著者

金 基弘 森 文哉 岩宮 眞一郎 キム キホン モリ フミヤ イワミヤ シンイチロウ Ki-Hong Kim Fumiya Mori Shin-ichiro Iwamiya

雑誌

メディアと情報資源 : 駿河台大学メディア情報学部紀要

巻号頁・発行日

vol.21, no.2, pp.15-28, 2015-03

著者

坪井 聡 上原 里程 Tsogzolbaatar Enkh-Oyun 小谷 和彦 青山 泰子 中村 好一

出版者

自治医科大学

雑誌

自治医科大学紀要 = Jichi Medical University Journal (ISSN:1881252X)

巻号頁・発行日

vol.35, pp.63-69, 2013-03

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目的 東日本大震災後の栃木県における自殺の動向を明らかにする。方法 2008年1月から2011年6月までの間に栃木県内で発生したすべての自殺者のデータ(警察データ)と,警察庁が公表している自殺統計を用いて記述疫学研究を行った。結果 2008-2010年の総自殺者数は栃木県で1,795人,全国で96,784人であり,2011年上半期では栃木県で281人,全国で15,906人であった。2011年上半期における栃木県の月別自殺率3月から5月にかけて増加していた。栃木県では,4月は45-64歳と65歳以上の男女で身体の病気の悩みによる自殺が多く,5月は20-44歳と45-64歳の男,20-44歳の女でうつ病の悩みによる自殺が多かった。結論 東日本大震災の後,全国と同様に栃木県においても自殺率の増加がみられた。被災地の周辺地域においても地域資源を活用した自殺予防を早期に開始するべきなのかもしれない。

著者

SUI Chung-Hsiung SATOH Masaki SUZUKI Kentaroh

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2020-024, (Released:2020-03-01)

被引用文献数

23

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Precipitation efficiency (PE) is a useful concept for estimating precipitation under a given environmental condition. PE is used in various situations in meteorology: to evaluate severe precipitation associated with a single storm event; as a parameter of cumulus convective parameterization; and to separate clouds and precipitation in climate projection studies. PE has been defined in several ways. In this review, we start with definitions of PE from microscopic and macroscopic perspectives, and provide estimates of PE based on observational and modeling approaches. Then, we review PE in shallow and organized deep convective systems that provide either a conceptual framework or physical constraints on representations of convection in models. Specifically, we focus on the roles of PE in cloud-radiative feedbacks to climate variability. Finally, we argue the usefulness of PE for investigating cloud and precipitation changes in climate projection studies.

著者

SEO Jaemyeong Mango LEE Hyunho MOON Sungju BAIK Jong-Jin

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2020-003, (Released:2019-10-20)

被引用文献数

3

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This study examines how upslope geometry controls aerosol effects on orographic precipitation through two-dimensional idealized simulations of orographic precipitation from shallow warm convective clouds over a bell-shaped mountain with 1-km height. A total of nine cases are simulated by considering three different prescribed aerosol number concentrations and three different windward-widths of the mountain. For a detailed representation of drop size distributions, the Weather Research and Forecasting (WRF) model that includes a bin microphysics scheme is used with a horizontal grid size of 250 m and 401 terrain-following vertical levels. A higher aerosol number concentration leads to production of more cloud droplets, inhibiting the growth of cloud droplets into raindrops in the cases with the symmetric mountain (the windward-side half-width a1 = 10 km). As a result, the total and maximum surface precipitation amounts decrease and the location of the maximum surface precipitation amount shifts downstream. The aerosol effects on orographic precipitation are more clearly seen in the cases with the narrow windward-width (a1 = 5 km) compared to the cases with the symmetric mountain and the wide windward-width (a1 = 20 km). In the cases with the narrow windward-width, the steep upslope generates strong convection with a short advection timescale (∼ 600 s), resulting in more precipitation being concentrated over a narrow area of the mountain downslope compared to the cases with the symmetric mountain and the wide windward-width. On the other hand, in the cases with the wide windward-width, the gentle upslope generates weak convection with a sufficiently long advection timescale (∼ 2400 s), so that a large portion of liquid drops precipitates out on the wide mountain upslope before reaching the peak.

