著者
谷山 茂人 高谷 智裕 反町 太樹 相良 剛史 久保 弘文 大城 直雅 小野 要 肖 寧 橘 勝康 荒川 修
出版者
公益社団法人 日本食品衛生学会
雑誌
食品衛生学雑誌 (ISSN:00156426)
巻号頁・発行日
vol.54, no.1, pp.49-55, 2013-02-25 (Released:2013-03-08)
参考文献数
37
被引用文献数
1 5

2009年1~6月に沖縄県沿岸で採集した小型巻貝8科15種計64個体のうち,5種にマウス毒性が認められた.このうち,キンシバイの毒力は総じて高く,筋肉で最高461 MU/gに達した.その他の4種(サツマビナ,ヘコミマクラ,イボヨフバイ,カゲロウヨフバイ)の毒力はおおむね10 MU/g前後であった.LC-MS分析により,有毒個体の毒の主体はいずれもTTXで,キンシバイではこれに加えて4,9-anhydroTTX,4-epiTTX,11-oxoTTXを含むことが示された.また,アワムシロの可食部からもTTX(5.08 MU/g)が検出された.一方,残りの9種には,マウス毒性もTTXも全く認められなかった.
著者
奥山 治美
出版者
公益社団法人 日本農芸化学会
雑誌
日本農芸化学会誌 (ISSN:00021407)
巻号頁・発行日
vol.69, no.5, pp.583-585, 1995-05-01 (Released:2008-02-14)
参考文献数
9
被引用文献数
1 3
著者
Shu Kondo
出版者
日本遺伝学会
雑誌
Genes & Genetic Systems (ISSN:13417568)
巻号頁・発行日
vol.89, no.1, pp.3-8, 2014 (Released:2014-05-10)
参考文献数
41
被引用文献数
7 17

Drosophila melanogaster has the longest history as a genetic model system and even in the present day remains the front runner in diverse fields of biology. However, lack of a convenient method to make specified modifications to endogenous genes has been a pain in the neck for many fly geneticists for decades. Synthetic nuclease technologies, especially the CRISPR/Cas9 system, hold great promise for a breakthrough. Synthetic nucleases are programmable nucleases that can be directed to cleave a specified sequence in the genome. Deleterious mutations can be efficiently induced by expression of a synthetic nuclease that targets a gene of interest. Precise modification of the target site, such as a reporter gene knock-in, is also possible by simultaneous delivery of a synthetic nuclease and a targeting vector. Here I summarize recent advances in synthetic nuclease technologies and discuss their possible applications to Drosophila genetics.
著者
渡邊 紀文 森 文彦 大森 隆司
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会誌 (ISSN:13426907)
巻号頁・発行日
vol.67, no.12, pp.J434-J440, 2013 (Released:2013-11-25)
参考文献数
12
被引用文献数
2

In daily life, our behavior is guided by various visual stimuli such as the information on direction signs. However, our environmentally based perceptual capacity is often challenged in crowded circumstances, or more so, in emergency evacuation circumstances. In these situations, we often fail to pay attention to important signs. In order to achieve more effective direction guidance, we considered the use of unconscious reflexes in human walking action. In this study, we experimented with vision-guided walking direction control by optic flow stimulus combined with body sway. We observed a shift in subjects' walking direction and body sway and discuss the possible mechanism.
著者
藤生 慎 沼田 宗純 高田 和幸 松原 全宏 大原 美保 目黒 公郎
出版者
公益社団法人 日本地震工学会
雑誌
日本地震工学会論文集 (ISSN:18846246)
巻号頁・発行日
vol.12, no.4, pp.4_177-4_188, 2012 (Released:2012-09-28)
参考文献数
8
被引用文献数
2

本研究では、東北地方太平洋沖地震時に発生した帰宅困難者に対してwebアンケートを実施し、帰宅困難者の基礎特性や帰宅経路などを明らかにした。その結果を集計したところ、火災の危険性や建物の倒壊の危険性が高い地域を経由し帰宅行動がなされていることが明らかになった。また、帰宅困難者を被災地内(都心)で受け入れるための施設の在り方の検討を行った結果、病院では、帰宅困難者が多数発生する一方、出勤困難者に対する対応も必要であることが明らかとなった。
著者
永田 尚人 西村 典子 山本 幸司
出版者
Japan Society of Civil Engineers
雑誌
土木計画学研究・論文集 (ISSN:09134034)
巻号頁・発行日
vol.22, pp.265-270, 2005-10-31 (Released:2010-06-04)
参考文献数
9

大都市部における大規模地震発災直後において, 主要な輸送機関である鉄道の運行停止等により多くの帰宅困難者の発生が予測されている. 帰宅困難者は徒歩により帰宅を行うものと考えられるが, 帰宅経路の安全状態や被害状況に関する情報とともに, 帰宅経路における食料や飲料水の確保が大きな課題となる. 本研究では, 東海地震に対する警戒宣言発令後における交通輸送機関の麻痺により発生する帰宅困難者の問題点を明らかにした上で, 飲食料等確保の観点からコンビニエンスストア活用のあり方について検討を行うことを目的とする.
著者
三功 浩嗣 内藤 整
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会誌 (ISSN:13426907)
巻号頁・発行日
vol.68, no.3, pp.J125-J134, 2014 (Released:2014-02-25)
参考文献数
12
被引用文献数
2 5

