著者

Tetsuo Minamino Shuichiro Higo Ryo Araki Shungo Hikoso Daisaku Nakatani Hiroshi Suzuki Takahisa Yamada Masaaki Okutsu Kouji Yamamoto Yasushi Fujio Yoshio Ishida Takuya Ozawa Kiminori Kato Ken Toba Yoshifusa Aizawa Issei Komuro EPO-AMI-II Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0889, (Released:2018-02-02)

参考文献数

21

被引用文献数

15

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Background:Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan. In total, 198 STEMI patients with low left ventricular ejection fraction (LVEF <50%) were randomly assigned to receive intravenous administration of EPO (6,000 or 12,000 IU) or placebo within 6 h of successful percutaneous coronary intervention. At 6 months, there was no significant dose-response relationship in LVEF improvement among the 3 groups tested (EPO 12,000 IU: 5.4±9.3%, EPO 6,000 IU: 7.3±7.7%, Placebo: 8.1±8.3%, P=0.862). Low-dose EPO also did not improve cardiac function, as evaluated by 99 mTc-MIBI SPECT or NT-proBNP at 6 months and did not increase adverse events.Conclusions:Administration of low-dose EPO did not improve LVEF at 6 months in STEMI patients (UMIN000005721).

著者

Hirotaka Yamamoto Atsushi Iga Kaoru Ishihara Yuuichi Mita Hirohisa Suzuki

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Transactions on Industry Applications (ISSN:09136339)

巻号頁・発行日

vol.115, no.6, pp.702-711, 1995-05-20 (Released:2008-12-19)

参考文献数

33

被引用文献数

7 8

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In the design, operation and evaluation of a photovoltaic power generation systems (PV systems), it is particularly important to accurately estimate the total amount of annual electric power generated by PV system. The authors applied a new I-V curve construction method developed for the calculation of output power from a photovoltaic array in order to develop a practical “simulation program for the calculation of the amount of electric power generated by PV system.” The following items were clarified by this research.

著者

Noriko Inoue Ryo Maeda Hideshi Kawakami Tomoki Shokawa Hideya Yamamoto Chikako Ito Hideo Sasaki

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.73, no.3, pp.549-553, 2009 (Released:2009-02-25)

参考文献数

31

被引用文献数

33 66

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Background: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. Methods and Results: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). Conclusions: An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men. (Circ J 2009; 73: 549 - 553)

著者

Toru Kubo Takayoshi Hirota Yuichi Baba Yuri Ochi Asa Takahashi Naohito Yamasaki Naohisa Hamashige Katsuhito Yamamoto Fumiaki Kondo Kanji Bando Eisuke Yamada Takashi Furuno Toshikazu Yabe Yoshinori L Doi Hiroaki Kitaoka

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0845, (Released:2018-01-13)

参考文献数

30

被引用文献数

21

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Background:There have been few studies on the clinical course of hypertrophic cardiomyopathy (HCM) in a community-based patient cohort in Japan.Methods and Results:In 2004, we established a cardiomyopathy registration network in Kochi Prefecture (the Kochi RYOMA study) that consisted of 9 hospitals, and finally, 293 patients with HCM were followed. The ages at registration and at diagnosis were 63±14 and 56±16 years, respectively, and 197 patients (67%) were male. HCM-related deaths occurred in 23 patients during a mean follow-up period of 6.1±3.2 years. The HCM-related 5-year survival rate was 94%. In addition, a total of 77 cardiovascular events that were clinically severe occurred in 70 patients, and the HCM-related 5-year event-free rate was 80%. Multivariate Cox proportional hazards model analysis showed that the presence of NYHA class III at registration was a significant predictor of HCM-related deaths and that the presence of atrial fibrillation, lower fractional shortening and presence of left ventricular outflow tract obstruction in addition to NYHA class III were significant predictors of cardiovascular events.Conclusions:In our unselected registry in an aged Japanese community, HCM mortality was favorable, but one-fifth of the patients commonly suffered from HCM-related adverse cardiovascular events during the 5-year follow-up period. Careful management of HCM patients is needed, particularly for those with the above-mentioned clinical determinants.

