著者

神戸 敏江 土屋 香誉子 堀 誠 浴本 久雄 高橋 良和 竹内 富雄

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.17, no.4, pp.527-530, 1994-04-15 (Released:2008-04-10)

参考文献数

5

被引用文献数

1

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Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical structure of anthracyclines and the anti-ras activity. The human tumor cell line T24, which has a mutated H-ras gene, responded to the anthracyclines, as did K- or H-ras 3T3 cells, in respect to the phenotypic alterations. Pirarubicin was more than 4 times as active as aclarubicin in inhibiting the growth of solid tumors of K-ras 3T3 cells in nude mice, possibly reflecting a difference in anti-ras activity between the two antibiotics.

著者

KATSUTOSHI TAKAHASHI HISAO EKIMOTO SHOKO AOYAGI AKIKO KOYU HIROSHI KURAMOCHI OSAMU YOSHIOKA AKIRA MATSUDA AKIO FUJII HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.32, no.1, pp.36-42, 1979 (Released:2006-04-12)

参考文献数

12

被引用文献数

30 31

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Pepleomycin (PEP), 3-[(S)-1'-phenylethylamino]propylaminobleomycin has potent activity and is less pulmonary toxic than bleomycin (BLM). Biological activity and toxicity of the following degradation products of PEP have been studied in detail: the product of carbamoyl migration (ISO), the product of decarbamylation (DC), the product of ring closure of the side chain on the pyrimidine moiety (RC), the depyruvamide product (DP) and the product of an enzymatic inactivation (DA). These degradation products showed much lower activity than PEP in vitro: antimicrobial and anti-HeLa activities, inhibition of DNA synthesis in AH66 cells and the DNA strand cleavage. Acute toxicity and pulmonary toxicity were tested in mice. Results indicated much lower acute toxicity corresponding to the decreased in vitro activity when compared to PEP. DP and RC did not cause lung fibrosis in mice, while ISO and DC showed 1/2.6 and 1/5.7 degree of pulmonary toxicity, respectively, in comparison with PEP.

著者

Hisao EKIMOTO Kimihiko TAKADA Takao OHNUKI Katsutoshi TAKAHASHI Akira MATSUDA Tomohisa TAKITA Hamao UMEZAWA

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.2, no.1, pp.25-31, 1987 (Released:2010-02-25)

参考文献数

26

被引用文献数

7 11

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Sensitivity to bleomycin-induced pulmonary fibrosis was tested in various strains of mice. Among the strains examined, ICR, C57BL/10(H-2b), and C3H/He(H-2k) mice were highly sensitive to the induced pulmonary fibrosis; C57BL/6(H-2b), DBA/2(H-2d), A/J(H-2a), B6C3F1 and BDF1 mice were moderately sensitive, and CBA/JN(H-2k), BALB/c(H-2d), CDF1 and CBF1 mice were less sensitive. In congenic mice, which differ from each other only in the H-2 locus, C57BL/10(H-2b) was highly sensitive; B10·D2(H-2d) was moderately sensitive; and B10·BR(H-2k) and B10·A(H-2a) were less sensitive. Thus, the sensitivity differed depending on the haplotype of the H-2 genes. Furthermore, non-H-2 genes also seemed to be involved in the sensitivity to the pulmonary fibrosis. There was no correlation between the sensitivity to pulmonary fibrosis and enzyme activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the lung tissues, but the levels of reducing agents such as ascorbic acid and tocopherol in the lungs were inversely correlated with the sensitivity to the pulmonary fibrosis, except in the case of BALB/c and its F1 mice.

著者

HISAO EKIMOTO HIROSHI KURAMOCHI KATSUTOSHI TAKAHASHI AKIRA MATSUDA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.33, no.4, pp.426-434, 1980 (Released:2006-04-12)

