著者

Haruki Imamura Takashi Yamaguchi Daiji Nagayama Atsuhito Saiki Kohji Shirai Ichiro Tatsuno

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.58, no.4, pp.577-583, 2017 (Released:2017-08-03)

参考文献数

38

被引用文献数

71

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Resveratrol has been reported to have potent anti-atherosclerotic effects in animal studies. However, there are few interventional studies in human patients with atherosclerogenic diseases. The cardio-ankle vascular index (CAVI) reflects arterial stiffness and is a clinical surrogate marker of atherosclerosis. The aim of the present study was to investigate the effect of resveratrol on arterial stiffness assessed by CAVI in patients with type 2 diabetes mellitus (T2DM).In this double-blind, randomized, placebo-controlled study, 50 patients with T2DM received supplement of a 100mg resveratrol tablet (total resveratrol: oligo-stilbene 27.97 mg/100 mg/day) or placebo daily for 12 weeks. CAVI was assessed at baseline and the end of study. Body weight (BW), blood pressure (BP), glucose and lipid metabolic parameters, and diacron-reactive oxygen metabolites (d-ROMs; an oxidative stress marker) were also measured.Resveratrol supplementation decreased systolic BP (-5.5 ± 13.0 mmHg), d-ROMs (-25.6 ± 41.8 U.CARR), and CAVI (-0.4 ± 0.7) significantly (P < 0.05) and decreased BW (-0.8 ± 2.1 kg, P = 0.083) and body mass index (-0.5 ± 0.8 kg/m2, P = 0.092) slightly compared to baseline, while there were no significant changes in the placebo group. Decreases in CAVI and d-ROMs were significantly greater in the resveratrol group than in the placebo group. Multivariate logistic regression analysis identified resveratrol supplementation as an independent predictor for a CAVI decrease of more than 0.5.In conclusion, 12-week resveratrol supplementation may improve arterial stiffness and reduce oxidative stress in patients with T2DM. Resveratrol may be beneficial in preventing the development of atherosclerosis induced by diabetes. However, a large-scale cohort study is required to validate the present findings.

著者

三島 徳雄 久保田 進也 永田 碩史

出版者

一般社団法人 日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.44, no.12, pp.919-927, 2004-12-01 (Released:2017-08-01)

被引用文献数

1

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専門家が高い立場から管理監督者を指導するリスナー研修はニーズに合わなくなりつつある. われわれは, 管理監督者が自ら傾聴の方法を発見する発見的体験学習法を開発した. ここでは背後にある発想を紹介し, 研修効果も報告する. この方法では最初は聴き方を説明しない. グループ練習で, 話し手が長く話すように聴き手が聴き万を工夫することを通して, 聴き方を発見するように促す. その後に参加者の発見を共有する際に指導者が参加者を傾聴する. この方法により某自治体職員を対象にリスナー研修を行い, 研修前, 1ヵ月後, 3ヵ月後に積極的傾聴態度評価尺度で効果を評価した. その結果, 傾聴態度の改善を認め, リスナー研修の有効性が示された. 本稿では, 職場のメンタルヘルス対策の1つとしてわれわれが行ってきた管理監督者を対象とする職場のリスナー研修について, その概要を報告する. これまでわれわれは, 独自に開発した方法を中心としてリスナー研修を進めてきた.

著者

三島 徳雄 久保田 進也

出版者

公益社団法人 日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:13410725)

巻号頁・発行日

vol.43, no.2, pp.27-31, 2001-03-20 (Released:2017-08-04)

参考文献数

17

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産業医学では,リスナー教育は一次予防として行われるのが普通である.ここでは積極的傾聴法を中心とする研修という点から,リスナー教育の現状について報告した.傾聴は,Rogersの3条件(共感,無条件の肯定的関心,自己一致)に基づく人間尊重の態度をもって相手の話を聴くことを意味する.このような研修の必要性は幅広く解説されているが,学術的な研究論文は乏しい.このレビューでは,これまでに報告されてきたリスナー教育に関する報告について,一貫して3条件に基づいて行われる狭義のリスナー教育と,Rogersの理論とは異なる技法を組み合わせた広義のリスナー教育に分けて検討した.前者の例としては,池見らによる人間尊重の態度の重要性に関する研究があり,久保田ら,三島ら,および宮城は実際の研修について報告している.後者の例としては,森崎および浜口らは,交流分析等を含む彼等の研修を報告している.最後に,今後はリスナー教育の評価に関する研究が必要であるだけでなく,人材育成の視点から傾聴を考える必要があることも指摘した.

