著者

Rokusuke YOSHIKAWA Eiji SATO Takayuki MIYAZAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.3, pp.347-350, 2012 (Released:2012-04-03)

参考文献数

16

被引用文献数

4 5

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We recently found that certain canine live attenuated vaccines produced using `non-feline' cell lines were contaminated with an infectious feline endogenous retrovirus, termed RD-114 virus. We suspected that RD-114 virus may have contaminated the seed stock of canine parvovirus (CPV) during the production of the contaminated vaccines. In this study, we collected stock viruses of CPVs propagated in a feline cell line, and checked the presence of infectious RD-114 virus. Consequently, we found that RD-114 viral RNA was present in all stock viruses, and 7 out of 18 stock viruses were contaminated with infectious RD-114 virus. We also found that RD-114 virus was stable physically and is capable of retaining its infectivity for a long period at -80°C.

著者

Akitake Suzuki Naoki Asazuma Eigo Kikuchi Takeshi Kawanobe Yoshihiko Horimoto Ryuichi Yokobari Shigeru Kotake Takahiro Okai

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.7, pp.813-816, 2012 (Released:2012-04-01)

参考文献数

9

被引用文献数

10 10 4

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Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL), recent reviews have introduced non-thromboembolic manifestations. We describe the case of a 58-year-old woman with vegetation on the aortic valve, whose initial presentation of APS abruptly developed into diffuse pulmonary hemorrhage. Despite consecutive plasma exchange procedures and the administration of corticosteroids and high-dose intravenous immunoglobulin, multiple brain infarctions developed, and the patient died of pneumonia. Although anecdotal, this case might serve as a useful example of the non-standard complications of fulminant APS.

著者

Ayami Ochi Takashi Takei Kayu Nakayama Chihiro Iwasaki Daigo Kamei Yuki Tsuruta Ari Shimizu Shunji Shiohira Takahito Moriyama Mitsuyo Itabashi Toshio Mochizuki Keiko Uchida Ken Tsuchiya Motoshi Hattori Kosaku Nitta

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.51, no.7, pp.759-762, 2012 (Released:2012-04-01)

参考文献数

15

被引用文献数

17 21

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We present two cases with steroid-resistant nephrotic syndrome (SRNS) and two cases with steroid-dependent nephrotic syndrome (SDNS) due to focal segmental glomerulonephritis (FSGS) who were treated with a single dose of rituximab (375 mg/m2). Although the two cases with SRNS showed no response, the two cases with SDNS achieved complete remission. The patients in whom the peripheral B-cell counts subsequently increased after the administration of rituximab demonstrated a relapse. Rituximab may be an effective treatment agent for SDNS with FSGS and the peripheral B-cell count may be a useful marker in such patients for preventing disease relapse.

著者

佐藤 一史

出版者

Japanese Society of Medical Instrumentation

雑誌

医療機器学 (ISSN:18824978)

巻号頁・発行日

vol.80, no.4, pp.355-361, 2010 (Released:2010-12-24)

参考文献数

15

著者

山田 涼子 佐藤 博明

出版者

一般社団法人 日本鉱物科学会

雑誌

岩鉱 (ISSN:09149783)

巻号頁・発行日

vol.93, no.8, pp.279-290, 1998 (Released:2006-08-22)

