著者

Hitoshi Hamamura Hisashi Adachi Mika Enomoto Ako Fukami Sachiko Nakamura Yume Nohara Nagisa Morikawa Akiko Sakaue Kenta Toyomasu Maki Yamamoto Yoshihiro Fukumoto

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.56390, (Released:2020-07-04)

参考文献数

38

被引用文献数

16

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Aim: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as an important regulator of low-density lipoprotein (LDL) receptor processing. Evolocumab and alirocumab are PCSK9 inhibitors; however, little is known about the association between PCSK9 levels and lipid profiles in a general population. Because PCSK9 inhibitors have LDL-C lowering effects, we investigated whether there is a positive correlation between serum PCSK9 levels and LDL-C or lipoprotein(a) [Lp(a)]. Methods: In Uku town, 674 residents (mean age; 69.2±8.3 years) received health check-ups. The participants underwent a physical examination and blood tests, including PCSK9 and Lp(a). Serum PCSK9 and Lp(a) were measured by ELISA and Latex methods, respectively. HOMA-IR was calculated by fasting plasma glucose×insulin levels/405. Results: The mean (range) of PCSK9 and Lp(a) were 211.2 (49-601) ng/mL and 60 (1-107) mg/dL, respectively. Because of a skewed distribution, the log-transformed values were used. With univariate linear regression analysis, PCSK9 levels were associated with Lp(a) (p=0.028), triglycerides (p<0.001), and HOMA-IR (p<0.001), but not with LDL-C (p=0.138) levels. Multiple stepwise regression analysis revealed that serum PCSK9 levels were independently associated with triglycerides (p<0.001), Lp(a) (p=0.033) and HOMA-IR (p=0.041). Conclusions: PCSK-9 is independently associated with triglycerides, Lp(a) levels, and HOMA-IR, but not LDL-C, in a relatively large general population sample.

著者

歴史学研究会編

出版者

青木書店

巻号頁・発行日

2003

著者

池 晃弘 大瀬 尚子 新谷 康 奥村 明之進

出版者

特定非営利活動法人 日本呼吸器外科学会

雑誌

日本呼吸器外科学会雑誌 (ISSN:09190945)

巻号頁・発行日

vol.33, no.1, pp.74-79, 2019-01-15 (Released:2019-01-15)

参考文献数

15

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排卵期に発症した月経随伴性気胸の症例を報告する.症例は40歳女性.39歳時,月経の3日前に右胸痛と呼吸困難感が出現した.右気胸の診断で胸腔ドレナージを施行されたが,気漏が遷延し,前医で胸腔鏡下右上葉部分切除術を施行された.術中,横隔膜に菲薄化病変を認め,ポリグリコール酸シートを貼付された.その4ヵ月後,月経終了後約10日目の排卵期に右気胸が再発し,胸膜癒着術を施行された.しかし,その2ヵ月後の排卵期に右気胸の再々発を認め,当院で再手術を行った.横隔膜腱中心に網目状の多数の小孔を認め,腹腔と交通し肝臓を視認できた.横隔膜病変を切除後縫縮し,酸化セルロースシートで横隔膜及び全肺胸膜を被覆した.病理組織学的に横隔膜内に子宮内膜様間質組織を認め,異所性子宮内膜症と診断した.排卵期に繰り返し発症した本症例は,月経周期に依存しない異所性子宮内膜症の存在を示唆する1例である.

著者

紫式部 著

出版者

中央公論社

巻号頁・発行日

vol.巻四, 1942

著者

川野 佐江子 カワノ サエコ Saeko KAWANO

雑誌

大阪樟蔭女子大学研究紀要

巻号頁・発行日

vol.1, pp.197-205, 2011-01-31

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本論は、プロレスラーの身体を題材にして「男性身体」という概念をいかに捉えたらよいのか、という問いを検討していく研究ノートである。「男性身体」は、「近代パラダイム」あるいは「覇権的なものの可視化されたフォルム(姿)」という位置づけで捉えられる。 まず、プロレスラーの身体がいかに「男性身体」を表象しているかについて検討する。つまりレスラーの身体がいかに「理性」に訴求するように身体加工されているのかということに着目する。次にプロレスとは、二項対立構造や権威的ヒエラルキー制度の中で展開されているのだということを指摘する。続いて、プロレスのスペクタクル性について指摘し、「男性身体」との関係を述べる。最後にレスラーのアイデンティティについて触れ、それが「男性身体」を変容させる可能性をもつという仮説を立てて本論は閉じられる。

出版者

世渡谷文吉

巻号頁・発行日

vol.明治10年4月改, 1877

著者

Haruka SHOZAKI-ITO Mayumi OHNISHI Tomoko SHIBAYAMA Yumi MATSUYAMA Rieko NAKAO Kanako MORIFUJI

出版者

The Japanese Society of Health and Human Ecology

雑誌

日本健康学会誌 (ISSN:24326712)