著者

Hideo Izawa Toshiko Yoshida Toshimi Ikegame Kazuhiro P. Izawa Yoshihiro Ito Hideo Okamura Naohiko Osada Shintaro Kinugawa Takuro Kubozono Yuji Kono Kiyonori Kobayashi Kazuhiko Nishigaki Taiki Higo Akihiro Hirashiki Yasushi Miyazawa Yuji Morio Masanobu Yanase Sumio Yamada Hisao Ikeda Shin-ichi Momomura Yasuki Kihara Kazuhiro Yamamoto Yoichi Goto Shigeru Makita the Japanese Association of Cardiac Rehabilitation Standard Cardiac Rehabilitation Program Planning Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0670, (Released:2019-11-09)

参考文献数

21

被引用文献数

52

著者

風間孝 キ-ス・ヴィンセント 河口和也編集

出版者

動くゲイとレズビアンの会

巻号頁・発行日

1998

著者

Jeong-Woo Lee Se-Won Yoon Jung-Hwan Kim Young-Pil Kim Yong-Nam Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.24, no.10, pp.991-994, 2012 (Released:2012-12-28)

参考文献数

32

被引用文献数

2 3

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[Purpose] This study examined the influence of range of motion of the ankle joints on elderly people’s balance ability. [Methods] We conducted a four-week experiment using 60 out of the 89 elderly people who used B senior health facility, as subjects. TETRAX stability, synchronization were conducted to measure balance ability. We examined correlations between TETRAX balance and ankle joint ROM. Student’s t-test and Pearson correlation coefficients were used for the statistical analyses. [Results] There were significant correlations between measurement items of TETRAX stability and synchronization and movement of the ankle joint. [Conclusion] It was found that as had plate was stable in measurement using ankle joint ROM and TETRAX after closing eyes, balance was maintained with Dorsi Flexion.

著者

Senda Joe Ito Keiichi Kotake Tomomitsu Kanamori Masahiko Kishimoto Hideo Kadono Izumi Nakagawa-Senda Hiroko Wakai Kenji Katsuno Masahisa Nishida Yoshihiro Ishiguro Naoki

出版者

Nagoya University Graduate School of Medicine, School of Medicine

雑誌

Nagoya Journal of Medical Science (ISSN:00277622)

巻号頁・発行日

vol.81, no.3, pp.359-373, 2019-08

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Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that is often used to prevent stroke and peripheral artery disease, and its administration has shown significant improvements for cognitive impairment. We investigate the potential of cilostazol for reducing or restoring cognitive decline during con-valescent rehabilitation in patients with non-cardioembolic ischemic stroke. The study sample included 371 consecutive patients with lacunar (n = 44) and atherothrombosis (n = 327) subtypes of non-cardioembolic ischemic stroke (224 men and 147 women; mean age, 72.9 ± 8.1 years) who were required for inpatient convalescent rehabilitation. Their medical records were retrospectively surveyed to identify those who had received cilostazol (n = 101). Patients were grouped based on cilostazol condition, and Functional Independence Measure (FIM) scores (total and motor or cognitive subtest scores) were assessed both at admission and discharge. The gain and efficiency in FIM cognitive scores from admission to discharge were significantly higher in patients who received cilostazol than those who did not (p = 0.047 and p = 0.035, respectively); we found no significant differences in other clinical factors or scores. Multiple linear regression analysis confirmed that cilostazol was a significant factor in FIM cognitive scores at discharge (β = 0.041, B = 0.682, p = 0.045); the two tested dosages were not significantly different (100 mg/day, n = 43; 200 mg/day, n = 58). Cilostazol can potentially improve cognitive function during convalescent rehabilitation of patients with non-cardioembolic ischemic stroke, although another research must be needed to confirm this potential.

著者

Yong Kwan KIM Seong-In LIM Jae-Jo KIM Yoon-Young CHO Jae-Young SONG In-Soo CHO Bang-Hun HYUN Sung-Hyun CHOI Seung-Hoe KIM Eun-Hye PARK Dong-Jun AN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0519, (Released:2015-07-16)

被引用文献数

3 6

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Classical swine fever (CSF) is a highly contagious systemic hemorrhagic viral disease of pigs. Wild boar plays a crucial role in the epidemiology of CSF. Between 2010 and 2014, samples were collected nationwide from 6,654 wild boars hunted in South Korea. Anti-CSF antibodies were identified in 0.59% (39 of 6,654) of the wild boar samples using a virus neutralization test and were primarily detected in wild boars living close to the demilitarized zone and the area of the Taebaek Mountains surroundings. The CSF virus (subgroup 2.1b) was isolated from two wild boars captured in a nearby border area. The criteria used to define high-risk areas for targeted CSF surveillance in South Korea should be further expanded to include other regions nationwide.

