著者

村上 元孝 上田 好雄 松田 保 梅田 俊彦

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.3, no.3, pp.212-217, 1962

著者

小竹 要 大江 国広 長谷田 恭子 吉野 公明 万見 新太郎 黒田 満彦 松田 保 竹田 亮祐 村上 元孝

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.15, no.5, pp.487-494, 1974

---

Studies on platelet functions of 21 patients with renal insufficiency have been preformed. Platelet counts were significantly decreased in uremic patients, although severe thrombocytopenia less than 100&times;10³ platelets/mm³ was detected only in two patients. Platelet adhesiveness to glass was remarkably decreased in uremic patients. Platelet factor-3 availability was impaired in some of these patients, while platelet factor-3 activity was not decreased. Clot retraction was slightly defective in few patients. The significant correlation was not found between platelet adhesiveness and BUN, creatinine, uric acid or inorganic phosphate level in the serum of these patients. The abnormalities of platelet functions were partially corrected after dialysis.<br>In vitro, urea at high concentration showed an inhibitory effect on platelet aggregation. Guanidinosuccinic acid had less inhibitory effect on platelet aggregation, and creatinine had no inhibitory effect.

著者

村上 元孝 松田 保 西野 哲夫 平丸 三樹 万見 新太郎 高瀬 雅子

出版者

Japan Heart Foundation

雑誌

心臓 (ISSN:05864488)

巻号頁・発行日

vol.1, no.11, pp.1131-1140, 1969

著者

山崎 義亀与 松田 保 黒田 満彦 内田 健三 嶋田 千恵子 大谷 逸子 村上 元孝 北川 正信

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.14, no.1, pp.81-87, 1973

---

A 25-year-old male was admitted because of dark-red urine, jaundice and purpura. 5 days prior to admission, the patient noticed that the urine color became dark red, and purpuric rash and jaundice were noted by his wife.<br>Examination revealed scleral icterus, pallor, numerous petechiae and an ecchymosis. The sensorium was clear. The neurologic examination was normal.<br>The patient had hemolytic anemia, thrombocytopenic purpura, fever and proteinuria. Shortly after admission, fluctuating neurologic symptoms developed, and the patient was diagnosed as thrombotic thrombocytopenic purpura.<br>He was treated with prednisolone and heparin without benefits, and expired on the 14 th hospital day.<br>Hyaline thromboses of the vessels of liver and kidney were demonstrated by the examination of the specimens obtained by post mortem needle puncture.<br>Coagulation studies disclosed that partial thromboplastin time and prothrombin time were slightly prolonged, however, factor V activity and fibrinogen titre were not low. Fibrinogen degradation products determined by tanned red cell hemagglutination inhibition immunoassay were markedly increased, although euglobulin lysis time was not shortened.<br>Immunological analysis of serum proteins showed the increase of acute phase reactants, the decrease of &beta;₁-AC and haptoglobin, and the appearance of fibrinogen degradation products.<br>These results were discussed in relation to the pathogenesis of the disease.

著者

村上 元孝 松田 保

出版者

大道学館出版部

雑誌

臨牀と研究 (ISSN:00214965)

