著者

宮脇 出

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.130, no.3, pp.211-215, 2007 (Released:2007-09-14)

参考文献数

25

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近年の世界的な薬物乱用の増加によって,適切な依存性評価の重要性が高まってきている.しかし,ICH(International Conference on Harmonization)では,依存性試験について積極的な議論はなされておらず,各極の依存性試験に対する対応や考え方は一様ではない.さらに,日米欧の三極から出されているガイドラインや指針には依存性評価の基本概念が記載されているだけで,具体的な試験の内容については触れられていない.このような理由から新薬製造メーカーの研究者は依存性試験の実施について戸惑う点も多いと推察される.本稿では(1)各極の依存性に関するガイドラインや指針の特徴,(2)一般的な薬物依存性試験の方法と問題点,(3)乱用/依存の可能性を評価する際の留意点について,筆者なりの見解をまとめた.

著者

浅沼 市男

出版者

一般社団法人 日本写真測量学会

雑誌

写真測量とリモートセンシング (ISSN:02855844)

巻号頁・発行日

vol.52, no.3, pp.106-107, 2013-07-12 (Released:2014-07-01)

著者

大蔵省印刷局 [編]

出版者

日本マイクロ写真

巻号頁・発行日

vol.1933年10月26日, 1933-10-26

著者

中森 康之 山川 歩夢 ナカモリ ヤスユキ ヤマカワ アユム Yasuyuki Nakamori Ayumu Yamakawa

出版者

豊橋技術科学大学

雑誌

雲雀野 : 豊橋技術科学大学人文科学系紀要 = The lark hill : bulletin of the School of Humanities, Toyohashi University of Technology (ISSN:0388757X)

巻号頁・発行日

no.41, pp.61-76, 2019

著者

仁平 政人

出版者

日本比較文学会

雑誌

比較文学 (ISSN:04408039)

巻号頁・発行日

vol.59, pp.168-171, 2018

出版者

気象庁

巻号頁・発行日

2009-03

著者

Katsuhiko SANDO Takeshi YAMAMOTO Kenji SAWADA Tomoyuki TANIGUCHI Nobuyuki SOWA Haruki MORI Takahiro KONDO

出版者

The Japan Society of Mechanical Engineers

雑誌

Mechanical Engineering Journal (ISSN:21879745)

巻号頁・発行日

pp.20-00497, (Released:2021-03-03)

参考文献数

11

被引用文献数

1

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This paper describes a design method of a friction reducer device using a loading cam to suppress unstable vibration. Nonlinear simulation and energy analysis of numerical solutions demonstrates that destabilization is caused by the large phase difference between the slipping velocity in the translation direction and that in the rotation direction. It was found that similarly unstable vibration occurs in various structures using wedge rollers with translational and rotational motion. The analytical equation could be simplified by focusing on the motion factor that affects the slip velocity of the power transmission surface, which is the factor of vibration. Consequently, the design method for suppressing vibration could be expressed by a mathematical formula. This equation is validated by using the results of experiments conducted in the previous work of the current authors. Furthermore, from this equation, we proposed that vibration could be suppressed by the parameter balance of the power transmission device without using damping. The power transmission surface slips when a quick torque is input and damping is used. The proposed design can handle a quick torque response and reduce the weight of the reducer. Specifically, the shape of the wedge roller is made lighter, so that the moment of inertia of the roller is not lowered, or the wedge roller is set as a small roller.

著者

原田 昌幸

出版者

日本建築学会

雑誌

日本建築学会環境系論文集 (ISSN:13480685)

巻号頁・発行日

vol.82, no.734, pp.309-315, 2017 (Released:2017-04-30)