著者

Taishi Okuno Jiro Aoki Kengo Tanabe Koichi Nakao Yukio Ozaki Kazuo Kimura Junya Ako Teruo Noguchi Satoshi Yasuda Satoru Suwa Kazuteru Fujimoto Yasuharu Nakama Takashi Morita Wataru Shimizu Yoshihiko Saito Atsushi Hirohata Yasuhiro Morita Teruo Inoue Atsunori Okamura Toshiaki Mano Kazuhito Hirata Yoshisato Shibata Mafumi Owa Kenichi Tsujita Hiroshi Funayama Nobuaki Kokubu Ken Kozuma Shiro Uemura Tetsuya Tobaru Keijiro Saku Shigeru Ohshima Kunihiro Nishimura Yoshihiro Miyamoto Hisao Ogawa Masaharu Ishihara on behalf of J-MINUET investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0995, (Released:2019-03-30)

参考文献数

40

被引用文献数

7

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Background: Beta-blockers are standard therapy for acute myocardial infarction (AMI). However, despite current advances in the management of AMI, it remains unclear whether all AMI patients benefit from β-blockers. We investigated whether admission heart rate (HR) is a determinant of the effectiveness of β-blockers for AMI patients. Methods and Results: We enrolled 3,283 consecutive AMI patients who were admitted to 28 participating institutions in the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) study. According to admission HR, we divided patients into 3 groups: bradycardia (HR <60 beats/min, n=444), normocardia (HR 60 to ≤100 beats/min, n=2,013), and tachycardia (HR >100 beats/min, n=342). The primary endpoint was major adverse cardiac events (MACE), including all-cause death, non-fatal MI, non-fatal stroke, heart failure (HF), and urgent revascularization for unstable angina, at 3-year follow-up. Beta-blocker at discharge was significantly associated with a lower risk of MACE in the tachycardia group (23.6% vs. 33.0%; P=0.033), but it did not affect rates of MACE in the normocardia group (17.8% vs. 18.4%; P=0.681). In the bradycardia group, β-blocker use at discharge was significantly associated with a higher risk of MACE (21.6% vs. 12.7%; P=0.026). Results were consistent for multivariable regression and stepwise multivariable regression. Conclusions: Admission HR might determine the efficacy of β-blockers for current AMI patients.

著者

Ioannis Kontogeorgos Nikos Kiamos Patricia Montiel-Ruiz Elisavet Georgopoulou Moysis Mylonas Stavros M Xirouchakis

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.18, no.1, pp.95-110, 2019 (Released:2019-01-29)

参考文献数

98

被引用文献数

4

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The diet composition and dietary patterns of the Long-eared Owl Asio otus were studied in Mediterranean agrosystems in central Crete (Greece) over the winters of 2009–2015. Overall, 2,819 prey items were recovered from 1,207 pellets, belonging to six taxa of mammals, 22 taxa of birds and four taxa of insects. Small mammals were the most common prey species, accounting for 75.8% by frequency and 79.7% by biomass, followed by birds (23.2% and 20.1%); the latter being rather an island component compared to continental regions. The House Mouse Mus musculus was the most important prey species in the owl's diet (56.3%) ahead of the Wood Mouse apodemus sylvaticus (9.51%) and the Black Rat Rattus rattus (7.9%). The species proved to be a significant rodent predator in olive groves and vineyards during winter months, selecting Wood Mouse and young Black Rat more than expected. Long-eared Owl feeding ecology studies could lead to improved land management and agricultural practices in the rural landscapes of the Mediterranean.

