著者

Naoshi Kakitsuba Igor B. Mekjavic Tetsuo Katsuura

出版者

日本生理人類学会

雑誌

Journal of PHYSIOLOGICAL ANTHROPOLOGY (ISSN:18806791)

巻号頁・発行日

vol.26, no.3, pp.403-408, 2007 (Released:2007-07-20)

参考文献数

12

被引用文献数

3 5

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The purpose of the study was to investigate the degree of subject variability in the peripheral and core temperature thresholds of the onset of shivering and sweating. Nine healthy young male subjects participated in three trials. In the first two trials, wearing only shorts, they were exposed to air temperatures of 5°C and 40°C until the onset of shivering and sweating, respectively. In the second experiment, subjects wore a water perfused suit that was perfused with 25°C water at a rate of 600 cc/min. They exercised on an ergometer at 50% of their maximum work rate for 10–15 min. At the onset of sweating, the exercise was terminated, and they remained seated until the onset of shivering, as reflected in oxygen uptake. In the first two trials, rectal temperature (Tre) was stable, despite displacements in skin temperature (Tsk), whereas in the third trial, Tsk (measured at four sites) was almost constant (30–32°C), and the thermoregulatory responses were initiated due to changes in Tre alone. The results of the first two trials established the peripheral interthreshold zone, whereas the results of the third trial established the core interthreshold zone. The results demonstrated individual variability in the peripheral and core interthreshold zones, a proportional correlation between both zones (r=0.87), and a relatively higher contribution of adiposity in both zones as compared with those of other non-thermal factors such as height, weight, body surface area, surface area-to mass ratio, and the maximum work load.

著者

B.ポティエ著 三宅徳嘉 南舘英孝訳

出版者

岩波書店

巻号頁・発行日

1984

著者

T Klein J Langner B Frankenberg J Svensson B Broman C Bennet T Langborg

出版者

CODATA

雑誌

Data Science Journal (ISSN:16831470)

巻号頁・発行日

vol.12, pp.1-9, 2013 (Released:2013-03-06)

参考文献数

24

被引用文献数

8

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Environment Climate Data Sweden (ECDS) is a new Swedish research infrastructure, furthering the reuse of scientific data in the domains of environment and climate. ECDS consists of a technical infrastructure and a service organization, supporting the management, exchange, and re-use of scientific data. The technical components of ECDS include a portal and an underlying data catalogue with information on datasets. The datasets are described using a metadata profile compliant with international standards. The datasets accessible through ECDS can be hosted by universities, institutes, or research groups or at the new Swedish federated data storage facility Swestore of the Swedish National Infrastructure for Computing (SNIC).

著者

高田 豊雄 ビスタ B.B. 吉本 道隆

出版者

岩手県立大学

雑誌

基盤研究(C)

巻号頁・発行日

2011

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近年、フィッシングやパスワード推測、不注意によるマルウェア感染といった人間を糸口とするセキュリティ被害が増えている。本研究では、ユーザビリティ工学や教育工学、認知科学といった人間を取り扱う学問の最新成果をとりいれたセキュリティ向上の方策を考案する。具体的な課題としては 1) 最新の認知科学の知識を導入した記憶容易性と安全性を両立させたパスワード認証方式、2) 最新の教育工学の知見を導入したセキュリティ教育システム設計方法論の確立、3) 可用性を重視した一般ユーザ向けセキュリティ対策ツールや対策システムの確立である。

著者

Ebisawa B.

出版者

美学会

雑誌

美學 (ISSN:05200962)

巻号頁・発行日

vol.11, no.3, 1960-12-20

著者

堀田 昌克 Tauber D.a. Holmes Jr.A.L. Miller B.I. Bowers J.E.

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. ED, 電子デバイス

巻号頁・発行日

vol.96, no.192, pp.19-24, 1996-07-25

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高出力、 広帯域な半導体レーザの実現を目指して、熱放散特性、高周波信号伝搬特性に優れたマイクロストリップレーザ(Microstrip laser: MSレーザ)という新たなレーザ構造を検討した。MS-レーザは下部クラッド層の直下に厚い金電極を有していることを特徴としている。本構造の作製工程を考案し、 試作した素子の諸特性を評価した。 ボンデイング工程及びその後のレーザプロセスが素子特性に悪影響を及ぼしていないことを、その閾値電流特性から確認した。また、CW発振特性、高周波信号伝搬実験から、本構造が従来の構造に比べて熱放散および高周波伝搬特性に関して優れていることを明らかにした。

著者

Agarie Sakae Hanaoka Naomi Ueno Osamu Miyazaki Akira Kubota Fumitake Agata Waichi Kaufman Peter B.

