著者
Kazuomi Kario Eiichiro Yamamoto Hirofumi Tomita Takafumi Okura Shigeru Saito Takafumi Ueno Daiki Yasuhara Kazuyuki Shimada on behalf of the SYMPLICITY HTN-Japan Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-18-1018, (Released:2019-02-13)
参考文献数
32
被引用文献数
27

Background: SYMPLICITY HTN-Japan is a prospective, randomized, controlled trial comparing renal denervation (RDN) with standard pharmacologic therapy for treatment of uncontrolled hypertension (HTN). Methods and Results: Patients enrolled had uncontrolled HTN, defined as office systolic blood pressure (SBP) ≥160 mmHg and 24-h ambulatory SBP ≥135 mmHg, on ≥3 antihypertensive drugs of maximally tolerated dose for at least 6 weeks prior to enrollment. Randomization was 1:1 to RDN or maintenance of current medical therapy (control). Patients were followed every 6 months post-randomization for up to 36 months. There were 22 patients randomized to RDN and 19 to control, and 11 patients were crossed over and received RDN at 6 months post-randomization. For the RDN group (n=22), office SBP reduction was −32.8±20.1 mmHg and office DBP reduction was −15.8±12.6 mmHg at 36 months post-procedure, both P<0.001. For the combined RDN and crossover group (n=33), office SBP reduction was −26.7±18.9 mmHg and office DBP reduction was −12.7±11.8 mmHg at 30 months post-procedure, both P<0.001. There were no procedural-, device- or treatment-related safety events through 36 months. Conclusions: SYMPLICTY HTN-Japan is the first randomized controlled trial to evaluate RDN in an Asian population. Despite the small number of enrollments, results show patients who received RDN therapy maintained SBP reduction out to 36 months.
著者
Kenji Tsuruta Hiroyuki Yamamoto Masanori Katsuyama Yoshiko Kosugi Motonori Okumura Naoko Matsuo
出版者
水文・水資源学会/日本地下水学会/日本水文科学会/陸水物理研究会
雑誌
Hydrological Research Letters (ISSN:18823416)
巻号頁・発行日
vol.13, no.1, pp.1-6, 2019 (Released:2019-02-02)
参考文献数
32
被引用文献数
14

Cryogenic vacuum distillation (CVD) methods have been widely used to extract water from unsaturated soil materials. However, recent studies have reported that extraction conditions (e.g. extraction time) and soil type can influence the stable isotope ratios of soil water extracted by CVD. We examined (i) the effects of extraction time on the stable isotope ratios of soil water extracted by CVD, and (ii) how the stable isotope ratios differed from those of soil water extracted by other methods. We first examined extraction times of 1–6 h, and observed no significant differences in the δ2H or δ18O values of extracted soil water for extraction times >2 h. However, extraction for 1 h collected only 48% of soil water, and the δ2H and δ18O values were significantly lower than those for extraction times >2 h. We then compared the stable isotope ratios of soil water extracted by CVD and centrifugation. Although the stable isotope ratios for both extraction methods were within the range of that of rainwater, the stable isotope ratios for water extracted by CVD were lower than those for water extracted by centrifugation. Our results highlight questions surrounding the use of CVD for stable isotope analysis of soil water.
著者
山本 美佐子 水島 禮子 堀込 和代 木浪 智佳子 萬 美奈子 三国 久美 ヤマモト ミサコ ミズシマ レイコ ホリゴメ カズヨ キナミ チカコ ヨロズ ミナコ ミクニ クミ Misako Yamamoto Reiko Mizushima Kazuyo Horigome Tikako Kinami Minako Yorozu Kumi Mikuni
雑誌
北海道医療大学看護福祉学部学会誌 = Journal of School of Nursing and Social Services, Health Sciences University of Hokkaido
巻号頁・発行日
vol.3, no.1, pp.7-14, 2007-03-31