著者

山本 忠行 Tadayuki Yamamoto

出版者

創価大学別科日本語研修課程

雑誌

創価大学別科紀要 (ISSN:09164561)

巻号頁・発行日

no.15, pp.28-49, 2003-01-01

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南アフリカ共和国ではマンデラ政権誕生後、憲法改正により11公用語政策をとることになったものの、英語の重要性は増すばかりである。中等教育以上の教育用言語としては英語が圧倒的である。しかし、これが多くの黒人から教育・就業の機会を奪っているとも言える。その一方でアフリカ土着の言語(以下、「アフリカン言語」とする)に対する意識には大きな変化が見られる。現状では教育用言語として発展する余地は少ないが、白人もアフリカン言語を学び始めるようになるなど、少なくとも英語を中心とする多言語社会に向かっていることは間違いない。

著者

Akatsuki Kubota Hiroyuki Ishiura Jun Mitsui Kaori Sakuishi Atsushi Iwata Tomotaka Yamamoto Ichizo Nishino Shoji Tsuji Jun Shimizu

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9588-17, (Released:2017-12-08)

参考文献数

24

被引用文献数

6

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A complete loss of merosin, which is encoded by LAMA2, causes congenital muscular dystrophy with leukoencephalopathy. Partial merosin deficiency can be caused not only by primarily LAMA2 mutations, but also secondarily by dystroglycanopathy. Although it can be molecularly diagnosed based on a genetic analysis, this method is labor-intensive because of its huge genome size. A 26-year-old male patient presented with mild muscular weakness, joint contractures, and epilepsy. Double immunofluorescence staining of a muscle biopsy specimen showed mislocalization of merosin, and a genetic analysis revealed a homozygous c.818G>A (p.Arg273Lys) mutation in LAMA2. Double immunofluorescence staining and whole exome sequencing were useful for the diagnosis of partial merosin deficiency.

著者

林 陸雄 山本 浩子 Rikuo HAYASHI Hiroko YAMAMOTO 桃山学院大学文学部 桃山学院大学非常勤講師

出版者

桃山学院大学総合研究所

雑誌

桃山学院大学人間科学 = HUMAN SCIENCES REVIEW, St. Andrew's University (ISSN:09170227)

巻号頁・発行日

no.16, pp.139-152, 1999-01-30

著者

Masayoshi Yamamoto Yoshihiro Seo Tomoko Ishizu Isao Nishi Yoshie Hamada-Harimura Tomoko Machino-Ohtsuka Kimi Sato Seika Sai Akinori Sugano Kenichi Obara Kazutaka Aonuma

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.11, pp.1662-1669, 2017-10-25 (Released:2017-10-25)

参考文献数

27

被引用文献数

9

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Background:Although experimental animal studies report many pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP-4i), their prognostic value has not been demonstrated in clinical trials.Methods and Results:Among 838 prospectively enrolled heart failure (HF) patients hospitalized for acute decompensated HF, 79 treated with DPP-4i were compared with 79 propensity score-matched non-DPP-4i diabetes mellitus (DM) patients. The primary endpoint was all-cause mortality; the secondary endpoint was a composite of cardiovascular death and hospitalization. During follow-up (423±260 days), 8 patients (10.1%) in the DPP-4i group and 13 (16.5%) in the non-DPP-4i group died (log-rank, P=0.283). The DPP-4i group did not have a significantly higher rate of all-cause mortality (log-rank, P=0.283), or cardiovascular death or hospitalization (log-rank, P=0.425). In a subgroup analysis of HF with preserved ejection fraction (HFpEF; n=75), the DPP-4i group had a significantly better prognosis than the non-DPP-4i group regarding the primary endpoint (log-rank, P=0.021) and a tendency to have better prognosis regarding the secondary endpoint (log-rank, P=0.119). In patients with HF with reduced EF (n=83), DPP-4i did not result in better prognosis.Conclusions:DPP-4i did not increase the risk of adverse clinical outcomes in patients with DM and HF. DPP-4i may be beneficial in HFpEF.

著者

MIHOKO YAMAMOTO TOKUJI IKENAKA

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.62, no.2, pp.141-149, 1967-08-25 (Released:2011-01-25)

参考文献数

23

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1. A simple method was developed for the preparative purification of large amounts of two soybean trypsin inhibitors, namely the Kunitzand the 1.9S-inhibitors.2. These two trypsin inhibitors were characterized in terms of their major chemical and physicochemical properties, and these results were compared with those of soybean trypsin inhibitors isolated by other investigators.The Kunitz-inhibitor was shown to be identical to that isolated by Kunitz and the 1.9S-inhibitor appears to be a new innibitor. Molecular weight of the 1.9S-inhibitor was determined to be 16, 400 and this protein contains more than 19 per cent of cystine and lacks cysteine and glycine.3. The inhibiting activites of the two inhibitors against several proteinases were investigated.