出版者

日本作物学会

雑誌

Plant production science (ISSN:1343943X)

巻号頁・発行日

vol.1, no.2, pp.96-103, 1998-06

参考文献数

54

被引用文献数

9

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To evaluate the positive effects of silicon on the stress tolerance of rice plants, we measured the electrolyte leakage (El) from leaf tissue caused by desiccation with polyethylene glycol (PEG) and by high temperature to estimate the integrity of cell membranes. The El caused by 30% and 40% solutions of PEG decreased with the increase in the level of Si in leaves. In leaves of plants grown with 100 ppm SiO_2, the level of polysaccharides in cell walls, which is one of the factors related to tolerance to desiccation, was 1.6-fold higher than that in leaves of plants grown without Si. Ultrastructural observations of leaves revealed that polymerized Si accumulated in the walls of epidermal cells but not in those of the mesophyll cells, which are probably the main sites of El. These findings suggested that silicon in rice leaves is involved in the water relations of cells, such as mechanical properties and water permeability and plays a role in preventing El through the synthesis and functions of cell walls. The El caused by high temperature (42.5℃) was also lower in the leaves grown with Si than in the leaves grown without Si, suggesting the involvement of silicon in the thermal stability of lipids in cell membranes. These results suggested that silicon prevents the structural and functional deterioration of cell membranes when rice plants are exposed to environmental stress.

著者

Yuki YAMAMOTO Tatsuya YAMAMOTO Natsuki YUTO Thomas B. HILDEBRANDT Imke LUEDERS Gudrun WIBBELT Osamu SHIINA Yasushi MOURI Keisuke SUGIMURA Sayuri SAKAMOTO Saroch KAEWMANEE Kentaro NAGAOKA Gen WATANABE Kazuyoshi TAYA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.1111070413-1111070413, (Released:2011-11-11)

被引用文献数

2 13

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The objective of the present study was to define the secretion of prolactin (PRL) in pregnant African and Asian elephants. Levels of immunoreactive (ir-) PRL in serum and placental homogenates were measured by a heterologous radioimmunoassay (RIA) based on an ovine and human RIA system, and the localization of immunoreactive (ir-) PRL in the placenta was detected by immunohistochemistry using anti-human PRL. Circulating ir-prolactin clearly showed a biphasic pattern during pregnancy in African and Asian elephants. Serum levels of ir-PRL started to increase from the 4-6th month of gestation and reached the first peak level around the 11-14th month. A second peak of circulating ir-PRL levels was observed around the 18-20th month of gestation followed by an abrupt decline after parturition. In contrast, in a case of abortion of an African elephant, the second peak of ir-PRL was not observed, and the levels remained low for about four months until parturition. The weight of the fetus delivered at the 17th month of gestation was 23.5 kg, which was quite small compared with normal fetuses in previous reports. Ir-PRL was detected in placental homogenates, and immunolocalization was observed in trophoblasts in both the African and Asian elephants, indicating that the placenta is the source of ir-PRL during pregnancy in elephants. The present results clearly demonstrated that circulating ir-PRL shows a biphasic pattern during normal pregnancy and that the placenta appears to be an important source of circulating ir-PRL during pregnancy in both African and Asian elephants.

著者

ビヤース B・F 入江 昭

出版者

財団法人 日本国際政治学会

雑誌

国際政治 (ISSN:04542215)

巻号頁・発行日

vol.1961, no.17, pp.61-72, 1961-12-15 (Released:2010-09-01)

参考文献数

45

著者

Augustin T. B. Orou Matilo Yoshiko Iida Takashi S. Kohyama

出版者

日本熱帯生態学会

雑誌

Tropics (ISSN:0917415X)

巻号頁・発行日

vol.22, no.2, pp.39-57, 2013-09-01 (Released:2013-09-05)

参考文献数

32

被引用文献数

3

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The Dahomey gap is a savanna region separating the West African rainforests to two regions. We set two sites in this woody savanna, at north and south regions in purpose to examine the differences in tree community properties between sites and among canopy-closure types, and to reveal the factors affecting the differences. Two sites are ca. 225 km distant from each other and have different rainfall patterns. Six 1-ha plots in each site were studied, which cover three types of canopy-closure (closed, semi-open and open). We recorded 3,720 trees that are equal to or more than 5 cm diameter at the breast height, consisted of 70 species belonging to 34 families. Most abundant three species, Isoberlinia doka, Vitellaria paradoxa and Pericopsis laxiflora appeared in both sites. The detrended correspondence analysis (DCA) based on species abundance divided 12 plots into groups of north and south sites along the first axis, whereas canopy-closure types were not associated with DCA axes. At any given total tree height, trees in the north site had slenderer stems with narrower crowns than those in the south site. The specific leaf area was smaller in the north site. Between-site differences in species abundance and allometry are possibly driven by rainfall variation.

