著者

Yuki Ikeda Junya Ako Koichi Toda Atsushi Hirayama Koichiro Kinugawa Yoshio Kobayashi Minoru Ono Takashi Nishimura Naoki Sato Takahiro Shindo Morimasa Takayama Satoshi Yasukochi Akira Shiose Yoshiki Sawa J-PVAD Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0476, (Released:2023-01-20)

参考文献数

30

被引用文献数

16

---

Background: The Impella®percutaneous left ventricular assist device has been available in Japan since 2017. This is the first large-scale registry study to analyze the efficacy and safety of Impella in Japanese patients with acute myocardial infarction with cardiogenic shock (AMICS).Methods and Results: The Japanese registry for Percutaneous Ventricular Assist Device (J-PVAD) has registered all consecutive Japanese patients treated with Impella. We extracted data for 593 AMICS patients from J-PVAD and analyzed 30-day survival and safety profiles. Overall 30-day survival was 63.1%. The 30-day survival of the Impella alone and Impella plus venoarterial extracorporeal membrane oxygenation (ECPELLA) groups was 80.9% and 45.7%, respectively. The Impella alone group was older and had a lower rate of cardiac arrest, milder consciousness disturbance, less inotrope use, lower serum lactate concentrations, higher B-type natriuretic peptide concentrations, and higher left ventricular ejection fraction (LVEF) than the ECPELLA group. Cox regression analysis revealed that older age and comorbid renal disturbance were common risk factors affecting 30-day mortality in both groups. Major adverse events were hemolysis (10.8%), hemorrhage/hematoma (7.6%), peripheral ischemia (4.4%), stroke (1.3%), and thrombosis (0.7%). LVEF improved in both groups during support.Conclusions: AMICS treatment with Impella showed favorable 30-day survival and safety profiles. The survival rate of patients treated with Impella alone was particularly high. Further studies are needed to improve outcomes of patients with ECPELLA support.

著者

Shoichi Sakaguchi Syun-ichi Urayama Yoshihiro Takaki Kensuke Hirosuna Hong Wu Youichi Suzuki Takuro Nunoura Takashi Nakano So Nakagawa

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.37, no.3, pp.ME22001, 2022 (Released:2022-08-24)

参考文献数

30

被引用文献数

9

---

RNA viruses are distributed throughout various environments, and most have recently been identified by metatranscriptome sequencing. However, due to the high nucleotide diversity of RNA viruses, it is still challenging to identify novel RNA viruses from metatranscriptome data. To overcome this issue, we created a dataset of RNA-dependent RNA polymerase (RdRp) domains that are essential for all RNA viruses belonging to Orthornavirae. Genes with RdRp domains from various RNA viruses were clustered based on amino acid sequence similarities. A multiple sequence alignment was generated for each cluster, and a hidden Markov model (HMM) profile was created when the number of sequences was greater than three. We further refined 426 HMM profiles by detecting RefSeq RNA virus sequences and subsequently combined the hit sequences with the RdRp domains. As a result, 1,182 HMM profiles were generated from 12,502 RdRp domain sequences, and the dataset was named NeoRdRp. The majority of NeoRdRp HMM profiles successfully detected RdRp domains, specifically in the UniProt dataset. Furthermore, we compared the NeoRdRp dataset with two previously reported methods for RNA virus detection using metatranscriptome sequencing data. Our methods successfully identified the majority of RNA viruses in the datasets; however, some RNA viruses were not detected, similar to the other two methods. NeoRdRp may be repeatedly improved by the addition of new RdRp sequences and is applicable as a system for detecting various RNA viruses from diverse metatranscriptome data.

著者

Arshin Adib-Moghaddam

出版者

独立行政法人 日本貿易振興機構アジア経済研究所

雑誌

中東レビュー (ISSN:21884595)

巻号頁・発行日

vol.6, pp.75-81, 2019 (Released:2019-05-30)

