著者

黄 銘 小野 直亮 Md. Altaf-UlAmin 金谷 重彦

出版者

公益社団法人 日本化学会・情報化学部会

雑誌

日本化学会情報化学部会誌 (ISSN:09133747)

巻号頁・発行日

vol.39, no.1, pp.2-131, 2021-06-30 (Released:2021-07-23)

参考文献数

17

著者

Shota YAMASHITA Ryuta SAITO Shin-ichiro OSAWA Kuniyasu NIIZUMA Kazushi UKISHIRO Masayuki KANAMORI Kazuo KAKINUMA Kyoko SUZUKI Teiji TOMINAGA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.61, no.11, pp.661-666, 2021 (Released:2021-11-15)

参考文献数

21

被引用文献数

3

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In cases of malignant gliomas located at language eloquent area, it is often difficult to preoperatively detect those area with functional MRI. Awake surgery is often used to spare the language eloquent area during surgery for such tumors; it is not available for a patient whose intracranial pressure is elevated due to the malignant tumor. The Wada test involves infusing anesthetic agents into the internal carotid artery to determine language dominancy before surgery for epilepsy or brain tumor. The super-selective Wada test is a technique to detect more detailed functional localization by infusing anesthetics into far distal middle cerebral artery branches. We present a 37-year-old man suffering from a left frontal lobe glioblastoma, in whom detection of an artery supplying Broca’s area was attempted by a super-selective Wada test. The super-selective Wada test successfully detected the branch of middle cerebral artery supplying Broca’s area. Total resection of the contrast-enhancing area was achieved without damaging the artery supplying Broca’s area without any neurological sequelae. This is the first report describing the usefulness of the super-selective Wada test in glioblastoma treatment. Our findings suggest that the super-selective Wada test is a powerful and useful means to distinguish the artery that supplies the language area from the tumor feeding artery in cases of tumors in the language eloquent area.

著者

Navarro-Remesal Victor Perez Zapata Beatriz

出版者

立命館大学ゲーム研究センター

雑誌

REPLAYING JAPAN (ISSN:24338060)

巻号頁・発行日

vol.4, pp.63-74, 2022-07

著者

Masahiko Umei Hiroshi Akazawa Akiko Saga-Kamo Hiroki Yagi Qing Liu Ryo Matsuoka Hiroshi Kadowaki Akito Shindo Ayaka Nakashima Kosuke Yasuda Kengo Suzuki Issei Komuro

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.2, pp.83-91, 2022-02-10 (Released:2022-02-10)

参考文献数

40

被引用文献数

1

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Background:Patients with heart failure (HF) often experience gastrointestinal problems such as constipation, diarrhea, and disturbances to drug absorption. In HF, hypoperfusion and congestion cause structural and functional changes in the gut, which, in turn, lead to impaired cardiac function.Euglena gracilisZ (hereafter “Euglena”), calledMidorimushiin Japanese, is a microalga that is used as a food or nutritional supplement. It is unclear whether Euglena is beneficial for bowel habitus and cardiac function in subjects with HF.Methods and Results:We injected C57BL/6 male mice subcutaneously with isoproterenol (ISO) (20 mg/kg/day) for 7 days to examine bowel movement in HF. Euglena was orally administered to mice on anad libitum-feeding to a normal chow containing 2% dietary mixture. ISO induced a decrease in bowel movement and an increase in fecal retention in the cecum, as well as a decrease in left ventricular (LV) contraction. Euglena accelerated intestinal transit, relieved fecal retention, and prevented the alterations in gut pathology in ISO-treated mice. Euglena also suppressed ISO-induced decreases in LV contraction, although it had no significant effect on LV hypertrophy.Conclusions:The results suggested that oral administration of Euglena alleviated constipation and cardiac dysfunction in a mouse model of ISO-induced HF, and highlight the potential clinical benefit of Euglena in patients with HF in preventing constipation and contractile deterioration.

著者

Lea Gigon Shida Yousefi Alexander Karaulov Hans-Uwe Simon

出版者

Japanese Society of Allergology

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.70, no.1, pp.30-38, 2021 (Released:2021-01-09)

参考文献数

167

被引用文献数

32

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Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction.