参考文献数

34

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Takamatsu crater has been identified and named by Kono et al., (1994), based on the presence of a concentric gravity low in the southern part of Takamatsu Plain, northeast Shikoku, Japan. The crater is 1∼2 km deep and ca. 4 km across, and buried under the Miocene volcanic formation and alluvium deposit. Both impact and volcanic origins have been proposed for the crater, but remained unresolved. We searched for the evidence of impact origin of the Takamatsu crater, such as shock metamorphic features of minerals, variable and extraordinarily high contents of SiO2, FeO, and NiO, together with low Na2O content of fresh glass in the Miocene deposit. The glass fragments in the pyroclastic flow deposit in the southern part of the Takamatsu crater are characterized by xenocrysts of quartz and feldspar and lack of idiomorphic phenocrysts. We did not find evidence for shock metamorphism in the minerals. The glass shows heterogeneous appearence with variable red tints and high vesicularity under the microscope, somewhat similar to the suevite of Ries crater. The glass of the Takamatsu crater, however, shows uniform and rhyolitic chemical composition, which is common for the calc-alkalic volcanics of the Miocene Setouchi volcanic suite. Furthermore, chemical composition of the glass is almost identical to those of welded tuff blocks and bulk matrix of the pyroclastic flow deposit, indicating that the glass fragments are of volcanic origin. The glass and associated rhyolite are dated by K-Ar method at around 14 Ma, which coincides with the age of the Setouchi volcanic activity. Although deep drilling has not been carried out for determining the subsurface structure, present analytical results argued for cauldron origin of the Takamatsu crater.

著者

Kenji KOROSUE Harutaka MURASE Fumio SATO Mutsuki ISHIMARU Takehiro HARADA Gen WATANABE Kazuyoshi TAYA Yasuo NAMBO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203280800, (Released:2012-04-02)

被引用文献数

5 11

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The purpose of this study was to demonstrate that a barren parous Thoroughbred mare with lactation induced by hormonal treatment can be introduced to an orphan foal at the same farm and that the mare can become pregnant after the end of the hormonal treatment. An additional purpose was to investigate the changes in the plasma concentrations of prolactin, estradiol-17β, progesterone, follicle-stimulating hormone, and luteinizing hormone before, during, and after hormonal treatment. The difference in body weight between the adopted foal and the control foals, which were at the same farm and raised by their natural mothers, was 17 kg at 24 weeks old, when the foals were weaned. However, the adopted foal and the control foals had almost the same weight at 35 weeks old and later. The first ovulation after hormonal treatment was confirmed 10 days after the end of hormonal treatment and then the normal estrous cycle resumed. Furthermore, the changes in plasma progesterone, estradiol-17β, follicle-stimulating hormone, and luteinizing hormone showed regular patterns after the first ovulation. Conception was confirmed in the fifth ovulation. Meanwhile, another study demonstrated that conception was confirmed in the first ovulation after hormonal treatment. The present study is the first to demonstrate the hormonal profiles during and after induction of lactation in a Thoroughbred mare. This approach is useful for solving the economic and epidemic problems of introducing a nurse mare to an orphan foal.

著者

Josué DÍAZ-Delgado Manuel ARBELO Simona SACCHINI Óscar QUESADA-CANALES Marisa ANDRADA Miguel RIVERO Antonio FERNÁNDEZ

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203280799, (Released:2012-04-02)

被引用文献数

4 10

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Vascular tumors and disorders, like angiomatosis, are rarely described in cetacean species. A retrospective histological study was carried out on lung samples from 35 common dolphins (Delphinus delphis) stranded in the Canary Islands coasts looking for morphological vascular changes and likely related causes. Twenty-five out of thirty-five (71%) common dolphins showed focal or multifocal angiomatosis-like lesions. A high association between this type of vascular proliferation and parasitic infestation was observed. In addition, a single pulmonary cavernous hemangioma not previously reported in common dolphins is presented.

著者

久野 義徳

出版者

一般社団法人 日本ロボット学会

雑誌

日本ロボット学会誌 (ISSN:02891824)

巻号頁・発行日

vol.29, no.1, pp.27-30, 2011 (Released:2011-02-25)

参考文献数

13

被引用文献数

2

著者

竹内 寛久 仲村 英也 綿野 哲

出版者

The Society of Powder Technology, Japan

雑誌

粉体工学会誌 (ISSN:03866157)

巻号頁・発行日

vol.49, no.3, pp.191-200, 2012-03-10 (Released:2012-03-22)