---

20世紀の初頭から欧米の主導で発明され、機能してきた「中東」の地域概念はもはや存在していない。同様に旧オスマン帝国の領域を指す「近東」概念もその有効性をすでに完全に喪失した。現在では「西アジアおよび北アフリカ」地域と呼ぶべき同地域において、(1)米国の影響が度重なる失政によってますます周辺化していること、(2)その間隙を埋める域外大国としてロシアと中国が急速に台頭していること、(3)域内の主要な外交アクターとしてイランとトルコが影響力を強めていること、以上の3つの顕著な傾向を指摘することができる。こうした前提でトルコ・イラン関係をみる時、両国関係が地域的な安定にもたらす影響はどのようなものだろうか。その場合両国間の歴史的な長いライバル関係や対立関係にもかかわらず、20世紀以降の時代における両国関係は比較的良好なままに推移してきた。1979年のイラン革命直後の一時期はその例外であって、この時期には世俗主義的なケマル主義との齟齬が前面に出ていた。近年においてイラン・トルコ関係が大きく変化したのはトルコの親イスラーム政党である公正発展党(AKP)の2002年における躍進以降である。1996年に政権に就いた後、イランとの大幅な接近を試みたものの政権基盤が比較的脆弱だったエルバカン首相時代から、AKPの政権運営の下で軍部など世俗エリート層との抗争を経て、さらにエルドアン大統領のもと権力の集中が進むと、両国関係の深化は経済関係から安全保障分野までに広く及ぶ新たな段階を迎えるに至った。本論稿では以上の展開を近年の対クルディスタン問題やシリア問題、対米関係およびトルコのNATO加入などの文脈で具体的に検証し、最後に結論部で「アラブの春」以降の地域再編のなかで両国間の互恵に基づく広範な連携関係が積極的に果たしうる役割について展望する。(文責・鈴木均)

著者

MIN Kyeong-Seok TSUBOKI Kazuhisa YOSHIOKA Mayumi K. MORODA Yukie KANADA Sachie

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2021-017, (Released:2020-12-04)

被引用文献数

3

---

A stationary line-shaped precipitation system (SLPS), which is one type of mesoscale convective systems (MCSs), is a typical heavy-rain-producing weather system formed during warm seasons in Japan. Although the Kinki district, western Japan, is known as a frequent occurrence region for SLPSs, their formation mechanisms in the region have not been sufficiently clarified yet because of their complex formation processes. This study investigated a SLPS event that occurred on 1 September 2015, using observational data and high-resolution numerical experiments. We also carried out numerical sensitivity experiments with regard to the orography and initial time.  The observational data showed that the relative humidity at lower levels was high during the SLPS event. The southwesterly was dominant at middle levels over the Kinki district during the formation of the SLPS. The formation of the SLPS was associated with neither a mesoscale low-pressure system nor a synoptic-scale cold front, demonstrating that these were not necessary conditions for the formation of the SLPS.  In the numerical experiments, we found that the SLPS was formed in a low-level convergence zone of the westerly with the warm and moist south-southwesterly from the Kii Channel. New convective cells formed over the north of Awaji Island and are propagated northeastward by the middle-level southwesterly. This cell formation process was repeated and resulted in the formation of the SLPS. The sensitivity experiments for the orography around the occurrence area of the SLPS indicated that the orography was not a significant factor for the formation of the SLPS in this event. The orography can modify the location of the SLPS.

著者

Tsukasa Takahashi Daisuke Hori Tomohiko Ikeda Yu Ikeda Nagisa Shiraki Christina-Sylvia Andrea Yuh Ohtaki Shotaro Doki Yuichi Oi Shinichiro Sasahara Ichiyo Matsuzaki

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.249, no.1, pp.57-64, 2019 (Released:2019-09-27)

参考文献数

34

被引用文献数

5 8

---

Non-regular employment is increasing and its mental health impact is a globally important problem. In Japan, non-regularly employed researchers are increasing, especially within young age groups, because employment quotas were not sufficiently expanded against rapid increasing number of doctorate holders. It is therefore important to understand the relationship between non-regular employment and mental health. The significance of our research is to contribute to the improvement of researchers’ mental health by clarifying the influence of employment status on psychological distress. We conducted a cross-sectional, web-based survey in 2017 via an anonymous, self-administered questionnaire distributed to workers in Tsukuba Science City, Japan. The survey questionnaire items included employment status, psychological distress, occupational stress, sex, age, and income. We analyzed 2,762 valid responses in two categories (1,850 regular employment, 912 non-regular employment) and two subcategories based on age according to the definition of “young researcher” by the Ministry of Health, Labor and Welfare (20-39 years vs. 40-59 years). Psychological distress was defined as a total K6 score of 5 or greater. Binomial logistic regression was used to calculate odds ratios and 95% confidence intervals for psychological distress. Non-regular employment was significantly associated with psychological distress in the age 20-39 group but not in the age 40-59 group. At the age 20-39 group, a negative association was shown between psychological distress and reward from work (i.e., pride in their job, ability utilization, and sense of accomplishment). Support to increase psychological work rewards may be important in reducing psychological distress for young non-regularly employed researchers.