参考文献数

18

被引用文献数

21 22

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The kinetics of the reaction of BLM-Fe(II)-O2 with DNA in the absence or presence of 2-mercaptoethanol (2-ME) were studied. The total number of bases released by BLM-Fe(II)-O2 in the presence of 2-ME increased about 6.5 times more than that in the absence of 2-ME in the reaction of 6 hours at 37°C. The molar ratios of the released bases ware little affected by the reaction time, temperature or 2-ME. Among the four bases, thymine was preferentially released. On the basis of a reaction scheme of BLM-Fe(II)-O2 with DNA, the equations were derived by the steady-state method. In the absence of 2-ME, the release of bases from DNA was dependent on the concentration of BLM-Fe(II)-O2, but independent of the concentration of DNA. In the presence of 2-ME, a biphasic reaction was observed; the first one is due to BLM-Fe (II) which originally existed and the second one is due to BLM-Fe(II) produced by the reduction of BLM-Fe(III) with 2-ME. In the second reaction, the rate of the release of bases from DNA was proportional to the concentration of BLM-Fe(II) and 2-ME, but inversely proportional to the concentration of DNA. The rate-determining step in the reaction of BLM-Fe(II)-O2 with DNA in the presence of 2-ME was found to be the reduction of BLM-Fe(III) to BLM-Fe(II). By these kinetic studies, the reaction of BLM-Fe(II)-O2 with DNA in the presence of 2-ME was elucidated to proceed in a catalytic fashion. Furthermore, the maximum number of bases released by BLM from DNA was one base per twelve to thirteen bases.

著者

埜渡 裕義 黒田 泰男 速水 宏 岡本 一也 浴本 久雄 高橋 克俊

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.37, no.9, pp.2406-2409, 1989-09-25 (Released:2008-03-31)

参考文献数

15

被引用文献数

14 18

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Novel alkyl-1, 4-butanediamine Pt(II) complexes having a seven-membered ring structure were synthesized and characterized by fast atom bombardment mass and infrared spectra and elemental analysis. Their antitumor activities in vivo toward lymphoid leukemia L1210 and LEwis lung carcinoma LL were studied in the case where the leaving group was either dichloride or cyclobutane-1, 1-dicarboxylate. 1, 4-Butanediamine Pt(II) complexes (seven-membered ring) showed higher antitumor activities than those of ethylenediamine Pt(II)(five-membered ring) and 1, 3-propanediamine Pt(II)(six-membered ring) complexes toward L1210 for both leaving groups. Alkyl-1, 4-butanediamine Pt(II) complexes showed high antitumor activities toward L1210, except for 1, 1-dimethyl-1, 4-butanediamine Pt(II) complexes. In particular, 2, 2-dimethyl-1, 4-butanediamine and 2, 3-dimethyl-1, 4-butanediamine Pt(II) complexes exhibited excellent antitumor activities with T/C% values higher than 300. None of the dichloro Pt(II) complexes showed antitumor activities toward LL, but the cyclobutane-1, 1-dicarboxylato Pt(II) complexes, which were moderately active toward L1210 with T/C% values aroung 200, also showed high antitumor activities toward LL with T/C% values of more than 200. Alkyl-1, 4-butanediamine Pt(II) complexes with a seven-membered ring structure were found to be stable and to have antitumor activities in vivo.

著者

海老原 和雄 浴本 久雄 一町田 裕子 安部 史紀 井上 博 青柳 祥子 山下 巧 小結 明子 高橋 克俊 吉岡 修 松田 明

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Japanese Journal of Antibiotics (ISSN:03682781)

巻号頁・発行日

vol.31, no.12, pp.872-885, 1978-12-25 (Released:2013-05-17)

参考文献数

19

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1962年, 梅沢, 等1) によつて発見されたブレオマイシン (以下BLM) は, 墓礎的研究をへで, 1965年はじめて市川, 等2) によつて臨床研究がおこなわれ, 陰茎癌に著るしい効果がみいだされた。その後, BLMは過去10年間の間に, 皮膚, 頭頚部, 口腔等の扁平上皮癌, ホジキン病, 睾丸腫瘍等に単独または併用によつて, 秀れた効果を発揮し, 固型癌の化学療法の治療体系の中に, 確固たる立殿確立した。BLMの臨床的研究は, 国の内外で広くおこなわれたが, その結果, 種々の扁平上皮癌, 睾丸腫瘍等の有効疾患, 投与方法, 併用療法について, 数多くの知見が得られたが, 薬剤の安全性の面からみると, BLMは多くの他の制癌剤と異なって, 骨髄毒性, 免疫抑制を示さない特徴をもっとともに, 肺に対する毒性が注目され, 高頻度ではないが, 時に致死的な副作用ともなる肺の線維症は, BLMの臨床使用上の1つの制限因子として, 臨床家の注目を集めた。梅沢, 等は3), BLMの研究の初期において, そのマウスの生体内分布性を抗菌活性および, 放射活性の両面から詳細に検討して, 抗腫瘍性をもつ物質の生体内分布の研究によつて, それが, 臨床応用されたばあいの有効性, 毒性の標的臓器を推定しうる方法論を確立した。それは, 「物質が高濃度に分布し, 分解を受けにくいか, 活性化を受けやすい腫瘍または臓器組織には有効性または毒性を発現する」と要約される。一方, 臨床研究の進行と平行しておこなわれたBLMの化学, 生化学, 発酵工学的研究の進歩によつて, 約300種に及ぶ末端アミンを異にする誘導体がつくられた。我々は4), これらの物質を梅沢の方法論にしたがつて, 従来のBLMと比較して,(1) BLMと同じ制癌スペクトルであるが, 抗腫瘍力が強い,(2) BLMより制癌スペクトルの拡大のあるもの,(3) 生体内分布に特徴をもつ,(4) 肺毒性が減少しているもの等を目標として選択をおこなつた。第1次スクリーニングにおいては, 抗菌, 抗腫瘍性 (HeLa S3細胞培養, マウスエールリッヒ腹水および固型癌) マウスを用いる臓器分布およびマウスを用いる肺線維化能について検討した。1次スクリーニングで選抜さ物質の中には, ラットAH66, AH66F, マウスL1210移植癌について検討したものもある。2次評価においては, 特定臓器の癌への有効性を検討することを主とし, 動物移植癌では代用し得ない癌においては, 実験方法および評価の困難性, 充分な動物数を得られない等の制約があるが, 動物自然発生腫瘍および, 化学発癌腫瘍を用いて検討した。本報告においては, 上記の方法によつて選抜した硫酸ペプレオマイシン (以下NK631と略) の諸性状について, 同時におこなったBLMの成績と対比して報告する。NK631の構造は, Fig.1に示すとおりである。

