著者

中山 裕子 國友 和善 磯野 忠大 熊本 浩志 木村 貴彦 橘 充弘

出版者

日本臨床外科学会

雑誌

日本臨床外科学会雑誌 (ISSN:13452843)

巻号頁・発行日

vol.72, no.7, pp.1695-1699, 2011 (Released:2012-01-25)

参考文献数

22

被引用文献数

1

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症例は37歳,女性.2009年3月末より右乳房CD領域に圧痛・熱感を伴う径7cm大の硬結を自覚し,4月,自潰し排膿を認めたことから当科外来初診となった.38℃の発熱を認め,血液検査でも炎症反応が高値であった.乳房超音波検査で右乳房全体に低エコー領域を認めた.針生検では,乳管周囲に類上皮細胞・組織球・リンパ球・形質細胞の浸潤と多核巨細胞を認め,悪性所見は認めなかった.外来で切開排膿した.5月より全身関節痛が出現した.血液検査上,自己免疫性関連抗体は陰性であり,肉芽腫性乳腺炎に伴う全身関節痛と診断し,7月よりステロイドの内服を開始した.関節症状・乳房所見ともに軽快し,2010年1月に投与を中止した.投与中止から1年経過し,症状の再燃なく当科外来通院中である.

著者

広瀬 信義 新井 康通 稲垣 宏樹 小島 俊男

出版者

日本脂質栄養学会

雑誌

脂質栄養学 (ISSN:13434594)

巻号頁・発行日

vol.17, no.1, pp.19-31, 2008 (Released:2009-02-17)

参考文献数

6

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In order to know how to live longer and healthy, we conducted centenarian study with multidisciplinary approach since 2000. We presented here the results of our study. The characteristics of centenarians are 1) low prevalence of diadetes mellitus, 2) frequency of illness is 97%,3) prevalence of dementia free and independent centenarian is 18%, 4)low level of albumin, 5) low-grade activation of inflammation, 6) high level of adiponectin. We proposed aging-inflammation hypothesis. Since centenarian is not the model of healthy longevity, we began to study semisupercentenarians (SSC). SSC are considered to be a real model of human longevity. Whole genome scan of both SSC and control group, is now in progress. We hope that longevity genes will identified within a few years.

著者

池田 央

出版者

日本行動計量学会

雑誌

行動計量学 (ISSN:03855481)

巻号頁・発行日

vol.39, no.1, pp.33-35, 2012 (Released:2012-10-02)

著者

神田 清子 飯田 苗恵 狩野 太郎

出版者

北関東医学会

雑誌

北関東医学 (ISSN:13432826)

巻号頁・発行日

vol.51, no.6, pp.379-387, 2001-11-01 (Released:2009-10-21)

参考文献数

32

被引用文献数

1 1

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【背景・目的】がん化学療法に伴う味覚変化に対して, 看護者が行っているセルフケア教育の内容を明らかにすることである.【対象と方法】全国の500病院で働く病棟の副婦長1000名であり, 郵送法による質問紙調査を施行した.回収は634名 (回収率63.0%) であり, 該当なし, 記入不備を除く568名について分析を行った.セルフケア教育内容は自由記述により回答を求め, 内容分析を行った.【結果】看護者の約59%が患者・家族を対象として, がん化学療法に伴う味覚変化に関するセルフケア教育を行っていた.セルフケア教育内容で一番多い項目は, 「味覚変化時の食事」, 次いで「症状・徴候の観察」, 「味覚回復のための含嗽液」であった.教育内容としては, 味覚変化の原因と出現時期, 観察, 食事, 含嗽, 味覚刺激方法など一連のセルフケア教育を行っていることが明らかになった.味覚を回復するための含嗽液として, イソジン, レモン水, 氷水が高頻度に指導されていた.【結論】セルフケア教育内容として, 味覚変化時の食事指導は定着しつつある.しかし, 薬剤投与中の金属味への対処方法の教育は行われておらず教育内容に含める必要があることが明らかになった.さらに味覚を回復するために実践されているレモン水については, その効果が曖昧のまま指導されており介入研究が必要であることが示唆された.

