著者
三宅 勉
出版者
札幌博物學會
雑誌
札幌博物学会会報
巻号頁・発行日
vol.2, pp.93-102, 1908-08-05
著者
生田 克哉 佐々木 勝則 伊藤 巧
出版者
旭川医科大学
雑誌
基盤研究(C)
巻号頁・発行日
2012-04-01

本研究は、鉄過剰による造血障害や鉄キレートによる造血回復の機序を、鉄過剰状態で血液中に出現する非トランスフェリン結合鉄(NTBI)の関与を含めて明らかにする目的で行った。骨髄鉄沈着、血清鉄とフェリチン上昇、さらにNTBI増加、および造血障害を呈する鉄過剰モデルマウスを作成し、このモデルに鉄キレートを行った群も作成した。骨髄細胞の網羅的遺伝子解析の比較から、糖代謝のTCA回路に関与するACO1やIDH遺伝子発現が鉄過剰に応じて亢進していることが判明した。さらに2-HG増加やDNAメチル化亢進も確認できた。鉄過剰によるこれらの変化が造血障害や白血化をきたす機序の一端を説明できる結果を得たと考えた。
著者
日下 和人 KUSAKA Kazuhito クサカ カズヒト
出版者
群馬大学社会情報学部
雑誌
群馬大学社会情報学部研究論集 (ISSN:13468812)
巻号頁・発行日
vol.25, pp.39-58, 2018-03-01

Does a declaration of intent to take legal action fall into the category of criminal intimidation? The above - mentioned precedent in 1914 claims, though it does in its obiter dictum, that the indication can fulfil the requirements for criminal intimidation. This judgment that can be traced back more than a century is still considered the leading case. Therefore, it has been argued in quite a few cases that this ruling presents the position and views of the judiciary that an indication or gesture of intent to accuse may meet the requirements for criminal intimidation when it forms an abuse of rights. This ruling's view, however, can be looked upon as defining the act of abusing one's rights in the narrowest way. Conversely, it can be pointed out that there is not much likelihood of the requirements for criminal intimidation being fulfilled according to this legal precedent.
著者
張替 秀郎
出版者
一般社団法人 日本内科学会
雑誌
日本内科学会雑誌 (ISSN:00215384)
巻号頁・発行日
vol.107, no.9, pp.1921-1926, 2018-09-10 (Released:2019-09-10)
参考文献数
6
著者
小澤 秀介 小林 愛子 高津 亜希子 神田 博仁 山折 大 塩沢 丹里 大森 栄
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.42, no.3, pp.202-208, 2016-03-10 (Released:2017-03-16)
参考文献数
20

We report the case of a 35-year-old pregnant woman treated with the calcium channel blocker, nifedipine, for maintenance tocolysis. She was hospitalized due to preterm labor at 21 weeks of gestation by her previous physician. A rash appeared following ritodrine hydrochloride administration for maintenance tocolysis. After changing to magnesium sulfate, a rash appeared again. As these rashes were suspected to have been induced by ritodrine hydrochloride and magnesium sulfate independently, consecutive treatment with these drugs was difficult. Therefore, she was transferred to our hospital for follow-up. At 28 weeks 6 days of gestation, treatment with nifedipine for maintenance tocolysis was started after receiving written informed consent, and the medication was approved by the institutional review board of our hospital. The attending pharmacist considered fetal/neonatal adverse effects of nifedipine, such as teratogenicity, fetotoxicity, and neonatal complications, as well as maternal side effects, such as headache, constipation, and excessive blood pressure drop. The pharmacist provided drug information about nifedipine to the attending physicians and nurses, and gave medication counseling to the patient. Following oral administration of 80 mg of nifedipine daily (20 mg every 6 hours), headache and constipation were evident but gradually improved. Neither excessive blood pressure drop nor exacerbated uterine contraction was observed throughout the period of nifedipine treatment. This medication was finished at 34 weeks 5 days of gestation and the patient was discharged at 36 weeks 2 days of gestation. She delivered a baby at 40 weeks 3 days of gestation.
著者
Itoh Hiroshi Nishida Shuhei
出版者
日本プランクトン学会、日本ベントス学会
雑誌
Plankton & benthos research (ISSN:18808247)
巻号頁・発行日
vol.2, no.3, pp.134-146, 2007-08-01
参考文献数
48
被引用文献数
3 14

A 17-month field survey and laboratory experiments were conducted to investigate the life cycle, seasonal population fluctuations, and salinity tolerance in the poecilostomatoid copepod Hemicyclops gomsoensis associated with the burrows of the mud shrimp Upogebia major and the ocypodid crab Macrophthalmus japonicus in the mud-flats of the Tama-River estuary, central Japan. On the basis of sample collections in the water column and from the burrows, it was revealed that H. gomsoensis is planktonic during the naupliar stages and settles on the bottom during the first copepodid stage to inhabit the burrows of U. major and, to a lesser extent, those of M. japonicus. While females carrying egg-sacs were present throughout the year, the copepods' reproduction took place mainly during early summer to autumn with a successive decrease from autumn to winter. Occasionally the copepod populations in the burrows suffered from severe flushes of river water that led to salinity decreases in the burrow water to fatal levels, but usually the salinity in the burrow was within optimal levels and permitted recovery and maintenance of the populations.
著者
鍛代 敏雄
出版者
東北福祉大学芹沢銈介美術工芸館
雑誌
東北福祉大学芹沢銈介美術工芸館年報 (ISSN:21862699)
巻号頁・発行日
no.11, pp.49-62, 2020-06-23