著者

Hiroshi Takagi Akihiko Ito Heon-Sook Kim Shamil Maksyutov Makoto Saito Tsuneo Matsunaga

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.17, pp.213-219, 2021 (Released:2021-12-14)

参考文献数

45

被引用文献数

2

---

Numerous wetlands, including the world's two largest contiguous wetlands, lie along the free-flowing Paraná and Paraguay Rivers that travel the length of subtropical South America (SSA) region. These wetlands are floodplains that are inundated with rising river water in flood events; their morphology and area are highly changeable with flooding extent. The long-term variability of methane emission from this wetland hotspot and its sensitivity to meteorological conditions are not well known. We herein explore this unknown using space-based estimates of methane flux for the SSA region between 2009 and 2015 along with data of water balance. We find that methane emission from this region coherently varies with precipitation and inundation areal extent.

著者

Hayato Tada Hirofumi Okada Atsushi Nohara Masakazu Yamagishi Masayuki Takamura Masa-aki Kawashiri

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.11, pp.2073-2078, 2021-10-25 (Released:2021-10-25)

参考文献数

23

被引用文献数

1 24

---

Background:Recent studies suggest that cumulative exposure to low-density lipoprotein-cholesterol (LDL-C) leads to the development of atherosclerotic cardiovascular disease (ASCVD). However, few studies have investigated whether this link extends to individuals with familial hypercholesterolemia (FH), a relevant patient population.Methods and Results:We retrospectively investigated the health records of 1,050 patients with clinical FH diagnosis between April 1990 and March 2019. We used Cox proportional hazards models adjusted for established ASCVD risk factors to assess the association between cholesterol-year-score and major adverse cardiovascular events (MACEs), including death from any cause or hospitalization due to ASCVD events. Cholesterol-year-score was calculated as LDL-C max × [age at diagnosis/statin initiation] + LDL-C at inclusion × [age at inclusion − age at diagnosis/statin initiation]. The median follow-up period for MACE evaluation was 12.3 (interquartile range, 9.1–17.5) years, and 177 patients experienced MACEs during the observation period. Cholesterol-year-score was significantly associated with MACEs (hazard ratio, 1.35; 95% confidence interval, 1.07–1.53; P=0.0034, per 1,000 mg-year/dL), independent of other traditional risk factors including age and LDL-C, based on cross-sectional assessment. Cholesterol-year-score improved the discrimination ability of other traditional risk factors for ASCVD events (C-index, 0.901 vs. 0.889; P=0.00473).Conclusions:Cumulative LDL-C exposure was strongly associated with MACEs in Japanese patients with FH, warranting early diagnosis and treatment initiation in these patients.

著者

李 相済 廣橋 容子 リ サンジェ ヒロハシ ヨウコ Lee Sang-jae Yoko Hirohashi

雑誌

国際研究論叢 : 大阪国際大学紀要 = OIU journal of international studies

巻号頁・発行日

vol.23, no.2, pp.107-118, 2010-01-31

---

This article considers the definition of discriminatory language and related problems. Aspects considered are the history of discrimination which is reflected in discriminatory language, the intentional use of discriminatory language to oppose discrimination and, how the language points to the existence of discrimination. The limitations of discriminatory language being viewed as a legal problem are clarified, as is the necessity for dialog between the majority and minorities to resolve these issues. It is necessary to radically change the current social structures and social relations that cause discrimination in order to achieve a solution to this problem.

著者

Sahar Hussein Rifat Falak Kantawalla Stephenie Dickie Piedad Suarez-Durall Reyes Enciso Roseann Mulligan

出版者

Japan Prosthodontic Society

雑誌

Journal of Prosthodontic Research (ISSN:18831958)

巻号頁・発行日

pp.JPR_D_20_00207, (Released:2021-07-15)