著者

金原 均二 石和田 靖章

出版者

石油技術協会

雑誌

石油技術協会誌 (ISSN:03709868)

巻号頁・発行日

vol.15, no.2, pp.83-86, 1950-03-30 (Released:2008-03-27)

著者

馬場 哲郎 浦本 秀隆 山田 壮亮 桑田 泰治 永田 好香 重松 義紀 下川 秀彦 小野 憲司 竹之山 光広 花桐 武志

出版者

特定非営利活動法人 日本呼吸器外科学会

雑誌

日本呼吸器外科学会雑誌 (ISSN:09190945)

巻号頁・発行日

vol.25, no.1, pp.002-006, 2011-01-15 (Released:2011-04-27)

参考文献数

12

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肺カルチノイド切除10例について臨床病理学的因子と治療成績に関して検討を行った.定型的カルチノイド(TC)が7例で非定型的カルチノイド(AC)が3例.平均年齢は49.5歳で,男性6例,女性4例(全例TC)であった.術前にカルチノイドの診断がついたのは4例であり,他組織型の肺癌と診断されたのが4例.術式は肺摘除が2例,二葉切除が1例,肺葉切除4例,区域切除1例,部分切除1例,気管支形成術1例であった.TCでは術後(平均観察期間63ヵ月)の再発例はなく,ACは全例が再発.カルチノイド全体での5年生存率は62.5%で,TCは100%,ACでは5年生存例はなかった.TCについては機能温存手術の適応の検討が,ACについては周術期の補助療法など集学的治療の検討が必要であると考える.

著者

新倉 貴士

出版者

日本消費者行動研究学会

雑誌

消費者行動研究 (ISSN:13469851)

巻号頁・発行日

vol.1, no.1, pp.29-45, 1993-09-20 (Released:2009-05-29)

参考文献数

40

被引用文献数

2

著者

Keita Noda Bo Zhang Atsushi Iwata Hiroaki Nishikawa Masahiro Ogawa Takashi Nomiyama Shin-ichiro Miura Hideto Sako Kunihiro Matsuo Eiji Yahiro Toshihiko Yanase Keijiro Saku on behalf of the STYLIST Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.6, pp.1335-1344, 2012 (Released:2012-05-25)

参考文献数

30

被引用文献数

10 15 4

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Background: Dietary habits are associated with obesity, and both are important contributing factors to lifestyle-related diseases. The STYLIST study examined the effects of dietary counseling by registered dietitians and the delivery of proper calorie-controlled meals (UMIN Registration No: 000006582). Methods and Results: Two-hundred adult patients with hypertension and/or diabetes mellitus were randomly divided into 2 groups with/without dietary counseling and consumed an ordinary diet for 4 weeks. Each group was then subdivided into 2 groups with/without dietary counseling and received calorie-controlled lunch and dinner boxes for the next 4 weeks. The calories in the delivered meals were based on the subject's ideal body weight (BW) and physical activity level. BW, waist circumference, blood pressure, and laboratory data, including glycoalbumin, were measured at 0, 4, and 8 weeks. BW and the other parameters were significantly reduced during the study period in patients who received diet counseling in the ordinary diet period and/or delivered meal period but not in patients without dietary counseling, as assessed by linear mixed models for longitudinal data. Conclusions: The combination of dietary counseling by dietitians and delivery of calorie-controlled meals was effective in reducing BW, as well as blood pressure and glycoalbumin, in patients with hypertension and/or diabetes mellitus. (Circ J 2012; 76: 1335-1344)

著者

持丸 正明

出版者

バイオメカニズム学会

雑誌

バイオメカニズム学会誌 (ISSN:02850885)

巻号頁・発行日

vol.33, no.1, pp.2-7, 2009 (Released:2012-01-31)