本稿は、福島県いわき市に鎮座する飯野八幡宮の宮司家・飯野氏に相伝された中世の古文書を読み解いて、石清水八幡宮の所領・好嶋庄(主に西方)について再検証を試みる基礎的な考察である。 本文書は福島県いわき市などの自治体史をはじめ、はやくから注目されてきたところの東北地域を代表する中世文書群であり、現在では重要文化財に指定されている。本文で述べるように、文書目録も整備されている。ところが、岩清水八幡宮の荘園史にかんする研究の立ち遅れもあって、本書の岩清水側からアプローチした研究がなされてこなかった。 そこで、新しい史料情報を提供するために、石清水八幡宮研究の観点から、「飯野家文書」を再検討することにした。その結果、従来の目録中に所載された石清水八幡宮関係文書14点を抽出し、文書内容の調査・研究に基づいて、文書名を修正し、新たな史料的価値を見出すことができた。 Writing reads and unties the medieval ancient document which was forwarded to Iino family of the Iino Hachimangu chief priest of a Shinto shrine work enshrined in Iwaki-shi, Fukushima, and is the basic consideration which tries reinspection about a domain in Iwashimizu hachimangu shrine and yoshimanoshou (mainly, the west). It's the medieval documentary crowd who represents the northeast area you have just done empty attention of fast including autonomous body history in Fukushima-ken and Iwaki-shi, and it's designated as an important cultural asset present. A documentary catalog is also maintained so that it may be told by a body. But, there was also lagging of a study about manor history in Iwashimizu hachimangu shrine, and the discussion I approached from the Iwashimizu side of Honjo was performed, and I did. So I decided to reconsider "Iino family document" from the angle of the Iwashimizu hachimangu shirine study to offer new information of historical sources. In the result and whole conventional inventory, shosai, 14 Iwashimizu hachimangu shirine related documents were picked out and a documentary name was corrected based on an investigation of document content and a study. and it was possible to find the new historical sources-like value. I'd like to utilize in a charge lecture of the paleography concerned with curator qualification acquisition about these outcomes.
著者
八木 徹 山口 敏和
出版者
江戸川大学
雑誌
江戸川大学紀要 = Bulletin of Edogawa University
巻号頁・発行日
no.30, pp.473-485, 2020-03

深層学習を含む機械学習が多くの人にとって身近なものとなり,各々の目的に活用するツールとなっていくことを想定した場合,機械学習を理解して活用できるようにするための教材が重要となる。本研究では,機械学習を体験し,学ぶためのシステムに求められる機能について考察した。さらにScratch 3.0 の拡張機能を活用し,TensorFlow やml5.js といったフレームワークを用いてScratch で機械学習を行うための拡張機能ブロック(Blocks for Machine Learning)を開発した。具体的には,画像分類を行うBML IC(Image Classifier)のほか,分類器にk 近傍法を用いるBML KNN(k-Nearest Neighbor), 転移学習を実行するBML TL(TransferLearning)という3 種類の機能を作成した。さらに,これらの機能を機械学習の体験に活用する方法についても検討をおこなった。
著者
山口 勝己 屋敷 和佳
出版者
東京都市大学
雑誌
基盤研究(C)
巻号頁・発行日
2014-04-01

引き戸タイプオープン型教室に対する教員評価から、授業に影響する音が軽減できる点、容易に開閉できる点から、引き戸タイプを評価する教員が非常に多いことが示された。また、雑誌掲載事例の分析及び大都市のオープン型教室設置の経年的分析により、ここ10年程度で完全オープンタイプがほとんどみられなくなり、引き戸タイプが急速に増えていることが明らかになった。標準的な間仕切りとして定着しているといえる。完全オープンタイプの問題点や引き戸タイプの利点と普及状況が設置者に認識されたためであると思われる。ただし、引き戸タイプでもオープンスペースの利用が必ずしも活発であるとは言えず、今後の計画的検討が必要である。
著者
徳田 剛
出版者
社会学研究会
雑誌
ソシオロジ (ISSN:05841380)
巻号頁・発行日
vol.46, no.3, pp.3-18,226, 2002-02-28 (Released:2016-11-02)

The idea of "social distance" is often used as a concept for the empirical research of social relations in American sociology. Georg Simmel, a German sociologist, adopted the idea of "distance" to describe one aspect of social interaction, that is, the discrepancy between spatial and "social" distance. Robert E. Park noticed its analytical importance and suggested the application of the idea to "the Race Relations Survey in Pacific Coast" (1923-). Emory S. Bogardus modified it far more, and invented "social distance scale" to measure the intimacy in racial relations, especially American citizens and Oriental immigrants. For Park and Bogardus, "social distance" had an important role in their research method because it compensated for the deficiencies in their main method, "life history". But they omitted some implications suggested in Simmel's motif. On the one hand, Park and Bogardus did not acknowledge the analytical importance of "spatial distance" in social relations. They paid much attention to the spatial "nearness", but could not find the meaning of spatial "remoteness" in social interaction. On the other, they treated the attitude of maintaining "social distance" too negatively. As Simmel and Goffman mentioned, the maintenance of "social distance", like etiquettes, is often indispensable in urban life. Park and his colleagues discovered the great efficiencies of "social distance" as a research method. However, they lost a chance to consider these aspects of social interaction because of their bias to "social distance".