著者

金子 浩之

出版者

立正大学考古学会

雑誌

考古学論究 (ISSN:09179747)

巻号頁・発行日

no.13, pp.57-66, 2010-12

著者

吉田 邦彦

出版者

北海道大学大学院法学研究科

雑誌

北大法学論集 (ISSN:03855953)

巻号頁・発行日

vol.72, no.1, pp.1-48, 2021-05-31

著者

Satoshi Yamamoto Kazuo Inui Yoshiaki Katano Hironao Miyoshi Kenji Notohara

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2022-012, (Released:2022-07-22)

参考文献数

23

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A 69-year-old woman suspected to have IgG4-related sclerosing cholangitis causing bile duct stenosis was transferred from another hospital after diarrhea, eosinophilia, and eosinophilic infiltration were detected and prednisolone was prescribed. Additional biliary imaging suggested primary sclerosing cholangitis, but the IgG4 level and inferior bile duct stenosis were alleviated by steroid therapy, suggesting IgG4-related sclerosing cholangitis. Therefore, prednisolone was continued. Bile duct biopsy findings suggesting adenocarcinoma led to a diagnosis of pancreatoduodenectomy. The latter specimen only displayed evidence of primary sclerosing cholangitis, and prednisolone was discontinued. Intractable cholangitis necessitated left hepatectomy, after which serum alkaline phosphatase levels increased and eosinophilic colitis recurred. The reintroduction of prednisolone effectively managed the diarrhea but only temporarily reversed the alkaline phosphatase elevation. When histologic sections from resection specimens were compared, the hepatectomy specimen exhibited greater eosinophil infiltration than the earlier pancreatoduodenectomy specimen, suggesting eosinophilic cholangiopathy superimposed on primary sclerosing cholangitis.

著者

栗原 聡 松尾 豊

出版者

一般社団法人 人工知能学会

雑誌

人工知能 (ISSN:21882266)

巻号頁・発行日

vol.29, no.2, pp.166, 2014-03-01 (Released:2020-09-29)

著者

Shoya Oyama Hiroshi Takahashi Hiroki Hayashi Shigehisa Koide Shigeru Nakai Kazuo Takahashi Daijo Inaguma Midori Hasegawa Junichi Ishii Yukio Yuzawa Naotake Tsuboi

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2022-004, (Released:2022-07-22)

参考文献数

28

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Objectives: Cardiovascular and renal diseases are closely related. Brain natriuretic peptide (BNP) and urinary albumin are established predictors for cardiac and renal morbidities, respectively. To date, no reports have investigated the combined predictive value of BNP and urinary albumin for long-term cardiovascular–renal events in patients with chronic kidney disease (CKD). The aim of this study was to investigate this theme.Methods: Four hundred eighty-three patients with CKD were enrolled into this study and followed-up for 10 years. The endpoint was cardiovascular–renal events.Results: During the median follow-up period of 109 months, 221 patients developed cardiovascular–renal events. Log-transformed BNP and urinary albumin were identified as independent predictors for cardiovascular–renal events, with a hazard ratio of 2.59 (95% confidence interval [CI], 1.81–3.72) and 2.27 (95% CI, 1.82–2.84) for BNP and urinary albumin, respectively. For the combined variables, the group with high BNP and urinary albumin had a markedly higher risk (12.41-times; 95% CI 5.23–29.42) of cardiovascular–renal events compared with that of the group with low BNP and urinary albumin. Adding both variables to a predictive model with basic risk factors improved the C-index (0.767, 0.728 to 0.814, p=0.009), net reclassification improvement (0.497, p<0.0001), and integrated discrimination improvement (0.071, p<0.0001) more than each of them alone.Conclusions: This is the first report to demonstrate that the combination of BNP and urinary albumin can stratify and improve the predictability of long-term cardiovascular–renal events in CKD patients.