巻号頁・発行日

vol.86, no.3, pp.111-120, 2020-05-31 (Released:2020-06-25)

参考文献数

27

被引用文献数

2

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親密なパートナーからの暴力は,社会的,経済的,宗教的あるいは文化的背景に関わらず,公衆衛生上の健康課題となっている.日本においても,他の諸国と比較して低い状況とはいえ,親密なパートナーからの暴力が発生している.本研究では,大学1年生に対して,交際相手からのデートDV被害を受けた経験とその後の援助希求行動について,25の被害経験シナリオを含む無記名自記式質問票を用いて横断研究を行った.371人から回答を得た.男子148人(60.2%)および女子81人(64.8%)が,交際経験があると回答した(χ2=0.754, df=1, p=0.385).交際経験がある学生中,男子69人(46.6%)および女子49人(60.5%)が,何らかのデートDV被害を受けており,女子の方が統計的有意にデートDV被害を経験していた(χ2=4.033, df=1, p=0.045).最も回答が多かった被害経験は,「交際相手から『ブス/ブサイク』や『バカ』などと言われたことがある」であり,男子24人(16.2%)および女子26人(31.2%)であった.デートDV被害後,援助希求行動について回答した115人中,19人(16.5%)が相談していたが,相談先としては,19人全員が「友人」,4人が「母親」と回答した.専門職・機関に相談した者はいなかった.自分の意志に反したキスあるいはセックスといった性行為の経験があると回答した11人のうち,誰かに相談した者は4人,またその後交際を解消した者は4人であった.デートDVの予防や早期に適切な相手・機関への援助希求行動を促進するための介入プログラムを講じる際には,性別や文化的要素について考慮する必要性が示唆された.

著者

Koki Ogawa Naoya Kato Shigeru Kawakami

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.68, no.7, pp.567-582, 2020-07-01 (Released:2020-07-01)

参考文献数

187

被引用文献数

17

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Because the brain is the most important human organ, many brain disorders can cause severe symptoms. For example, glioma, one type of brain tumor, is progressive and lethal, while neurodegenerative diseases cause severe disability. Nevertheless, medical treatment for brain diseases remains unsatisfactory, and therefore innovative therapies are desired. However, the development of therapies to treat some cerebral diseases is difficult because the blood–brain barrier (BBB) or blood–brain tumor barrier prevents drugs from entering the brain. Hence, drug delivery system (DDS) strategies are required to deliver therapeutic agents to the brain. Recently, brain-targeted DDS have been developed, which increases the quality of therapy for cerebral disorders. This review gives an overview of recent brain-targeting DDS strategies. First, it describes strategies to cross the BBB. This includes BBB-crossing ligand modification or temporal BBB permeabilization. Strategies to avoid the BBB using local administration are also summarized. Intrabrain drug distribution is a crucial factor that directly determines the therapeutic effect, and thus it is important to evaluate drug distribution using optimal methods. We introduce some methods for evaluating drug distribution in the brain. Finally, applications of brain-targeted DDS for the treatment of brain tumors, Alzheimer’s disease, Parkinson’s disease, and stroke are explained.

著者

明宋應星撰

出版者

河内屋茂八等刊

巻号頁・発行日

vol.[1], 1771

著者

佐藤 幸子 渡邉 菜月 浜守 杏奈 松岡 康浩

出版者

実践女子大学

雑誌

実践女子大学生活科学部紀要 = Bulletin of Jissen Women's University Faculty of Human Life Sciences (ISSN:24336645)

巻号頁・発行日

no.56, pp.9-22, 2019-03-09

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The principle of cosmic dualism (yin and yang) and the Five Elements (Wu-Xing), based on the philosophy of "food as medicine," serve as the basis of Korean food culture. Korean cuisine features rice, soup, and kimchi along with various side dishes. As soup is treated as one of its main dishes, Korean daily meals generally contain more water than Japanese cuisine. Earlier, traditional tea culture in Korea was enjoyed only by people of specific privileged classes, and consequently, the tea-drinking custom faded during the Joseon dynasty. Currently, "traditional tea, " made from ingredients including wild herbs, fruits, and grains used in Chinese medicine , is widely accepted in the everyday lives of Korean people. This traditional tea is made by blending and brewing ingredients such as fruits, flowers, grains, and leaves used in traditional medicine, and is based on the philosophy of "food as medicine." It is then mixed with, for example, honey to make it drinkable. Thus, many varieties of traditional tea are available. The results of a survey revealed that the reasons for drinking traditional tea vary from those related to health, such as cold prevention, fever suppression, and recovery from fatigue, to taking "coffee breaks." From this, it was inferred that traditional tea in Korea is used in everyday lives by people with hopes to advance their health based on the claimed functions of its ingredients.