著者

Carlito B. Lebrilla

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.2, no.Special_Issue, pp.S0016-S0016, 2013-04-15 (Released:2013-05-03)

参考文献数

18

被引用文献数

1 3

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The role of glycosylation and their biological functions whether as free oligosaccharides or glycoconjugates has been made possible by the recent advancements in the analyses of these compounds. The heterogeneity and the large structural diversity have made oligosaccharide analysis significantly more difficult than other biopolymers. The next stage of development is to achieve high throughput analysis. However, the structural elucidation of oligosaccharides remains an extremely difficult task. Recent reports reveal that the diversity of structures in a given biological system is finite and may not be large. It may be possible to create a database of structures that can be used to determine the identity of known compounds. This capability would therefore make high throughput glycomics possible. Achieving this task depends on the proper selection of chemical characteristics to identify the compound. In this presentation, nanoflow liquid chromatography retention times, accurate mass, and tandem MS is used to determine structure with a high degree of certainty. The method is used to determine the biological function of milk oligosaccharides as well as to discover glycan-based biomarkers for diseases.

著者

村山建大 Bチーム著

出版者

銀河書房

巻号頁・発行日

1990

著者

Charles V. Steiner jr. Richard B. Davis[著] 岩村博夫訳

出版者

興仁舎

巻号頁・発行日

1982

著者

山原 條二 Li Yuhao Qian Li George Roufogalis Basil B.

出版者

和漢医薬学会

雑誌

和漢医薬学雑誌 (ISSN:13406302)

巻号頁・発行日

vol.20, 2003-08-05

著者

STANGER B. Z.

雑誌

Cell

巻号頁・発行日

vol.81, pp.513-523, 1995

被引用文献数

15 759

著者

長塚 仁 LEFEUVRE M.B.

出版者

岡山大学

雑誌

特別研究員奨励費

巻号頁・発行日

2010

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我々の研究グループは、頭頸部扁平上皮癌における新規癌抑制遺伝子候補の同定のために、ヘテロ接合性消失解析(LOH解析)を行ってきた。これまでの研究成果では、染色体1p36において高頻度にLOHが生じている3つの領域を新たに同定し、新規癌抑制遺伝子候補としてp73、DFFB、UBE4B、RIZ、Rap1GAP、EphB2、RUNX3を同定した。本研究ではこれらの新規癌抑制遺伝子候補について機能解析を行う。平成23年度はRIZ遺伝子について継続して研究を行うとともに、LOH解析で11p15.2領域に新たに同定したDkk-3遺伝子の機能解析を行った。RIZ遺伝子についての研究では、頭頸部扁平上皮癌組織を用いて、これまで他臓器で報告されていたP704 polym OrphismとAsp283Glu polymorphismの二種類の遺伝子多形が頭頸部扁平上皮癌でも生じていることが明らかとなった。polymorphismの有無と臨床データとの相関を検討したところ、P704polymorphismを有する群は、wild type群よりも無疾患生存率、期間生存率ともに長い傾向を示した。また、Asp283Glu polymporphism群は、wild type群に比較して、無疾患生存率、期間生存率ともに短い傾向を示した。RIZの頭頸部扁平上皮癌における詳細な機能については今後さらなる研究が必要であるが、癌抑制遺伝子以外の機能を有する可能性が考えられた。本研究結果は国際英文誌に投稿中である。Dkk-3遺伝子についての研究では、頭頸部扁平上皮癌90症例を用いて。Dkk-3タンパク発現と生存解析を行った。その結果、Dkk-3はLOHで高頻度に欠失している遺伝子であるにも関わらず、腫瘍細胞で84.4%(76/90例)と非常に高頻度に発現していた。さらに興味深いことに、Dkk-3を発現する患者は有意に無疾患生存率が短く(p=0.038)、特に遠隔転移を生じるまでの期間(metastasis free survival)が有意に低い(p=0.013)ことが示された。この結果からは、Dkk-3遺伝子は頭頸部扁平上皮癌では癌抑制遺伝子として機能するのではなく、むしろ転移を促進しているかのような結果であった。この現象については考察を加え、国際英文雑誌Oncology Lettersに掲載された。本研究で得られた成果は、頭頸部扁平上皮癌における抑制遺伝子の理解を深めるものである。

著者

James B. Maas with Megan L. Wherry ...