著者

Patricia Arias-Fernández Macarena Romero-Martin Juan Gómez-Salgado Daniel Fernández-García

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.9, pp.1193-1201, 2018 (Released:2018-09-04)

参考文献数

39

被引用文献数

59

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[Purpose] To review the literature that examines rehabilitation and early mobilization and that involves different practices (effects of interventions) for the critically ill patient. [Materials and Methods] A PRISMA-Systematic review has been conducted based on different data sources: Biblioteca Virtual en Salud, CINHAL, Pubmed, Scopus, and Web of Science were used to identify randomized controlled trials, crossover trials, and case-control studies. [Results] Eleven studies were included. Early rehabilitation had no significant effect on the length of stay and number of cases of Intensive Care Unit Acquired Weaknesses. However, early rehabilitation had a significant effect on the functional status, muscle strength, mechanical ventilation duration, walking ability at discharge, and health quality of life. [Conclusion] Rehabilitation and early mobilization are associated with an increased probability of walking more distance at discharge. Early rehabilitation is associated with an increase in functional capacity and muscle strength, an improvement in walking distance and better perception of the health-related quality of life. Cycloergometer and electrical stimulation can be used to maintain muscle strength. Further research is needed to establish stronger evidences.

著者

Sok-Sithikun Bun Decebal Gabriel Latcu Tahar Delassi Mohammed El Jamili Alaa Al Amoura Nadir Saoudi

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.3, pp.579-586, 2016-02-25 (Released:2016-02-25)

参考文献数

34

被引用文献数

3 22

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The advantages of ultra-high-definition (UHD) mapping are presented in the context of different atrial arrhythmias, whether focal or macroreentrant. Not only are these sophisticated systems time-saving, but they also allow accurate identification of the substrate (scar quantification), as well as a more precise characterization of the critical isthmuses or focal sources of the atrial circuits. UHD mapping may become a standard approach for their curative treatment. This new technology allows automatic acquisition and accurate annotation of the electrograms, without the need for manual correction. Owing to better resolution, critical isthmuses and low-voltage regions of interest may now be successfully targeted without the need for entrainment maneuvers. Finally, the system also allows rapid assessment of the completeness of the lesions once delivered. (Circ J 2016; 80: 579–586)

著者

Myung-Jin Cha Youngjin Cho Il-Young Oh Eue-Keun Choi Seil Oh

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0218, (Released:2018-10-04)

参考文献数

37

被引用文献数

12

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Background: There is little evidence that focuses on the ethnic variability of clinical risk factors for thromboembolism (TE) in atrial fibrillation (AF). We aimed to investigate the effect of each traditional risk factor in the Korean AF population. Methods and Results:Medical records of 12,876 consecutive patients (aged >18 years) newly diagnosed and followed up with non-valvular AF from 2000 to 2013 were reviewed. TE events, including ischemic stroke and systemic embolism, were investigated for risk factor validation. Among the total of 12,876 patients, 1,390 (10.8%) had TE events. In univariate/multivariate analysis adjusting for clinical factors and antithrombotic medications, traditional risk factors included in the CHA2DS2-VASc scheme showed statistical significance, except for female sex, which was not a predictor of events. Additionally, chronic kidney disease (CKD; hazard ratio 1.62, P<0.001) was shown to be an independent predictor of TE events. Based on the analysis, we developed a novel stratification system, CHA2DS2-VAK, omitting the female sex category and adding CKD. The new scoring system showed greater discrimination in event rates between score 0 and 1 patients. Conclusions: Female sex was not associated with TE events in a Korean non-valvular AF population. The novel CHA2DS2-VAK scoring system, with substitution of CKD for female sex, might be more appropriate for the Korean population.

