著者

Kimiko Yamamoto Joji Ando

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.11, pp.2691-2698, 2018-10-25 (Released:2018-10-25)

参考文献数

59

被引用文献数

29

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Vascular endothelial cells (ECs) maintain circulatory system homeostasis by changing their functions in response to changes in hemodynamic forces, including shear stress and stretching. However, it is unclear how ECs sense changes in shear stress and stretching and transduce these changes into intracellular biochemical signals. The plasma membranes of ECs have recently been shown to respond to shear stress and stretching differently by rapidly changing their lipid order, fluidity, and cholesterol content. Such changes in the membranes’ physical properties trigger the activation of membrane receptors and cell responses specific to each type of force. Artificial lipid-bilayer membranes show similar changes in lipid order in response to shear stress and stretching, indicating that they are physical phenomena rather than biological reactions. These findings suggest that the plasma membranes of ECs act as mechanosensors; in response to mechanical forces, they first alter their physical properties, modifying the conformation and function of membrane proteins, which then activates downstream signaling pathways. This new appreciation of plasma membranes as mechanosensors could help to explain the distinctive features of mechanotransduction in ECs involving shear stress and stretching, which activate a variety of membrane proteins and multiple signal transduction pathways almost simultaneously.

著者

村上 博巳 山岡 憲二 山本 武司 田阪 登紀夫 ムラカミ ヒロミ ヤマオカ ケンジ ヤマモト タケシ タサカ トキオ Murakami Hiromi Yamaoka Kenji Yamamoto Takeshi Tasaka Tokio

出版者

同志社大学スポーツ健康科学会

雑誌

同志社スポーツ健康科学 (ISSN:18834132)

巻号頁・発行日

no.2, pp.26-37, 2010-03

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原著(Original investigation)社会人(S群):7名,大学生(U群)22名,高校生(H群)32名,中学生(JH群)19名,小学生(ES群)49名のトップクラスの女子卓球選手を対象にスポーツビジョン研究会で実施している(1)静止視力(2)KVA動体視力(3)DVA動体視力(4)コントラスト感度(5)眼球運動(6)深視力(7)瞬間視力(8)眼と手の協応動作の測定を行い、競技力に重要な因子である動体視力(KVA,DVA)の特性について検討した。対照群は一般女子学生90名の中から日常運動習慣の無い一般女子学生10名(NA群)抽出した。各群とも静止視力1.0以上を対象とした。KVA動体視力,DVA 動体視力を各群間の平均値で見るとKVA動体視力の各群間の平均値に有意な差が見られなかったが、DVA動体視力のU群の平均値はH,ES群の平均値より有意に高い値を示した。KVA動体視力に対する測定項目の貢献度の高い視機能は静止視力,眼と手の協応動作,コントラスト感度、DVA動体視力は瞬間視,眼球運動,眼と手の協応動作であった。そして静止視力,コントラスト感度と競技歴との間には有意な相関関係は認められなかったが、瞬間視,眼球運動と競技歴との間には有意な正の相関関係が認められた。眼と手の協応動作と競技歴との間には有意な負の相関関係が認められた。以上のことから、女子卓球選手のKVA動体視力は潜在的、DVA動体視力はトレーニングの要因が影響し、競技力の向上を目指し動体視力を高めるにはKVA動体視力は視力矯正を含み最適な静止視力を有すること、DVA動体視力は継続したトレーニングが必要であることが示唆された。A study was conducted to investigate the characteristics of kinetic vision in women's table tennis players. There are kinetic visual acuity and dynamic visual acuity in kinetic vision. In the present experiment, sports vision of women's table tennis players were measured; member of society women's table tennis players (S group: aged 24.7±1.3yrs),university women's table tennis players(U group: aged 19.5±1.1yrs),high school women's table tennis players (H group: aged 16.3±0.8yrs),junior high school women's table tennis players(JH group: aged 13.6±0.8yrs),elementary school women's table tennis players(ES group: aged 11.1±1.0yrs), and Kyoto sangyo university student women's non-athletes (NA group: aged 18.7±0.5yrs). Then players 7 numbers in S group,22 numbers in U group,32 numbers in H group,19 numbers in JH group,49 numbers in ES group and 10 numbers in NA groups(their static visual acuity>1.0) were selected as subjects. Static visual acuity, kinetic visual acuity, dynamic visual acuity, contrast sensitivity, ocular motor skill, depth perception, visual reaction time and eye-hand coordination of them were measured. Physical characteristics and experience of training of table tennis were investigated using questionnaire. Mean values of kinetic visual acuity were no significantly among all groups, dynamic visual acuity in U groups were significantly higher than H,ES groups. Kinetic visual acuity and dynamic visual acuity showed difference about contribution rates for measurement item. Static visual acuity, contrast sensitivity and eye-hand coordination showed greater contribution rates for kinetic visual acuity. Visual reaction time, ocular motor skill and eye-hand coordination showed greater contribution rates for dynamic visual acuity. Significant correlations between static visual acuity, contrast sensitivity and experience of training were not found, but significant positive correlations between visual reaction time, ocular motor skill and experience of training were found and significant negative correlation between eye-hand coordination and experience of training was found. These results suggest that the improvement of kinetic visual acuity hold the best static visual acuity, the improvement of dynamic visual acuity are caused by heavier training and these are the important for the level up game ability.