著者

廣 尚典

出版者

公益社団法人 日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:13410725)

巻号頁・発行日

vol.43, no.1, pp.1-6, 2001-01-20 (Released:2017-08-04)

参考文献数

20

被引用文献数

3 5

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本稿は, 職場のストレス対策において管理監督者が担うべき役割を論じた過去の文献を概観し, それを推進するための教育研修のあり方をまとめた.従来から職場で行われるストレス対策およびメンタルヘルス対策の多くで, 管理監督者教育は, 重要な活動のひとつとして位置付けられている.その効果についても, 職場のストレスの軽減や労働者の仕事に対する満足度の向上の面で, 高く評価する報告がみられる.しかしながら, その数はまだ多くなく, 前向きの介入研究により評価を行った研究報告は極めて少ない.さまざまな管理監督者教育プログラムの有用性に関する検討は今後の課題といえる.また, 最近多くの企業で組織や勤務形態などに変化がみられており, 従来型の上司-部下関係も徐々に変貌しつつある.それに伴って, ストレス対策において管理監督者に求められる役割も見直される余地があるであろう.

著者

外尾 善次郎 小出 治彦 幡谷 敬二 文蔵 良 橋谷田 次郎 尾石 照雄 酒井 証

出版者

一般社団法人 資源・素材学会

雑誌

日本鉱業会誌 (ISSN:03694194)

巻号頁・発行日

vol.74, no.843, pp.535-552, 1958-09-25 (Released:2011-07-13)

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Underground working place in coal mine in Japan became dipper and dipper, and we can not product coal so efficiently with our mining system, so called “inclined sys em.”In order to more efficiently product coal, many people recognized, it is necessary to adapt the mining system in Europe, for instance in Germany and France, namelly so called “horizontal system”.It is said, the translation from the inclined system to horizontal system is for our coal mine in Japan very urgent and important problem.After War, many shafts were already excavated for the above mentioned purpose. As we know in Japan, many superior shaft sinking technic in Europe especially in Germany was introduced and technic in Japan was also very improved. But it is not yet so gut as in Europe. Till today many mechanization and rationalization was achieved, for instance, mechanization of loading (Adaption of Greifer) and rationalization of working system etc. Sinking speed in Japan is about 40-50m, in Europe. about 50-70m per month. In U. S. S. R, it is said, they excavated per month 241.1m.From now ono we must force to achieve the mechanization of not only loading, but bohring, walling as in U. S. S. R. and also the rationalization of working-system and cycle.

著者

小林 隆志

出版者

一般社団法人 情報科学技術協会

雑誌

情報の科学と技術 (ISSN:09133801)

巻号頁・発行日

vol.68, no.1, pp.41-41, 2018-01-01 (Released:2018-01-01)

著者

西 真紀子

出版者

公益社団法人 日本人間ドック学会

雑誌

人間ドック (Ningen Dock) (ISSN:18801021)

巻号頁・発行日

vol.23, no.5, pp.1110-1121, 2009-03-31 (Released:2012-08-20)

著者

山崎 一夫

出版者

日本環境動物昆虫学会

雑誌

環動昆 (ISSN:09154698)

巻号頁・発行日

vol.27, no.1, pp.17-20, 2016 (Released:2016-10-25)

著者

有馬 雄祐 大岡 龍三 菊本 英紀

出版者

日本建築学会

雑誌

日本建築学会環境系論文集 (ISSN:13480685)

巻号頁・発行日

vol.81, no.729, pp.1047-1054, 2016 (Released:2016-11-30)