参考文献数

21

被引用文献数

2 1

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Numerical modeling of individual particle motion and fluid flow in an impact pulverizer was conducted using a Computational Fluid Dynamics (CFD) - Discrete Phase Model (DPM) coupling model. The impact pulverizer consists of high-speed rotating hammers and a static concavo-convex stator. Influences of the rotor geometries on particle impacts against stator walls were investigated. It was found that particles in the impact pulverizer were accelerated by the fluid drag force caused by the rotating hammers but not by the impact force from the hammers, resulting in impacts against walls of the static stator. Velocities and frequencies of the impacts between particles and walls of the static stator were analyzed under various number of hammers and clearances. As the number of hammers increased, the velocity and frequency increased because velocity of the fluid in circumference of the grinding chamber increased. The number of particle impacts against walls of the static stator decreased with an increase in the clearance. The impact energy which was calculated from the velocity and frequency of the particle impacts has the similar tendency with the experimental ones.

著者

Teramage Mengistu Onda Yuichi Kato Hiroaki Gomi Takashi

出版者

日本森林学会

雑誌

日本森林学会大会発表データベース 第123回日本森林学会大会

巻号頁・発行日

pp.I14, 2011 (Released:2012-02-29)

著者

恩田 裕一 加藤 弘亮 河守 歩

出版者

日本森林学会

雑誌

日本森林学会大会発表データベース 第123回日本森林学会大会

巻号頁・発行日

pp.I12, 2011 (Released:2012-02-29)

著者

Masaru Ohtani Shigeo Kawada Taizo Seki Yasuyuki Okamoto

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.50, no.2, pp.162-168, 2012 (Released:2012-02-28)

参考文献数

46

被引用文献数

6 8

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The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people. One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study. A mixture supplementation with amino acids containing arginine (500 mg/day), glutamine (600 mg/day), and leucine (1200 mg/day), and 11 kinds of vitamins was daily administrated for 8 weeks. In both groups, general blood biomarkers such as white blood cell count, natural killer cell activity, and C-reactive protein levels were measured. All measurements were taken before (baseline), at 4 weeks (mid-point), and after each trial (post-point). At mid-point, natural killer cell activity in the outpatient group increased significantly compared to baseline. At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline. The other blood biomarkers did not show any significant change throughout the trial. This pilot study suggested that a mixture of arginine, glutamine, leucine, and vitamins is useful to support innate immunity in unhealthy older people, even if their diseases, symptoms, and prescribed medicines are different.

著者

津末 昭生 石原 舜三

出版者

The Society of Resource Geology

雑誌

鉱山地質 (ISSN:00265209)

巻号頁・発行日

vol.24, no.123, pp.13-30, 1974-03-04 (Released:2009-12-14)

参考文献数

42

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The iron-titanium oxides in the granitic rocks of Southwest Japan have been examined under the microscope and analyzed with the electron probe micro-analyzer. Ilmenite containing up to 4 mole percent hematite molecule is almost sole iron-titanium oxide present as an early accessory constituent of the granitic rocks in the Outer zone, Ryoke zone, and Sanyo. Naegi zone of Southwest Japan. While, magnetite, magnetite intergrown with ilmenite, and hemo-ilmenite containing up to 20 mole percent hematite molecule are present as early accessory constituents in the Sanin-Shirakawa zone.From the chemical composition of the granitic rocks of Southwest Japan, it is suggested that the granitic magmas in the Sanin-Shirakawa zone were more oxidized than those in other three zones.Residual ilmenite sand deposits derived from gabbroic rocks are found only in the Ryoke zone, while residual magnetite sand deposits originated in granitic rocks are found only in the Sanin-Shirakawa zone. Thus, the distribution of residual iron sand deposits well corresponds to the generalization stated above.