著者

YAMAMOTO Tetsuya SATO Miho IWASE Aiko

出版者

Springer Japan

雑誌

Japanese journal of ophthalmology (ISSN:00215155)

巻号頁・発行日

vol.48, no.6, pp.578-583, 2004-11-01

参考文献数

13

被引用文献数

22 30

著者

Saori Yamamoto Tasuku Nagasawa Koichiro Sugimura Atuhiro Kanno Shunsuke Tatebe Tatsuo Aoki Haruka Sato Katsuya Kozu Ryo Konno Kotaro Nochioka Kimio Sato Hiroaki Shimokawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0959-18, (Released:2018-10-17)

参考文献数

16

被引用文献数

8

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Anderson-Fabry disease (AFD) is a rare X-linked disorder caused by deficient activity of the lysosomal enzyme α-galactosidase A (α-GAL A). We herein report 10 cases of AFD in 5 families (3 men and 7 women) that were found to have a specific common mutation in R301Q (G-to-A transition in exon 6 [codon 301] resulting in the replacement of a glutamine with an arginine residue). We evaluated their clinical characteristics, residual enzymatic activity, and plasma concentrations of globotriaosylsphingosine (Lyso-Gb3). Although all 10 cases had cardiac and renal manifestations in common, their clinical manifestations were markedly divergent despite the same genetic abnormality.

著者

Yamamoto Yohei

出版者

公益社団法人 日本化学会

雑誌

Bull. Chem. Soc. Jpn. (ISSN:00092673)

巻号頁・発行日

vol.84, no.1, pp.17-25, 2011

被引用文献数

12

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Self-assembly of &pi;-conjugated molecules is attractive for construction of well-defined, nanometer-scale electroactive materials. This account describes our developments on self-assembled nanotubes from Gemini-shaped hexa-<i>peri</i>-hexabenzocoronenes (HBCs). At first, detailed molecular arrangement in the nanotube is presented, which is perfectly revealed by a synchrotron radiation X-ray diffraction analysis of a macroscopic fiber consisting of highly aligned HBC nanotubes. Next, electroconductive properties of the HBC nanotubes are investigated. By means of direct current and noncontact methods, anisotropic charge-transport properties in the nanotubes are confirmed. The effect of the surface oligoether chains on intertubular conduction is also examined by field-effect transistor measurements. Finally, optoelectronic applications are developed by constructing newly designed nanotubes. These nanotubes possess a coaxial configuration, where an electron-donating graphitic bilayer of &pi;-stacked HBC arrays is laminated by an electron-accepting molecular layer. Due to the molecular-layer donor/acceptor heterojunction, the nanotubes exhibit remarkable photoconduction and photovoltaic outputs. Furthermore, the optoelectronic properties are modulated by changing the density of electron acceptors on the nanotube surfaces by coassembly of multiple components or utilizing photochromism. These results will advance to electronic and optoelectronic applications of supramolecular nanomaterials.