著者

Yuki Higashimoto Masaru Ihira Yoshiki Kawamura Masato Inaba Kazuya Shirato Tadaki Suzuki Hideki Hasegawa Tsutomu Kageyama Yohei Doi Tadayoshi Hata Tetsushi Yoshikawa

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2022-003, (Released:2022-07-22)

参考文献数

38

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Objectives: To establish a point-of-care test for coronavirus disease 2019 (COVID-19), we developed a dry loop-mediated isothermal amplification (LAMP) method to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA.Methods: We carried out reverse transcription (RT)-LAMP using the Loopamp SARS-CoV-2 Detection kit (Eiken Chemical, Tokyo, Japan). The entire mixture, except for the primers, is dried and immobilized inside the tube lid.Results: To determine the specificity of the kit, 22 viruses associated with respiratory infections, including SARS-CoV-2, were tested. The sensitivity of this assay, determined by either a real-time turbidity assay or colorimetric change of the reaction mixture, as evaluated by the naked eye or under illumination with ultraviolet light, was 10 copies/reaction. No LAMP product was detected in reactions performed with RNA from any pathogens other than SARS-CoV-2. After completing an initial validation analysis, we analyzed 24 nasopharyngeal swab specimens collected from patients suspected to have COVID-19. Of the 24 samples, 19 (79.2%) were determined by real-time RT-PCR analysis as being positive for SARS-CoV-2 RNA. Using the Loopamp SARS-CoV-2 Detection kit, we detected SARS-CoV-2 RNA in 15 (62.5%) of the 24 samples. Thus, the sensitivity, specificity, positive predictive value, and negative predictive values of the Loopamp 2019-CoV-2 detection reagent kit were 78.9%, 100%, 100%, and 55.6%, respectively.Conclusions: The dry LAMP method for detecting SARS-CoV-2 RNA is fast and easy to use, and its reagents can be stored at 4°C, solving the cold chain problem; thus, it represents a promising tool for COVID-19 diagnosis in developing countries.

著者

岡島 義 金井 嘉宏 笹川 智子 金澤 潤一郎 秋田 久美 陳 峻要 坂野 雄二

出版者

一般社団法人 日本認知・行動療法学会

雑誌

行動療法研究 (ISSN:09106529)

巻号頁・発行日

vol.34, no.3, pp.297-309, 2008-09-30 (Released:2019-04-06)

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本研究の目的は、社会不安を測定するSocialPhobiaandAnxietyInventory(SPAI)の翻訳版を開発することであった。大学生431名を対象に自己記入式の調査を行い、探索的因子分析を行った。その結果、SPAI日本語版は原版と同様の2因子45項目で構成され、各因子を「社会恐怖」「広場恐怖」と命名した。各因子の内的整合性(α=.88〜.96)、および再検査法による信頼性(r=.67〜.72)は高かった。既存の社会不安測定尺度と相関は中程度であったため、高い併存的妥当性が認められた。また、「社会恐怖」下位尺度において、確認的因子分析を行ったところ、原版と同様の5因子構造であることが確認された。以上の結果から、SPAI日本語版は高い信頼性と妥当性を有することが明らかにされた。

著者

Yusuke Funato Yuki Higashimoto Yoshiki Kawamura Yoshiko Sakabe Minori Iwakura Masaru Ihira Kazuya Shiogama Masafumi Miyata Haruki Nishizawa Takao Sekiya Takuma Fujii Isao Kosugi Tetsushi Yoshikawa

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2022-001, (Released:2022-07-22)