著者

Hiroki Taguchi Masaharu Kataoka Ryoji Yanagisawa Takashi Kawakami Yuichi Tamura Keiichi Fukuda Hideaki Yoshino Toru Satoh

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.1203131639, (Released:2012-03-16)

参考文献数

30

被引用文献数

15 21

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Background: The recent development of various effective drugs, such as epoprostenol, sildenafil, and bosentan, has improved the prognosis for patients with idiopathic pulmonary arterial hypertension (IPAH). This study sought to determine survival rates and to identify predictive prognostic factors in patients with IPAH in the current era of combination therapy with new and more effective vasodilators. Methods and Results: In 65 consecutive IPAH patients treated from 2004 to 2009, hemodynamic parameters were significantly improved and brain natriuretic peptide was significantly decreased by combination therapy (observation period: 35±18 months). The Kaplan-Meier survival curves were determined, and 22 prognostic variables, including 9 hemodynamic variables and 6 biomarkers, were evaluated to obtain the best variables. The 1-year and 3-year survival rates were 98% and 86%, respectively. Only the platelet level was correlated with death (P<0.05), and the platelet level was significantly correlated with mean pulmonary arterial pressure (P<0.01). Patients with a lower platelet level (<20×104/μl (median value)) before treatment had a higher mortality rate compared to the other patients (78% vs. 95% for 3-year survival, P<0.01). Conclusions: Combination therapy contributed to an improvement in the prognosis of IPAH patients. Platelet level is a significant prognostic predictor in this new treatment era.

著者

永田 浩一 伊山 篤

出版者

日本大腸肛門病学会

雑誌

日本大腸肛門病学会雑誌 (ISSN:00471801)

巻号頁・発行日

vol.64, no.3, pp.133-139, 2011 (Released:2011-03-03)

参考文献数

27

被引用文献数

2

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目的:大腸3D-CT検査の炭酸ガス手動注入時に直腸内圧をモニターすることは,腸管拡張程度の改善に寄与するか比較検討した. 方法:大腸3D-CT検査を施行した合計140例を対象として圧力計未使用群70例,炭酸ガス手動注入時に圧力計で直腸内圧をモニターした圧力計併用群70例の2群に分けた.大腸を6区分に分類し,2体位分で合計1,680の大腸区分の腸管拡張程度を評価者2名が4段階の腸管拡張スコアで評価した.圧力計併用群では,ガス注入中止時の直腸内圧を記録した. 結果:圧力計併用群では圧力計未使用群に比較し,両体位でガス注入量が増加し,2体位目の腸管拡張程度では下行結腸を除いた大腸5区分で有意な改善がみられた.ガス注入中止時の平均直腸内圧は,1体位目が32.6mmHg,2体位目は31.2mmHgであった. 結論:大腸3D-CT検査の送気時に直腸内圧をモニターすることは,腸管拡張程度の改善に有用である.

著者

信田 修壱 原田 邦明 川崎 伸一 森山 兼司 安田 浩司 上野 昌之 高島 弘幸

出版者

公益社団法人 日本放射線技術学会

雑誌

日本放射線技術学会雑誌 (ISSN:03694305)

巻号頁・発行日

vol.63, no.7, pp.796-805, 2007-07-20 (Released:2007-10-04)

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(抄録はありません)

著者

山口 淳 加藤 敬行 菅 裕明

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.26, no.6, pp.584-592, 2011-11-30 (Released:2012-02-29)

参考文献数

29

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新たな創薬の基盤技術として,我々は1013を超える多様性の擬天然特殊ペプチドライブラリーの構築を可能とするFIT(Flexible In-vitro Translation)システムと,生理活性を有した特殊ペプチドの迅速な探索を実現したRaPID(Random non-standard Peptides Integrated Discovery)システムを開発した.本稿ではこれら新規基盤技術の紹介と共に,特殊ペプチド創薬におけるDDSとの連携の重要性についても言及する.