著者

Imanishi Tadashi Itoh Takeshi Suzuki Yutaka O'Donovan Claire Fukuchi Satoshi Koyanagi Kanako O. Barrero Roberto A. Tamura Takuro Yamaguchi-Kabata Yumi Tanino Motohiko Yura Kei Miyazaki Satoru Ikeo Kazuho Homma Keiichi Kasprzyk Arek Nishikawa Tetsuo Hirakawa Mika Thierry-Mieg Jean Thierry-Mieg Danielle Ashurst Jennifer Jia Libin Nakao Mitsuteru Thomas Michael A. Mulder Nicola Karavidopoulou Youla Jin Lihua Kim Sangsoo Yasuda Tomohiro Lenhard Boris Eveno Eric Suzuki Yoshiyuki Yamasaki Chisato Takeda Jun-ichi Gough Craig Hilton Phillip Fujii Yasuyuki Sakai Hiroaki Tanaka Susumu Amid Clara Bellgard Matthew Bonaldo Maria de Fatima Bono Hidemasa Bromberg Susan K. Brookes Anthony J. Bruford Elspeth Carninci Piero Chelala Claude Couillault Christine Souza Sandro J. de Debily Marie-Anne Devignes Marie-Dominique Dubchak Inna Endo Toshinori Estreicher Anne Eyras Eduardo Fukami-Kobayashi Kaoru R. Gopinath Gopal Graudens Esther Hahn Yoonsoo Han Michael Han Ze-Guang Hanada Kousuke Hanaoka Hideki Harada Erimi Hashimoto Katsuyuki Hinz Ursula Hirai Momoki Hishiki Teruyoshi Hopkinson Ian Imbeaud Sandrine Inoko Hidetoshi Kanapin Alexander Kaneko Yayoi Kasukawa Takeya Kelso Janet Kersey Paul Kikuno Reiko Kimura Kouichi Korn Bernhard Kuryshev Vladimir Makalowska Izabela Makino Takashi Mano Shuhei Mariage-Samson Regine Mashima Jun Matsuda Hideo Mewes Hans-Werner Minoshima Shinsei Nagai Keiichi Nagasaki Hideki Nagata Naoki Nigam Rajni Ogasawara Osamu Ohara Osamu Ohtsubo Masafumi Okada Norihiro Okido Toshihisa Oota Satoshi Ota Motonori Ota Toshio Otsuki Tetsuji Piatier-Tonneau Dominique Poustka Annemarie Ren Shuang-Xi Saitou Naruya Sakai Katsunaga Sakamoto Shigetaka Sakate Ryuichi Schupp Ingo Servant Florence Sherry Stephen Shiba Rie Shimizu Nobuyoshi Shimoyama Mary Simpson Andrew J. Soares Bento Steward Charles Suwa Makiko Suzuki Mami Takahashi Aiko Tamiya Gen Tanaka Hiroshi Taylor Todd Terwilliger Joseph D. Unneberg Per Veeramachaneni Vamsi Watanabe Shinya Wilming Laurens Yasuda Norikazu Yoo Hyang-Sook Stodolsky Marvin Makalowski Wojciech Go Mitiko Nakai Kenta Takagi Toshihisa Kanehisa Minoru Sakaki Yoshiyuki Quackenbush John Okazaki Yasushi Hayashizaki Yoshihide Hide Winston Chakraborty Ranajit Nishikawa Ken Sugawara Hideaki Tateno Yoshio Chen Zhu Oishi Michio Tonellato Peter Apweiler Rolf Okubo Kousaku Wagner Lukas Wiemann Stefan Strausberg Robert L. Isogai Takao Auffray Charles Nomura Nobuo Gojobori Takashi Sugano Sumio

出版者

Public Library of Science

雑誌

PLoS Biology (ISSN:15449173)

巻号頁・発行日

vol.2, no.6, pp.856-875, 2004-06

被引用文献数

3 226

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The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, geneprediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level.Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following:integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates(1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for nonprotein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causingphenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology.

著者

MASAMI OHMORI KAZUHIRO HARADA SHUICHI TSURUOKA KOH-ICHI SUGIMOTO EIJI KOBAYASHI AKIO FUJIMURA

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.46, no.4, pp.579-583, 1999 (Released:2006-11-25)

参考文献数

5

被引用文献数

3 9

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Here we report a case of levothyroxine-induced liver dysfunction. T4 (levothyroxine) has been more commonly used for the treatment of hypothyroidism than T3 active hormone (triiodothyronine), because with the former drug a stabler plasma concentration is obtained after oral administration. Although there are few reports on levothyroxine-induced liver dysfunction, we treated a primary hypothyroid patient with high serum aminotransferase after administration of levothyroxine. Liver dysfunction was improved after cessation of the drug administration. Antibody to T4 was found in the serum of the patient after this event. From clinical course and laboratory data of the patient, the episode of liver damage was considered to be induced by levothyroxine. We then administrated triiodothyronine, and it did not induce liver dysfunction. Changing levothyroxine to triiodothyronine resulted in a successful clinical course in this case, as re-administration of the doubtful drug is strictly limited.