参考文献数

4

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子どもの死亡原因の第1位である不慮の事故を低減するための工学的アプローチの必要性について述べる.事故の中でも,危険が潜在的であり,かつ,命に関わる重篤な傷害を引き起こす恐れのある「ハザード」をいかに発見して,いかにして取り除くかについて,病院を基点に網羅的に事故情報を集め,それらを知識化して,環境や製品の改善につなげるという「安全知識循環型社会」の考え方について述べる.これを形づくる工学的研究として,病院を基点にした事故サーベイランス技術,子どもの体形・行動の計測,子どもシミュレータによる事故原因究明の研究について概要を紹介する.また,これらの知識を,安全規格,商品開発,子どもや両親への啓蒙というかたちで社会に循環させる取り組みについて紹介する.

著者

植松 利晃

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.7, pp.528-531, 2012-10-01 (Released:2012-10-01)

著者

Reeko SATO Saori KOBAYASHI Yuya ABE Hiroaki KAMISHINA Shinichi ODA Jun YASUDA Juso SASAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1177-1183, 2012 (Released:2012-10-01)

参考文献数

24

被引用文献数

1

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This study reported detailed clinical effects of bovine lactoferrin on 2 canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a long duration improved their clinical signs (severe uveitis in the female dog and coughing from pneumonia in the male dog). Their backcross dogs that have the same father didn’t show clinical signs of bacterial infection. Neutrophil function tests revealed that the backcross dogs didn’t have any disorders. It is likely that abnormal clinical signs are associated with neutrophil dysfunction in the colony, and the mother dog of these cases might be the genetic carrier of this dysfunction.

著者

Kazuya EDAMURA Jonathan N. KING Wolfgang SEEWALD Nobuhiro SAKAKIBARA Masahiro OKUMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1121-1131, 2012 (Released:2012-10-01)

参考文献数

23

被引用文献数

5 18 10

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The efficacy and tolerability of robenacoxib for the treatment of osteoarthritis in dogs were evaluated in a prospective, multicenter, randomized, noninferiority design clinical trial. A total of 32 dogs presenting with osteoarthritis were allocated randomly to receive, orally once daily for 28 days, either 1–2 mg/kg robenacoxib (n=21) or 3.5–5 mg/kg carprofen (n=11). Dogs were assessed by clinicians and owners using numerical rating scale scores at baseline and days 14 and 28. The primary efficacy endpoint was the global functional disability score, which was the sum of clinician scores for standing posture, lameness at walk, lameness at trot, willingness to raise the contralateral limb and pain at palpation. There was a good to excellent level of efficacy in both treatment groups. Differences between days 14 and 28 compared to day 0 were significant for all 11 clinician and owner scores for robenacoxib, and for 6 of 11 scores for carprofen. The efficacy of robenacoxib was numerically superior to carprofen for all 13 endpoints, but differences were not statistically significant. For the global functional disability score, the estimated efficacy of robenacoxib was 1.244 (95% confidence interval 0.555–2.493) relative to carprofen. The tolerability of both treatments was good as assessed from adverse events, clinical signs, and hematology and serum biochemistry variables. In conclusion, once daily administration of robenacoxib tablets had noninferior efficacy and tolerability compared to carprofen for the treatment of the clinical signs of osteoarthritis in dogs.

著者

Hyun-Ah PARK Ju-Won KIM Hee-Myung PARK

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1233-1236, 2012 (Released:2012-10-01)

参考文献数

12

被引用文献数

2

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A 7-year-old intact female Maltese dog was referred with ptyalism and intermittent vomiting but no regurgitation for over 1 month. Survey radiographs including a contrast study revealed a large circular dilated cavity from the carina to the diaphragm. Additionally, multi-detector computed tomography and three-dimensional reconstruction were performed. These images revealed large idiopathic distal esophageal diverticula. This case report represents the first report using multi-detector computed tomography and three-dimensional reconstruction for evaluation of esophageal diverticula in a dog.