参考文献数

28

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Objectives: Fetal human cytomegalovirus (HCMV) infection might be involved in fetal growth restriction (FGR). Maternal serostatus and the prevalence of congenital HCMV infection are affected by various factors, such as socioeconomic status and ethnicity. Therefore, the prevalence of congenital HCMV-related FGR should be examined in each region.Methods: Seventy-eight cases of FGR with delivery between January 2012 and January 2017 at Fujita Health University Hospital were studied. Twenty-one non-FGR cases were also included as a control group. Placental sections obtained from the FGR and control cases were immunostained with two primary antibodies for detecting immediate early antigens.Results: Nineteen placental samples from FGR cases with another etiology were excluded. Finally, 59 placental samples from FGR cases of unknown etiology were included in the pathological analysis. Four of 59 (6.8%) placental samples were positive for HCMV antigen. All four positive cases were stained with the M0854 antibody, and cases showed positivity for the MAB 810R antibody. Neither maternal nor infantile clinical features were different between the HCMV-positive and -negative FGR cases. A pathological examination showed a hematoma in three of four cases and infarction in two of four cases.Conclusions: HCMV antigen was detected in 6.8% of placental samples obtained from FGR cases without an obvious etiology. No remarkable maternal or neonatal clinical features discriminated HCMV-related FGR from FGR due to other causes. Vasculitis and inflammation might play important roles in the pathogenesis of HCMV-related FGR.

著者

Kensei Naito Seiji Horibe Yosuke Tanabe Hisayuki Kato Satoshi Yoshioka Ichiro Tateya

出版者

Fujita Medical Society

雑誌

Fujita Medical Journal (ISSN:21897247)

巻号頁・発行日

pp.2021-029, (Released:2022-07-22)

参考文献数

125

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There are many methods and types of equipment for measuring the nasal airway, but there is no consensus regarding the results of various clinical studies on nasal obstruction. In this review, we discuss the two major methods of objectively assessing the nasal airway: rhinomanometry and acoustic rhinometry. The Japanese standard of rhinomanometry in Japanese adults and children was established by the Japanese Standardization Committee on Rhinomanometry in 2001 and 2018, respectively. However, the International Standardization Committee has proposed different standards because of differences in race, equipment, and social health insurance systems. The standardization of acoustic rhinometry in Japanese adults is making progress in several Japanese institutes, but the international standardization of acoustic rhinometry has not yet begun. Rhinomanometry is the physiological expression of nasal airway breathing, whereas acoustic rhinometry is the anatomic expression. In this review, we introduce the history and methods of the objective assessment of nasal patency and the physiological and pathological issues regarding nasal obstruction.

著者

Takanori Matsubara Chinami Seki Hidekazu Yasunaga

出版者

The Society of Cosmetic Chemists of Japan

雑誌

日本化粧品技術者会誌 (ISSN:03875253)

巻号頁・発行日

vol.56, no.2, pp.130-140, 2022-06-20 (Released:2022-06-21)

参考文献数

21

被引用文献数

1

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In this study, the authors investigated hair colouring by utilising chemical oxidation of biocatechols, which are obtained from organisms and have catechol (o-dihydroxybenzenes) groups such as (+)-catechin (Cat), (-)-epicatechin (EC), L-3,4-dihydroxyphenylalanine (DOPA), hematoxyline (HX), braziline (BZ), rosmarinic acid (RA), caffeic acid (CA) and chlorogenic acid (ChA). The three types of dyeing methods for the chemically decolourised white human hair were tried as follows: the dyeing by using the solution of the oxidised bio-catechols at 30 °C and pH = 7 (redissolution dyeing), the dyeing by using the oxidation solution of bio-catechol reacting at 30 °C and pH = 10.8 with the introduction of O2 gas continuously (simultaneous oxidation dyeing) and the oxidation by O2 at 30 °C and pH = 11.6 after the treatment of hair with the bio-catechol solution at 30 °C (post-oxidation dyeing). The order of the hair dyeability of the methods using Cat as the bio-catechol was found to be post-oxidation>redissolution>simultaneous oxidation dyeing. Moreover, the resulting colour of hair dyed with Cat by post-oxidation dyeing was reddish brown. The results demonstrate that EC, HX and BZ are also available for hair dyeing by using post-oxidation dyeing and the colours of the dyed hair are yellowish brown, deep brown and reddish brown, respectively. It was found that the bio-catechols having a chroman (3,4-dihydro-2H-1-benzopyran) structure with the catechol part work effectively as dye precursors for colouring hair by the post-oxidation dyeing technique.