著者

山本 二三丸 ヤマモト フミマル Fumimaru Yamamoto

出版者

立教大学経済学研究会

雑誌

立教経済学研究 (ISSN:00355356)

巻号頁・発行日

vol.28, no.1, pp.59-109, 1974-05

著者

山本 二三丸 ヤマモト フミマル Fumimaru Yamamoto

出版者

立教大学経済学研究会

雑誌

立教経済学研究 (ISSN:00355356)

巻号頁・発行日

vol.25, no.2, pp.39-83, 1971-07

著者

Takashi SUZUKI Narumi YAMAMOTO Hirotaka KONDO Hisashi SHIBUYA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0382, (Released:2018-09-19)

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The neoplastic mass developed in the left flank of a Border Collie dog. The tumor was resected surgically and evaluated histologically and immunohistochemically. Histologically a moderate number of spindle cells were proliferated with staghorn, placentoid, and myxoid growth patterns and a lack of perivascular whirling. Immunohistochemically, the tumor cells were positive to vimentin, laminin, S-100 protein, CD34 and CD117 antibodies. They were negative to cytokeratin AE1/3, desmin, α-SMA and calponin antibodies. Endothelial cells of the staghorn channels were positive for vWF antibody. The present case was diagnosed as spindle cell tumor, but it was similar to human classical hemangiopericytoma (HEP) and canine HEP classified by Avallon and others.

著者

山本 啓二 Keiji Yamamoto 京都産業大学文化学部

雑誌

京都産業大学総合学術研究所所報 (ISSN:13488465)

巻号頁・発行日

vol.10, pp.49-57, 2015-07

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11世紀のカイロで医者として活躍したアリー・イブン・リドワーンは,プトレマイオスによる占星術書『テトラビブロス』に対してアラビア語で全文註解を施している。この『テトラビブロス註解』は13世紀にラテン語に翻訳され,さらに15世紀には印刷され,広くラテン世界にも知られるようになった。アリーはその註解を書く際に,フナイン・イブン・イスハークによるアラビア語版を用いていた。筆者は現在フナイン版テキストの校訂版を準備しているが,その場合に,13世紀以降のものしか残っていないフナイン版の写本以外に,11世紀にアリーによって註解書に引用されたフナインのテキストも参照すべきであることを認識するに至った。

著者

Naohiko ONO Yasundo YAMASAKI Noriyuki YAMAMOTO Akihiko SUNAMI Hidekazu MIYAKE

出版者

The Japanese Pharmacological Society

雑誌

The Japanese Journal of Pharmacology (ISSN:00215198)

巻号頁・発行日

vol.42, no.3, pp.431-439, 1986 (Released:2006-09-15)

参考文献数

23

被引用文献数

4 5

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The possible mechanism of the anti-inflammatory activity of proglumetacin maleate (PGM), a new indomethacin (IND) derivative interacting with arachidonic acid (AA) metabolism, was investigated to elucidate the contributions of PGM itself and its two major metabolites, desproglumideproglumetacin maleate (DPP) and IND. PGM caused much less inhibition of PGE2 formation by sheep seminal vesicle microsomes (IC50=310 μM) and TXB2 formation by a washed rabbit platelet suspension (IC50=6.3 μM) than IND. DPP also caused less inhibition of cyclooxygenase than IND. Moreover, PGM had less effect on sodium arachidonate (SAA)-induced rat platelet aggregation ex vivo and AA-induced sudden death in rabbits than IND. These results show that PGM has anti-inflammatory activity after its conversion to the active metabolite IND. However, the inhibitory effects of PGM and DPP were as strong as that of IND on SAA- or collageninduced rabbit platelet aggregation in vitro. These activities are considered to be associated with platelet membrane interaction. Moreover, unlike IND, PGM (IC50=1.5 μM) and DPP (IC50=16.3 μM) strongly inhibited 5-HETE formation by the cytosol of guinea pig polymorphonuclear leukocytes. This unique activity of PGM on 5-lipoxygenase may contribute to its anti-inflammatory activity.

著者

Takanobu Yamamoto Akira Hasuike Ryosuke Koshi Yasumasa Ozawa Manami Ozaki Tatsuya Kubota Shuichi Sato

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.17-0362, (Released:2018-08-12)

参考文献数

16

被引用文献数

3

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We used radiological and histological analyses to evaluate the effects of mechanical barrier permeability in a rat model of calvarial guided bone augmentation (GBA). The calvaria of 20 rats were exposed, and one of four types of plastic caps (an occlusive cylindrical plastic cap; a plastic cap with no top; a plastic cap with three holes; and a plastic cap with four holes) was randomly placed on both sides. Newly generated bone in the plastic caps was evaluated with micro-computed tomography (micro-CT) and histological analysis. Micro-CT volumetric analysis and decalcified hematoxylin and eosin-stained sections showed that GBA barrier permeability was inversely associated with the quantity of augmented bone obtained. Masson’s trichrome staining showed that collagen in newly generated bony tissue was more mature in plastic caps with three holes than in those with more-permeable or more-occlusive barriers. Bone augmentation was inhibited in specimens exhibiting invasion of soft tissue through penetrating holes, and barrier permeability was associated with the quantity of augmented bone developed. In conclusion, moderate barrier permeability is optimal for development of mature augmented bone.