参考文献数

67

被引用文献数

15

---

Purpose: To evaluate whether poor oral health is associated with a higher risk of malnutrition based on the Mini Nutritional Assessment (MNA) or MNA-SF (short form) in older adults. Study Selection: For this meta-analysis, cohort and cross-sectional studies with adults 65 years and older, reporting oral health outcomes (i.e. edentulism, number of teeth) and either the MNA or MNA-SF were selected. Four electronic databases were searched (Medline via PubMed, Web of Science, Cochrane Library and EMBASE) through June 2020. Risk of bias was assessed with the checklist by the Agency for Healthcare Research and Quality scale. Results: A total of 928 abstracts were reviewed with 33 studies, comprising 27,559 participants, aged ≥65 being ultimately included. Meta-analyses showed that the lack of daily oral hygiene (teeth or denture cleaning), chewing problems and being partially/fully edentulous, put older adults at higher risk of malnutrition (p < 0.05). After adjustment for socio-demographic variables, the included studies reported lack of autonomy for oral care, poor/moderate oral health, no access to the dentist and being edentulous with either no dentures or only one denture were risk factors significantly associated with a higher risk of malnutrition (p < 0.05). Conclusions: These findings may imply that once elders become dependent on others for assistance with oral care, have decreased access to oral healthcare, and lack efficient chewing capacity, there is increased risk of malnourishment. Limitations of the study include heterogeneity of oral health variables and the observational nature of the studies. Further studies are needed to validate our findings.

著者

Kentaro Kamiya Takanobu Yamamoto Miyuki Tsuchihashi-Makaya Toshimi Ikegame Tetsuya Takahashi Yukihito Sato Norihiko Kotooka Yoshihiko Saito Hiroyuki Tsutsui Hiroaki Miyata Mitsuaki Isobe

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.7, pp.1546-1552, 2019-06-25 (Released:2019-06-25)

参考文献数

20

被引用文献数

15 70

---

Background:The purpose of this study was to clarify the implementation rate of multidisciplinary heart failure (HF) care and cardiac rehabilitation (CR) in Japan, as well as the relationship between implementation rates and characteristics of the facility.Methods and Results:Survey participants were cardiologists who are members of the Japan Heart Failure Society and belonged to 1 of 845 medical institutions that are members of the Japan Heart Failure Society, as of April 2016. A total of 288 institutions (34.1%) returned the questionnaire. The percentages of hospitals implementing multidisciplinary HF care were 78.5% for inpatients and 32.6% for outpatients with HF. Inpatient and outpatient CR for HF had implementation rates of 80.4% and 56.5%, respectively. In addition, very few HF patients (7.3%, 3,741/51,323 patients) received outpatient CR. Both the presence of nurses certified in chronic HF care and registered CR instructors on staff were consistently associated with implementation of multidisciplinary HF care, and Japanese Circulation Society training hospitals, lower number of hospital beds, and presence of registered CR instructors on staff were consistently associated with implementation of CR.Conclusions:This first nationwide survey demonstrated that the implementation rates of multidisciplinary care and CR for HF, especially for outpatients, are low in Japan. Skilled healthcare professionals are expected to play important roles in the widespread implementation of this type of HF care in Japan.

著者

Miho Hirai Yoshihiro Takaki Fumie Kondo Masayuki Horie Syun-ichi Urayama Takuro Nunoura

出版者

Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology / Japanese Society of Plant Microbe Interactions / Japanese Society for Extremophiles

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.36, no.2, pp.ME20152, 2021 (Released:2021-05-01)

参考文献数

17

被引用文献数

18

---

Fragmented and primer ligated dsRNA sequencing (FLDS) is a sequencing method applicable to long double-stranded RNA (dsRNA) that enables the complete genome sequencing of both double- and single-stranded RNA viruses. However, the application of this method on a low amount of dsRNA has been hindered by adaptor dimer formation during cDNA amplification and sequence library preparation. We herein developed FLDS ver. 3 by optimizing the terminal modification of an oligonucleotide adaptor and the conditions of adaptor ligation. We also examined the concentration of Mg2+ in the PCR reaction for cDNA amplification and the purification method of amplified cDNA. Fine sequence reads were successfully obtained from metagenomic shotgun sequencing libraries constructed from 10 and 100 pg dsRNA, and these libraries exhibited weaker detection sensitivity for low-abundance dsRNAs (viral genomes and genome segments) than that constructed from 1‍ ‍ng of dsRNA. We also report the utility of capillary electrophoresis for dsRNA quantification. The FLDS ver. 3 package expands the frontiers of our knowledge in RNA virus diversity and evolution.