著者

渡辺 満久 中田 高 後藤 秀昭 鈴木 康弘

出版者

The Association of Japanese Geographers

雑誌

日本地理学会発表要旨集

巻号頁・発行日

pp.100137, 2011 (Released:2011-11-22)

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1.日本海溝沿いの活断層の特徴と地震・津波との関係を検討する。立体視可能なアナグリフ画像は、海上保安庁海洋情報部とJAMSTECの統合測深データ(0.002°間隔のGMT grd format、東経138-147°・北緯34-42°)と、250mグリッド地形DEM(岸本、2000)を用いて作成した。本研究では、平成23年~25年度科学研究費補助金(基盤研究(B)研究代表者:中田 高)、平成21~24年度科学研究費補助金(基盤研究(C)研究代表者:渡辺満久)を使用した。2 海底活断層は、以下の3種類に区分できる。(1) アウターライズの正断層群は、三陸沖から牡鹿半島南東沖にかけてはほぼ南北走行に延びるが、それ以南では海溝軸と斜交するように北東-南西走行となり、房総半島沖においては再び海溝軸と並走するようになる。正断層は、日本海溝軸から東側50~60km程度の範囲内に分布している。断層崖の比高には変位の累積性が認められ、海溝軸に近いものほど大きい(最大で500m以上)。(2) 三陸沖や房総半島沖の海溝陸側斜面の基部では、長さ200km程度の逆断層が複数認定できるが、連続性は良好ではない。その西側では、三陸北部沖から茨城県沖にかけて400km程度連続する長大な逆断層が認められ、隆起側には大きな垂直変位が生じていることを示す背斜構造がある。さらに陸側には、一回り小規模な逆断層(延長50km程度)がある。三陸沖以北の日本海溝斜面基部には、アウターライズより密に正断層が分布する可能性が高い3 日本海溝沿いの活断層と地震・津波との関係は、以下のように整理できる。(1) アウターライズには、鉛直変位速度が1mm/y程度の正断層が10程度並走する。正断層帯における伸長量は2cm/yに達する可能性もある。アウターライズの正断層起源とされる1933年三陸津波地震の起震断層は特定できない。(2) 延長400kmに達する連続性の良い逆断層は、その位置・形状から、2011年東北地方太平洋沖地震に関連する活断層であると判断される。今回の地震は複数の活断層が連動したものではなく、長大な活断層から発生する固有地震であった可能性が高い。同様の地震は、869年と1611年にも発生した可能性がある。1793年の地震時の津波は、分布は広いがあまり高くはないため、他の活断層が引き起こしたものであろう。海溝の陸側に分布する正断層に関しては、不明な点が多い。(3) 長さ200km程度の活断層はM8クラスの地震に、陸側の数10km程度の活断層はM7クラスの地震に関連するであろう。歴史地震との対応も比較的良好である

著者

Nian-Zhang ZHANG Yue-Feng CHU Peng-Cheng GAO Ping ZHAO Ying HE Zhong-Xin LU

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203180795, (Released:2012-03-26)

被引用文献数

5 11

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Haemophius parasuis is known to produce a group of virulence-associated autotransporter (AT) proteins, VtaAs; however, no other ATs have been characterized yet. On the basis of reported sequence of a putative espP2 gene for extracellular serine protease (ESP)-like protein of H. parasuis, this putative AT gene was successfully amplified from H. parasuis serotype 5 field strain HPS0819, cloned and sequenced. The confirmed ORF sequence showed 100% identity with the reported putative espP2 gene. The recombinant ESP-like protein purified from Escherichia coli with pET expression system was used for immunological characterization. An approximately 85 kDa antigen was detected in cultured H. parasuis by using antiserum to the purified ESP-like protein and antibodies against the recombinant ESP-like protein was detected in a selected serum from pigs with experimental H. parasuis infection. The results indicated that H. parasuis could produce ESP-like protein in vitro and in vivo. In an immune protection study using guinea pigs, 6 out of 10 animals immunized with the recombinant ESP-like protein survived after challenge with 5×109 bacteria of strain HPS0819 whereas 7 out of 10 animals immunized with formalin-inactivated H0819 bacterin survived after challenge. The results suggest that ESP-like protein could be one of vaccine antigen candidates for H. parasuis infection.