出版者

京都大学化学研究所

雑誌

黄檗

巻号頁・発行日

vol.38, 2013-02

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<特集>若手研究者が語る : 化研らしい融合的・開拓的研究 (若手研究者座談会)吾郷友宏, 正井博和, 川本純, 福島達也, TEX David, 佐藤直樹, 増渕 雄一 [1-3]<ICR NEWS>化研らしい融合的・開拓的研究 [4]共同利用・共同研究拠点 2012年活動報告 [5]<研究ハイライト>ラマン分光法が見せる奥深さ長谷川健 [6]<研究ハイライト>癌に集積する「有機化合物でくるんだ」酸化ガドリニウムナノ粒子 : 患者に負担をかけない癌の検出法を目指して年光昭夫 [7]<研究トピックス JSTさきがけプロジェクト>新しい人工光合成系を目指したナノ粒子超構造の構築坂本雅典 [8]<研究トピックス 研究ルポ>中性子の加速を自在に制御する手法を開発、実証岩下芳久 [8]新任教員紹介 [9]報道記録2012 [9]化学研究所のアウトリーチ活動 [10]<碧水会便り>定期役員会・涼飲会・所内ミニツアー・涼風ミニコンサートを開催 [10-11]<碧水会便り>会員のひろば浅川直幸, 岩田善次, Shanfeng Zhu [11-12]<碧水会便り>第3回 京都大学風景写真コンテスト [12]掲示板 [13-18]<化研点描>ビームとともに歩んで野田章 [裏表紙]

著者

吉村 哲彦 酒井 徹朗

出版者

森林利用学会

雑誌

森林利用学会誌 (ISSN:13423134)

巻号頁・発行日

vol.13, no.3, pp.193-200, 1998-12-15

被引用文献数

5

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林道は公道の整備が十分でない山間部において木材輸送だけでなく交通網の一部としての役割を担っている。本研究では,効率のよいネットワーク形成を目的として,紀伊半島中央部の熊野川流域6村を対象に,ネットワーク分析を用いて林道を含めた道路網の評価を行った。アルファ指数を用いて評価を行った結果,道路の規格が下がるにつれて,この地域の道路網は循環型ではなく突っ込み型の線形が増加することが示された。ベータ指数の値は,わずかに1以上であり,いくつかの地点で代替経路が存在していたが,土砂崩れなどにより道路が遮断された場合に適当な代替経路を探すのは困難である。イータ指数の値も,道路の規格が下がるにつれて減少傾向を示し,市町村道のレベルでネットワークの細分化が進んでいることがわかった。Croftonの公式によりネットワークの連結性を評価した結果,下北山村と野迫川村,下北山村と大塔村の連結性が最も低く,次いで十津川村と天川村,大塔村と天川村の連結性が低いことが示された。逆に道路の連結性が最も高いのは天川村と野迫川村の間であった。このような連結性の低い区間には,既存道路の改良も含めた峰越し連絡道路の整備が必要である。

出版者

土佐文庫発行所

巻号頁・発行日

vol.第1輯 第6号, 1916

著者

Yudai Nonaka Tetsuo Takagi Makoto Inai Shuhei Nishimura Shogo Urashima Kazumitsu Honda Toshiaki Aoyama Shin Terada

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

pp.ess16069, (Released:2016-07-15)

被引用文献数

34

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Coconut oil has recently attracted considerable attention as a potential Alzheimer’s disease therapy because it contains large amounts of medium-chain fatty acids (MCFAs) and its consumption is thought to stimulate hepatic ketogenesis, supplying an alternative energy source for brains with impaired glucose metabolism. In this study, we first reevaluated the responses of plasma ketone bodies to oral administration of coconut oil to rats. We found that the coconut oil-induced increase in plasma ketone body concentration was negligible and did not significantly differ from that observed after high-oleic sunflower oil administration. In contrast, the administration of coconut oil substantially increased the plasma free fatty acid concentration and lauric acid content, which is the major MCFA in coconut oil. Next, to elucidate whether lauric acid can activate ketogenesis in astrocytes with the capacity to generate ketone bodies from fatty acids, we treated the KT-5 astrocyte cell line with 50 and 100 μM lauric acid for 4 h. The lauric acid treatments increased the total ketone body concentration in the cell culture supernatant to a greater extent than oleic acid, suggesting that lauric acid can directly and potently activate ketogenesis in KT-5 astrocytes. These results suggest that coconut oil intake may improve brain health by directly activating ketogenesis in astrocytes and thereby by providing fuel to neighboring neurons.