著者

Saiko Shikanai Ly Koung Ry Hitomi Takeichi Suzuki Emiko Pann San Nobuko Sarukura Sumiko Kamoshita Shigeru Yamamoto

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.1.2, pp.72-78, 2014 (Released:2014-04-04)

参考文献数

21

被引用文献数

4 11

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Because of the tastiness of sugars, it is easy to consume more than an adequate amount. There are many research reports that excess sugar intake contributes to dental decay, obesity, diabetes etc. Continuing economic development in Cambodia has made it easier than before for people to consume sugars in their daily life. Currently, isomerized sugar (a mixture of glucose and fructose) made from starches is commonly used in commercial beverages because of its low price. However, in Cambodia and Japan, sugar composition tables that include not only sucrose but also glucose, fructose, lactose and maltose have not been available. Prior to the present nutrition surveys, we made sugar composition tables for both countries. In this study we tried to estimate the intakes of various sugars by children in Cambodia and Japan and to determine the relationship between intake and body weight. Nutrition surveys of children aged 7, 10 and 13 years old were conducted for 3 nonconsecutive days by the 24 h recall method in 89 Cambodian children living in the capital city of Cambodia, Phnom Penh, and 151 Japanese children living in 3 prefectures from north to south. Height and weight of children in Cambodia and Japan were similar until 10 years old but at 13 years old, the Cambodians were shorter and lighter than the Japanese. We could not observe any differences in BMI in either country. The sugar intakes from beverages and snacks were not different among the different gender and age. Thus we combined the mean total sugar intake for Cambodian and Japanese, 28.42 ± 25.28 g and 25.69 ± 16.16 g respectively. These were within the range of WHO recommendations (less than 10% of energy intakes). Cambodian children consumed about 46% of sugars from commercial beverages and snacks and Japanese children 26%. This means that for Cambodians half of the sugars came from isomerized sugar made from starches. Relationships between sugar intake and body weight were not observed in both countries. In conclusion, the Cambodian children consumed about 46% of sugar from glucose and fructose (probably in the form of isomerized sugar), while the Japanese children took 26%; however, the intakes in both countries met the WHO recommendation and there was no relationship to body weight. J. Med. Invest. 61: 72-78, February, 2014

著者

山本 須美子 ヤマモト スミコ Sumiko YAMAMOTO

出版者

東洋大学社会学部

雑誌

東洋大学社会学部紀要 = The Bulletin of Faculty of Sociology,Toyo University (ISSN:04959892)

巻号頁・発行日

vol.49, no.1, pp.5-23, 2012-01

著者

Hideharu Hagiya Koji Miyawaki Norihisa Yamamoto Hisao Yoshida Akihiro Kitagawa Tadafumi Asaoka Hidetoshi Eguchi Yukihiro Akeda Kazunori Tomono

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.8774-16, (Released:2017-09-25)

参考文献数

17

被引用文献数

13

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Ceftriaxone is a widely used third-generation cephalosporin showing advantageous pharmacokinetic properties and a broad antimicrobial spectrum. We herein report a case of ceftriaxone-induced neurotoxicity in a 56-year-old man on hemodialysis. Seven days after initiating high-dose ceftriaxone, the patient developed impaired consciousness along with facial myoclonus and sporadic phonation. The symptoms clearly disappeared shortly after withdrawal of the drug. Ceftriaxone is considered a safe antibiotic for patients with renal insufficiency, since it is excreted via both haptic and renal pathways. Physicians should note that antibiotic-associated encephalopathy may develop in patients administered ceftriaxone, especially in those complicated with renal dysfunction.

著者

Yasuo Ito Takashi Mitsufuji Yoshio Asano Tomokazu Shimazu Yuji Kato Norio Tanahashi Yuichi Maruki Fumihiko Sakai Toshimasa Yamamoto Nobuo Araki

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.8865-17, (Released:2017-09-06)