参考文献数

7

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Currently, a restaurant or a cafeteria is often used not only as a place to have a meal but also as a place to work, take a rest, or just kill time. This change has become significantly enhanced by the development and wider availability of wireless networking services that facilitate all types of internet interaction from recreational use to work from just about any place. At many self-service restaurants, customers can not only select their own seats but also move one or more tables together to create more space for themselves. However, when customers are allowed this freedom, it is not uncommon that other customers are inconvenienced because a single customer has taken up many seats, especially during peak operating hours. The objectives of this study are to identify and clarify the characteristics of seat use and over-use behaviors based on customer behaviors in the food court of a shopping mall. The observation target for this research was a food court in a large shopping center in Nagoya, Japan where customers are free to choose their seats and connect tables as they like. Activities besides eating and drinking, such as studying are also tacitly permitted by the establishment. The observation time was from 10:00 a.m. to 2:00 p.m. and included both crowded and relatively empty time periods. The observation survey was conducted on 13 weekdays and 10 weekends, and more than 600 groups and more than 1, 400 customers were observed. The observed items included customer age categories and gender (estimated by the observer), the number of group members, arrival and departure times, tables and seating choices, and the activities in which they engaged. After observation, it was found that the customers ranged widely in terms of age, from young children (even less than 10-year olds) to senior citizens, with a large number of teenage customers too. There were many single customers on weekdays, whereas on weekends nearly all customers were in groups. The seats chosen most often on weekdays were the bench seats with the atrium to its back, with a slight difference in choosing bench or chair seating on the weekends. Also, looking at how customers tended to choose seats, they regarded the distance or nearness to other customers, which indicated that interpersonal distance had an effect on seat selection in this study. Regarding extra seat usage, during the week people in age groups from teenagers to 40-year olds used seats for longer than necessary, with a shift on the weekends to teenagers and people in their 20s, especially teenagers. People who were engaged in chatting were the predominant long-users, with people studying on weekends spending inordinate amounts of time taking up space in the food court observation area during the hours of the study. Taking up extra seats was observed much more on weekdays compared to weekends, and decreased significantly on crowded weekends. During the week men more than women took up more extra seats, which likely reflects a cultural norm regarding personal space. However, on both weekdays and weekends, single people and people 70 years old or older tended to take up extra seats for themselves. Interestingly, during the week, resting and reading seemed to require the most seat overuse, but studying took over the number one slot on weekends, followed by resting and reading. Again, the need for more interpersonal distance might be important to being comfortable resting and reading in such a public place.

著者

小林 裕子 杉本 幸枝

出版者

一般社団法人 日本静脈経腸栄養学会

雑誌

日本静脈経腸栄養学会雑誌 (ISSN:21890161)

巻号頁・発行日

vol.33, no.4, pp.1054-1056, 2018 (Released:2018-10-20)

参考文献数

10

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【目的】胃瘻カテーテル内腔の栄養剤残留は細菌の温床となるので、ガイドラインでは洗浄を推奨しているが、半固形状流動食の場合は検討されていない。そこで、本研究では半固形状流動食注入後の洗浄について高い洗浄効果が期待される寒天を使用し、胃瘻カテーテルの留置期間に対応した30日間で実験を行い検討した。【対象及び方法】チューブ型バルーンタイプの胃瘻カテーテルを用いて、半固形状流動食(pH4.0以下)注入後洗浄を行った。寒天洗浄40mLと水洗浄40mLを各3本ずつで行い、これを30日間繰り返し行った。カテーテル内腔の回収液のpHを測定し生菌培養検査を行った。【結果】寒天洗浄ではpHは6.6で生菌数は20コロニーであった。一方、水洗浄はpH6.7で生菌数は1,000コロニー以上であった。【結論】寒天洗浄は胃瘻カテーテルの生菌繁殖が抑えられる有用な方法である。

著者

米田 利昭

出版者

日本文学協会

雑誌

日本文学 (ISSN:03869903)

巻号頁・発行日

vol.36, no.11, pp.62-65, 1987

著者

小林 巖雄 立石 雅昭 安井 賢 風岡 修 黒川 勝己 油井 裕 渡辺 其久男

出版者

一般社団法人 日本地質学会

雑誌

地質学雑誌 (ISSN:00167630)

巻号頁・発行日

vol.92, no.5, pp.375-390, 1986-05-15 (Released:2008-04-11)

参考文献数

41

被引用文献数

6 5

著者

松岡 利康

出版者

情況出版

雑誌

情況. 第五期 : オピニオンのステージをひらく : 変革のための総合誌

巻号頁・発行日

vol.2, no.3, pp.144-147, 2019

著者

張 新民

出版者

日本映像学会

雑誌

映像学 (ISSN:02860279)