著者

田崎 勝也 申 知元

出版者

青山学院大学国際研究センター

雑誌

Aoyama journal of international studies (ISSN:21881960)

巻号頁・発行日

no.2, pp.103-121, 2015

著者

伊達竜城 著

出版者

明治図書出版協会

巻号頁・発行日

1932

著者

原口 卓 松下 春奈 西尾 芳文

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. NLP, 非線形問題 (ISSN:09135685)

巻号頁・発行日

vol.108, no.174, pp.5-10, 2008-07-24

被引用文献数

1

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自己組織化マップ(Self-Organizing Map:SOM)はKohonen氏によって提案された教師なしニューラルネットワークであり,近年クラスタリングへの応用として注目されている.過去の研究で,SOMの学習率係数が更新回数に依存するのに対し,ニューロンの性格にのみ依存する学習率係数を持つLazy Self-Organizing Map (LSOM)を提案した.さらに,そのLSOMの振る舞いを調査することで,SOMよりも入力データの分布状態をより反映したマップを取得できる反面,ねじれが生じやすいという傾向を確認した.そこで本研究では,学習率係数がニューロンの性格,怠け者の割合に依存し,さらに更新回数に従って減少する新しいLazy Self-Organizing Mapを提案する.そして,改良版LSOMの怠けニューロンの割合を変えて,様々な入力データに適用しその振る舞いと有効性を確認する.

著者

北原 斗紀彦 Tokihiko KITAHARA 日本マス・コミュニケーション学会

出版者

尚美学園大学総合政策学部総合政策学会

雑誌

尚美学園大学総合政策論集 = Shobi journal of policy studies, Shobi University (ISSN:13497049)

巻号頁・発行日

vol.14, pp.43-65, 2012-06-30

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日本の稼動可能な原発50基は全国13道県に立地しており、そこでは県紙とブロック紙計17紙が発行されている。これら原発立地県の地方紙は、東日本大震災によって東京電力福島第一原子力発電所で起きた事故や、地元の原発についてどのように報道してきたか、3.11後の1年余にわたる社説を分析した。その結果、(1)脱原発の明確な主張を掲げる新聞は少数派であり、半面、原発維持の積極的主張を掲げる新聞はない、(2)各紙が一致して最も強調しているのは地元の原発の徹底的な安全確保であり、事故後、政府が打ち出した安全対策に厳しい批判の眼を向けている、(3)地元に原発が存在することへの強い不安とともに、原発が地元自治体にもたらしてきた各種交付金や雇用なしに地域住民の生活が成り立つのか不安を表明している-ことが分かった。これは原発が「よそごと」「他人ごと」でなく、足元に原発が存在することによっていやおうなく「当事者」の立場に立たされる地方紙の特性の表れであり、それが原発是非論への新たなアプローチの視点を提供する可能性を指摘した。Japan has 50 nuclear power plants workable in 13 prefectures, where 17 regionalnewspapers publish. The purpose of this essay is learning how the unique experience oflocal residents living in proximity to nuclear power plants is reflected in the viewpointsof these regional newspapers. By analyzing editorials which refer to Fukushima nuclearaccident and their local nuclear power plants, published after 3.11 for more than oneyear, those points as follows come to appear. (1)The number of newspaper that advocatesreducing reliance on nuclear power is a few. On the other hand, opinions that promotenuclear power, are hard to be found out in those newspapers. (2)All of those newspapersput maximum stress on the necessity to keep safety of their local nuclear power plants,and are very critical to the governmental measures taken after 3.11 to ensure safety. (3)Those papers express strong anxiety to the existence of nuclear power plants, and at thesame time are skeptical of the possibility for residents to earn a livelihood without plants,they depend on economically.

著者

Saejong YOO Jiyong KIM Hyun-Wook MYUNG Suhan WOO Dai-Jung CHUNG A-Jin LEE Han-Jun KIM Sun-Hee DO Hwi-Yool KIM

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0186, (Released:2016-10-15)

被引用文献数

4

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A 12-year-old, spayed female Schnauzer presented with constipation. A mass was observed in the pelvic cavity, and metastasis was not identified. Mass resection was performed through celiotomy with pubic osteotomy, and hemangiosarcoma was diagnosed. At 10 weeks post-operatively, the patient died of multiple metastasis. Primary intrapelvic hemangiosarcoma is rare in dogs.