著者

Kazuyuki Furuya Noriko Yamamoto Yuki Ohyabu Teruyuki Morikyu Hirohide Ishige Michael Albers Yasuhisa Endo

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.3, pp.442-451, 2013-03-01 (Released:2013-03-01)

参考文献数

56

被引用文献数

8 26

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Selective androgen receptor modulators (SARMs) comprise a new class of molecules that induce anabolic effects with fewer side effects than those of other anabolic agents. We previously reported that the novel SARM S-101479 had a tissue-selective bone anabolic effect with diminished side effects in female animals. However, the mechanism of its tissue selectivity is not well known. In this report, we show that S-101479 increased alkaline phosphatase activity and androgen receptor (AR) transcriptional activity in osteoblastic cell lines in the same manner as the natural androgen ligand dihydrotestosterone (DHT); conversely, stimulation of AR dimerization was very low compared with that of DHT (34.4%). S-101479 increased bone mineral content in ovariectomized rats without promoting endometrial proliferation. Yeast two-hybrid interaction assays revealed that DHT promoted recruitment of numerous cofactors to AR such as TIF2, SRC1, β-catenin, NCoA3, gelsolin and PROX1 in a dose-dependent manner. SARMs induced recruitment of fewer cofactors than DHT; in particular, S-101479 failed to induce recruitment of canonical p160 coactivators such as SRC1, TIF2 and notably NCoA3 but only stimulated binding of AR to gelsolin and PROX1. The results suggest that a full capability of the AR to dimerize and to effectively and unselectively recruit all canonical cofactors is not a prerequisite for transcriptional activity in osteoblastic cells and resulting anabolic effects in bone tissues. Instead, few relevant cofactors might be sufficient to promote AR activity in these tissues.

著者

Masataka Yamamoto Koji Shimatani Masaki Hasegawa Takuya Murata Yuichi Kurita

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.8, pp.966-970, 2018 (Released:2018-07-24)

参考文献数

24

被引用文献数

7

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[Purpose] The purpose of this study was to investigate the effect of changing the plantar flexion resistance of an ankle-foot orthosis on knee joint reaction and knee muscle forces. Furthermore, the influence of an ankle-foot orthosis with an over-plantar flexion resistance function on knee joint reaction force was verified. [Participants and Methods] Ten healthy adult males walked under the following three conditions: (1) no ankle-foot orthosis, and with ankle-foot orthoses with (2) a strong and (3) a weak plantar flexion resistance (ankle-foot orthosis conditions). The knee flexion angle, quadricep muscle force, hamstring muscle force, and knee joint reaction force during the stance phase were measured using a motion analysis system, musculoskeletal model, and ankle-foot orthosis model. [Results] The peak knee joint reaction force, knee flexion angle, and quadricep muscle force in the early stance phase significantly increased in the strong plantar flexion resistance condition in comparison with the “no ankle-foot orthosis” condition. [Conclusion] Increased knee joint reaction force with over-plantar flexion resistance suggests that over-plantar flexion resistance causes various knee problems such as knee pain and knee osteoarthritis.

著者

Kinji Ishikawa Ken Kanamasa Iwao Ogawa Toshihiko Takenaka Takeo Naito Noriaki Kamata Tadahiko Yamamoto Shoji Nakai Junkichi Hama Miki Oyaizu Akio Kimura Kentaro Yamamoto Naoko Aso Miyuki Arai Hiroshi Yabushita Ryo Katori on behalf of the Secondary Prevention Group

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.60, no.10, pp.779-788, 1996 (Released:2001-12-25)

参考文献数

27

被引用文献数

50 63

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Background Nitrates dilate coronary arteries, ameliorate myocardial ischemia, minimize left ventricular remodeling, and reduce mortality in patients with acute myocardial infarction. However, the effects of long-term treatment with nitrates on cardiac events in patients with healed myocardial infarction are not known. Methods and Results A total of 1,002 patients with healed myocardial infarction (789 male and 213 female) were randomly divided into 2 groups: treatment with nitrates or nontreatment. The mean observation period was 18.0 ±19.9 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics of the 2 groups were also compared to determine any effects on outcome. Among the 621 cases treated with nitrates, 41 cases (6.6%) experienced cardiac events during the observation period, whereas only 12 of the 381 cases that were not treated with nitrates (3.1%) had cardiac events. This difference was statistically significant (p<0.05; odds ratio 2.17; 95% confidence interval 1.13-4.19). There were no differences in the incidence of noncardiac death or being lost to follow-up between the 2 groups. Although the precise mechanism of this increase in the occurrence of cardiac events by long-term treatment with nitrates is not clear, nitrate tolerance with possible rebound and neurohormonal effects may be involved. Conclusion Long-term treatment with nitrates increased cardiac events in patients with healed myocardial infarction. (Jpn Circ J 1996; 60: 779 - 788)

