著者

Tetsuji Nagao Naomi Takada Noriko Onoda

出版者

日本環境変異原学会

雑誌

Genes and Environment (ISSN:18807046)

巻号頁・発行日

vol.33, no.2, pp.50-60, 2011 (Released:2011-05-25)

参考文献数

82

被引用文献数

1 2

---

Congenital malformations can be induced in the offspring of laboratory animals treated with the mutagens, ethylnitrosourea, methylnitrosourea, mitomycin C, triethylenemelamine or procarbazine before copulation. The spectra of malformations in the offspring classified as male-mediated malformations after exposure of paternal mice to mutagens showed no evidence of mutagen-specificity or germ-cell stage-dependent variations. Recently, we demonstrated the increased incidence of congenital malformations in the offspring of male mice exposed in utero to synthetic estrogens such as diethylstilbestrol (DES), 17β-estradiol (E2) or ethynyl estradiol (EE), and that the induction of male-mediated malformations by DES, E2 or EE showed a clear threshold effect. Developmental exposure to DES, E2 or EE caused partial atrophy and feminization in the genital tract. They also showed transgenerational effects when applied prenatally at a dose which caused histopathological changes in the testes. Germ-cell series in normal testis have mechanisms to select against spontaneously arising mutation; but these selection mechanisms may not function efficiently in chemically-damaged testes. Based on these results and considerations, we propose as a hypothesis that transgenerational teratogenesis by prenatal exposure to synthetic estrogens may occur as a consequence of testicular toxicity. Moreover, since DES has been reported to be non-genotoxic, epigenetic mechanisms such as DNA methylation may be involved in the transgenerational teratogenesis induced by estrogenic drugs. The expression patterns of DNA methyltransferases (Dnmts) mRNA, global DNA methylation levels in testicular cells of embryos exposed to estrogenic drugs or in epididymal sperm of mature male mice exposed prenatally to estrogenic drugs were different from those in the controls. Results shown in this review support the proposal that, when evaluating the toxicities of environmental chemicals including endocrine disruptors, epigenetic effects such as DNA methylation should be taken into account.

著者

長岡 鋭 坂本 隆一 斎藤 公明 堤 正博 森内 茂

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.23, no.4, pp.309-315, 1988 (Released:2010-02-25)

参考文献数

15

被引用文献数

3 6

---

In order to clarify the diminution characteristics of terrestrial gamma ray exposure rate due to snow cover, measurements were performed on the ground with and without snow cover. The diminution factors observed were 0.36-0.17 for 12-23g/cm2 of water equivalent of the snow cover. According to a calculation by the Monte Carlo method, the corresponding diminution factors were 0.32-0.16. They agreed well as a whole, while the fluctuation of the diminution factors based on the measured exposure rate were fairly large. The fluctuation is deemed to be due to the inhomogeneity in the distribution of the snow cover as well as the gamma ray field. The fluctuation is expected to decrease with increase in the degree of their homogeneity.

著者

鈴木 明夫 粟津 俊二

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.81, no.1, pp.1-8, 2010 (Released:2010-08-13)

参考文献数

23

被引用文献数

1

---

In order to examine the importance of fully representing graphic information items in graphic aids to facilitate comprehension of explanatory texts, we established and randomly assigned fifty university students into the following four groups: (a) participants who study the text without the aid, (b) participants who study the text with the aid, whose literal (key words) and graphic (arrows, boxes, etc.) information items are fully displayed, (c) participants who study the text with the aid, whose graphic information items are fully displayed but whose literal information items are partially displayed, and (d) participants who study the text with the aid, whose literal and graphic information items are partially displayed. The results of two kinds of comprehension tests “textbase and situation model” revealed that groups (b) and (c) outperformed groups (a) and (d). These findings suggest that graphic aids can facilitate students' text comprehension when graphic information items are fully displayed and literal information items are displayed either fully or partially; however, the aid cannot facilitate comprehension when both literal and graphic elements are displayed partially.