著者

Shingo MIYAWAKI Makoto WASHIZU Sadatoshi MAEDA Sanae SHIBATA Kazuhiro WATANABE Kazuaki YAMAZOE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1191-1193, 2012 (Released:2012-10-01)

参考文献数

12

被引用文献数

1

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Portal vein aneurysm (PVA) is a rare abnormal dilatation of the portal vein, which has not been reported in dogs. We describe the findings of ultrasound and computed tomography in a case of PVA in a young male toy poodle, with the final diagnosis established by explorative surgical observation. The dog had an aneurysmal fusiform dilatation in the extrahepatic portal vein with portal hypertension and multiple portsystemic shunts. This is the first report of canine PVA.

著者

Mariko SAWA Akira YABUKI Noriaki MIYOSHI Kou ARAI Osamu YAMATO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1133-1138, 2012 (Released:2012-10-01)

参考文献数

22

被引用文献数

2

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The Papanicolaou stain is a gold-standard staining method for tumor diagnosis in human cytology. However, it has not been used routinely in veterinary cytology, because of its complicated multistep procedure and requirement for wet fixation. Currently, a rapid Papanicolaou stain using air-dried smears is utilized in human cytology, but usefulness of this rapid-air-dry Papanicolaou (RAD-Pap) stain in the veterinary field has not been fully evaluated. The purpose of this study was to evaluate the usefulness of the RAD-Pap stain by using quantitative analysis. Air-dried impression smears were collected from tumor specimens and stained with RAD-Pap and Giemsa. Twelve parameters representing the criteria of malignancy were quantitated, and characteristics of the RAD-Pap were evaluated statistically. The RAD-Pap stain could be applied to all the smears, and images of nucleoli and chromatin patterns were clear and detailed. In quantitative analysis with the RAD-Pap stain, but not with the Giemsa stain, dispersion of nucleolus size and dispersion of nucleolus/nucleus ratio in malignant tumors were significantly higher than those in benign tumors. These findings demonstrated that the RAD-Pap stain was useful for obtaining detailed nuclear information, and the ability to differentiate benignity and malignancy by nucleolus findings was a principal advantage of this stain. This RAD-Pap stain could be routinely used as a supportive staining method in veterinary diagnostic cytology.

著者

Bandula Kumara WICKRAMASEKARA RAJAPAKSHAGE Masahiro YAMASAKI Shiang-Jyi HWANG Noboru SASAKI Masahiro MURAKAMI Yu TAMURA Sue Yee LIM Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1139-1148, 2012 (Released:2012-10-01)

参考文献数

34

被引用文献数

9 16

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The stability of the characteristics of the diminazene aceturate (DA)-resistant B. gibsoni isolate was initially determined invitro. Part of the DA-resistant B. gibsoni isolate was cultured without DA for 4 weeks, and then newly exposed to 200 ng/ml DA. As a result, this isolate could proliferate the same as the DA-resistant isolate, indicating that the characteristic of DA resistance was stable in the DA-resistant isolate. Additionally, the level of parasitemia in the DA-resistant isolate was comparatively lower than in the wild-type, suggesting that the proliferation potential of the DA-resistant isolate would be lower than that of the wild-type. Subsequently, to investigate the involvement of mitochondrial DNA (mtDNA) in DA resistance in B. gibsoni, the nucleotide sequences and deduced amino acid sequences of mitochondrial genes such as COXI, COXIII, and CYTb genes of the DA-resistant isolate, were compared with those of the wild-type. As a result, these three genes were not altered in the DA-resistant B. gibsoni isolate. Moreover, the transcription levels of COXI, COXIII, and CYTb genes were observed by semi-quantitative RT-PCR. As a result, the gene transcription of those genes in the DA-resistant isolate was not significantly altered. These results indicated that DA did not affect mtDNA directly in DA-resistant B. gibsoni. Thus, it is suggested that mtDNA should not be deeply involved in DA resistance in B. gibsoni.