巻号頁・発行日

vol.54, no.11, pp.p3506-3511, 1977-11

著者

村上 元孝 上田 好雄 松田 保 梅田 俊彦 太田 五六

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.3, no.1, pp.52-59, 1962

著者

松田 保 児玉 直子 秀野 啓子 小河原 緑 松崎 俊久 村上 元孝 山之内 博

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.2, pp.146-150, 1976

---

Apparent blood viscosity was measured on freshly shed blood from 127 healthy subjects, ages 21 to 88, and patients hospitalized in Tokyo Metropolitan Yoikuin Geriatrics Hospital, over age 60. Determination of blood viscosity was performed at 37&deg;C using rotational viscometer at shear rates between 0.07 and 4.6sec^-1.<br>Mean blood viscosity in 43 healthy older subjects over age 60 (mean age: 74&plusmn;6) was 45&plusmn;25cp at 0.07sec^-1 and 8&plusmn;2cp at 4.6sec^-1, respectively. Yield stress was calculated from Casson plot at very low shear rates (between 0.44 and 0.07sec^-1) by the method of least squares. Mean value of yield stress in the healthy older subjects was 0.011 dynes/cm². Blood viscosity in the healthy subjects was significantly correlated with hematocrit values. Yield stress in these subjects was also correlated with hematocrit values and blood viscosity at very low shear rates. In these healthy subjects, blood viscosity, yield stress and hematocrit values were highest in the group at age 30-39. Blood viscosity and yield stress showed a slight decline with age in the healthy older subjects.<br>In the hospitalized patients, blood viscosity was higher than 70cp at 0.07sec^-1, and/or higher than 11cp at 4.6sec^-1 in 107 measurements (86 cases) out of 1443 determinations from December 1973 to October 1974. These patients with blood high viscosity included 12 cases of cancer (one of them was accompanied with disseminated intravascular coagulation (DIC); three of them developed DIC thereafter), 5 cases of acute myocardial infarction, 4 cases of acute cerebral infarction, 5 cases of angina pectoris, 6 cases of old myocardial infarction, 18 cases of old cerebrovascular diseases, 11 cases of diabetes mellitus, and 5 cases of stress polycythemia or polycythemia vera. In these cases, viscosity at 4.6sec^-1 was significantly correlated with hematocrit values, whereas viscosity at 0.07sec^-1 was not. All patients with blood high viscosity and relatively low hematocrit values suffered from cancer. In 6 cases of acute myocardial, cerebral of renal infarction, in whom changes in blood viscosity, yield stress and hematocrits were investigated before and after the development of infarction, changes in blood viscosity and yield stress were parallel with hematocrits.<br>From these results, it was concluded that high hematocrits caused blood high viscosity and were regarded as one of the risk factors in the pathogenesis of thrombosis, although the other factors than hematocrits might also influence blood viscosity at very low shear rates.

著者

松田 保 村上 元孝

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.3, no.4, pp.447-455, 1976

---

Coagulability of blood was measured in 80 cases of acute myocardial infarction, 98 cases of acute cerebral infarction and 33 cases of acute cerebral hemorrhage. Platelet counts, activated partial thromboplastin times, prothrombin times, plasma fibrinogen content, levels of plasma antithrombin III, α₂-macroglobulin and fibrin degradation products (FDP) determined within 1 month before the attack of myocardial infarction or stroke, and those measured within 48 hours or 3 to 7 days following the onset of these diseases were compared with data obtained from 370 healthy subjects over age sixty.<br>Concentrations of plasma antithrombin III were apparently decreased before and after the development of myocardial infarction. In ten autopsied patients with acute myocardial infarction, three cases with extremely low levels of plasma antithrombin III (less than 2 mg/d<i>l</i>) were complicated with disseminated intravascular coagulation (DIC), acute cerebral infarction and/or thromboembolism of lower extremities, while no thromboembolic episodes following myocardial infarction were observed in the other seven cases in whom plasma antithrombin III concentrations were more than 20mg/d<i>l</i>. Levels of the other thrombin inhibitor in plasma than antithrombin III, i. e. α₂-macroglobulin, were increased immediately after the occurrence of cerebral hemorrhage. Plasma fibrinogen content was markedly increased after the development of myocardial infarction or cerebrovascular diseases. Activated partial thromboplastin times, prothrombin times and FDP did not significantly change before and after the development of these diseases. These data suggest that there may be a relation between development of myocardial infarction and the low levels of plasma antithrombin III. Increased levels of plasma fibrinogen, as a result of myocardial infarction or stroke, may not accelerate coagulation mechanism but act disadvantageously by elevating blood viscosity.<br>Relationship between activated partial thromboplastin times, prothrombin times, plasma fibrinogen content, levels of plasma antithrombin III, α₂-niacroglobulin or FDP, determined within 1 month before death, and grade of atherosclerosis of aorta, cerebral, coronary or femoral artery, classified grossly with the naked eye, was investigated in 186 autopsied cases without cancer or DIC, retrospectively. There were no correlations between these parameters and the grade of atherosclerosis, except that levels of FDP were significantly increased in cases with severe atherosclerosis of femoral artery. From these results, direct evidences supporting thrombogenic hypothesis of atherosclerosis suggested by Duguid were not obtained. However, atherosclerotic lesion of peripheral artery may activate clotting processes and increase FDP.

