased UBQ and glial activation might be involved in CCD pathogenesis, but β-amyloid deposition, especially SP, is not a direct pathogenic factor of CCD.

著者

大島 郁葉

出版者

千葉大学

雑誌

若手研究(B)

巻号頁・発行日

2012-04-01

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本研究では、スキーマ療法の概念である早期不適応的スキーマと発達障害(自閉症スペクトラム障害)の関連性を調べ、認知行動療法の効果を検討した。媒介分析を行った結果、早期不適応的スキーマが媒介すると成人の自閉症スペクトラム障害のメンタルヘルスが損なわれることがわかった。したがって、成人の自閉症スペクトラム障害には早期不適応的スキーマの介入がターゲットとなりうることが示唆された。

著者

的場 崇

出版者

チャネル

雑誌

企業と広告 (ISSN:02858746)

巻号頁・発行日

vol.30, no.3, pp.48-51, 2004-03

著者

佐々木 由美子

出版者

立正大学社会福祉学会

雑誌

立正社会福祉研究 (ISSN:13454609)

巻号頁・発行日

vol.15, no.1, pp.21-26, 2013-10

著者

豊田 秀樹 拜殿 怜奈 久保 沙織 池原 一哉 磯部 友莉恵

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.86, no.6, pp.535-544, 2016 (Released:2016-02-25)

参考文献数

30

被引用文献数

1

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The purpose of this study is to propose a method of factor analysis for analyzing contingency tables developed from the data of unlimited multiple-choice questions. This method assumes that the element of each cell of the contingency table has a binominal distribution and a factor analysis model is applied to the logit of the selection probability. Scree plot and WAIC are used to decide the number of factors, and the standardized residual, the standardized difference between the sample, and the proportion ratio, is used to select items. The proposed method was applied to real product impression research data on advertised chips and energy drinks. Since the results of the analysis showed that this method could be used in conjunction with conventional factor analysis model, and extracted factors were fully interpretable, and suggests the usefulness of the proposed method in the study of psychology using unlimited multiple-choice questions.

著者

藤垣 裕子 立石 裕二

出版者

社会学研究会

雑誌

ソシオロジ (ISSN:05841380)

巻号頁・発行日

vol.57, no.1, pp.159-167, 2012-06-30 (Released:2015-05-13)

著者

杉野 健太郎

出版者

信州大学人文学部

雑誌

人文科学論集 文化コミュニケーション学科編

巻号頁・発行日

vol.36, pp.101-119, 2002-03-15

著者

関口 佐紀

出版者

政治哲学研究会

雑誌

政治哲学 = A journal of political philosophy

巻号頁・発行日

no.19, pp.66-91, 2015-10

著者

塙 賢哉 福島 亜梨花 山本 詩子 廣安 知之

出版者

人工知能学会

雑誌

人工知能学会全国大会論文集 (ISSN:13479881)

巻号頁・発行日

vol.28, 2014

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fNIRS装置から得られる脳血流変化量が生体的な特徴と相関があるかどうかは議論の余地がある。本研究では、脳血流変化量を特徴量とし被験者の識別を行い、その結果の優位差を検討することで、着目する相関を議論する。本発表では、記憶タスク時に音環境を変化させた際に男女の成績の違いが見られた知的作業時の脳血流変化量をDeepLearningを用い,男女の識別を行う。結果から、着目する相関が見られることを示す。

著者

日本電池株式会社 編

出版者

日本電池ジーエスニユース編輯部

巻号頁・発行日

1933

著者

ニシオ ハリー・K 竹中 和郎

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.20, no.1, pp.73-90,131, 1969-07-30 (Released:2010-05-07)