著者

Tobias Koenig Jens Vogel-Claussen Johann Bauersachs L. Christian Napp

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0074, (Released:2022-03-18)

参考文献数

2

著者

Akiko SEGUCHI Kazutaka MOGI Ei-ichi IZAWA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.84, no.4, pp.520-524, 2022 (Released:2022-04-13)

参考文献数

30

被引用文献数

2

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Mesotocin (MT) is an avian homologue of oxytocin (OT). Behavioral pharmacological studies in birds have suggested the involvement of MT in socially affiliative behavior. However, investigations of peripheral MT levels associated with social behavior are lacking because non-invasive methods to measure surrogate plasma MT have yet to be established. This study aimed to measure urinary MT in crows using a commercially available OT enzyme-linked immunosorbent assay kit. Urine samples were collected after intravenous injection of MT and centrifuged to separate urine and fecal components. We found that urinary MT was significantly elevated 15–30 min after MT injection. These results validate our method for the use of urine samples for the measurement of peripheral MT levels in crows.

著者

北海道大学 CoSTEP 北海道大学 化学反応創成研究拠点 (WPI-ICReDD) 北海道大学 広報課 学術国際広報担当 梶井 宏樹 ステッカー コリン ピント ソハイル・キーガン 南波 直樹 リスト ベンジャミン 辻 信弥

出版者

北海道大学 高等教育推進機構 オープンエデュケーションセンター 科学技術コミュニケーション教育研究部門(CoSTEP)

巻号頁・発行日

pp.1-2, 2022-03-28

著者

Hiroyuki Tsutsui Shin-ichi Momomura Akira Yamashina Hiroaki Shimokawa Yasuki Kihara Yoshihiko Saito Nobuhisa Hagiwara Hiroshi Ito Masafumi Yano Kazuhiro Yamamoto Junya Ako Takayuki Inomata Yasushi Sakata Takashi Tanaka Yasushi Kawasaki on behalf of the J-SHIFT Study Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0227, (Released:2019-08-08)

参考文献数

18

被引用文献数

24 49

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Background:Increased heart rate (HR) is an independent risk factor for cardiovascular outcomes in chronic heart failure (HF). Ivabradine, anIfinhibitor, improved outcomes in patients with HF and reduced ejection fraction (HFrEF) in the SHIFT study. We evaluated its efficacy and safety in Japanese HFrEF patients in a randomized, double-blind, placebo-controlled phase III study: the J-SHIFT study. The main objective was to confirm a hazard ratio of <1 in the primary composite endpoint of cardiovascular death or hospital admission for worsening HF.Methods and Results:Patients with NYHA functional class II–IV, left ventricular EF ≤35%, and resting HR ≥75 beats/min in sinus rhythm under optimal medical therapy received ivabradine (n=127) or placebo (n=127). Mean reduction in resting HR was significantly greater in the ivabradine group (15.2 vs. 6.1 beats/min, P<0.0001). However, symptomatic bradycardia did not occur. A total of 26 (20.5%) patients in the ivabradine group and 37 (29.1%) patients in the placebo group had the primary endpoint event (hazard ratio 0.67, 95% CI 0.40–1.11, P=0.1179) during median follow-up of 589 days. Mild phosphenes were reported in 8 (6.3%) patients in the ivabradine group and 4 (3.1%) patients in the placebo group (P=0.3760).Conclusions:The J-SHIFT study supported the efficacy and safety of ivabradine for Japanese HFrEF patients, in accord with the SHIFT study.

著者

Kyoko Yamane Yasuaki Sugiyama Yuan-Xue Lu Na Lű Kenichi Tanno Eri Kimura Hirofumi Yamaguchi

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-065, (Released:2015-07-30)

被引用文献数

4 11

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This paper reports the level of genetic differentiation between two Japanese and one Chinese species of Eutrema: E. japonicum, “wasabi”; its wild relative in Japan, E. tenue; and their wild relative in China, E. yunnanense. Phylogenetic analyses were based on the DNA sequence of the chloroplast trnK/matK region of 16 Brassicaceae and an outgroup species. Neighbor joining (NJ) and maximum parsimony (MP) trees were constructed, revealing that the three Eutrema species form a single clade clearly separated from other Brassicaceae species. The two Japanese Eutrema species are highly differentiated from Chinese E. yunnanense, and it is estimated that they diverged from E. yunnanense approximately 5 million years ago. An ethnobotanical survey was conducted among ethnic Chinese in Yunnan Province, and the results indicate that E. yunnanense is not perceived as “hot” in taste, while a pungent flavor is associated with wasabi; in addition, no evidence was found for the domestication of E. yunnanense. On the basis of the present molecular phylogenetic study and the ethnobotanical survey, we conclude that wasabi acquired its specific pungent flavor during its long botanical history in Japan, and that its subsequent domestication in Japan was because of this acquired pungent flavor. The culinary habit of using wasabi with raw fish has since become an important feature of Japanese cuisine and culture.