著者

HISAO EKIMOTO KATSUTOSHI TAKAHASHI AKIRA MATSUDA TOMOHISA TAKITA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.38, no.8, pp.1077-1082, 1985 (Released:2006-04-19)

参考文献数

12

被引用文献数

25 34

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Lipid peroxidation catalyzed by bleomycin (BLM)-metal complexes was studied in vitro using arachidonic acid as the substrate. Iron complexes of BLM caused extensive lipid peroxidation, but other metal complexes did not. The lipid peroxidation caused by the iron complexes was inhibited by antioxidants such as dl-α-tocopherol, ascorbic acid etc., but not by other scavengers of hydroxyl and superoxide radicals, and of singlet oxygen. Cyanide ion suppressed the lipid peroxidation caused by BLM-Fe(II), but did not suppress the peroxidation activity of BLM-Fe(III). The peroxidation activity of BLM-Fe(II) was lost instantly by pre-incubation of the complex at 37°C before mixing with arachidonic acid, but that of BLM-Fe(III) was not. These results indicate that the active form for the lipid peroxidation derived from BLM-Fe(II) differs from that of BLM-Fe(III).

著者

HISAO EKIMOTO MINAKO AIKAWA TAKAO OHNUKI KATSUTOSHI TAKAHASHI AKIRA MATSUDA TOMOHISA TAKITA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.38, no.1, pp.94-98, 1985 (Released:2006-04-19)

参考文献数

16

被引用文献数

5 6

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Pulmonary fibrosis in mice induced by peplomycin (PEP) was suppressed by administration of anti-inflammatory agents such as prednisolone and D-penicillamine during or after the administration of PEP. Pulmonary fibrosis was also suppressed by administration of cyclophosphamide, an immunosuppressive antitumor agent before, during or after the administration of PEP. The pulmonary fibrosis in athymic nude mice induced by PEP was less than that in normal mice. The low response in the nude mice was enhanced by transfer of thymocytes to the same level as that in the normal mice. This suggests that the immune system, especially thymus-dependent immunity, is involved in the pulmonary fibrosis induced by PEP.

著者

Hidetoshi Nakatake Hisao Ekimoto Mariko Aso Atsushi Ogawa Asami Yamaguchi Hiroshi Suemune

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.59, no.6, pp.710-713, 2011-06-01 (Released:2011-06-01)

参考文献数

20

被引用文献数

9 17

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Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have HA affinity and antitumor activity, and become a drug for metastatic bone tumor. In this study, the authors synthesized platinum complexes that had dialkyl bisphosphonic acid as a ligand, and evaluated the possibility of the synthesized complexes as a drug for metastatic bone tumor. The synthesized dialkyl bisphosphonate platinum(II) complex was characterized, and its stability in an aqueous solution was also confirmed. The synthesized platinum complex showed higher HA affinity than other platinum complexes such as cisplatin and carboplatin in an experiment of adsorption to HA. In vitro, the platinum complex showed tumor growth inhibitory effect stronger than or equal to cisplatin, which is the most commonly used antitumor agent. Moreover, the platinum complex showed a bone absorption inhibitory effect on the osteoclast. These results suggest potential of dialkyl bisphosphonate platinum(II) complexes as a drug for metastatic bone tumor.