著者

Senta Gewalt Shqipdona Lahu Gjin Ndrepepa Costanza Pellegrini Isabell Bernlochner Franz-Josef Neumann Maurizio Menichelli Tanja Morath Bernhard Witzenbichler Jochen Wöhrle Katharina Hoppe Gert Richardt Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastrati Stefanie Schüpke Katharina Mayer

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.62776, (Released:2021-04-16)

参考文献数

31

被引用文献数

3

---

Aim: Sex-specific analyses of direct head-to-head comparisons between newer P2Y12 inhibitors are limited. This study was conducted to assess the efficacy and safety of ticagrelor versus prasugrel in women and men with acute coronary syndromes (ACS) planned for an invasive strategy. Methods: This pre-specified analysis of the ISAR-REACT 5 trial included 956 women and 3,062 men with ACS randomly assigned to either ticagrelor or prasugrel. The primary endpoint was the 12-month incidence of death, myocardial infarction, or stroke; the safety endpoint was the 12-month incidence of bleeding (type 3–5 according to the Bleeding Academic Research Consortium [BARC]). Results: The primary endpoint occurred in 42 women (8.9%) in the ticagrelor group and 39 women (8.3%) in the prasugrel group (hazard ratio [HR]=1.10, 95% confidence interval [CI] 0.71–1.70, P=0.657) and in 142 men (9.4%) in the ticagrelor group and 98 men (6.5%) in the prasugrel group (HR=1.47 [1.13–1.90], P=0.004; P for interaction [Pint]=0.275). BARC type 3–5 bleeding occurred in 36 women (9.7%) in the ticagrelor group and 34 women (9.7%) in the prasugrel group (HR=1.04 [0.65–1.67], P=0.856) and in 59 men in the ticagrelor group (4.4%) and 46 men (3.6%) in the prasugrel group (HR=1.24 [0.85–1.83], P=0.266; Pint=0.571). Conclusions: Although there was no significant interaction between sex and treatment effect of study drugs, the superior efficacy of prasugrel was more evident among men. No difference in bleeding between the two study groups was seen for both women and men.

著者

Jian SHOU Pei-Jie CHEN Wei-Hua XIAO

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.65, no.5, pp.383-389, 2019-10-31 (Released:2019-10-31)

参考文献数

44

被引用文献数

3 27

---

The toxic catabolic intermediates of branched chain amino acids can cause insulin resistance, and are involved in different mechanisms in different metabolic tissues. In skeletal muscle, 3-hydroxy-isobutyrate produced by valine promotes skeletal muscle fatty acid uptake, resulting in the accumulation of incompletely oxidized lipids in skeletal muscle, causing skeletal muscle insulin resistance. In the liver, branched-chain α-keto acids decompose in large amounts, promote hepatic gluconeogenesis, and lead to the accumulation of multiple acylcarnitines, which damages the mitochondrial tricarboxylic acid cycle, resulting in the accumulation of incomplete oxidation products, oxidative stress in mitochondria, and hepatic insulin resistance. In adipose tissue, the expression of branched-chain amino acid catabolic enzymes (branched-chain amino acid transaminase, branched-chain α-keto acid dehydrogenase) is reduced, resulting in an increased level of plasma branched-chain amino acids, thereby causing massive decomposition of branched-chain amino acids in tissues such as skeletal muscle and liver, and inducing insulin resistance. However, branched-chain amino acids, as a common nutritional supplement for athletes, do not induce insulin resistance. A possible explanation for this phenomenon is that exercise can enhance the mitochondrial oxidative potential of branched-chain amino acids, alleviate or even eliminate the accumulation of branched-chain amino acid catabolic intermediates, and promotes branched-chain amino acids catabolism into beta-aminoisobutyric acid, increasing plasma beta-aminoisobutyric acid concentration, improving insulin resistance. This article reveals the mechanism of BCAA-induced insulin resistance and the relationship between exercise and BCAAs metabolism, adds a guarantee for the use of BCAAs, and provides a new explanation for the occurrence of diabetes and how exercise improves diabetes.