In this paper, we propose a robust object tracking scheme for multi-view cameras and consecutive frames for rendering an immersive free-viewpoint video in a large outdoor space such as a soccer stadium. For a free-viewpoint video that provides users with an immersive experience, each object has to be identified consistently among all cameras for every frame to share the textures of the same objects and replace the textures when an occlusion occurs. To satisfy this requirement, the proposed method extracts objects' silhouette regions and tracks each identified object by associating a closed silhouette region with a tracking ID for every camera. During the frame by frame process, our method confirms whether occlusion occurs for each tracking region and modifies the texture region by projecting the world coordinate of the object in 3D-space, which can be estimated from a camera image without occlusion if one is available. The experimental results revealed that the proposed method achieved more robust texture extraction of multiple objects especially for occluded regions compared to the conventional methods. Furthermore, it was confirmed that the proposed scheme can improve the subjective image quality for free-viewpoint video as a result of precise reconstruction of occluded regions.
著者
松久 ひとみ 橋本 学
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会誌 (ISSN:13426907)
巻号頁・発行日
vol.68, no.6, pp.J252-J255, 2014 (Released:2014-05-23)
参考文献数
10
被引用文献数
3

Identifying subtle human facial expressions is important in human interactions such as human-robot communications. We propose a method to classify two types of facial expression, neutral (expressionless) and the subtle expression of happiness, using an image acquired with a camera. In the proposed method, facial shape features such as wrinkle-angle or unevenness of face surface are extracted via Gabor filters in multiple ROIs on a human face. High angle resolution Gabor filters are used to detect subtle facial expressions and the positions of the detection window and Gabor filter parameters are optimized by a learning process using AdaBoost. Changes to facial expression are estimated by comparing an input image to a learned database with the features. Experimental results showed that the proposed system has a 0.84 precision rate and a 0.91 recall rate in the case of detecting subtle changes.
著者
山川 大貴 福元 清剛 海老澤 嘉伸
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会誌 (ISSN:13426907)
巻号頁・発行日
vol.68, no.6, pp.J232-J237, 2014 (Released:2014-05-23)
参考文献数
18

It is difficult for gaze detection systems to detect pupils in camera images containing eyeglasses reflections caused by the infrared light sources necessary for gaze detection. In a previous study with a system using two cameras, we proposed a geometrical pupil detection algorithm. However, depending on the positional relationship between the pupil and the reflection, the algorithm was not always effective. In the present study, we arranged three cameras—one at each vertex of a triangle—and composed three camera pairs with different base line directions. We propose several new algorisms, and in the basic algorithm, pupil candidates indicating the suprathreshold angle between two planes, each of which includes the cameras composing a camera pair and the candidate detected by one of the two cameras, are removed from the candidate list. A significant improvement of pupil detection is experimentally demonstrated.
著者
池田 拓也 小山田 雄仁 杉本 麻樹 斎藤 英雄
出版者
一般社団法人 映像情報メディア学会
雑誌
映像情報メディア学会誌 (ISSN:13426907)
巻号頁・発行日
vol.67, no.4, pp.J124-J133, 2013 (Released:2013-03-25)
参考文献数
13

Optical consistency between the real world and virtual objects is an important issue in augmented reality (AR). We propose a method to estimate illumination from an object shadow and incomplete object shape information captured by an RGB-D camera. The environmental illumination can be estimated without any prior knowledge of the object shape. The radiance of each light source is computed by solving linear equations derived from color and depth images. Since prior knowledge of the object shape is not necessary, we can flexibly use/combine any objects. Thus, we can use/combine multiple objects in the target scene to increase the accuracy and flexibility. Our experimental results show the characteristics of our proposed method.
著者
伊藤 美保 飯田 奈美子 南谷 かおり 中村 安秀
出版者
日本国際保健医療学会
雑誌
国際保健医療 (ISSN:09176543)
巻号頁・発行日
vol.27, no.4, pp.387-394, 2012-12-20 (Released:2013-01-24)
参考文献数
22