本研究の目的は,NICUに入院した子ども(以下NICU児)の母親の対児感情と母性意識の入院中から退院後1年間の経時的変化と,満期産児の母親との比較による特徴を明らかにすることである.接近と回避の下位尺度から成る対児感情評定尺度と育児肯定,育児否定,葛藤,成長志向から成る母性意識尺度を用い,入院中・退院後3ヶ月前後・退院後1年前後の調査を行った結果,以下のことが明らかになった.1)子どもへの接近は,入院中は満期産の母親よりも有意に低く,在胎過数と正の相関が見られたが,退院後は増加し1年後には在胎過数による相関も,満期産との差も見られなくなった.2)成長志向得点は入院中満期産と比較し有意に低く,退院後は職業との相関が見られた.育児肯定得点は入院中のみ初産のNICU児の母親が有意に低かった.NICUに入院する子どもの母親には,特に入院初期,初産で在胎過数が少ないほど母親のこころの回復過程を見守りながら,母子の相互交流を手助けする看護の重要性が確認された.The aim of this study was to determine changes in maternal consciousness and feelings toward babies admitted to Neonatal Intensive Care Unit (NICU) , and to compare their characteristics with mothers who had given birth to full-term infants. Two scales were used in this study : (1) a rating scale of feelings toward babies based on a measurement of approach and avoidance, and (2) a maternal consciousness scale that measured infant care, childcare rejection, complications, and growth. Data was collected three times : during hospitalization, three months after discharge, and one year after discharge. 1) Mothers of NICU infants were significantly less likely to approach their infants during hospitalization than mothers of full-term infant births with a positive correlation with the number of weeks of pregnancy lacking for a full-term birth. However, after hospital discharge, the degree to which mothers of NICU infants approached their infants increased. After one year, there was no correlation with weeks of pregnancy, and the previous difference with full-term infant births became indistinguishable. 2) Growth scores for NICU infants of mothers who had been discharged were significantly lower when compared with those during hospitalization. Furthermore, a correlation between infant growth and employment was found among mothers after hospital discharge. Infant care scores of mothers of NICU infants were significantly lower for mothers who were having their first child. For mothers of infants admitted to NICU, especially for mothers giving birth for the first time or being hospitalized for the first time, it is important for nurses to encourage a mutual exchange between mother and infant while also ensuring that the mother recovers psychologically.
著者
萬 美奈子 木浪 智佳子 三国 久美 山本 美佐子 ヨロズ ミナコ キナミ チカコ ミクニ クミ ヤマモト ミサコ Minako YOROZU Chikako KINAMI Kumi MIKUNI Misako YAMAMOTO
雑誌
北海道医療大学看護福祉学部紀要
巻号頁・発行日
vol.13, pp.51-58, 2006

近年、わが国において肥満傾向児の割合が増加している。これらの児は将来的に、肥満に起因する健康障害を引き起こす可能性が高いことから、小児期からの予防対策が重要である。本稿では、小児肥満の予防と生活習慣に焦点をあて、効果的な予防的介入方法について、それらに関する文献をもとに検討することを目的とし、以下の知見を得た。1.小児肥満を予防するためには、乳幼児期からの一次予防レベルの介入が、必要かつ効果的である。2.学童期以降では、一次予防レベルでの介入を継続するだけでなく、児の発達段階とニーズに応じ、プライバシーに配慮した二次予防レベルの介入が必要である。特に児への動機づけは重要である。3.効果的な介入を行なっていくためには、先行研究で明らかになった肥満に関連する生活習慣の改善を目指した予防活動の実施による評価研究、長期的視野に立った縦断的研究、肥満に対する認識と行動の変化に着目した研究が必要である。In Japan, the ratio of obese children has increased in the past several years. Because of a high possibility of causing health problems that originate in obesity in the future, these children's preventive measures from the infant period are important. This paper aims to investigate effective preventive interventions focusing onto the prevention and the lifestyle of the children's obesity based on the research documents. The results are obtained ; 1. To prevent childhood obesity, primary preventive interventions from early childhood are necessary and effective. 2. At school age, it is important not only to continue primary preventive interventions but also to apply the secondary preventive interventions according to the children's developmental stage and their needs with the consideration of privacy. Especially, the motivation within children is indispensable. 3. In order to actualize effective interventions, the following researches are necessary ; 1). The evaluation research on preventive activities that aim at the improvement of lifestyle related to obesity 2). Longitudinal studies of both process and outcome analysis upon interventions 3). The research focusing on the changes in the perceptions and behaviors from both obese children's and their parents' perspectives
著者
山本 歩 Ayumu Yamamoto
雑誌
日本文藝研究 (ISSN:02869136)
巻号頁・発行日
vol.68, no.特別号, pp.187-205, 2017-03-10 (Released:2017-12-16)
著者
Yuichi KAWAMOTO Hiroki NISHIYAMA Nei KATO Naoko YOSHIMURA Shinichi YAMAMOTO
出版者
The Institute of Electronics, Information and Communication Engineers
雑誌
IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)
巻号頁・発行日
vol.E97-D, no.10, pp.2568-2575, 2014-10-01