著者

辻 竜平 針原 素子

出版者

数理社会学会

雑誌

理論と方法 (ISSN:09131442)

巻号頁・発行日

vol.25, no.1, pp.31-47, 2010-03-31 (Released:2010-10-03)

参考文献数

20

---

成人までの発達段階の途中にある中学生に,さまざまな人間関係についての認知と評価を問う質問紙調査を行った.認知については,9つの人間関係のカテゴリについてトライアド・テストとコレスポンデンス分析を,評価については,それらのカテゴリについて「身近さ」と「信頼」という側面から評価する尺度を,それぞれ用いて測定した.その結果,第1に,トライアド・テストとコレスポンデンス分析によって得られる「第1次元」が,特に「身近さ」や「信頼」の評価と関係が強く重要であることが示された.第2に,その「第1次元」・「身近さ」・「信頼」と「一般的信頼」との相関を見たところ,「友だち」「クラスメイト」「中学校」のカテゴリにおいて強い正相関が見られた.ここから,中学生という発達段階においては,いわゆる「還元アプローチ」の過程によって一般的信頼が形成されていることが示唆された.

著者

原田 英二 渡辺 怜子 児嶋 紀子 水野 充

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.45, no.11, pp.770-780, 2003 (Released:2003-02-01)

---

インターネット時代の到来により,電子ジャーナル出版は加速され,学術雑誌の世界では一般的なものとなってきた。電子出版には従来の冊子体ベースの出版物にはないさまざまなメリットが見られるが,電子化により,雑誌に縛られない,論文単位での扱いが容易となった点もそのひとつである。そして,それに応じて論文の個別売り,いわゆる一部売りサービスが登場してきた。一部売りサービスによる論文の購入は,出版社だけでなく,アグリゲータ,二次データベース経由によっても可能となってきている。ここではそれら一部売りを扱う業者を出版社,アグリゲータ,二次データベースサービスに分けて整理し,それぞれの特徴をまとめた。さらに,提供業者ごとの価格を調査し,比較を行った。

著者

鈴木 寿 大西 弘之 有本 卓

出版者

日本ロボット学会

雑誌

日本ロボット学会誌 (ISSN:02891824)

巻号頁・発行日

vol.5, no.6, pp.431-441, 1987-12-15 (Released:2010-08-25)

参考文献数

20

被引用文献数

1

---

連想データベースを自己組織化する簡単で効率の良い方法を提案すると共に, 自律移動知能ロボットへ応用する.システムは, 予め規定された処理部と, 初期状態では空白な記憶部とから成る.現時点の入力信号に対し, 処理部はこれに似ている過去の入力信号を記憶部から検索し, その関連情報を呼び出す.もし現入力信号の随伴情報がこの関連情報と一致しなければ, 新たな情報が記憶部のデータベースに付加され, その影響は次回の処理に反映される.このように記憶状態と入力信号の双方に依存して, データベースは自己組織化的に成長してゆく.データベース組織化の履歴は入力系列に依存するので, 個々のデータベースは固有な構造を獲得する.もし十分な長さの入力系列が与えられると, 入力信号と関連情報の対応関係は, 入力系列のそれに一致するようになる.脳における直観的情報処理の概念的ではあるが本質的なモデルを与えているという点で, また実用的立場からは, 要求された応答をユニパーサルに学習する学習機構へ応用できるという点で, 本システムは意義深い.この学習機構を利用した廊下用のカメラ方式自律移動ロボットを紹介する.ロボットの頭脳は, プロセッサーi80286を搭載したマイクロ計算機によって構成され, ロボットの行動は, C言語に追加設計した小規模のロボット言語を用いて制御される.良好な実験結果が示される.

著者

Takao Sakurai Yoshihiro Momose Keiji Nakayama

出版者

公益社団法人 日本表面科学会

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.3, pp.179-183, 2005 (Released:2005-06-02)

参考文献数

14

被引用文献数

5 7

---

The influence of surface states on photoelectron emission phenomena was investigated to determine the work function precisely. A new method for analyzing the yield spectra of photoelectron emission as a function of temperature has been developed. This method was used to decide the work function and surface state of aluminum metal sheets mechanically scratched and ultrasonically cleaned in organic solvent. The yield spectrum as a function of photon energy exhibited a greatly changed shape with an increase and subsequent decrease in temperature in flowing Q gas under the irradiation of 220 nm wavelength light. The ionization energy of a surface state generated at the surface by the influence of temperature and light was estimated. [DOI: 10.1380/ejssnt.2005.179]