著者

渋谷 光美

出版者

立命館大学大学院先端総合学術研究科

雑誌

Core Ethics : コア・エシックス = Core Ethics : コア・エシックス (ISSN:18800467)

巻号頁・発行日

vol.7, pp.165-175, 2011

著者

岩田一輝 武井圭一 森本貴之 山本満

出版者

社団法人 日本理学療法士協会関東甲信越ブロック協議会

雑誌

関東甲信越ブロック理学療法士学会 第35回関東甲信越ブロック理学療法士学会 (ISSN:09169946)

巻号頁・発行日

pp.50, 2016 (Released:2021-03-12)

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【目的】歩数を用いた身体活動(PA)量を継続する自信(SECPA)の評価法を開発し、その信頼性と妥当性を明らかにすることである。【方法】当院教育入院に参加した糖尿病患者30 名を対象に、退院前日にSECPA と岡らが作成したPA セルフ・エフィカシー尺度(SEPA)を評価した。SECPA は、8 日間の歩数の平均を軸に平均±2000 歩・±1000 歩の5 つの階級を設定し、「週3 日以上の頻度でその歩数を継続できる自信」を0-100%で他記式にて評価した。SEPA は、歩行や階段などのPA について時間や階数で5 つの階級を設定し、各階級を遂行できる自信を0-100%で表す評価法である。分析は、SECPA とSEPA 歩行・階段の5 階級の平均値を求め、2 群を比較した。SECPA とSEPA の5 階級平均、およびSECPA の平均歩数以上の階級とSEPA の5 階級平均について相関分析を行った。あらかじめ、健常者20 名に対してSECPA を2 週間の間隔をおいて2 回評価し、α係数と検査・再検査間の級内相関係数を求めた。本研究は、当院倫理委員会の承認を得て実施した。【結果】SECPA のα係数は0.93、級内相関係数は0.63 であった。SECPA 各階級の平均は、-2000 歩から順に95%、92%、84%、77%、68%であった。5 階級平均は、SECPA が83±16%、SEPA 歩行が59±30%、階段が69±21%であり、SECPA の方が有意に高かった。SECPA の5 階級平均および平均歩数とSEPA の間に有意な相関はなかった。SECPA の+1000 歩・+2000 歩とSEPA 歩行の間に有意な相関(r=0.37・r=0.47)を認めた。【考察】SECPA の信頼性は概ね確保されたと考えた。SECPA は、過去に達成した平均歩数を軸に対象者個々に階級設定するためSEPA より高くなったと考えた。SECPA の高階級とSEPA 歩行に関連を認めたことから、SECPA が歩行というPA を遂行する自信度を反映した評価法であると考えた。また、SECPA が実際に達成できた平均歩数に対して84%程度であったことは、今後の継続性を反映していることが示唆された。

著者

中村憲吉 著

出版者

岩波書店

巻号頁・発行日

1924

著者

鴨井 正樹 清水 能人 河内 光男 藤井 靖久 菊池 武久 水川 士郎 吉岡 薄夫 木畑 正義 三橋 正和

出版者

The Japanese Society of Nutrition and Dietetics

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.30, no.4, pp.153-158, 1972-07-25 (Released:2010-10-29)

参考文献数

15

被引用文献数

5 5

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The metabolism of orally administered maltitol was investigated and compared with clinical study, especially in two groups, one which exhibited diabetic type and the other non-diabetic type (contained intermediate type) in 50g glucose tolerance test.The following results were obtained. The variation curves of blood sugar, immunoreactive insulin, and non-esterified fatty acids levels effected by 50g maltitol tolerance test in both groups had been extremely lower than those effected by 50g glucose tolerance test.So, it was considered that maltitol per se had been hardly absorbable through intestinal wall, clinically as so with animal study. In the case of concurrent administration of 50g maltitol and 50g glucose, the absorption of glucose was inhibited, resulting in a lower increase of blood sugar level than in the case of an individual administration of 50g glucose.