The recent development of communication devices and wireless network technologies continues to advance the new era of the Internet and telecommunications. The various “things”, which include not only communication devices but also every other physical object on the planet, are also going to be connected to the Internet, and controlled through wireless networks. This concept, which is referred to as the “Internet of Things (IoT)”, has attracted much attention from many researchers in recent years. The concept of IoT can be associated with multiple research areas such as body area networks, Device-to-Device (D2D) communications networks, home area networks, Unmanned Aerial Vehicle (UAV) networks, satellite networks, and so forth. Also, there are various kinds of applications created by using IoT technologies. Thus, the concept of the IoT is expected to be integrated into our society and support our daily life in the near future. In this paper, we introduce different classifications of IoT with examples of utilizing IoT technologies. In addition, as an example of a practical system using IoT, a tsunami detection system (which is composed of a satellite, sensor terminals, and an active monitoring system for real-time simultaneous utilization of the devices) is introduced. Furthermore, the requirements of the next generation systems with the IoT are delineated in the paper.
著者
Kazushige Goto Kazumasa Takahashi Masato Yamamoto Kaoru Takamatsu
出版者
PHYSIOLOGICAL SOCIETY OF JAPAN
雑誌
The Journal of Physiological Sciences (ISSN:18806546)
巻号頁・発行日
vol.58, no.1, pp.7-14, 2008 (Released:2008-02-23)
参考文献数
33
被引用文献数
22 34

This study examined acute hormone and recovery responses to resistance exercise with slow movements. Six men performed three types of exercise regimens (five sets of knee extension exercise): (1) high-intensity resistance exercise with normal movement (HN; 1 s for lifting action, 1 s for lowering action), (2) low-intensity resistance exercise with slow movement (LS; 3 s for lifting action, 3 s for lowering action), and (3) low-intensity resistance exercise with normal movement (LN; 1 s for lifting action, 1 s for lowering action). The intensity in the first set was set at approximately 80% of 1RM for HN and 40% of 1RM for LS and LN. In the HN and LS, the subjects performed each exercise set until exhaustion. In the LN, both intensity and number of repetitions were matched with those for LS. The total work volume in the HN showed approximately double the value of LS and LN (P < 0.05). Electromyography (EMG) data indicated that LS showed sustained EMG signals throughout the exercise. During the exercise, the HN and LS showed lower muscle oxygenation levels. After the exercise, LS caused significantly greater norepinephrine and free testosterone responses (delta value) than in the HN and LN (P < 0.05). However, no significant difference was observed in the recovery of maximal isometric strength, isokinetic strength, and jump performance between the HN and LS. These results indicate that slow movements during the resistance exercise are important for the enhancement of hormonal responses, especially catecholamine and free testosterone, but they do not affect muscle strength recovery.
著者
Shinichi HATAMA Kenji MURAKAMI Shinji YAMAMOTO Koichi KADOTA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.80, no.10, pp.1544-1548, 2018 (Released:2018-11-01)
参考文献数
29

An 8-month-old male Japanese Black calf was referred for the evaluation of a slow-growing conjunctival mass in the right eye. A superficial keratectomy was performed followed by recurrence on two occasions. No metastases were found in surrounding tissues. Histological, immunohistochemical, and ultrastructural investigation revealed that both the primary and the recurrent lesions were benign, conjunctival, myofibroblastomas. Interestingly, bovine papillomavirus type 2 (BPV-2) DNA was detected in both myofibroblastoma lesions. Archival bovine myofibroblastomas from the vulva and neck were also analyzed for papillomaviral genomes. BPV-2 DNA was also amplified from these lesions. To the best of our knowledge, this is the first report describing a potential causal relationship between BPV-2 infection and conjunctival myofibroblastoma.
著者
湯浅 学 Umetani Masafumi Yamamoto Nawo DAS M. K.
出版者
近畿大学
雑誌
理工学総合研究所研究報告 (ISSN:09162054)
巻号頁・発行日
vol.17, pp.1-7, 2005-02-28

It happens frequently that the observational data is not complete but missing partly by various reasons. A preliminary study for supplementing adjusted values to such imperfect data based on Principal Component Analysis (PCA) is executed. IRAS 3 colors of mass-losing stars and their expanding velocity on the ground based observations are adopted for the experiment. One of these 4 data is eliminated for each star and the adjusted value is restored. The original data and the restored one are compared and the distribution of the restored errors is studied.本文データの一部は、CiNiiから複製したものである。
著者
Kanae Sasaki Ryota Komori Mai Taniguchi Akie Shimaoka Sachiko Midori Mayu Yamamoto Chiho Okuda Ryuya Tanaka Miyu Sakamoto Sadao Wakabayashi Hiderou Yoshida
出版者
Japan Society for Cell Biology
雑誌
Cell Structure and Function (ISSN:03867196)
巻号頁・発行日
pp.18031, (Released:2018-11-28)
被引用文献数
15