目的本研究は、医療通訳を実施している当事者に対して質問紙調査を行い、医療通訳業務や研修の内容、医療通訳の現場での課題などを明らかにすることを目的とした。方法通訳者を派遣しているNPO、地域の国際化協会や、通訳者を雇用している医療機関等に通訳者への配布を依頼し、郵送にて直接回収し分析した。結果有効回答数は284名(有効回答率33.4%)であった。5年以上の経験者が46.1%いたが、常勤の通訳者は少なく、76.4%が派遣の形態をとっていた。対応言語は、手話を含む14言語であった。通訳頻度が月4回以下のものが68.3%であったが、8.5%は月20回以上の医療通訳の機会があった。回答者の54.4%が総時間20時間以上の研修を受けていた。医療従事者と患者の間に位置する通訳者として、種々の困難さに直面している実態が明らかになった。考察医療通訳者を直接対象とした本調査により、すでに多くの医療通訳者が現場で活動している実態が明らかとなった。研修を受ける機会が少なく、通訳技術の維持向上に必要不可欠な研修体制の充実が必要であった。医療従事者側と患者側の双方に、通訳者の効果的な活用方法と公平性という業務範囲を明確に説明し、同時に通訳者を精神的にも支える立場のコーディネーターが必要である。
著者
森岡 郁晴 和泉 有里奈 井上 雅 岡田 佳奈子 坂口 佳穂 宮井 那津季
出版者
日本衛生学会
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.69, no.2, pp.146-152, 2014 (Released:2014-05-24)
参考文献数
28

Objectives: The purpose of this study was to clarify the effect of stone spa bathing (Ganban-yoku) and hot-spring bathing on brachial-ankle pulse wave velocity (baPWV) in healthy, late middle-aged females. Methods: The subjects were 13 females (mean age, 47.3 years). The skin and tympanic temperatures, blood pressure, and baPWV were measured before and after stone spa bathing and hot-spring bathing. For the stone spa bathing, the subjects lay down three times for approximately 10 min each time over warm stone beds. Results: Although body weight showed no change after the hot-spring bathing, it significantly increased after the stone spa bathing. The increase was significantly related to the amount of water intake. The skin and tympanic temperatures increased to a smaller degree after the stone spa bathing than after the hot-spring bathing. The diastolic blood pressure decreased to a smaller degree after the stone spa bathing. BaPWV showed no significant change after bathing both in the stone spa and in the hot-spring. The results of multiple regression analysis showed that the factors significantly related to the change in baPWV after the stone spa bathing were the changes in skin and tympanic temperatures and habit of smoking, and that after the hot-spring bathing was the change in skin temperature. Conclusions: The results suggest that, compared with the hot-spring bathing, stone spa bathing causes less strain on the body. The stone spa bathing and hot-spring bathing showed no marked effect on baPWV. However, there is a possibility that the stone spa bathing may be used as a load for investigating arterial stiffness.
著者
中村 照也
出版者
日本結晶学会
雑誌
日本結晶学会誌 (ISSN:03694585)
巻号頁・発行日
vol.56, no.2, pp.123-128, 2014-04-30 (Released:2014-05-01)
参考文献数
30

DNA, which carries genetic information, is easily damaged by reactive oxygen species,UV radiation and chemical agents, and DNA integrity is maintained by various nucleic acid enzymes. We carried out X-ray crystallographic studies of two types of nucleic acid enzymes, oxidative nucleotide hydrolase MutT and translesion DNA polymerase η. In this review, I will describe the mechanism of high substrate specificity for oxidative nucleotides by E. coli MutT and the visualization of nucleotidyl transfer reaction by human DNA polymerase η.
著者
Chuzo Iwamoto
出版者
一般社団法人 情報処理学会
雑誌
Journal of Information Processing (ISSN:18826652)
巻号頁・発行日
vol.22, no.1, pp.40-43, 2014 (Released:2014-01-15)
参考文献数
20
被引用文献数
2 15

Yosenabe is one of Nikoli's pencil puzzles, which is played on a rectangular grid of cells. Some of the cells are colored gray, and two gray cells are considered connected if they are adjacent vertically or horizontally. A set of connected gray cells is called a gray area. Some of the gray areas are labeled by numbers, and some of the non-gray cells contain circles with numbers. The object of the puzzle is to draw arrows, vertically or horizontally, from all circles to gray areas so that (i) the arrows do not bend, and do not cross other circles or lines of other arrows, (ii) the number in a gray area is equal to the total of the numbers of the circles which enter the gray area, and (iii) gray areas with no numbers may have any sum total, but at least one circle must enter each gray area. It is shown that deciding whether a Yosenabe puzzle has a solution is NP-complete.
著者
Hiroaki Kikuchi Makoto Aoyagi Kiyotaka Nagahama Yu Yajima Chisato Yamamura Yohei Arai Suguru Hirasawa Shota Aki Naoto Inaba Hiroyuki Tanaka Teiichi Tamura
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.53, no.11, pp.1131-1135, 2014 (Released:2014-06-01)
参考文献数
14
被引用文献数
3 11

A 76-year-old woman with a history of lumbar fracture and marked proteinuria, bilateral pitting edema, malaise and pruritus was referred for an evaluation of an impaired renal function. A renal biopsy led to a tentative diagnosis of acute interstitial nephritis (AIN) with minimal change disease caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Following the discontinuation of oral NSAIDs, the patient's symptoms disappeared spontaneously. However, nephrotic-range proteinuria relapsed one month after discharge, following loxoprofen patch use. The withdrawal of the topical loxoprofen patches once again resulted in the disappearance of all symptoms. This is the first case report of nephrotic-range proteinuria and AIN secondary to topical NSAID patch use.