著者

諏訪 好英

出版者

日本エアロゾル学会

雑誌

エアロゾル研究 (ISSN:09122834)

巻号頁・発行日

vol.36, no.4, pp.246-252, 2021-12-20 (Released:2021-12-24)

参考文献数

19

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Worldwide pandemic by COVID-19 still continues. Ventilation is recommended as one of the important measures against virus infection. However, if ventilation measures are taken in the wrong way, not only the measures can’t reduce the risk of infection, but also they may make increase it. The effect of ventilation as an infection control, how to determine the volume flow rate requirement, and the ventilation method for effective air exchange has been studied. Based on these results, how we should consider effective ventilation to reduce the risk of viral infections were discussed in this paper.

著者

山辺 晋吾 片山 和明 望月 眞人

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.65, no.5, pp.497-511, 1989-05-20 (Released:2012-09-24)

参考文献数

21

被引用文献数

1 1

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In order to investigate the role of progesterone in the maintenance of pregnancy, an anti-progesterone agent, RU486 (RU) was injected subcutaneously into pregnant rats on day12 (D12), and morphological changes of the uterus as well as endocrinological changes were observed.In all rats injected with RU, abortion occurred with macroscopic and microscopic intrauterine hemorrhage and degeneration or delivery of conceptuses. Endocrinologically, the levels of progesterone decreased rapidly 48 hours after the injection, while the levels of estradiol showed a tendency to increase.As progesterone is mainly produced by the corpus luteum but not by the placenta in rats, the decrease in progesterone is suspected to be due to luteolysis. Then in order to clarify the mechanism of luteolysis induced by RU and the effects of progesterone on this phenomenon, the dynamics of the luteotrophic factors (estradiol, LH, PRL) and specific binding capacity of the ovaries to LH/hCG were investigated in D7 pregnant rats treated with RU 1 mg/kg alone (RU group) or with both RU 1mg/kg and progesterone 50mg/kg (RU+P group).The serum levels of progesterone in the RU group decreased significantly after 72 hours of administration, while those in the RU+P group remained within the levels of the control group. However, serum levels of luteotrophic factors in the RU group did not de-crease, and some of them were even higher than those in the control group. In the RU+P group, luteotrophic factors remained within control levels.On the other hand, the specific bindings of LH/hCG to ovarian homogenates decreased significantly after 72 hours in the RU group. But in the RU+P group, the specific bindings were kept at the same levels as the controls. Scatchard analysis of these results disclosed that in the RU group, both affinity and numbers of receptors decreased compared to the controls, and that in the RU+P group only affinity decreased transiently and afterwards recovered quickly.From these results, it is concluded that deterioration of affinity and numbers of ovarian LH/hCG receptors seems to be one of the factors which induce luteolysis in pregnant rats treated with RU, and that progesterone can spare the effect of RU on the corpus luteum during pregnancy.

著者

植村 善博 大邑 潤三 土田 洋一

出版者

公益社団法人 日本地理学会

雑誌

日本地理学会発表要旨集 2010年度日本地理学会秋季学術大会

巻号頁・発行日

pp.76, 2010 (Released:2010-11-22)