The Golgi stress response is a homeostatic mechanism that augments the functional capacity of the Golgi apparatus when Golgi function becomes insufficient (Golgi stress). Three response pathways of the Golgi stress response have been identified in mammalian cells, the TFE3, HSP47 and CREB3 pathways, which augment the capacity of specific Golgi functions such as N-glycosylation, anti-apoptotic activity and pro-apoptotic activity, respectively. On the contrary, glycosylation of proteoglycans (PGs) is another important function of the Golgi, although the response pathway upregulating expression of glycosylation enzymes for PGs in response to Golgi stress remains unknown. Here, we found that expression of glycosylation enzymes for PGs was induced upon insufficiency of PG glycosylation capacity in the Golgi (PG-Golgi stress), and that transcriptional induction of genes encoding glycosylation enzymes for PGs was independent of the known Golgi stress response pathways and ER stress response. Promoter analyses of genes encoding these glycosylation enzymes revealed the novel enhancer elements PGSE-A and PGSE-B (the consensus sequences are CCGGGGCGGGGCG and TTTTACAATTGGTC, respectively), which regulates their transcriptional induction upon PG-Golgi stress. From these observations, the response pathway we discovered is a novel Golgi stress response pathway, which we have named the PG pathway. Key words: Golgi stress, proteoglycan, ER stress, organelle zone, organelle autoregulation
著者
大谷 哲弘 山本 奬 OHTANI Tetsuhiro YAMAMOTO Susumu
出版者
岩手大学大学院教育学研究科
雑誌
岩手大学大学院教育学研究科研究年報 = Research Journal of the Iwate University Professional School for Teacher Education (ISSN:2432924X)
巻号頁・発行日
vol.2, pp.85-94, 2018-03-30

本研究は,いじめ発見に資する観点に裏づけされた具体的ないじめの予兆を収集することを目的に行われた。大学生62人に対して,自由記述により,教師には見えにくい,わかりにくいいじめ発見のポイントについて回答を求めた。その結果,325項目が収集された。重複する項目を整理したところ128項目になった。内容分析を行い,いじめの態様として「能動的攻撃」「使役」「忌避」「受動的攻撃」「ストレス反応や失敗している対処およびその結果」にまとめることができた。次にこれらの態様の軸に発見の機会となる場面や学校生活上の注目すべき要点の軸を加えて2 軸でとらえ分類した。収集した項目は,従来の視点では見られなかった具体的な項目が収集できた。
著者
大谷 哲弘 山本 奬 OHTANI Tetsuhiro YAMAMOTO Susumu
出版者
岩手大学大学院教育学研究科
雑誌
岩手大学大学院教育学研究科研究年報 = Research Journal of the Iwate University Professional School for Teacher Education (ISSN:2432924X)
巻号頁・発行日
vol.2, pp.85-94, 2018-03-30

本研究は,いじめ発見に資する観点に裏づけされた具体的ないじめの予兆を収集することを目的に行われた。大学生62人に対して,自由記述により,教師には見えにくい,わかりにくいいじめ発見のポイントについて回答を求めた。その結果,325項目が収集された。重複する項目を整理したところ128項目になった。内容分析を行い,いじめの態様として「能動的攻撃」「使役」「忌避」「受動的攻撃」「ストレス反応や失敗している対処およびその結果」にまとめることができた。次にこれらの態様の軸に発見の機会となる場面や学校生活上の注目すべき要点の軸を加えて2 軸でとらえ分類した。収集した項目は,従来の視点では見られなかった具体的な項目が収集できた。
著者
Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Tomomi Ohishi Naoko Okino Toshihito Kitamura Weinong Guo
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.82, no.10, pp.2575-2583, 2018-09-25 (Released:2018-09-25)
参考文献数
17
被引用文献数
1 15

Background: The objective of the present analyses was to describe the baseline characteristics and treatment of the Japanese patients with HFrEF in THE PARALLEL-HF study. Methods and Results: Key demographic, clinical and laboratory findings, along with treatment, were reported and compared with patients enrolled in the PARADIGM-HF trial and other contemporary randomized clinical trials and registries of Japanese patients with HFrEF. In addition, the MAGGIC and EMPHASIS-HF risk scores were calculated. A total of 225 Japanese patients were randomized in PARALLEL-HF with a mean age of 67.9 years and the majority of the patients being male (85.8%) and in NYHA Class II (93.8%). Key baseline characteristics in PARALLEL-HF were generally comparable with PARADIGM-HF, and other contemporary clinical trials and registries of Japanese HFrEF patients. Patients enrolled in PARALLEL-HF were well treated with conventional evidence-based therapy at baseline (angiotensin-converting enzyme inhibitor inhibitor/angiotensin receptor blocker, 62.7%/37.3%; β-blockers, 94.7%; mineralocorticoid receptor antagonist, 59.1%). Despite the evidence-based treatment and most patients being in NYHA Class II, these patients had a low LVEF (mean 28.1%) and were at high risk of cardiovascular mortality and morbidity as assessed by the MAGGIC and EMPHASIS-HF risk scores. Conclusions: Overall, the patients in PARALLEL-HF were largely representative of contemporary ambulatory patients with HFrEF who are well treated with evidence-based therapies. PARALLEL-HF will determine whether sacubitril/valsartan provides similar improvements in clinical outcomes in Japanese HFrEF patients as observed in the PARADIGM-HF study.