巻号頁・発行日

vol.94, pp.38-43, 2015-05-25 (Released:2017-08-07)

参考文献数

4

著者

章 琳 LIN ZHANG

出版者

筑波大学 (University of Tsukuba)

巻号頁・発行日

2019

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2018

著者

加藤 拓巳

出版者

日本感性工学会

雑誌

日本感性工学会論文誌 (ISSN:18845258)

巻号頁・発行日

vol.20, no.1, pp.19-26, 2021 (Released:2021-02-26)

参考文献数

36

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Color has long been considered important by both the manufacturing industry and academia because it affects people’s perceptions, emotions, and behaviors. However, the evaluation of purchasing behavior until now has mainly been only in an experimental environment, and there have been concerns that differed from the actual consumer behavior. Therefore, the causal effect of the strong impression of a manufacturer’s brand color on the purchase behavior in the Japanese automobile industry was verified. Covariate was homogenized by propensity score matching based on the online survey, and the causal effect on purchase intention was extracted. As a result, the impression of the brand color had a positive effect on the purchase intention. This effect was estimated to be 5.739 in odds ratio. Commercial brands, logos, emblems, car body colors, dealers, showrooms, and even professional baseball teams were found to be factors that foster brand color.

著者

細谷 聡 野上 悟 斎藤 健治 金井 博幸

出版者

日本感性工学会

雑誌

日本感性工学会論文誌 (ISSN:18845258)

巻号頁・発行日

vol.8, no.2, pp.279-283, 2009-01-20 (Released:2016-01-25)

参考文献数

10

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The purpose of this study is to examine tightening pressure of the supporter and effect of the elastic property on muscle fatigue through electromyogram measurement. Wearing a magic tape style taping supporter, several healthy students carried out the flexion experiment of the elbow. At this time, the electromyogram of biceps brachii was measured, and MFCV(Muscle Fiber Conduction Velocity) by which, the muscle fatigue index was calculated. As a result, it became clear that the tightening pressure of the supporter which relieves fatigue was 21-28gf/cm2. The elastic property of the supporter which relieved muscle fatigue was almost 0.8kgf/cm as a tension stretch. Local clothes pressure seems to affect that the supporter with the moderate elastic property is fixed in the appropriate tightening pressure in muscle contraction and muscle blood flow. This was assumed to be the reason why muscle fatigue is reduced.

著者

八木 修 清水 駿平

出版者

公益社団法人 日本化学会

雑誌

日本化学会誌(化学と工業化学) (ISSN:03694577)

巻号頁・発行日

vol.1995, no.1, pp.74-78, 1995-01-10 (Released:2011-05-30)

参考文献数

12

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塩化物イオソを含まない,高純度な水酸化テトラメチルアンモニウム水溶液を合成した.オートクレープを用いトリメチルアミンと炭酸ジメチルをメタノール中で反応させ,炭酸テトラメチルアンモニウムメチルを得た.この場合,トリメチルアミンと炭酸ジメチルとのモル比を2としたが,炭酸塩は得られず,1対1付加物である炭酸メチル塩が得られた.この炭酸メチル塩を加水分解し,炭酸水素塩を得た.更にこの炭酸水素塩を,陽イオン交換膜を配した電解層を用いて電気分解し,目的の水酸化テトラメチルアンモニウム水溶液を効率良く得た.炭酸水素塩を電気分解した場合,他の塩類,例えばギ酸硫酸,塩化物を電気分解した場合と比べて,電流効率の低下という現象は見られず,効率良く電解生成物が得られた.このような電流効率が良い理由として,炭酸水素塩の場合,他の塩類と異なり,陽極液中に酸性物質が蓄積されないためである,と推察した.このようにして得られた水溶液中の金属イオン濃度は,すべて10ppb以下であった.また,炭酸塩の濃度は10ppm以下であった.

著者

曽我重郎 著

出版者

雄山閣

巻号頁・発行日

1933

著者

毛利正直 著

出版者

麑城館[ほか]

巻号頁・発行日

vol.上, 1885

著者

毛利正直 著

出版者

麑城館[ほか]

巻号頁・発行日

vol.下, 1885