著者

山之内 博 東儀 英夫 亀山 正邦 村上 元孝 松田 保

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.13, no.4, pp.207-214, 1976

被引用文献数

2

---

脳卒中発症前後のヘマトクリット (Hct) 値, ヘモグロビン (Hb) 値, 赤血球 (RBC) 数, 血清総蛋白 (TP) 値の変動について検討し, これらの値の変動と脳硬塞および頭蓋内出血発症との関係について考察することを目的に本研究を行なった.<br>対象は60歳以上の脳卒中例のうち, 急死あるいはこの研究の為の検査が不充分な症例を除外し, かつ剖検によって病変を確認しえた脳硬塞21例, 頭蓋内出血16例, 計37例である. Hct, Hb, RBC, TP値の測定は自動測定装置によった. 発症前値については発症4日以内 (直前値) と5日以上の値に分けて検討した.<br>結果; 1) 脳硬塞においては, Hct 値は発症前値 (37.2±3.3%) に比し, 発症日の値 (38.9±3.0%) は高かった. Hb, RBC, TP値についても同様の結果が得られた. しかし, 頭蓋内出血においては, 発症日における Hct, Hb, RBC, TP値は発症前値に比し, やや高い傾向がみられたが有意の差は認められなかった. 以上の結果より, 急激な Hct 値の上昇と脳硬塞の発症との間に何らかの関係が存在する可能性が推定された. 2) 脳硬塞では頭蓋内出血群に比し, Hct, Hb, RBC値が発症前, 発症日ともに有意の高値であった. しかし, TP値には両者で差が認められなかった. 脳硬塞発症前の Hct 値は同年代の対照群に比し有意の差が認められなかった. 3) 脳硬塞, 頭蓋内出血ともに Hct, Hb, RBC値は, 発症後数日間漸増する傾向がみられた. しかし,TP値は両者とも発症後急速に低下した.

著者

村上 元孝 松田 保 万見 新太郎 平丸 三樹 大江 国広

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.1, no.6, pp.857-864, 1970

著者

村上 元孝 松田 保 恩地 一彰 万見 新太郎 梅田 俊彦 西野 哲夫 平丸 三樹 高瀬 雅子 横山 鉄夫

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.11, no.3, pp.388-396, 1970

---

Two families of congenital factor VII deficiency were described.<br>The propositus of the first family was 35-year-old female, who was admitted for anemia. Spontaneous epistaxis, limited to her youth, was main hemorrhagic symptom. The patient delivered two normal children without unusual bleeding. On admission, the physical examination revealed no abnormalities except for the presence of iron deficiency anemia. Results of liver function tests were normal. Coagulation data confirmed the diagnosis of pure factor VII deficiency. Her factor VII complex level was 5% of normal and factor X level was 100%. There was no history of bleeding in her family. However, her daughter was discovered to have factor VII deficiency. Her factor VII complex level was 27% and factor X level was 75%. Factor VII levels of father, three half siblings, husband and son of the propositus were within normal limits.<br>The propositus of the second family was 25-year-old female, who was admitted complaining of spontaneous nose bleeding, gum bleeding, subcutaneous hemorrhage and menorrhagia. The patient was hospitalized for right oophorectomy at the age af 22. The hematoma in the right ovary was found, however, no unusual bleeding was noted either during surgery or in the postoperative period. On admission, she appeared healthy except for a few ecchymoses. Liver function chemistries were normal. Laboratory data demonstrated factor VII deficiency with increased vascular fragility. Her factor VII complex level was 17% and factor X level was 80%. Mixture of this patient's plasma with that of the propositus of the first family did not result in shortening of the long one-stage prothrombin time, proving an identical deficiency in these patients. The family history revealed that the patient's paternal grandfather were siblings. One brother of the propositus, his daughter and grandmother on the father's side of the porpositus had bleeding tendency. Neither of her parents nor any other family members had any bleeding episodes. Coagulation studies on the brother of the propositus revealed that he had factor VII deficiency. His factor VII complex level was 12% and factor X level was 105%. Factor VII level of the other family members could not be measured.