著者

柳田 智

出版者

公益社団法人 日本放射線技術学会

雑誌

日本放射線技術学会雑誌 (ISSN:03694305)

巻号頁・発行日

vol.66, no.7, pp.816-820, 2010 (Released:2010-08-10)

被引用文献数

2

著者

Jae-Woo Jung Hye-Ryun Kang Jae-Woo Kwon Tae-Eun Kim So-Hee Lee Kyoung Sup Hong Kyung-Sang Yu Sang-Heon Cho

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.224, no.4, pp.293-300, 2011 (Released:2011-07-29)

参考文献数

28

被引用文献数

4 5

---

Revaprazan is the first acid pump antagonist with a function similar to that of proton pump inhibitors (PPIs). It has a dual action, active suppression of gastric acid secretion and gastric mucosa protection. While PPIs are known to enhance the prolongation of prothrombin time by warfarin, no research has been done on the drug interaction between revaprazan and warfarin. This study was conducted in order to verify the potential drug interaction between revaprazan and warfarin. Omeprazole, a representative PPI, was used as the control for revaprazan. We searched for patients who were given either revaprazan or omeprazole along with warfarin using the medical record database of Seoul National University Hospital between July 2007 and June 2010. Among the 15 patients who took revaprazan and warfarin together, 73.3% (11/15) showed more than 30% reduction of anticoagulation effect by warfarin after revaprazan was added. The revaprazan group showed a significant shortening of prothrombin time during revaprazan administration compared to pre- and post-revaprazan medication (P < 0.05) while the omeprazole group did not show such difference. Revaprazan seems to have cumulative dose-dependent anti-warfarin or anti-coagulation effect, as judged from the fact that the longer medication with revaprazan showed correlation with the shortening of prothrombin time (R = −0.632, P < 0.05). This study shows a possible interaction between revaprazan and warfarin and suggests that revaprazan can cause shortening of prothrombin time. Therefore, when revaprazan is prescribed to patients on warfarin therapy, prothrombin time should be frequently monitored.

著者

Mohammad Mahbubur RAHMAN Hiroaki KAWAGUCHI Noriaki MIYOSHI Akira YABUKI Yuya NAKAMOTO Tsuyoshi OZAWA Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.485-489, 2012 (Released:2012-04-29)

参考文献数

27

被引用文献数

1 3

---

Salivary gland cysts are often concurrent with GM1 gangliosidosis in Shiba dogs. Although the etiology is unknown, these cysts may be misdiagnosed as malignant due to the accumulation of foamy cells. The present study investigated the cytological, histopathological, immunohistochemical and electron microscopic characteristics of salivary gland cysts in a Shiba dog affected with GM1 gangliosidosis. The salivary gland masses were surgically enucleated and examined clinicopathologically and pathologically in a 7-month-old Shiba dog with GM1 gangliosidosis. Many large cells with rich cytoplasm including vacuoles of various sizes, i.e., foamy cells, were observed in stamp smears from the cut-surface of the masses and histopathologically in major parts of the cyst wall. Some of these foamy cells presented features similar to a spider-web appearance. The foamy cells were confirmed to have originated from macrophages based on marked immunohistochemical expression of vimentin, HLA-DR, lysozyme and Iba1. An ultrastructural study demonstrated electron-dense vesicular structures in the vacuolated cells. Therefore, the masses were diagnosed pathologically as benign salivary gland cysts with accumulation of foamy cells. In conclusion, the histopathological features of the salivary gland cysts in this Shiba dog were similar to those of lipoma and/or liposarcoma. In such cases, immunohistochemical and ultrastructural examinations were useful in the differential diagnosis. Practitioners, clinical pathologists and pathologists should take GM1 gangliosidosis into consideration when they encounter salivary gland cysts in Shiba dogs.

著者

相原 良太 横山 明彦 野見山 史敏 小杉 成史

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌B(電力・エネルギー部門誌) (ISSN:03854213)

巻号頁・発行日

vol.132, no.1, pp.86-94, 2012-01-01 (Released:2012-01-01)

参考文献数

13

被引用文献数

3 9

---

In recent years, a substantial amount of photovoltaic (PV) generations have been installed in power systems. However, the power output from the PVs is random and intermittent in nature. Therefore, the PV generations pose many challenges to the power system operation. To solve these issues, we propose that pumped storage hydro power plant (PSHPP) is used effectively. In this paper, a new method for scheduling effective operating patterns for PSHPP that make it possible to improve both reliability and economy is presented.