参考文献数

13

被引用文献数

9

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Objective Naratriptan has been reported to reduce the frequency of cluster headache. The purpose of this study was to determine whether naratriptan is effective as a prophylactic treatment for cluster headache in Japan. Methods We retrospectively reviewed all 43 patients with cluster headache who received preventive treatment with naratriptan from April 2009 to April 2015. The International Classification of Headache Disorders, 3rd Edition (beta version) (ICHD-3 beta) was used to diagnose cluster headache. This study was conducted at 3 centers (Department of Neurology, Saitama Medical University; Saitama Neuropsychiatric Institute; Saitama Medical University International Medical Center). Patients were recruited from these specialized headache outpatient centers. Naratriptan was taken before the patient went to bed. Results The study population included 30 men (69.8%) and 13 women (30.2%). Twenty-two cases received other preventive treatments (51.2%), while 21 cases only received naratriptan (48.8%). Among the 43 cases, 37 patients (86.0%) achieved an improvement of cluster headache on naratriptan. Conclusion Naratriptan has been suggested as a preventive medicine for cluster headache because of the longer the biological half-life in comparison to other triptans. The internal use of naratriptan 2 hours before attacks appears to achieve a good response in patients with cluster headache.

著者

山本 恒夫 Tsuneo Yamamoto

雑誌

淑徳大学研究紀要 = Shukutoku University bulletin (ISSN:02851245)

巻号頁・発行日

vol.4, pp.121-150, 1970-03-15

著者

Rei Yamamoto Norio Hibiki

出版者

日本オペレーションズ・リサーチ学会

雑誌

日本オペレーションズ・リサーチ学会論文誌 (ISSN:04534514)

巻号頁・発行日

vol.60, no.3, pp.244-261, 2017-07-25 (Released:2017-07-31)

参考文献数

13

被引用文献数

2

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Pairs trading strategy has a history of at least 30 years in the stock market and is one of the most common trading strategies used today due to its understandability. Recently, Yamamoto and Hibiki [13] studied optimal pairs trading strategy using a new approach under actual fund management conditions, such as transaction costs, discrete rebalance intervals, finite investment horizons and so on. However, this approach cannot solve the problem of multiple pairs because this problem is formulated as a large scale simulation based non-continuous optimization problem. In this research, we formulate a model to solve an optimal pairs trading strategy problem using multiple pairs under actual fund management conditions. Furthermore, we propose a heuristic algorithm based on a derivative free optimization (DFO) method for solving this problem efficiently.

著者

山本 亞実 大城 未緒 南 由歩 竹谷 怜子 小野 久江 A. Yamamoto M. Oshiro Y. Minami R. Taketani H. Ono

出版者

関西学院大学心理科学研究室

雑誌

関西学院大学心理科学研究 = Kwansei Gakuin University, bulletin of psychological science research (ISSN:21876355)

巻号頁・発行日

vol.42, pp.1-5, 2016-03

著者

Syuji Yonekura Yoshitaka Okamoto Daiju Sakurai Toshioki Sakurai Tomohisa Iinuma Heizaburou Yamamoto Toyoyuki Hanazawa Shigetoshi Horiguchi Yuichi Kurono Kohei Honda Yuichi Majima Keisuke Masuyama Noriaki Takeda Shigeharu Fujieda Mitsuhiro Okano Satoshi Ogino Kimihiro Okubo

出版者

一般社団法人日本アレルギー学会

雑誌

Allergology International (ISSN:13238930)

巻号頁・発行日

vol.66, no.3, pp.425-431, 2017 (Released:2017-07-25)

参考文献数

38

被引用文献数

13

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Background: Complementary and alternative medicine (CAM) is extensively used in patients with allergic diseases worldwide. The purpose of this study was to investigate the actual situation of CAM practice in the treatment of allergic rhinitis.Methods: We distributed questionnaires to otolaryngologists at 114 facilities in Japan. The subjects who participated in this study included children <16 years of age and adults ≥16 years of age diagnosed with allergic rhinitis by otolaryngologists. The survey was performed in the period from September 2007 to August 2009. Furthermore, we performed the same investigation out of the hospital setting, such as during general health examinations. All questionnaires were returned to Chiba University and analyzed.Results: The proportions of patients who had ever experimented with CAM in the hospital survey were 7.1% (225/3170) and 19.2% (1416/7363) of children and adults, respectively. Approximately 36.2% of the adult patients thought that the treatments were effective. The main reasons for CAM use were safety, convenience and low price. However, the group who spent more than $1000 on CAM felt more dissatisfaction and anxiety related to treatment at the hospital. The situation of CAM practice was not consistent and was instead influenced by the backgrounds of the subjects.Conclusions: Many patients who receive CAM report feeling that the effects of treatment provided by hospitals are insufficient and have concerns about the side effects of such treatments. Information regarding standard treatments, as described in the guidelines, should become widely known and diffused, and strong communication with patients should be considered.