著者

Takatsugu ABE Kuniyasu NIIZUMA Atsushi KANOKE Daisuke SAIGUSA Ritsumi SAITO Akira URUNO Miki FUJIMURA Masayuki YAMAMOTO Teiji TOMINAGA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.oa.2018-0054, (Released:2018-08-03)

参考文献数

32

被引用文献数

16

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We performed metabolomic analyses of mouse brain using a transient middle cerebral artery occlusion (tMCAO) model with Matrix Assisted Laser Desorption/Ionization (MALDI)-mass spectrometry imaging (MSI) to reveal metabolite changes after cerebral ischemia. We selected and analyzed three metabolites, namely creatine (Cr), phosphocreatine (P-Cr), and ceramides (Cer), because these metabolites contribute to cell life and death. Eight-week-old male C57BL/6J mice were subjected to tMCAO via the intraluminal blockade of the middle cerebral artery (MCA) and reperfusion 60 min after the induction of ischemia. Each mouse was randomly assigned to one of the three groups; the groups were defined by the survival period after reperfusion: control, 1 h, and 24 h. Corrected samples were analyzed using MALDI-MSI. Results of MSI analysis showed the presence of several ionized substances and revealed spatial changes in some metabolites identified as precise substances, including Cr, P-Cr, Cer d18:1/18:0, phosphatidylcholine, L-glutamine, and L-histidine. Cr, P-Cr, and Cer d18:1/18:0 were changed after tMCAO, and P-Cr and Cer d18:1/18:0 accumulated over time in ischemic cores and surrounding areas following ischemia onset. The upregulation of P-Cr and Cer d18:1/18:0 was detected 1 h after tMCAO when no changes were evident on hematoxylin and eosin staining and immunofluorescence assay. P-Cr and Cer d18:1/18:0 can serve as neuroprotective therapies because they are biomarker candidates for cerebral ischemia.

著者

Costansia Bureta Hiroyuki Tominaga Takuya Yamamoto Ichiro Kawamura Masahiko Abematsu Kazunori Yone Setsuro Komiya

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

vol.2, no.3, pp.226-229, 2018-07-25 (Released:2018-07-27)

参考文献数

21

被引用文献数

12

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Introduction: One complication after scoliosis surgery is ileus; however, few reports have described the frequency of and risk factors for this complication. We conducted a retrospective clinical study with logistic regression analysis to confirm the frequency of and risk factors for ileus after scoliosis surgery.Methods: After a retrospective review of data from patients who underwent surgical correction of spinal deformity from 2009 to 2014, 110 cases (age range, 4-73 yr; median, 14 yr) were included in the study. We defined postoperative ileus (POI) as a surgical complication characterized by decreased intestinal peristalsis and the absence of stool for more than 3 days postoperatively. Various parameters were compared between patients with POI and those without POI. Logistic regression analysis was performed to assess the risk factors associated with ileus; a P value of <0.05 was considered statistically significant.Results: Fifteen of 110 (13.6%) cases developed POI. The median height, weight, operation time, and blood loss volume of the patients with versus without POI were 146 versus 152 cm, 39.0 versus 44.0 kg, 387 versus 359 min, and 1590 versus 1170 g, respectively. There were no significant differences between patients with versus without POI in the measured parameters, with the exception of patient height, bed rest period, and presence of neuromuscular scoliosis. Multiple logistic regression analysis revealed neuromuscular scoliosis as a significant risk factor for POI (odds ratio, 4.21; 95% CI, 1.23-14.40).Conclusions: Our findings indicate a high probability of POI after scoliosis surgery, with an incidence of 13.6%. Neurogenic scoliosis, but not lowest instrumented vertebra or correction rate, was a risk factor for POI after scoliosis surgery. Digestive symptoms should be carefully monitored after surgery, particularly in patients with neuromuscular scoliosis.