参考文献数

36

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The social sciences, sociology in particular, have aimed to develop an empirically-verifiable body of theory through application of the structural-functional analysis of social action in general. Functional sociologists, whether they be the Grand Theorists or Middle-range Theorists, have therefore concerned themselves with “objective” and “scientific” investigation of phenomena, rejecting metaphysical as well as positivistic interpretations of social reality. While the voluntaristic theory of social action caught the imagination of sociologists articulating the theoretical position of sociology vis-a-vis social idealism, radical utilitarianism and Social Darwinism, a new, though somewhat “off-beat” sociological approach has begun to appear, challenging the theoretical foundation of systematic sociology in general. Ethnomethodology is one of such challenges posed upon against the Orthodox Sociology.Ethnomethodology finds its origin in the work of Alfred Schutz, an Austrian sociologist who wrote a three-volume work titled Collective Papers, in which most of his ideas are contained. His “subjective” approach to social action, tied with his interest in phenomenology, appealed to social scientists in New York and California. Included in this group of ethnomethodologists are Harold Garfinkel, Aron Cicourel, Peter Mcllugh, Marvin Scott and many young sociologists.What these sociologists aim to accomplish may be summarized in the following : 1) in the process of scientific enquiries, a priority should be given to the subjective aspect of social interaction based on mutual understanding and on the accepted “rules of the game”, 2) instead of developing generalized rules arbitarity constructed by scientists, ethnomethodologists, by taking the position of social actors, attempt to understand not only the expressed symbolic interaction but also more subtle, unstated, unpredictable definitions of situations, 3) the ethnomethodologists treat the acting individuals not merely as “actors” but as “theorists” capable of defining the situation, impressing others in ways they desire and to some extent manipulating the given social structure to their advantage, and 4) in this type of observation, it is indispensable for the observer to react with those whom he analyses so as to enable him to identify the processes by which new shared knowledge and group experiences emerge and become sanctioned. In ethnomethodology, however, emphasis is upon culturally unstated social facts, rather than those formally institutionalized or stated. Because of this interest, ethnomethodologists tend to preoccupy themselves with many unusual, off-beat topics such as homosexuality, the social system of gamblers, social interaction in horse racing, etc. They are convinced that orthodox sociology is able to deal with only a very small portion of social reality which appears above the surface while a gigantic mass of unstated social interaction remaining beneath totally untouched. With this approach, E. Goff man attempts to analyse the communication processes which are primarily being “give-off” by the social performers. He uses a dramaturgical approach and cynically examines social interaction in terms of the performance that takes place in front or back of the curtain in relation to the audience. Aron Cicourel, articulating the theory of Harold Garfinkel, attempts to develop the theory-methodology of Ethnomethodology in his recent work by pointing out the theoretical, methodological shortcomings of the conventional survey methods.Ethnomethodology is still theoretically ambiguous and methodologically unclear to many. For one thing, where should we draw a line between ethnomethodology and social interactionist approach?

著者

渡沼 英二

出版者

日本フランス語フランス文学会

雑誌

フランス語フランス文学研究 (ISSN:04254929)

巻号頁・発行日

no.45, pp.80-89, 1984-10-20

著者

福島 政裕

出版者

東海大学

雑誌

東海大學紀要. 政治経済学部 (ISSN:0389200X)

巻号頁・発行日

vol.35, pp.43-63, 2003-08-30

著者

原田 正純 三村 孝一 高木 元昭 藤田 英介 住吉 司郎 宮川 洸平 堀田 宣之 藤野 糺 小鹿原 健一 本岡 真紀子

出版者

熊本学園大学

雑誌

社会関係研究 (ISSN:13410237)

巻号頁・発行日

vol.15, no.2, pp.1-42, 2010-03-26

著者

三井 斌友

出版者

一般社団法人 日本応用数理学会

雑誌

応用数理 (ISSN:09172270)

巻号頁・発行日

vol.18, no.2, pp.153-155, 2008

著者

「クール・ジャパンマーケット/オタク市場の徹底研究」編集プロジェクトチーム調査・編集

出版者

矢野経済研究所

巻号頁・発行日

2011

著者

Hiroe Sato Junichiro James Kazama Akira Murasawa Hiroshi Otani Asami Abe Satoshi Ito Hajime Ishikawa Kiyoshi Nakazono Takeshi Kuroda Masaaki Nakano Ichiei Narita

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.2, pp.121-126, 2016 (Released:2016-01-15)

参考文献数

33

被引用文献数

3 34

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Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease accompanied by periarticular and systemic osteoporosis. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes, circulates to the kidneys and regulates bone metabolism. We herein assessed serum FGF23 and its relationship to inflammation and osteoporosis in patients with RA. Methods Sixty-one patients with RA were included. Serum concentrations of FGF23 were determined using a sandwich enzyme-linked immunosorbent assay. Results The mean (± standard deviation) serum FGF23 concentration was 34.9±9.2 (range, 21.0-61.0) pg/mL. The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261, p=0.044, r=0.280, p=0.029, r=0.409, p=0.001 and r=0.421, p=0.001, respectively). The serum matrix metalloproteinase-3 level was also significantly and positively correlated with the serum FGF23 level (r=0.331, p=0.015). Concentrations of type I collagen cross-linked N-telopeptide in the serum was significantly correlated with the serum FGF23 level (r=0.272, p=0.034). Neither the bone mineral density in the femoral neck nor lumbar was significantly correlated with the serum FGF23 level. Serum phosphate, calcium, 25-hydroxy vitamin D, and intact parathyroid hormone were not related to the serum FGF23 level. Conclusion In patients with RA, serum FGF23 is correlated with inflammation, the disease activity of RA, and bone absorption markers. Serum FGF23 may be associated with abnormal bone absorption related to RA inflammation. Further studies are necessary to clarify the mechanism underlying this association.

著者

鈴木 道子 片山 一男 Michio Suzuki Kazuo Katayama

出版者

尚絅学院大学

雑誌

尚絅学院大学紀要 (ISSN:13496883)

巻号頁・発行日

vol.61, pp.87-100, 2011-12

被引用文献数

1 2

著者

今西 一

出版者

小樽商科大学

雑誌

小樽商科大学人文研究 (ISSN:0482458X)

巻号頁・発行日

vol.121, pp.1-54, 2011-03-31

著者

山室静著

出版者

社会思想社

巻号頁・発行日

1982