著者

Hiroshi Kadowaki Junichi Ishida Hiroshi Akazawa Hiroki Yagi Akiko Saga-Kamo Masahiko Umei Ryo Matsuoka Qing Liu Hiroshi Matsunaga Hisataka Maki Yusuke Sato Haruki Kume Issei Komuro

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-21-0008, (Released:2021-03-10)

参考文献数

24

被引用文献数

6

---

Background:Axitinib is a tyrosine kinase inhibitor (TKI) that inhibits vascular endothelial growth factor receptor signaling and is approved for second-line treatment of advanced renal cell carcinoma (RCC). Although the occurrence of hypertension with axitinib use has been documented, it is unclear whether a first-line TKI regimen can significantly affect the development of hypertension when axitinib is used as second-line therapy.Methods and Results:In this single-center retrospective study, advanced RCC patients treated with axitinib after first-line chemotherapy were divided into 2 groups according to the use of TKIs as part of first-line treatment before the initiation of axitinib. Clinical outcomes were compared between patients who were treated with (TKI(+); n=11) or without (TKI(–); n=11) a TKI. Although 63.6% of all patients had hypertension at baseline, axitinib-induced hypertension developed in 81.8% of patients, and 36.4% of patients experienced Grade 3 hypertension. After initiation of axitinib, both systolic and diastolic blood pressures and the hypertension grade were significantly elevated both in the TKI(+) and TKI(–) groups, and the number of antihypertensive drugs was significantly increased among all patients.Conclusions:This study suggests the need for proper monitoring and management of blood pressure in RCC patients treated with axitinib, regardless of a prior regimen with or without TKIs.

著者

上田 江里子 久保 孝富 村重 哲史 永澤 美保 池田 和司 瀧本-猪瀬 彩加

出版者

THE JAPANESE SOCIETY FOR ANIMAL PSYCHOLOGY

雑誌

動物心理学研究 (ISSN:09168419)

巻号頁・発行日

vol.70, no.2, pp.27-39, 2020 (Released:2020-12-22)

参考文献数

57

---

Behavioral synchronization is shown not only between intra-species but also between inter-species. Previous studies reported that behavioral synchronization occurs between dogs and their owners by affiliative bonds and dogs' social skills for communicating with humans acquired by domestication. Horses also have such bonds and skills like dogs, however, there have been few empirical studies of behavioral synchronization between horses and humans. Therefore, we investigated whether the gait synchronization occurs between the horse and his/her familiar human participant while they were walking together by using angular statistics and how horses and umans interacted by analyzing entrainment. Only when human gait rhythm was controlled to be constant, gait synchronization between horse and human participants was found, though entrainment occurred only in humans. When horses and humans were walking in a more natural and uncontrolled situation, entrainment occurred in both horses and humans, though their walk adjustment did not reach synchronization. These results suggest that gait synchronization occurs between horses and humans and walk adjustment from humans is involved in such synchronization.

著者

SONG Hwan-Jin KIM Sunyoung ROH Soonyoung LEE Hyesook

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2020-044, (Released:2020-06-02)

被引用文献数

6

---

This study compares the regional characteristics of heavy rain clouds in terms of Cloud Top Height (CTH) and Storm Height (SH) from long-term Tropical Rainfall Measuring Mission (TRMM) observations. The SH is derived from Precipitation Radar reflectivity and the CTH is estimated using Visible and InfraRed Scanner brightness temperature (10.8 μm) and reanalysis temperature profiles. As the rain rate increases, the average CTH and average SH increase, but by different degrees in different regions. Heavy rainfall in continental rainfall regimes such as Central Africa and the United States is characterized by high SH, in contrast to oceanic rainfall regions such as the northwestern Pacific, Korea, and Japan; the increase of atmospheric instability in dry environments is interpreted as a mechanism of continental floods. Conversely, heavy rain events in Korea and Japan occur in a thermodynamically near-neutral environment with large amounts of water vapor; these are characterized by the lowest CTH, SH, and ice water content. The northwestern Pacific exhibits the lowest SH in humid environments, similar to Korea and Japan; however, this region also characteristically exhibits the highest convective instability condition as well as high CTH and CTH–SH values, in contrast to Korea and Japan. The observed CTH and SH characteristics of heavy rain clouds are expected to be useful for the evaluation and improvement of satellite-based precipitation estimation and numerical model cloud parameterization.