著者

the imperial procession Stephan Yerasimos the miniatures of Sûrnâme-i Vehbi Doğan Kuban notes to the miniatures Mertol Tulum editor Ahmet Ertuğ

出版者

Ertuğ & Kocabıyık

巻号頁・発行日

2000

著者

落合-大平 知美 倉島 治 赤見 理恵 長谷川 寿一 平井 百樹 松沢 哲郎 吉川 泰弘

出版者

一般社団法人 日本霊長類学会

雑誌

霊長類研究 (ISSN:09124047)

巻号頁・発行日

vol.22, no.2, pp.123-136, 2006 (Released:2007-03-13)

参考文献数

64

被引用文献数

7 9

著者

Miho Nishitani-Yokoyama Hiroyuki Daida Kazunori Shimada Akiko Ushijima Keisuke Kida Yuji Kono Yasuhiko Sakata Masatoshi Nagayama Yutaka Furukawa Nagaharu Fukuma Keijiro Saku Shin-ichiro Miura Yusuke Ohya Youichi Goto Shigeru Makita for the Japanese Association of Cardiac Rehabilitation (JACR) Registration Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-20-0087, (Released:2020-11-27)

参考文献数

25

被引用文献数

2

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Background:Cardiac rehabilitation (CR) is categorized as a Class I recommendation in guidelines for the management of patients with acute coronary syndrome (ACS); however, nationwide studies on CR in patients with ACS remain limited in Japan.Methods and Results:The Japanese Association of Cardiac Rehabilitation (JACR) Registry is a nationwide, real-world database for patients participating in CR. From the JACR Registry database, we analyzed 924 patients participating in Phase II CR in 7 hospitals between September 2014 and December 2016. The mean age of patients was 65.9±12.0 years, and 80% were male. The prevalence of ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), and unstable angina pectoris (UAP) was 58%, 9%, and 33%, respectively. The prevalence of hypertension, diabetes, dyslipidemia, current smoking, and a family history was 55%, 27%, 67%, 21%, and 10%, respectively. Among the entire CR cohort at baseline, 96%, 78%, and 92% were treated with aspirin, β-blockers, and statins, respectively. After CR, the values of body mass index, the lipid profile, and exercise capacity significantly improved in the STEMI, NSTEMI and UAP groups.Conclusions:In the JACR Registry, a high rate of guideline-recommended medications at baseline and improvements in both coronary risk factors and exercise capacity after CR were observed in patients with ACS.

著者

Natsuko SOGABE Rieko MARUYAMA Takayuki HOSOI Masae GOSEKI-SONE

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.53, no.3, pp.219-224, 2007 (Released:2007-11-27)

参考文献数

46

被引用文献数

17 24

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Alkaline phosphatase (ALP) hydrolyzes a variety of monophosphate esters into inorganic phosphoric acid and alcohol at a high optimal pH, and is thought to play an important role in phosphate metabolism. Intestinal ALP, located at the brush border of intestinal epithelial cells, is known to be affected by several kinds of nutrients, but little is known about the physiological function of intestinal ALP. Vitamin K is an essential cofactor for the post-translational carboxylation of glutamate residues into gamma-carboxy glutamate (Gla). Recently, novel functions of vitamin K have been clarified, but no data exist on the relation between vitamin K and intestinal ALP. The aim of this study was to examine the effects of both vitamin Ks (K1: phylloquinone, and K2: menaquinone) on ALP activity. Sprague-Dawley rats (6-wk-old) were divided into three groups: a control, phylloquinone (PK: 600 mg/kg diet), or menaquinone-4 (MK-4: 600 mg/kg diet) diet group. After 3 mo of feeding, we measured intestinal ALP activity by dividing it into five segments. In each segment, both PK and MK-4 increased intestinal ALP activity. The levels of intestinal ALP activity in the duodenum and proximal jejunum from the PK group were significantly higher than in the control group (p<0.05). Moreover, the levels of intestinal ALP activity from the proximal jejunum and distal ileum of the intestine in the MK group were significantly higher than in the control group (p<0.05). In this study, we clarified for the first time that both vitamin K1 and K2 as nutritional factors enhance intestinal ALP activity.

著者

David del Val Teresa Bastante Carlos H. Gordillo Rio Aguilar Javier Cuesta Fernando Rivero Pablo Diez-Villanueva Fernando Alfonso

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0079, (Released:2021-06-16)

参考文献数

2

著者

崔 艶娜 山崎 好裕 Cui Yan-Na Yamazaki Yoshihiro

出版者

福岡大学研究推進部

雑誌

福岡大学経済学論叢 = Fukuoka University Review of Economics (ISSN:02852772)

巻号頁・発行日

vol.59, no.1-2-3-4, pp.41-51, 2015-03

著者

Pin-Ying Wu Tetsuya Takemi

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2021-024, (Released:2021-06-23)