著者

Sogo Nishio Shingo Terakami Toshimi Matsumoto Toshiya Yamamoto Norio Takada Hidenori Kato Yuichi Katayose Toshihiro Saito

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.OKD-093, (Released:2017-07-21)

被引用文献数

16

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The chestnut (genus Castanea) has a long juvenile phase, and breeders have to wait three years or more to evaluate nut traits. Therefore, molecular markers associated with genes of interest are required to speed the selection process in chestnut breeding programs. Genetic linkage maps of the Japanese chestnut were constructed using two breeding populations derived from crosses between ‘Kunimi’ and breeding line ‘709-034’ (Kx709), and between ‘Porotan’ and ‘Tsukuba-43’ (Px43). Maps of the four parents and two integrated maps (one representing each cross) were constructed using 443 simple sequence repeat markers (SSRs) and 554 single-nucleotide polymorphism markers. In the Kx709 integrated map, which was the most saturated of the six maps, 12 linkage groups were identified that covered 668.1 cM with an average distance of 0.8 cM between loci. Using anchor SSRs, these six maps were successfully aligned to the Chinese chestnut consensus map. We evaluated eight important traits, including several nut traits, to identify molecular markers associated with these traits. At least one significant quantitative trait locus (QTL) was detected for each of the eight traits (21 in total). Logarithm of odds (LOD) values and phenotypic variance explained by these QTLs ranged from 2.60 to 7.90 and from 11.6% to 29.1%, respectively. In the Kx709 population analysis, several QTLs for nut harvesting date (HARVEST) and pericarp splitting (SPLIT) were detected. Under the assumption that the effects of these QTLs are additive, the percentage of total phenotypic variance explained by the combination of QTLs was high for both HARVEST (47.5%–60.8%) and SPLIT (33.4%–41.7%). Because these mapping populations and their parents are essential materials for Japanese chestnut breeding programs, these QTLs will soon be used for marker-assisted selection to improve breeding efficiency.

著者

Takashi Fukuda Sekiya Koike Syumpei Miyakawa Hiroto Fujiya Yuki Yamamoto

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.6, no.4, pp.241-249, 2017-09-25 (Released:2017-07-12)

参考文献数

41

被引用文献数

3

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The aim of this study is to understand the head impact during actual collisions between American football players from Japanese universities. The subjects of this study were 23 players who belonged to T university in the Kantoh Collegiate American Football Association Division 2. We used a Vector Mouthguard (i1 Biometrics Inc.) equipped with 6 degrees of freedom (DOF) to measure the head linear acceleration (LA) and rotational acceleration (RA) as well as the head injury criterion (HIC), impact location, and number of impacts during collisions. The average number of collisions per player during a practice and during a game was 14.3 and 15.7, respectively. In terms of positions, the ratio (1:1.3) of total number of impacts for backs to linemen in Japan is lower than that (1:3) in the USA. Both during the games and practices, the range of 10 g < X ≤ 15 g in the average peak LA values was the most frequent, and the distributions were largely skewed toward low values (p < 0.05). The medians during the games and practices were 16.77 g and 15.87 g, respectively. The number of collisions during practices in Japan was significantly higher than that in the USA. Particularly, linemen undergo more head collisions than those of backs. Another common factor is that the impact of head collision during a game is significantly higher than that during a practice. However, data on Japanese university players is limited, and further data collection should be done before determining an accurate estimate of the practical concussion risk threshold.

著者

Kudo Toshiyuki Yamamoto Hiroaki Sato Seiji SUTOU Shizuyo

出版者

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

雑誌

The Journal of reproduction and development (ISSN:09168818)

巻号頁・発行日

vol.42, no.2, pp.101-107, 1996-05-01

参考文献数

28

被引用文献数

1 10

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Aromatase (EC 1.14.14.1.) is a key enzyme of feminizing hormone biosynthesis and catalyzes the conversion of androgens to estrogens. In birds, sex-steroid hormones, especially estrogens, play a critical role in the development of the gonadal glands and the aromatase is one of the most important factors in sex determination. Herein, we cloned the 5' upstream regions of chicken and quail aromatase genes and determined these sequences, which showed high homology between chicken and quail. Moreover, the transcription initiation site of the chicken aromatase gene in early development was determined by the 5'-RACE method. The findings showed that the transcription of the chicken aromatase gene starts from a more upstream site than previously reported.