著者

Susumu Yokoya Manabu Iwadate Hiroki Shimura Satoru Suzuki Takashi Matsuzuka Satoshi Suzuki Shigeyuki Murono Seiji Yasumura Kenji Kamiya Yuko Hashimoto Shin-Ichi Suzuki

出版者

THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

pp.2019-26, (Released:2019-12-13)

参考文献数

12

被引用文献数

2

---

The Great East Japan Earthquake, which occurred on March 11, 2011, and its subsequent Fukushima Daiichi Nuclear Power Plant accident, prompted implementation of the Thyroid Ultrasound Examination (TUE) program as a part of the Fukushima Health Management Survey. The purpose of this program is to support residents of Fukushima Prefecture, and to analyze the health effects of the released radionuclides. Regardless of relatively high participation rates and a well-planned diagnostic flow, it is conceivable that not all thyroid cancer cases can be detected by the TUE program. The aims of the present study were to identify and characterize these “outside” cases, targeting patients at Fukushima Medical University (FMU) Hospital. As of June 30, 2017, we have successfully identified 11 outside cases. These corresponded to 5.7% of the 194 subjects who were identified as having thyroid cancer or suspected thyroid cancer in the TUE program. Although the outside subjects of other institutes were not investigated, the present study may have identified the majority of outside subjects in Japan, considering that FMU Hospital treats a large number of thyroid cancer subjects. Furthermore, the characteristics of the 11 subjects were not different from those of the subjects identified in the TUE program. These findings confirm that the TUE program was able to identify subjects of thyroid cancer adequately and sufficiently.

著者

Jiro Sakamoto Yugo Yamashita Takeshi Morimoto Hidewo Amano Toru Takase Seiichi Hiramori Kitae Kim Maki Oi Masaharu Akao Yohei Kobayashi Mamoru Toyofuku Toshiaki Izumi Tomohisa Tada Po-Min Chen Koichiro Murata Yoshiaki Tsuyuki Syunsuke Saga Yuji Nishimoto Tomoki Sasa Minako Kinoshita Kiyonori Togi Hiroshi Mabuchi Kensuke Takabayashi Yusuke Yoshikawa Hiroki Shiomi Takao Kato Takeru Makiyama Koh Ono Toshihiro Tamura Yoshihisa Nakagawa Takeshi Kimura on behalf of the COMMAND VTE Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0515, (Released:2019-09-20)

参考文献数

28

被引用文献数

5 57

---

Background:There is a paucity of data on the management and prognosis of cancer-associated venous thromboembolism (VTE), leading to uncertainty about optimal management strategies.Methods and Results:The COMMAND VTE Registry is a multicenter registry enrolling 3,027 consecutive acute symptomatic VTE patients in Japan between 2010 and 2014. We divided the entire cohort into 3 groups: active cancer (n=695, 23%), history of cancer (n=243, 8%), and no history of cancer (n=2089, 69%). The rate of anticoagulation discontinuation was higher in patients with active cancer (43.5%, 27.0%, and 27.0%, respectively, at 1 year, P<0.001). The cumulative 5-year incidences of recurrent VTE, major bleeding, and all-cause death were higher in patients with active cancer (recurrent VTE: 17.7%, 10.2%, and 8.6%, P<0.001; major bleeding: 26.6%, 8.8%, and 9.3%, P<0.001; all-cause death: 73.1%, 28.6%, 14.6%, P<0.001). Among the 4 groups classified according to active cancer status, the cumulative 1-year incidence of recurrent VTE was higher in the metastasis group (terminal stage group: 6.4%, metastasis group: 22.1%, under chemotherapy group: 10.8%, and other group: 5.8%, P<0.001).Conclusions:In a current real-world VTE registry, patients with active cancer had higher risk for VTE recurrence, bleeding, and death, with variations according to cancer status, than patients without active cancer. Anticoagulation therapy was frequently discontinued prematurely in patients with active cancer in discordance with current guideline recommendations.

著者

Kazuhiro Yamamoto Miyuki Tsuchihashi-Makaya Yoshiharu Kinugasa Yuki Iida Kentaro Kamiya Yasuki Kihara Yuji Kono Yukihito Sato Norio Suzuki Harumi Takeuchi Taiki Higo Yasushi Miyazawa Isao Miyajima Akira Yamashina Katsushi Yoshita Koichi Washida Masafumi Kuzuya Tetsuya Takahashi Yutaka Nakaya Naoyuki Hasebe Hiroyuki Tsutsui on behalf of The Japanese Heart Failure Society Expert Consensus Writing Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0322, (Released:2020-07-10)

参考文献数

206

被引用文献数

21

著者

辻野 亮 揚妻-柳原 芳美

出版者

一般社団法人 日本生態学会

雑誌

保全生態学研究 (ISSN:13424327)

巻号頁・発行日

vol.11, no.2, pp.167-171, 2006-12-05 (Released:2018-02-09)

参考文献数

14

被引用文献数

2