被引用文献数

1

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Identical twin experiments with and without topography are conducted with the Weather Research and Forecasting (WRF) model in an idealized framework to investigate the impact of topography on the initial error growth associated with moist convection. A topography is set as a single Gaussian shape mountain with a peak height of about 1000 m. Both experiments show clear diurnal cycles, while moist convection develops earlier and organizes to a larger size in the experiment with topography. To evaluate the initial error growth, a metric referred to as moist difference total energy (MDTE) is proposed to represent the differences between the two simulations in twin experiments. The horizontal spatial distribution, temporal evolution, and horizontal wavenumber space of the MDTE suggest that the error growth is greatly dominated by the different features of convection development between the two experiments. The analysis based on individual cloud areas shows that the convective clouds developing over the mountain have smaller MDTE at the early stage of development.

著者

Kandai Doi Fumiaki Yamasaki Takuya Kato Shin-ichi Hayama

出版者

Arachnological Society of Japan

雑誌

Acta Arachnologica (ISSN:00015202)

巻号頁・発行日

vol.70, no.1, pp.47-48, 2021-06-28 (Released:2021-07-05)

参考文献数

11

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A pseudoscorpion was found in the underfur of a feral raccoon (Procyon lotor) captured in western Tokyo in December 2019. Based on the morphological features, we identified the specimen as Haplochernes sp. This arboreal pseudoscorpion rides other arthropods and small mammals for dispersion, but little is known that the species rides medium-sized mammals such as raccoons. To our knowledge, this is the first case report of Haplochernes sp. riding a feral raccoon. Given that raccoons are an invasive species in Japan, further records of pseudoscorpions riding feral raccoons may elucidate the relationship between feral raccoons and pseudoscorpions.

著者

Long Trinh-Tuan Jun Matsumoto Fredolin T. Tangang Liew Juneng Faye Cruz Gemma Narisma Jerasorn Santisirisomboon Tan Phan-Van Dodo Gunawan Edvin Aldrian Thanh Ngo-Duc

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.15, pp.1-6, 2019 (Released:2019-01-19)

参考文献数

38

被引用文献数

7 27

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The Quantile Mapping (QM) bias correction (BC) technique was applied for the first time to address biases in the simulated precipitation over Vietnam from the Regional Climate Model (RegCM) driven by five Coupled Model Intercomparison Project Phase 5 (CMIP5) Global Climate Model (GCM) products. The QM process was implemented for the period 1986-2005, and subsequently applied to the mid-future period 2046-2065 under both Representative Concentration Pathway (RCP) 4.5 and RCP 8.5. Comparison with the original model outputs during the independent validation period shows a large bias reduction from 45% to 3% over Vietnam and significant improvements in representing precipitation indices (PI) after applying the QM technique. Moreover, the ensemble average of the BC products generally performed better than an individual BC member in capturing the spatial distribution of the PIs. A drier condition with a longer rainfall break, and shorter consecutive rainfall events are anticipated over Northern and Central Vietnam during their respective wet seasons in the mid-future. Furthermore, this study showed that the QM method minimally modified the future changes in PIs over most of Vietnam; thus, these corrected projections could be used in climate impacts and adaptation studies.

著者

Ryo Nakabayashi Noriko Takeda-Kamiya Yutaka Yamada Tetsuya Mori Mai Uzaki Takashi Nirasawa Kiminori Toyooka Kazuki Saito

出版者

Japanese Society for Plant Biotechnology

雑誌

Plant Biotechnology (ISSN:13424580)

巻号頁・発行日

pp.21.0504a, (Released:2021-06-24)

参考文献数

27

被引用文献数

7

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Plants release specialized (secondary) metabolites from their roots to communicate with other organisms, including soil microorganisms. The spatial behavior of such metabolites around these roots can help us understand roles for the communication; however, currently, they are unclear because soil-based studies are complex. Here, we established a multimodal metabolomics approach using imaging mass spectrometry (IMS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially assign metabolites under laboratory conditions using agar. In a case study using Catharanthus roseus, we showed that 58 nitrogen (N)-containing metabolites are released from the roots into the agar. For the metabolite assignment, we used 15N-labeled and non-labeled LC-MS/MS data, previously reported. Four metabolite ions were identified using authentic standard compounds as derived from monoterpene indole alkaloids (MIAs) such as ajmalicine, catharanthine, serpentine, and yohimbine. An alkaloid network analysis using dot products and spinglass methods characterized five clusters to which the 58 ions belong. The analysis clustered ions from the indolic skeleton-type MIAs to a cluster, suggesting that other communities may represent distinct metabolite groups. For future chemical assignments of the serpentine community, key fragmentation patterns were characterized using the 15N-labeled and non-labeled MS/MS spectra.