著者

Nagano Kasuke Umeda Yumi Saito Misae NISHIZAWA Tomoshi IKAWA Naoki ARITO Heihachiro YAMAMOTO Seigo FUKUSHIMA Shoji

出版者

公益社団法人日本産業衛生学会

雑誌

Journal of occupational health (ISSN:13419145)

巻号頁・発行日

vol.49, no.4, pp.249-259, 2007-07-01

参考文献数

44

被引用文献数

3

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Subchronic toxicity of carbon tetrachloride (CCl_4) was examined by inhalation exposure of F344 rats and BDF_1 mice of both sexes to 0, 10, 30, 90, 270 or 810 ppm (v/v) CCl_4 vapor for 13 wk (6 h/d and 5 d/wk). In the high exposure levels at 270 and 810 ppm, altered cell foci in the livers of both rats and mice, and fibrosis and cirrhosis in the rat liver were observed. Hematoxylin and eosin-stained altered cell foci of rats were recognized as glutathione-S-transferase placental form (GST-P) positive foci, which are preneoplactic lesions of hepatocarcinogenesis. The most sensitive endpoint of CCl_4-induced toxicity was fatty change with large droplets in rats of both sexes and male mice, and cytoplasmic globules in male mice, as well as increased relative liver weight in male rats. Those endpoints were manifested at 10 ppm and the LOAEL was determined as 10 ppn for the hepatic endpoints in rats and mice. Enhanced cytolytic release of liver transaminases into plasma in rats and mice and its close association with hepatic collapse in mice were observed at medium and high levels of inhalation exposure. Both CCl_4-induced hematotoxicity and nephrotoxicity were observed in both rats and mice, but those toxicities were manifested at higher exposure concentrations than hepatotoxicity. The LOAEL for the hepatic endpoint and the GST-P-stained altered cell foci provide relevant animal data for reconsidering the occupational exposure limit value of 5 ppm for CCl_4 and strengthen the evidence of CCl_4-induced hepatocarcinogenicity which is used in its carcinogenicity classification.

著者

Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Tomomi Ohishi Naoko Okino Toshihito Kitamura Weinong Guo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-1424, (Released:2018-07-26)

参考文献数

17

被引用文献数

15

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Background:The objective of the present analyses was to describe the baseline characteristics and treatment of the Japanese patients with HFrEF in THE PARALLEL-HF study.Methods and Results:Key demographic, clinical and laboratory findings, along with treatment, were reported and compared with patients enrolled in the PARADIGM-HF trial and other contemporary randomized clinical trials and registries of Japanese patients with HFrEF. In addition, the MAGGIC and EMPHASIS-HF risk scores were calculated. A total of 225 Japanese patients were randomized in PARALLEL-HF with a mean age of 67.9 years and the majority of the patients being male (85.8%) and in NYHA Class II (93.8%). Key baseline characteristics in PARALLEL-HF were generally comparable with PARADIGM-HF, and other contemporary clinical trials and registries of Japanese HFrEF patients. Patients enrolled in PARALLEL-HF were well treated with conventional evidence-based therapy at baseline (angiotensin-converting enzyme inhibitor inhibitor/angiotensin receptor blocker, 62.7%/37.3%; β-blockers, 94.7%; mineralocorticoid receptor antagonist, 59.1%). Despite the evidence-based treatment and most patients being in NYHA Class II, these patients had a low LVEF (mean 28.1%) and were at high risk of cardiovascular mortality and morbidity as assessed by the MAGGIC and EMPHASIS-HF risk scores.Conclusions:Overall, the patients in PARALLEL-HF were largely representative of contemporary ambulatory patients with HFrEF who are well treated with evidence-based therapies. PARALLEL-HF will determine whether sacubitril/valsartan provides similar improvements in clinical outcomes in Japanese HFrEF patients as observed in the PARADIGM-HF study.

著者

木村 瑞生 山本 正彦 Mizuo Kimura Masahiko Yamamoto 東京工芸大学工学部基礎教育研究センター 東京工芸大学工学部基礎教育研究センター

雑誌

東京工芸大学工学部紀要 = The Academic Reports, the Faculty of Engineering, Tokyo Polytechnic University (ISSN:03876055)

巻号頁・発行日

vol.35, no.1, pp.1-5, 2012

著者

山本 裕二 横山 慶子 Yamamoto Yuji Yokoyama Keiko

出版者

名古屋大学総合保健体育科学センター

雑誌

総合保健体育科学 (ISSN:02895412)

巻号頁・発行日

vol.35, no.1, pp.1-7, 2012-03-30