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研究目的 1927年の北丹後地震は郷村・山田両地表地震断層が共役的に出現し,変位地形や活動性から活断層の用語が日本で最初に使用され,地震断層沿いの集落で激甚な被害が発生したこと,などで注目される。地震学や活断層学的研究は進められてきたが,現状では被害分析,救援・救護、復興に関する研究は十分ではない(藤巻2000、追谷他2002など)。ここでは北丹後地震による竹野郡網野町網野区での被害発生の特徴と発生要因,および復興過程について調査し,新たにえられた結果を述べる。 調査結果 1)福田川低地の西縁に郷村断層下岡セグメントが出現した。この地表地震断層は沖積低地内をN20W走向で断続的に現れ,記載された変位量は左ずれ55cm(1カ所),東側隆起60~90cm(3カ所)である。市街地はこの地表地震断層から直線距離で東へ650~950m隔たっている。 2)網野区は海岸に砂丘列が発達する福田川の沖積平野下流に位置する。市街地は三方を古砂丘や旧砂丘列に囲まれ,西側は低湿地に接しており,市街地は逆三角形状の概形をなす。地下地質は沖積基底砂礫層の上に約30mの完新層が堆積しており,中部泥層(N値=1~3)の層厚は20~25mに達する。市街地の大部分は上部砂層(中粒砂、N=5~10)と上部泥層(シルト、N=1以下~3)の上に位置している。 3)網野区の被害状況は,人口2409人中死者199名,負傷者263名であり,全514戸中全壊477戸,全焼290戸であった(永濱1929)。約19カ所から出火し,市街地東半部を焼き尽くした。死亡率8.3%,全壊率92.8%,焼失率60.8%の値を示す。峰山町での死亡率(26%)全壊率(99%)と比較して前者が著しく低い原因は焼失が約6割にとどまり,住民が外へ逃げ出す余裕があったためと推定される。 4)網野区では区長森元吉らのリーダーシップを中心に独自の復旧・復興活動を進めることになる。翌8日に区の全7組長を招集し,被害を免れた森宅を区事務所として使用。10日に組長会を開き,区画整理と沈下地の埋め立を確認,11日までに組長が区画整理計画案もって住民間をまわり,ほぼ全員の承認をえた。5月24日には網野町第1耕地整理組合・震災復旧組合を設立。この間,地主や債権者の金融機関などの強い反対を粘り強い説得と毅然たる決意により乗り越えた。11月5日に網野区東部耕地整理組合(面積23町5反,組合員386名)が府の認可を受けた。1928年1月10日に着工,1929年10月30日工事完了した。整理後約4,100坪の減少となり,減歩率は8.1%である。工事経費の48,100円は,区補助12,000円,町助成金8,083円,その他組合員からの徴収分24,714円をあてた。 4)震災前の網野区は基準道路などは存在せず,無秩序・無計画な開発により発達してきた。耕地整理事業による都市プランは全38の方形ブロックを設定した。ただし、地形の制約から外周部は三角形など不整形なものが多い。典型的なブロックは100m×48~50mおよび80m×48~50mの区画をなし、これに24戸および20戸を割当て,全ての間口が通り面するように設定されている。本計画においては公園や緑地,シビックセンターなどは設置されなかった。

著者

櫻井 秀雄

出版者

金沢大学人文学類考古学研究室 = Department of Archaeology, School of Humanities, Kanazawa University

雑誌

金沢大学考古学紀要 = ARCHAEOLOGICAL BULLETIN KANAZAWA UNIVERSITY (ISSN:09192573)

巻号頁・発行日

no.38, pp.59-73, 2017-02-28

著者

不破 輝彦 本田 寛享 大友 勇人 二宮 敬一 池田 知純 貴志 浩久

出版者

Polytechnic University of Japan 職業能力開発総合大学校

雑誌

技能科学研究 (ISSN:24343706)

巻号頁・発行日

vol.38, no.4, pp.11-15, 2022 (Released:2022-07-11)

参考文献数

6

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The purpose of this study was to evaluate the workers' skill levels quantitatively by biological measurement during performance of milling work. We evaluated the relationship between the workers' skill levels, the difficulty levels of the tasks, and the workers' nervous system activities, i.e., changes in oxyhemoglobin and deoxyhemoglobin in prefrontal cortex as central nervous system activities and LF/HF as autonomic nervous system activities. Subjects were divided into two groups, i.e., an expert group and an intermediate subject group. As a result, it was shown that there is a certain relationship between workers' skill levels, the difficulty level of the tasks and nervous system activities. In conclusion, there is a possibility that changes in nervous system activities can evaluate the workers' milling skill level quantitatively.