著者

HISAO EKIMOTO KINIIHIKO TAKADA KATSUTOSHI TAKAHASHI AKIRA MATSUDA TOMOHISA TAKITA HAMAO UMEZAWA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.37, no.6, pp.659-663, 1984 (Released:2006-04-19)

参考文献数

30

被引用文献数

7 5

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The pulmonary fibrosis caused by peplomycin (PEP) was studied in terms of oxygen toxicity using ICR mice. When 16μg of PEP was administered intratracheally in mice after exposure to the air containing 75% O2 for 10 days, the pulmonary fibrosis was completely suppressed, while when mice were exposed to 75% O2 after the administration of PEP, the fibrosis was much severe than that of mice raised in atmospheric air. In 50% O2 similar oxygen effect was also observed, but it was weaker than that in 75% O2. In 90% O2 the oxygen toxicity was observed in mice without administration of PEP. When mice were exposed to 75% O2 the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, which are relevant to the detoxication of active oxygen species, were not increased in the lung, but the levels of reducing agents such as glutathione and ascorbic acid, and high molecular substances having 1O2-scavenging activity were enhanced. The results suggest that these materials have some roles to decrease the pulmonary fibrosis caused by PEP.

著者

鈴木 雪夫

出版者

一般社団法人 日本数学会

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.42, no.4, pp.372-378, 1990-11-09 (Released:2008-12-25)

参考文献数

8

著者

Omer BESALTI Zeynep AKTAS Pinar CAN Eylul AKPINAR Eser A. ELCIN Murat Y. ELCIN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0571, (Released:2016-06-10)

被引用文献数

14

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The aim of this study was to investigate the effects of percutaneous transplanted autologous neurogenically-induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in paraplegic dogs without deep pain perception (DPP) secondary to external spinal trauma. Thirteen client owned dogs that had failed in improvement neurologically at least 42 days after conservative management, decompression and decompression-stabilization were included in the study. Each dog received two doses of autologous 5.0 × 106 NIBM-MSCs suspension, which were positive to 2',3′-Cyclic-nucleotide-3′-phosphodiesterase (CNPase) and Microtubule-associated protein 2 (MAP-2), as well as to Glial fibrillary acidic protein (GFAP) and beta III tubulin. The cells were injected into the spinal cord through the hemilaminectomy or laminectomy defects percutaneously with 21 days interval for 2 times. The results were evaluated using Texas Spinal Cord Injury Scale (TSCIS), somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) at the admission time, cell transplantation procedures and during 2, 5, 7 and 12th months after the second cell transplantation. Improvement after cell transplantation in gait, nociception, proprioception, SEP and MEP results was observed in just 2 cases, and only gait score improvement was seen in 6 cases, and no improvement was recorded in 5 cases. All progresses were observed until 2nd month after the second cell transplantation, however, there was no improvement after this period. In conclusion, percutaneous transplantation of autologous NIBM-MSCs is a promising candidate modality for cases with spinal cord injury after spinal trauma and poor prognosis.

著者

吉田 泰将 香田 郡秀 坪井 三郎

出版者

日本武道学会

雑誌

武道学研究 (ISSN:02879700)

巻号頁・発行日

vol.21, no.2, pp.137-138, 1988-11-30 (Released:2012-11-27)

参考文献数

5

著者

大城 政一 及川 卓郎 平川 守彦

出版者

公益社団法人 日本畜産学会

雑誌

日本畜産学会報 (ISSN:1346907X)

巻号頁・発行日

vol.63, no.6, pp.645-648, 1992-06-25 (Released:2008-03-10)

参考文献数

12

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絶食下のヤギにおける反芻行動について検討を行なった.実験にはザーネン雑種成雌ヤギ3頭を供試した.自由採食期における1時間当りの吐出回数と反芻時間は24時間でほぼ一定していた.絶食期第1日における1時間当りの吐出回数と反芻時間は絶食後5時間に著しい増加を示したが,絶食期第2日と第3日では24時間一定していた.反芻時間は自由採食期で329.8分/日を示し,絶食期第1日の反芻時間は自由採食期に137%に増加したが,第2日は59%,第3日は22%に減少した.吐出回数は自由採食期で334.5回/日であったが,絶食期第1日は自由採食期の130%,第2日は156%と増加した.第3日は89%で自由採食期に近い値に回復した,絶食期における1反芻当りの休止時間を除く反芻行動は絶食期第1日において自由採食期と同じ値を示したが,第2日と第3日には顕著に減少した.