著者

三ツ井 紀子

出版者

社団法人 繊維学会

雑誌

繊維学会誌 (ISSN:00379875)

巻号頁・発行日

vol.65, no.5, pp.P_166-P_170, 2009-05-10 (Released:2009-06-10)

被引用文献数

1 1

著者

船水 尚行 大仲 孝昌 高桑 哲男

出版者

Japan Society of Civil Engineers

雑誌

環境工学研究論文集 (ISSN:13415115)

巻号頁・発行日

vol.37, pp.345-354, 2000-11-13 (Released:2011-06-27)

参考文献数

8

被引用文献数

1

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The lab-scale experiments were performed to study suspended growth of heterotrophic bacteria and decay process of free and combined chlorine in reclaimed water. It was found that suspended growth of bacteria was suppressed by combined chlorine and that the rapid growth began after combined chlorine had been consumed completely. It was also found that the initial dose of the chlorine could delay their growth, but could not control the maximum count of bacteria. Decay process of free chlorine was described by the simple first-order reaction. To simulate disappearance of combined chlorine, two steps model of first-order reaction was required. The values of rate constants for the first-order reactions depended on the initial chlorine concentration. The simple model for simulating bacteria growth was developed with aid of the activated sludge model No.2 and data from experiments without chlorine dose. It was found that the simple model was also applicable to the experimental results with chlorine dose.

著者

立岡 弓子

出版者

一般社団法人 日本女性心身医学会

雑誌

女性心身医学 (ISSN:13452894)

巻号頁・発行日

vol.21, no.3, pp.282-284, 2016 (Released:2017-04-13)

参考文献数

2

著者

Yoshimasa Takeuchi Mika Furuchi Atsushi Kamimoto Kazuya Honda Hideo Matsumura Ryutaro Kobayashi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.3, pp.350-351, 2020 (Released:2020-06-23)

参考文献数

6

被引用文献数

34

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The outbreak of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Nasopharyngeal swabs are widely used in polymerase chain reaction (PCR) test to detect SARS-CoV-2. However, the collection of nasopharyngeal swabs has a series of drawbacks concerning exposure of healthcare staff, difficulty in collection, and discomfort of patients. Therefore, an alternative noninvasive sample for diagnostic of emerging viral diseases is required. The usefulness of saliva screening tests is compared to conventional swab tests in this report. The results suggest that saliva could be a reliable sample for detecting SARS-CoV-2.

著者

山崎 基嘉 瓜生 恵理子 嘉悦 佳子 瓦谷 光男 根来 淳一 西田 真子

出版者

大阪府環境農林水産総合研究所

巻号頁・発行日

no.2, pp.29-31, 2009 (Released:2013-10-08)

著者

Atsuko Hotta Yasuki Uchida Yasuhiro Namura Mizuki Inaba Mitsuru Motoyoshi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.3, pp.318-321, 2020 (Released:2020-06-23)

参考文献数

30

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This study used finite element (FE) analysis to investigate the stability of miniscrews (screws) placed at the median palate. FE models with variable suture maturity and screw-suture distances were used to examine the relationship with screw stability. Four groups were classified by extent of maturation of the midpalatal suture (0%, 60%, 75%, and 100%). The placement position was set at the center of the suture (0.0 mm), or 0.5, 1.0, and 1.5 mm to the side of the suture, and von Mises stress values in bone and screw displacement were compared among models. The stress value for the unsutured model, in which the screw was placed at the center of the suture, was greater than 30 MPa. Stress values for models in which screws were placed to the side (0.5-1.5 mm) were less than 28 MPa. Maximum screw displacement was greater in the 0.0-mm incomplete suture model than at other placement positions. Because bone conditions vary among patients, placement position and suture maturation should be examined on cone beam-computed tomography images, to ensure screw stability.

出版者

航空・鉄道事故調査委員会

巻号頁・発行日

2002

著者

小林 雄志

出版者

教育システム情報学会

雑誌

教育システム情報学会誌 (ISSN:13414135)

巻号頁・発行日

vol.37, no.3, pp.198-205, 2020-07-01 (Released:2020-07-01)

参考文献数

31

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Since the 1991 amendment of the Standards for the Establishment of Universities, physical education (PE) courses in the liberal arts program have been reduced or abolished in several universities. However, the Japanese Association of University Physical Education and Sports (JAUPES) and some universities have continued efforts for the survival of PE. In these activities, many workshops and studies for faculty development (FD) have been implemented. Besides, several classes in PE have been improved. In this paper, we will outline these trends in the FD for PE.

著者

後藤 満津子 藤原 理恵子 松脇 喜久美 中井 芙美子 村木 士郎

出版者

日本精神保健看護学会

雑誌

日本精神保健看護学会誌 (ISSN:09180621)

巻号頁・発行日

vol.29, no.1, pp.97-105, 2020-06-30 (Released:2020-06-30)

参考文献数

19

著者

松本市美術館編集

出版者

松本市美術館

巻号頁・発行日

2002