出版者

Villard

巻号頁・発行日

1998

著者

Ildikó V. TÓTH Inês C. SANTOS Cláudia F. M. AZEVEDO Jorge F. S. FERNANDES Ricardo N. M. J. PÁSCOA Raquel B. R. MESQUITA António O. S. S. RANGEL

出版者

(社)日本分析化学会

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.29, no.5, pp.563-570, 2013-05-10 (Released:2013-05-10)

参考文献数

30

被引用文献数

3 5

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In this work, aiming to develop a simple, inexpensive method for the determination of low bromate levels in water samples, a liquid waveguide capillary cell (LWCC) was coupled to a FIA system. The long optical path (100 cm) of the LWCC was used to improve the sensitivity and the limit of detection without resorting to any off-line or in-line preconcentration processes. The spectrophotometric determination was based on the oxidation of chlorpromazine by bromate in an acidic medium, resulting in the formation of a colored radical product. Sulfamic acid was added to the reagent for minimizing the interference of nitrite, and a chelating ion exchange resin was used to remove major cationic interferences. The developed system allowed the determination of bromate within the range between 1 – 20 μg L−1 with a detection limit of 0.2 μg L−1.

著者

風間 洋一 PINANSKY S. B. PINANSKY Samuel Bernard PINANSKY Samuel Barnard

出版者

東京大学

雑誌

特別研究員奨励費

巻号頁・発行日

2007

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Pinanskyは、2年前にBerensteinと共に提唱した、素粒子の標準模型と非常に良く似た性質を示すMinimal Quiver Standard Modelの性質の研究を継続して行った。具体的には、このモデルのパラメーターに対する従来よりはるかに正確なバウンドの計算、および加速器実験における崩壊確率と計測確率の計算を遂行した。この計算により、近い将来にLHC実験から得られるデータとの比較の準備が整ったと言える。この研究成果は、Physical Review Dに掲載されることが確定している。この種のモデルにおける困難な点は、その背景にある超弦理論との関係が完全には明確になっていないことである。その鍵となるゲージ/弦対応については膨大な「証拠」が得られており、ある種の曲がった時空の境界にクイヴァーゲージ理論が現れることが知られているが、そのメカニズムをより明確にするために、トーリック幾何と呼ばれる代数幾何のクラスに関する研究も継続して行った。一方風間は、前年度に引き続き、ゲージ/弦対応の理解に不可欠であるにも拘わらず発展が遅れているラモン・ラモン場を含む曲がった時空中の超弦理論の研究を行った。この種の問題のプロトタイプである平面波背景場中の超弦理論をグリーン・シュワルツ形式で共形不変性を保ったまま量子化する方法を開発し、量子化されたヴィラソロ代数を構成することに成功した。さらに、系の持つ対称性代数の生成子の量子的な構成、および物理的状態に対応する頂点関数の構成の研究を進めたが、実はこうした研究は、平坦な時空の場合でさえ行われていないことが判明したため、まず平坦な時空の場合の構成を進めることとし、ほぼそれが完成しつつある状況である。

著者

Yoshiki YUI Tetsuya SUMIYOSHI Kazuhisa KODAMA Atsushi HIRAYAMA Hiroshi NONOGI Katsuo KANMATSUSE Hideki ORIGASA Osamu IIMURA Masao ISHII Takao SARUTA Kikuo ARAKAWA Saichi HOSODA Chuichi KAWAI JMIC-B Study Group

出版者

日本高血圧学会

雑誌

Hypertension Research (ISSN:09169636)

巻号頁・発行日

vol.27, no.7, pp.449-456, 2004 (Released:2004-08-07)

参考文献数

19

被引用文献数

21 27

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We stratified findings from the Japan Multicenter Investigation for Cardiovascular Diseases-B according to whether or not the patients had diabetes and compared the incidence of cardiac events occurring over a 3-year period between treatment with nifedipine retard and angiotensin converting enzyme (ACE) inhibitor. The primary endpoint was the overall incidence of cardiac events (cardiac death or sudden death, myocardial infarction, hospitalization for angina pectoris or heart failure, serious arrhythmia, and coronary interventions), and the secondary endpoints were a composite of other events (cerebrovascular accidents, worsening of renal dysfunction, non-cardiovascular events, and total mortality). The results showed no significant difference in the incidence of the primary endpoint between the nifedipine group (n =199) and the ACE inhibitor group (n =173) in diabetic patients: 15.08% vs. 15.03%, relative risk 1.06, p =0.838. Also in nondiabetic patients, no significant difference was observed between the former (n =629) and the latter (n =649): 13.67% vs. 12.33%, relative risk 1.04, p =0.792. Similar results were obtained for the incidence of the secondary endpoints: in diabetic patients, 5.03% vs. 5.20%, relative risk 0.89, p =0.799; in nondiabetic patients, 2.70% vs. 2.47%, relative risk 1.07, p =0.842. Achieved blood pressure levels were 138/76 and 136/77 mmHg in the nifedipine group and 140/78 and 138/79 mmHg in the ACE inhibitor group in diabetic and nondiabetic patients, respectively. This study showed that nifedipine retard was as effective as ACE inhibitors in reducing the incidence of cardiac events in extremely high-risk hypertensive patients with complications of diabetes and coronary artery disease. (Hypertens Res 2004; 27: 449-456)