著者

Atsushi TSUKAMOTO Koichi OHNO Mitsuhiro IRIE Aki OHMI Shingo MAEDA Ko NAKASHIMA Kenjiro FUKUSHIMA Yasuhito FUJINO Kazuyuki UCHIDA Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.503-506, 2012 (Released:2012-04-29)

参考文献数

14

被引用文献数

6 12 3

---

Endoscopic polypectomy and argon plasma coagulation (APC) were performed in a refractory case of inflammatory colorectal polyps in a 7-year-old male Miniature Dachshund. Colonoscopic examination revealed a large sessile polyp and multiple diffuse small polyps, localized to the descending colon and rectum. The case showed a poor therapeutic response to prednisolone and cyclosporine. Under anesthesia, piecemeal resections were performed by polypectomy. APC was carried out to cauterize the polyp remnants. After treatment, reduction of the lesions and the improvement in clinical signs were observed, without recurrence of lesions for at least 10 months. Endoscopic treatment by polypectomy and APC is suggested to be a therapeutic option for refractory cases of inflammatory colorectal polyps in dogs.

著者

Hojung CHOI Youngwon LEE Kitae PARK Seongchan YEON Heechun LEE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.491-494, 2012 (Released:2012-04-29)

参考文献数

19

被引用文献数

1 4

---

The detection of small amounts of free peritoneal gas in the canine patient can pose a diagnostic dilemma. The objective of this study was to determine how much of this free gas could be detected ultrasonographically. Ultrasound examinations were carried out after increments (0.1 ml) of air were intraperitoneally injected. Via ultrasonography, 0.4 ml of free gas can be reliably detected. The authors concluded that ultrasonography is a very sensitive modality for the detection of small amounts of peritoneal free gas (above 0.4 ml).

著者

Meina TEI Kazuyuki UCHIDA Mayu MUTSUGA James K. CHAMBERS Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.481-483, 2012 (Released:2012-04-29)

参考文献数

17

被引用文献数

1 3

---

Curcumin is a constituent phenol compound of turmeric, and has been used as a dietary spice and Indian medicine. Curcumin has been reported to inhibit the formation of amyloid β fibrils and aggregation. In this study, the binding activity of curcumin to various types of canine amyloid was examined. Tissue samples used were lesions of AA, AL, amyloid of canine amyloid-producing odontogenic tumor (Aapot), and senile cardiovascular amyloid (ScA). Curcumin stained all types of amyloid. The binding of curcumin to AA, ScA, and AL was lost by the KMnO4 treatment, but Aapot maintained the binding. These findings indicate that curcumin binds several types of amyloid, while the binding sites of amyloid molecules might be different from that of Congo red.

著者

Junko DOI Junichi HIROTA Akihiko MORITA Kanae FUKUSHIMA Hiromi KAMIJYO Hiroshi OHTA Masahiro YAMASAKI Toru TAKAHASHI Ken KATAKURA Yuzaburo OKU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.4, pp.413-417, 2012 (Released:2012-04-29)

参考文献数

19

被引用文献数

7 21

---

Tritrichomonas suis (=T. foetus) has recently been reported to be a causative agent of chronic large-bowel diarrhea in cats. While the disease was previously attributed to Pentatrichomonas hominis, the etiologic agent for feline trichomonal diarrhea was identified as T. suis. Although feline trichomonosis due to T. suis has been reported at prevalences ranging from 14 to 31% in Europe and the U.S., no reports of the pathogen have been published to date in Japan. In 2008, however, we encountered a case of feline trichomonosis at the Veterinary Teaching Hospital of Hokkaido University. The parasite was identified as T. suis by nested PCR amplification of partial internal transcribed spacer region 1 and 5.8S ribosomal RNA gene sequences with T. suis-specific primers and DNA sequencing of the amplified products. We then conducted surveys for feline trichomonosis in three different animal hospitals using either cultivation and/or PCR-based assays. The results revealed that 13 of 147 samples (8.8%) were positive for T. suis, and that 5 of the 13 infected cats, which ranged between 1 month and 7.5 years-old, showed chronic diarrhea. Seven of the infected cats were purebred and 6 were mixed breed. These findings suggested that feline trichomonosis is prevalent in Japan, and that T. suis may play a role as a causative agent of feline chronic diarrhea.