著者

Atsushi TSUKAMOTO Koichi OHNO Shingo MAEDA Ko NAKASHIMA Kenjiro FUKUSHIMA Yasuhito FUJINO Masatoshi HORI Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1103-1108, 2012 (Released:2012-10-01)

参考文献数

33

被引用文献数

7 15

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Previous report demonstrated that prokinetic agent mosapride has anti-ulcerogenic action in rat-indomethacin gastric mucosal injury model. Here, we assessed the prophylactic effect of mosapride on gastric mucosal injury and emptying disorder induced by prednisolone in dogs. Crossover study design was employed. Six healthy beagles were administered prednisolone alone (2 mg/kg, twice a day [BID] subcutaneously) and prednisolone with mosapride (1 mg/kg, BID, orally), followed by an interval of at least 6 weeks. In each treatment, gastric mucosal injury was scored endoscopically according to the modified Lanza scale, and gastric emptying was assessed with 13C-octanoic acid breath test. The incidence of gastrointestinal adverse events was also investigated. Coadministration of mosapride with prednisolone significantly (P

著者

日根 文男 保田 昌樹

出版者

公益社団法人 日本材料学会

雑誌

材料 (ISSN:05145163)

巻号頁・発行日

vol.23, no.251, pp.654-659, 1974-08-15 (Released:2009-06-03)

参考文献数

20

被引用文献数

4 8

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It is well-known that the corrosion rate of iron and steel is affected by the Fe3+ concentration in acidified solutions. Experimental works on oxidation from Fe2+ to Fe3+ by the dissolved oxygen in various electrolytes have been carried out. Generally, the process is first order with respect to Fe2+, and it depends much on the pH. The reaction rate increased with decreasing pH in HCl, while the rate decreased with decreasing pH in other solutions such as phosphate, sulfate and citrate buffer solutions. The reaction rate was less than 10-3min-1 in solutions of pH<4, or the increment of Fe3+ was only 10-5M/min in solutions containing Fe2+ of 10-2M. The limiting current density for the cathodic process of those Fe3+ to Fe2+ would be 1.6×10-5ma/cm2, which is very small in comparison with the corrosion rate of Fe in aerated solutions. Therefore, it is concluded that the effect of oxidation of Fe2+ by the dissolved oxygen is negligible on corrosion of iron and steel.

著者

名和 小太郎

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.7, pp.521-523, 2012-10-01 (Released:2012-10-01)

被引用文献数

1

著者

Kaoru TANIGUCHI Mitsuhisa WATANABE Yasuhiro SUZUKI Hiroshi SAWA

出版者

SEISMOLOGICAL SOCIETY OF JAPAN

雑誌

Zisin (Journal of the Seismological Society of Japan. 2nd ser.) (ISSN:00371114)

巻号頁・発行日

vol.64, no.1, pp.11-21, 2011-08-25 (Released:2011-10-18)

参考文献数

28

被引用文献数

1 2

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The 150 km long Itoigawa-Shizuoka Tectonic Line Active Fault System (ISTL) in central Japan is one of the most active fault systems in Japan. Paleoseismologcal studies 1980s have revealed that the most recent event and the average recurence interval of the ISTL. The approximately 7 km long portion of the fault system between Matsumoto and Okaya has been regarded as a gap without any active fault trace. The gap namely the “Shiojiri Pass Gap” has long been taken as a segment boundary owing to the geometric discontinuity. Recent geomorphological analyses of the gap have demonstrated a through-going left-lateral slip assocaited with recent earthquakes in this area, based on aerial photograph interpretation and excavation studies. Excavation study on this portion revealed that the latest faulting event occurred between 1,700 cal. B.P. to 1,310 cal. B.P. (255 A.D. -645 A.D.). The timing of the last faulting event at this study area coincides with the timing in the Gofukuji fault and Okaya fault. The active faults extending from the Matsumoto basin as far as the northwestern margin of the Suwa basin display the evidence for its recent reactivation at the same time.