参考文献数

21

被引用文献数

2

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The outputs of weather and climate models have been used in various application fields. For example, future weather data for the building energy simulation (BES) can be provided based on a climate model prediction. However, as the model output has systematical errors (called the bias), some type of bias correction is necessary in order to use the model output for an application field. For temperature or humidity, we often assume normal distribution and correct bias using statistical parameters, such as the average and the standard deviation. However, for solar radiation, a bias correction method (BCM) that uses only the average and standard deviation is insufficient and can result in negative values after bias correction. Consequently, the solar radiation bias is often corrected using only its average. In general, climate models can accurately predict the daily maximum amount of solar radiation on clear days at a given site because solar radiation depends mainly on its geolocation (latitude, longitude, and elevation) and the season (solar altitude). However, it is difficult to model cloud physics processes accurately to establish the weaker amounts of solar radiation on cloudy days. As a result, when we correct the solar radiation bias using only the average value, the daily maximum value deviates from the observed results instead of correcting the average. In this paper, we present a method called quantile mapping (QM) for the bias correction of solar radiation to provide the bias corrected weather data for the BES. The QM has been developed mainly for the correction of precipitation or temperature biases, although there are few studies that apply QM to the correction of solar radiation. In previous studies, QM was applied to the daily or monthly average. However, for the BES, the daily maximum value is also as important as the daily or monthly average, because the peak energy load depends mainly on the daily maximum. In this study, we also applied QM to obtain the daily maximum amount of solar radiation. In addition, we conducted BESs using the bias corrected weather data and evaluated the efficiency of each BCM. From the simulation results, the average energy consumption did not differ according to the difference in the BCM. However, the simulation that used the weather data corrected by only the monthly average could not predict the maximum cooling load; it was underestimated by 12%. Conversely, the simulation with the data corrected by QM, which used either the daily cumulative or the maximum amount of solar radiation, could predict the maximum cooling loads, which were under estimated by only 6% and 2%, respectively.

著者

作田 正明

出版者

一般社団法人植物化学調節学会

雑誌

植物の生長調節 (ISSN:13465406)

巻号頁・発行日

vol.44, no.1, pp.49-55, 2009-05-31 (Released:2017-09-29)

参考文献数

30

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The red pigments, anthocyanins and betacyanins have never been demonstrated to occur together in the same plant. Although anthocyanins are widely distributed as flower and fruit pigments in higher plants, betacyanins have replaced anthocyanins in the Caryophyllales. Anthocyanins have not been reported to occur in these betacyanin-producing plants, and the evolutionary gain and loss of the two pigments remain a mystery, as do the molecular bases underlying their mutual exclusion. The accumulation of flavonols in the Caryophyllales suggests that the step (s) of anthocyanin biosynthesis from dihydroflavonols to anthocyanins could be blocked in the Caryophyllales. Some insights can be gained from DFR and ANS, which are involved in the biosynthetic pathway from dihydroflavonols to anthocyanins. The cDNAs encoding DFR and ANS were isolated from Spinacia oleracea and Phytolacca americana, plants that belong to the Caryophyllales. The experiments using recombinant DFR and ANS expressed in Escherichia coli revealed that the Caryophyllales plants posses functional DFR and ANS. The expression profiles showed that DFR and ANS were not expressed in most tissues and organs expect seed in S. oleracea. These result indicated that the suppression or limited expression of the DFR and ANS may cause the luck of anthocyanin in the Caryophyllales.

著者

Koji Inagaki Yoshiyuki Yamashita

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.50, no.2, pp.136-141, 2017-02-20 (Released:2017-02-20)

参考文献数

10

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Simulated moving-bed chromatography (SMBC) separation of a solution containing three different saccharides was investigated by real-time, inline monitoring of the concentration of each saccharide with Fourier transform near-infrared spectroscopy (FT-NIRS). We built partial least squares (PLS) regression models to estimate the saccharide concentrations based on preprocessed spectral data in the wavenumber range 6,100–5,440 cm−1 that excludes the water absorption band. To verify the calibration model, we performed separation of the raw material solution of the test set using SMBC, and confirmed that the predicted concentration of each saccharide from the calibration model corresponds well with the actual measured concentration of each saccharide obtained by HPLC. The collection range can be adjusted online using the monitoring values in order to maximize the purity and yield of the target saccharides.