著者

村上 元孝 松田 保 万見 新太郎 平丸 三樹

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.2, no.3, pp.411-417, 1971

著者

村上 威夫 大西 隆

出版者

公益社団法人 日本都市計画学会

雑誌

都市計画論文集 (ISSN:09160647)

巻号頁・発行日

vol.33, pp.103-108, 1998

被引用文献数

1

---

Coordination of local planning powers is important in a decentralized planning system. For this concer, we made a case study in Portland, Oregon, U.S., where a regional government called Metro was created over the jurisdiction of existing local governments for this coordination. We found that 1) the development of Metro was promoted by the existence of a strong central city and the state land use planning legislature; and 2) an advisory committee comprised of the local government officials plays an important role in the policy making process of Metro.

著者

古川 恵子 今村 正治 村上 健 名主川 久仁

出版者

立命館大学大学行政研究・研修センター

雑誌

大学行政研究 = 大学行政研究 (ISSN:18808271)

巻号頁・発行日

vol.5, pp.111-128, 2010-03

著者

百川 裕希 西山 知宏 村上 朝夫 石塚 直美 長柄 陽子 水村 宣司 五十嵐 仙一

出版者

一般社団法人エレクトロニクス実装学会

雑誌

エレクトロニクス実装学術講演大会講演論文集 第23回エレクトロニクス実装学術講演大会

巻号頁・発行日

pp.70-71, 2009 (Released:2014-07-17)

著者

井上 卓彦 村上 文敏 岡村 行信 池原 研

出版者

地震研究所

雑誌

東京大学地震研究所彙報 (ISSN:00408972)

巻号頁・発行日

vol.82, no.4, pp.301-312, 2007

---

The 2007 Noto Hanto Earthquake (MJMA 6.9) occurred on 25 March, 2007 at 37°13.2′N, 136°41.1′E, under the northwestern coast of Noto Peninsula, Ishikawa Prefecture. To clarify distribution and activity of active fault, a high-resolution multi-channel seismic survey was carried out in the source area using Boomer and a 12 channel streamer cable. Seismic profiles depict geologic structure up to 150 meters deep under sea floor. Sedimentary sequences ranging in age from Miocene to Holocene time are deformed by ENE-WSW to N-S trending folds and faults. The deformed sediments were truncated by erosional surfaces. The age of erosion is not clear in the offshore area, but the most remarkable erosion surface was formed at the Last Glacial Maximum (LGM) age. The surface is covered by Holocene sediments up to 40m thick. A NW downthrown fault continues in the ENE-WSW direction for more than 21 kilometers. The fault cuts Neogene sediments, but the deformation in the Holocene sediments is recognized as flexure. The fault is located near the northern margin of the aftershock area of the 2007 earthquake, supporting that the fault is connected to the source fault of the 2007 earthquake. The deformations in the Holocene sediments increase downward, indicating that the fault slipped repeatedly during the period of Holocene time. Comparison between the 3.5kHz SBP profiles obtained in 1988 and twelve channel seismic profiles after the earthquake suggests that the deformation during the 2007 earthquake occurred on the seafloor along the fault.

著者

堀川 晴夫 岡村 行信 村上 文敏

出版者

産業技術総合研究所地質調査総合センター

雑誌

活断層・古地震研究報告 (ISSN:18839681)

巻号頁・発行日

no.11, pp.83-96, 2011

著者

村上 謙吉

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.10, no.8, pp.663-669, 1961-07-20 (Released:2011-10-11)

参考文献数

20

著者

近藤 駿介 村上 陽一郎 秋庭 悦子

出版者

経済産業調査会

雑誌

経済産業ジャーナル (ISSN:13462172)

巻号頁・発行日

vol.39, no.1, pp.10-19, 2006-01

著者

村上 恭通 佐々木 正治 笹田 朋孝

出版者

愛媛大学

雑誌

基盤研究(B)

巻号頁・発行日

2008

---

古くは蜀と呼ばれた四川省成都平原において、製鉄遺跡の発掘調査を実施した。成都市蒲江県鉄牛村遺跡では前漢代・後漢代、そして古石山遺跡では後漢代の製鉄関連施設を検出した。これらの発掘調査により、成都平原における漢代製鉄炉の特徴と生産物を明らかにした。