著者

河野 泰久

出版者

公益社団法人 日本農芸化学会

雑誌

日本農芸化学会誌 (ISSN:00021407)

巻号頁・発行日

vol.62, no.7, pp.1112-1116, 1988-07-15 (Released:2009-02-18)

参考文献数

29

被引用文献数

2 2

著者

太田 敬之 山岡 博之 古川 安志 下村 裕子 中野 好夫 若崎 久夫 古田 浩人 西 理宏 佐々木 秀行 南條 輝志男

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.98, no.6, pp.1375-1377, 2009 (Released:2012-08-02)

参考文献数

9

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症例は68歳,女性.画像診断で異常を指摘できない意識障害を認めた.橋本病の存在から橋本脳症を疑い,血清抗N末端α-enolase抗体陽性であった.橋本脳症は抗甲状腺抗体に関連した自己免疫性の脳症と考えられており,多彩な神経症状を呈する.原因不明の脳症を診た場合は,本症を考慮することが重要である.比較的まれな疾患である橋本脳症の1例を経験したので文献的考察を加えて報告する.

著者

李 汝培

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.66, no.1, pp.85-112, 1973 (Released:2011-12-12)

参考文献数

74

被引用文献数

1 1

著者

吉村 稔

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.102, no.2, pp.131-143, 1993-04-25 (Released:2010-11-18)

参考文献数

12

被引用文献数

4 14

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In order to reconstruct the march of climate before instrumental observations in Japan, Historical Weather Data Base has been constructed. Weather descriptions in historical documents, such as official diaries of Feudal Clans in Edo Era, or of local offices in each clan, are objects of the data base. Other descriptions are in those diaries of large temples, large shrines and large farmers, and in some of private diaries Considering the description of weather phenomena in old diaries, they were grouped into 13 weather conditions In this data base, “weather range” means weather conditions in a day. A rough tendency of the weather in a day (HN), or remarkable conditions such as hot, cold, dry and wet (HT), are also important to understand weather conditions for each day. Accompanied phenomena (TK) and wind conditions (KT, TT, KH) are also objects to encode. Daily weather records for the years from 1700 to 1889 are mainly under collections. So far, more than 2, 500 years weather records have been inputted in the daily data base. The main files of the system are PC-DA (paleo climatic data), and PC-REC (paleo climatic record). The former consists of encoded weather data which will be used chiefly to retrieve weather conditions and to draw maps or to make tables. The latter contains weather descriptions in each day with Katakana, one of the Japanese characters. This will support detailed investigationAs an index of wet or dry condition for each month, “PI” is proposed. Weather conditions having some relations with precipitation are grouped to three kinds. Monthly frequencies of each type are multiplied by constants. These are 1 for “little rain”, 2 for “rain” and 5 for “much rain”. The total value in each month in each day is “PI”, which is useful for the comparison within the same daily series. The scatter diagrams of PI in Kokura Kita Kyushu City and Precipitation at Moji for each season are shown in Fig. 4. Time series of PI in 6 cities show the existence of different march in summer precipitations over Japan (Fig. 5). The monthly conditions in summer months from 1781 to 1789 are reconstructed in Fig. 6.

著者

小関 成樹 伊藤 和彦

出版者

社団法人 日本食品科学工学会

雑誌

日本食品科学工学会誌 (ISSN:1341027X)

巻号頁・発行日

vol.47, no.12, pp.907-913, 2000-12-15 (Released:2009-02-19)

参考文献数

9

被引用文献数

3 9

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強酸性電解水によるカット野菜(キャベツ,レタスおよびキュウリ)の殺菌において,強アルカリ性電解水を前洗浄に用いた場合の影響について検討した結果,以下の知見が得られた.(1) キャベツおよびレタスを対象にした場合,強酸性電解水による殺菌が1分間のときには,強アルカリ性電解水で前洗浄することによって強酸性電解水による単独5分間の殺菌効果と同等以上の効果が示された.このことから強アルカリ性電解水の利用により処理時間の短縮が可能であることが示唆された.(2) カットキャベッおよびカットキュウリを対象にした場合,強酸性電解水による殺菌において,強アルカリ性電解水などで前洗浄をすることにより,殺菌時の強酸性電解水の性能低下(ORP,ACCの低下)を抑制することが示された.

著者

大沢 はま子

出版者

一般社団法人 日本調理科学会

雑誌

調理科学 (ISSN:09105360)

巻号頁・発行日

vol.6, no.3, pp.135-143, 1973-09-10 (Released:2013-04-26)

参考文献数

8

被引用文献数

2