著者

淺羽 茂

出版者

国際ビジネス研究学会

雑誌

国際ビジネス研究 (ISSN:18835074)

巻号頁・発行日

vol.8, no.2, pp.167-172, 2016 (Released:2017-11-06)

著者

Takahiro USHIGUSA Yoshiyuki KOYAMA Tomoko ITO Kenichi WATANABE James K. CHAMBERS Aya HASEGAWA Kazuyuki UCHIDA Ryoji KANEGI Shingo HATOYA Toshio INABA Kikuya SUGIURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0466, (Released:2018-01-01)

被引用文献数

6

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By using a complex of DNA, polyethylenimine and chondroitin sulfate, the in vivo transfection of early secretory antigenic target-6 (ESAT-6) gene into tumor cells was found to cause significant suppression of the tumor growth. In order to apply the method in clinical cancer treatment in dogs and cats, mechanisms underlying the suppressive effects were investigated in a tumor-bearing mouse model. The transfection efficiency was only about 10%, but the transfection of ESAT-6 DNA nevertheless induced systemic immune responses against ESAT-6. By triple injection of ESAT-6 DNA at three day intervals, the tumor was significantly reduced and almost disappeared by 5 days after the start of treatment, and did not increase for more than 15 days after the final treatment. In the immunohistochemistry, a larger number of dendritic cells (DCs)/macrophages expressing ionized calcium-binding adapter molecule 1 and CD3+ T cells was observed in tumors treated with ESAT-6 DNA, and their population further increased significantly by day 5. Moreover, the amount of tumor necrosis factor, which is an apoptosis-inducing factor produced mainly by DCs/macrophages, was greater in the ESAT-6 DNA treated tumors than in controls, and increased with repeat of the treatment. These results indicate that in vivo transfection of ESAT-6 DNA into tumor cells elicits significant inhibition of tumor growth, by inducing potent activity of innate immunity mediated by DCs/macrophages, which may be followed by adaptive immunity against tumor associated antigens, which was elicited by the costimulation with ESAT-6 antigen.

著者

Aprilia MAHARANI Keisuke AOSHIMA Shinichi ONISHI Kevin Christian Montecillo GULAY Atsushi KOBAYASHI Takashi KIMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0561, (Released:2018-01-01)

被引用文献数

15

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Canine hemangiosarcoma (HSA) is one of the most common mesenchymal tumors in dogs. Its high metastatic and growth rates are usually associated with poor prognosis. Neoplastic cells of HSA can show various levels of cellular atypia in the same mass and may consist of various populations at different differentiated stages. Up to present, however, there is no report analyzing their differentiation states by comparing cellular atypia with differentiation-related protein expressions. To evaluate whether cellular atypia can be used as a differentiation marker in HSA, we analyzed correlation between cellular atypia and intensities of CD31 and von Willebrand Factor (vWF) staining in HSA cases. We also compared cellular atypia and expression levels of CD31 and vWF in each growth patterns. Our results show that cellular atypia was negatively correlated to CD31 and vWF expression levels but no significant correlation was found between growth patterns and cellular atypia or CD31 and vWF expression levels. Our study suggests that cellular atypia is useful for identifying differentiation levels in HSA cases. This study also provides useful information to determine differentiation levels of cell populations within HSA based only on morphological analysis, which will aid further HSA research such as identifying undifferentiation markers of endothelial cells or finding undifferentiated cell population in tissue sections.

著者

高田 洋

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.67, no.3, pp.356-357, 2016 (Released:2017-12-31)

著者

森川 美絵

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.67, no.3, pp.354-356, 2016 (Released:2017-12-31)

著者

浅野 智彦

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.67, no.3, pp.347-348, 2016 (Released:2017-12-31)

著者

高畑 幸

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.67, no.3, pp.340-341, 2016 (Released:2017-12-31)

著者

遠藤 知巳

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.67, no.3, pp.358-359, 2016 (Released:2017-12-31)

著者

桂 利行

出版者

一般社団法人 日本応用数理学会

雑誌

応用数理 (ISSN:24321982)

巻号頁・発行日

vol.14, no.3, pp.290-294, 2004-09-28 (Released:2017-04-08)