著者

Takashi Yazawa Yoshitaka Imamichi Kaoru Miyamoto Md. Rafiqul Islam Khan Junsuke Uwada Akihiro Umezawa Takanobu Taniguchi

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ16-0373, (Released:2016-09-29)

被引用文献数

11

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Steroid hormones are mainly produced in adrenal glands and gonads. Because steroid hormones play vital roles in various physiological processes, replacement of deficient steroid hormones by hormone replacement therapy (HRT) is necessary for patients with adrenal and gonadal failure. In addition to HRT, tissue regeneration using stem cells is predicted to provide novel therapy. Among various stem cell types, mesenchymal stem cells can be differentiated into steroidogenic cells following ectopic expression of nuclear receptor (NR) 5A subfamily proteins, steroidogenic factor-1 (also known as adrenal 4 binding protein) and liver receptor homolog-1, with the aid of cAMP signaling. Conversely, these approaches cannot be applied to pluripotent stem cells, such as embryonic stem cells and induced pluripotent stem cells, because of poor survival following cytotoxic expression of NR5A subfamily proteins. However, if pluripotent stem cells are first differentiated through mesenchymal lineage, they can also be differentiated into steroidogenic cells via NR5A subfamily protein expression. This approach offers a potential suitable cells for future regenerative medicine and gene therapy for diseases caused by steroidogenesis deficiencies. It represents a powerful tool to investigate the molecular mechanisms involved in steroidogenesis. This article highlights our own and current research on the induction of steroidogenic cells from various stem cells. We also discuss the future direction of their clinical application.

著者

末次 浩詩 本谷 高寛 小久保 欣哉

出版者

日本リアルオプション学会

雑誌

リアルオプション研究 (ISSN:18815774)

巻号頁・発行日

vol.6, no.1, pp.17-29, 2013-02-20 (Released:2013-02-26)

参考文献数

12

被引用文献数

1

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We devised a business portfolio design framework for pharmaceutical development projects. In general, pharmaceutical development projects have a high option value because there’s much technological uncertainty and development period is long. First of all, we built one project evaluation model using binomial lattice model to calculate the probability of NPV including abandonment option. Second, we built the business portfolio design model to evaluate the risk and required investment. We used the probability of NPV as input, and set the number of pipelines in each development phase as variables. We clarified the effect of scale that the more the number of pipelines in each phase, the less likely the probability of negative NPV would be. In the assumption we built about the virtual pharmaceutical development project, 15 pipelines are required to reduce the probability of negative NPV in phase III to 8%, which means that it’s required to invest 45 billion yen per year for phase III.

著者

今西 靖治 イマニシ ノブハル Imanishi Nobuharu

出版者

大阪大学大学院国際公共政策研究科

雑誌

国際公共政策研究 (ISSN:13428101)

巻号頁・発行日

vol.19, no.1, pp.67-82, 2014-09

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Since the end of the Cold War, the United Nations has changed and developed its policies on peacekeeping operations. During this period, Japan has been committed to peacebuilding as one of its primary diplomatic policies and has played a role in Cambodia, Afghanistan, and Iraq, and more recently, it has made efforts in countries such as Haiti and South Sudan. This paper points out some challenges Japan faces in the field of peacebuilding as it aims for a more proactive contribution for international peace and security.

巻号頁・発行日

vol.一,

著者

高林 徹 本間 康文 武田 拓哉

出版者

一般社団法人映像情報メディア学会

雑誌

映像情報メディア学会技術報告 (ISSN:13426893)

巻号頁・発行日

vol.36, no.42, pp.7-10, 2012-10-11

被引用文献数

1

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赤坂サカス広場(TBSテレビ放送センター前広場)で実施した夏サカスイベントにおいて、コンテンツマネージメントシステムからIP回線で受けたサイネージ用コンテンツを他のサイネージ端末ヘエリア放送として配信するシステムの実施成果を報告する。このシステムは、通信とエリア放送を組み合わせて効率的にサイネージ用コンテンツを配信することができる。

著者

大嶋 孝之

出版者

公益社団法人日本生物工学会

雑誌

生物工学会誌 : seibutsu-kogaku kaishi (ISSN:09193758)

巻号頁・発行日

vol.81, no.9, 2003-09-25

著者

竹原 直道

出版者

日本歯科医史学会

雑誌

日本歯科医史学会会誌 (ISSN:02872919)