著者

ファシズム研究婦人グル-プ 松本 洋子

出版者

駒澤大学

雑誌

駒沢大学外国語部論集 (ISSN:03899837)

巻号頁・発行日

no.22, pp.p185-205, 1985-09

著者

Yugo Yamashita Ryuji Uozumi Yasuhiro Hamatani Masahiro Esato Yeong-Hwa Chun Hikari Tsuji Hiromichi Wada Koji Hasegawa Hisashi Ogawa Mitsuru Abe Satoshi Morita Masaharu Akao

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-1337, (Released:2017-04-19)

参考文献数

27

被引用文献数

108

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Background:The current status and outcomes of direct oral anticoagulant (DOAC) use have not been widely evaluated in unselected patients with atrial fibrillation (AF) in the real world.Methods and Results:The Fushimi AF Registry is a community-based prospective survey of AF patients who visited the participating medical institutions (n=80) in Fushimi, Kyoto, Japan. Follow-up data with oral anticoagulant (OAC) status were available for 3,731 patients by the end of November 2015. We evaluated OAC status and clinical outcomes according to OAC status. The number (incidence rate) of stroke/systemic embolism (SE) and major bleeding events during the median follow-up of 3.0 years was 224 (2.3%/year) and 177 (1.8%/year), respectively. After the release of DOAC, the prevalence of DOAC use increased gradually and steadily, and that of warfarin, DOAC and no OAC was 37%, 26% and 36%, respectively in 2015. On Cox proportional hazards modeling incorporating change in OAC status as a time-dependent covariate for stroke/SE and major bleeding events, use of DOAC compared with warfarin was not associated with stroke/SE events (HR, 0.95; 95% CI: 0.59–1.51, P=0.82) or major bleeding events (HR, 0.82; 95% CI: 0.50–1.36, P=0.45).Conclusions:In real-world clinical practice, there were no significant differences in stroke/SE events or major bleeding events for DOAC compared with warfarin in patients with AF.

著者

Gook-Joo Kim Jioun Choi Sangyong Lee Chunbae Jeon Kwansub Lee

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.11, pp.3197-3199, 2016 (Released:2016-11-29)

参考文献数

7

被引用文献数

2 32

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[Purpose] The purpose of this study was to examine the effects of high intensity laser therapy (HILT) on pain and function in patients with knee osteoarthritis. [Subjects and Methods] In this study, an experiment was conducted on 20 subjects who were divided into the control group (n=10), which would receive conservative physical therapy (CPT), and the experimental group (n=10), which would receive effects of high intensity laser therapy after conservative physical therapy. All patients received their respective therapies three times each week over a four-week period. In terms of the intensity of the high intensity laser therapy, it was applied to each patient in the tibia and femoral epicondyle for five minutes while the patient’s knee joint was bent at around 30° and the separation distance between the handpiece and the skin was maintained at around 1 cm. The visual analogue scale was used to measure pain, and the Korean Western Ontario and McMaster Universities Osteoarthritis Index was used for functional evaluations. [Results] The comparison of differences in the measurements taken before and after the experiment within each group showed a statistically significant decline in both the VAS and the K-WOMAC. The comparison of the two groups showed that the high intensity laser therapy group had statistically significant lower scores in both the visual analogue scale and the Korean Western Ontario and McMaster Universities Osteoarthritis Index than the conservative physical therapy group. [Conclusion] High intensity laser therapy is considered an effective non-surgical intervention for reducing pain in patients with knee osteoarthritis and helping them to perform daily activities.

著者

Yeong-Deok Choi Jung-Ho Lee

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.11, pp.3084-3087, 2016 (Released:2016-11-29)

参考文献数

12

被引用文献数

12

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[Purpose] The purpose of this study was to investigate the impact on the edema and pain when applying transcutaneous electrical nerve stimulation. [Subjects and Methods] Eleven patients who were diagnosed with lymphedema were selected as the subjects of the study. The experimental group received transcutaneous electrical nerve stimulation treatment on edema regions three times per week for four weeks. Surface tape measurement was used to measure changes in lower extremity edema. Pain intensity was measured using the visual analog scale. [Results] The edema decrements in the experimental group were significantly larger than those in the control group. The pain decrements in the experimental group were significantly larger than those in the control group. [Conclusion] In conclusion, application of transcutaneous electrical nerve stimulation was confirmed to be effective in reducing edema and pain.