著者

菅井 裕一 佐々木 久郎 松葉谷 治 中 秀男 田中 富士夫

出版者

一般社団法人 資源・素材学会

雑誌

資源と素材 (ISSN:09161740)

巻号頁・発行日

vol.121, no.10,11, pp.513-520, 2005 (Released:2007-02-24)

参考文献数

13

被引用文献数

4 6

---

The green tuff from Hinai town, Akita is popular for architectural materials because of its beautiful pale green color and thermal and moisture retaining properties. When this stone is quarried and grinded for making products, approximately 60% of all quarried stone becomes the waste stone and it is required to be utilized effectively. Hinai-Green tuff is a porous media and it has abilities to neutralize acids and elute some minerals. These abilities may be effective for growth of microbes and our research group carries out the development of effective utilizations of Hinai-Green tuff as microbial activator. In this paper, the effects of Hinai-Green tuff on pH adjustment and microbial activities are described.Hinai-Green tuff had an ability to neutralize both acid and alkaline water and especially neutralized acids effectivelly. For example, acid water of initial pH3 was neutralized to pH7 by adding 10(w/v)% Hinai-Green tuff into the acid water. Therefore, Hinai-Green tuff can neutralize acid soil and water and adjust acid environments to adaptable environments for microbes. Moreover, Hinai-Green tuff could buffer decrease in pH. The pH of water containing Hinai-Green tuff did not decrease rapidly with adding drops of 0.1M HCl, and especially the buffer action was strongly observed at pH 7 to 8. Hinai-Green tuff is very helpful to maintain pH appropriate for microbes for long time against decrease in pH caused by acid rain and/or acid metabolites of microbes. And pH adjustment effects of Hinai-Green tuff were caused by the ion exchange between Ca2+ leached from the stone and H+.Consequently, microbes grew actively in a medium containing Hinai-Green tuff because of its pH adjustment effects. However, microbes did not grow in a medium containing natural zeolite from Futatsui town, Akita. The effects of Futatsui-Zeolite on pH adjustment for acid were low compared with Hinai-Green tuff.

著者

Tsugunobu Andoh Qun Zhang Takumi Yamamoto Manabu Tayama Masao Hattori Ken Tanaka Yasushi Kuraishi

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.114, no.3, pp.292-297, 2010 (Released:2010-11-16)

参考文献数

30

被引用文献数

7 17

---

Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G. lucidum extract would inhibit allergic itch. In mice sensitized with an extract of salivary gland of mosquito (ESGM), an intradermal injection of ESGM elicited scratching, which was suppressed by oral administration of G. lucidum extract (100 and 300 mg/kg). The scratching was inhibited by the H1 histamine–receptor antagonist azelastine, but not by the peripherally acting H1-antagonist terfenadine, at the oral dose of 30 mg/kg. In sensitized mice, ESGM increased the activity of cutaneous nerve, which was suppressed by G. lucidum extract (300 mg/kg). Although terfenadine (30 mg/kg) inhibited plasma extravasation induced by ESGM in the sensitized mice, G. lucidum extract (300 mg/kg) was without effect. These results suggest that G. lucidum extract relieves allergic itch through a peripheral action. The results support the idea that mast cells and H1 histamine receptors are not the primary sites of the antipruritic action of G. lucidum extract.

著者

羽田 積男

出版者

日本比較教育学会

雑誌

日本比較教育学会紀要 (ISSN:02871106)

巻号頁・発行日

vol.1986, no.12, pp.75-81, 1986-03-31 (Released:2010-08-06)

参考文献数

24

著者

水原 克敏

出版者

一般社団法人 日本教育学会

雑誌

教育学研究 (ISSN:03873161)

巻号頁・発行日

vol.48, no.2, pp.154-164, 1981-06-30 (Released:2009-01-13)

参考文献数

71

著者

AB生 杉本 東造

出版者

財団法人 日本消化器病学会

雑誌

日本消化機病学会雑誌 (ISSN:04466586)

巻号頁・発行日

vol.21, no.3, pp.167-168, 1922-05-30 (Released:2011-06-17)