巻号頁・発行日

vol.29, no.4, pp.300-301, 2012-09-30

著者

飯坂 達也 松井 哲郎 福山 良和

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌B(電力・エネルギー部門誌) (ISSN:03854213)

巻号頁・発行日

vol.124, no.3, pp.347-354, 2004 (Released:2004-06-01)

参考文献数

22

被引用文献数

8 13

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This paper presents a daily peak load forecasting method using an analyzable structured neural network (ASNN) in order to explain forecasting reasons. In this paper, we propose a new training method for ASNN in order to explain forecasting reason more properly than the conventional training method. ASNN consists of two types of hidden units. One type of hidden units has connecting weights between the hidden units and only one group of related input units. Another one has connecting weights between the hidden units and all input units. The former type of hidden units allows to explain forecasting reasons. The latter type of hidden units ensures the forecasting performance. The proposed training method make the former type of hidden units train only independent relations between the input factors and output, and make the latter type of hidden units train only complicated interactions between input factors. The effectiveness of the proposed neural network is shown using actual daily peak load. ASNN trained by the proposed method can explain forecasting reasons more properly than ASNN trained by the conventional method. Moreover, the proposed neural network can forecast daily peak load more accurately than conventional neural network trained by the back propagation algorithm.

著者

高橋 基治

出版者

東洋英和女学院大学

雑誌

人文・社会科学論集 (ISSN:09157794)

巻号頁・発行日

vol.28, pp.33-56, 2011-03

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It has widely been believed that when it comes to learning a new language as asecond/foreign language,"the younger the better"is the rule that applies. On the otherhand, recent studies have demonstrated that although younger learners may have anadvantage in mastering native-like pronunciation, adults might actually learn second/foreign languages more easily and quickly than younger learners in such areas asvocabulary acquisition and syntax.The claim that an authentic pronunciation of a second/foreign language isunattainable after a certain age has been supported by certain kinds of evidence.However, at the same time, it is also true that there are, in actuality, some individualswho have acquired a native-like accent even after the so-called "critical period."With this conflicting evidence in mind, in this paper, I will discuss theprobability of obtaining native-like phonological performance by reviewing the existingempirical and theoretical literature on Second Language Acquisition, especially thatwhich focuses on the Critical Period Hypothesis and foreign accent. In addition, I willconsider the viability of direct phonological instruction as a subject in school basedon the information and insights gained through this review of key studies in the field.

巻号頁・発行日

2015-07-03

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世界のルールの作り方・使い方 第1回 : 食の安全と国際経済‐成長ホルモン・遺伝子組み換え食品の輸出入をめぐる攻防. 2015年7月3日(金). 北海道大学法学研究科附属高等法政教育研究センター、北海道大学附属図書館, 札幌市

著者

Yuki KINOSHITA Tetsuo YAMADA Surendra M. GUPTA Aya ISHIGAKI Masato INOUE

出版者

一般社団法人 日本機械学会

雑誌

Journal of Advanced Mechanical Design, Systems, and Manufacturing (ISSN:18813054)

巻号頁・発行日

vol.10, no.3, pp.JAMDSM0052-JAMDSM0052, 2016 (Released:2016-07-01)

参考文献数

22

被引用文献数

8

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For green supply chains, it is essential to disassemble and recycle end-of-life (EOL) assembled products for material circulation. In order to establish disassembly plants environmentally friendly and economical manner, a disassembly parts selection is often carried out. Each part has a different recycling rate and cost, and all parts have precedence relationships among disassembly tasks. Igarashi et al. (2014) [International Journal of Industrial Engineering and Management Systems, Vol.13, No.1, pp.52-66] proposed a disassembly parts selection method that is carried out in an environmentally friendly and economical manner with non-destructive or destructive disassembly with integer programming with ε constraint. However, calculated efforts are required to achieve optimum solutions for the ε constraint method. On the other hand, goal programming is well known as an effective way to solve multi-criteria decision-making problems. This study proposes a bi-objective disassembly parts selection with recycling rate and cost using goal programming, and analyzes multiple types of EOL assembled products and disassembly parts selection. First, an environmentally friendly and economical disassembly parts selection is addressed using a 3D-CAD and Recyclability Evaluation Method (REM) developed by Hitachi Ltd. Next, the environmentally friendly and economical disassembly parts selection is formulated with goal programming. Finally, a case study is quantitatively discussed by comparing different types of assembled products and goal programming parameters. It is demonstrated that the proposal method by goal programming in this study finds the same solutions with the lower number of numerical experiments as that with the ε constraint method.