著者

有田市誌編集委員会 編

出版者

有田市

巻号頁・発行日

1974

著者

神戸 徳蔵 熊谷 八百三

出版者

公益社団法人 電気化学会

雑誌

電気化学および工業物理化学 (ISSN:03669297)

巻号頁・発行日

vol.52, no.7, pp.432-437, 1984-07-05 (Released:2019-09-30)

著者

Reiya HORINOUCHI Kae HARADA Mamoru MURAKAMI Yusuke YAMASHITA Yuji KAMASHITA Naohiro SHIMOTAHIRA Taizo HAMADA Yasuhiro NISHI Masahiro NISHIMURA

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2022-007, (Released:2022-06-28)

参考文献数

36

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The need for denture adhesives is increasing worldwide, but few denture-care products target denture adhesive users. Foam denture cleaners have been recently marketed to assist brush denture cleaning, but there is a lack of objective evaluation. In this study, we compared the detergency of denture adhesives using six commercial foam-denture cleaners. For removing the adhesives, most of the tested cleaners were effective in immersion experiments, and three cleaners were more effective in the denture cleaning experiment compared to control water. However, only one could effectively remove the slime that is derived from the adhesive and detergency of artificial dirt. The surface roughnesses of the denture base and the relining material revealed that prolonged immersion in some cleaners could be affected. The results suggest that different commercial foam denture cleaners have different detergency levels, and that some cleaners may affect the properties of denture materials upon long-term use.

著者

糟谷 史代

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.35, no.6, pp.598-599, 1999-06-01 (Released:2018-08-26)

参考文献数

4

著者

田浦 太志

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.34, no.6, pp.592, 1998-06-01 (Released:2018-08-26)

参考文献数

4

著者

早瀬 環

出版者

日本毒性学会

雑誌

日本トキシコロジー学会学術年会 第33回日本トキシコロジー学会学術年会

巻号頁・発行日

pp.68, 2006 (Released:2006-06-23)

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Nicotine (NC) has been reported to cause both sedative and anxiogenic effects, and participation of various brain receptors, including brain cannabinoid (CB) receptors, has been demonstrated. In the present study, the behavioral effects of repeated NC were examined in male ICR mice. Methods and Results: In the repeated subcutaneous NC (0.5 mg/kg, 4 days) administration group, unlike the acute single dose group, prolonged anxiety-related behavioral alterations were observed in the elevated plus-maze test, and sedative hypolocomotion was also caused at an earlier time point. Furthermore, NC caused stress-related depressive behavioral alterations in the forced swimming test, and these alterations were prolonged by repeated administration. Against the anxiety-related symptoms, the serotonin receptor antagonist WAY 100635 and the mixed agonist/antagonist virodhamine provided significant antagonistic effects. For the early sedative hypolocomotion, the non-CB1/non-CB2 brain CB receptor agonist O2093 had some antagonist activity. Furthermore, O2093 and virodhamine antagonized the stress-related depressive behavioral alterations in the forced swimming test. Discussion and Conclusion: These results demonstrated a prolongation of the NC-induced anxiety-related and stress-related behavioral alterations by repeated administration, which was accompanied by early sedative effects and may contribute to the persistent use of this drug. Furthermore, a characteristic participation of brain CB receptors in these prolonged behavioral effects was elucidated.

著者

大里 浩二

出版者

帝塚山大学現代生活学部

雑誌

帝塚山大学現代生活学部紀要 = Journal of contemporary human life science, Tezukayama University (ISSN:24357960)

巻号頁・発行日

vol.18, pp.65-70, 2022-03-31

著者

内山 奈穂子 花尻(木倉) 瑠理 正田 卓司 福原 潔 合田 幸広

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.7, pp.1141-1147, 2011-07-01 (Released:2011-07-01)

参考文献数

12

被引用文献数

11 12

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Recently, many psychotropic herbal products, named such as “Spice”, were distributed worldwide via the Internet. In our previous study, several synthetic cannabinoids were identified as adulterants in herbal products being available in Japan due to their expected narcotic effects. Among those, two derivatives of Δ9-tetrahydrocannabinol (Δ9-THC), which is major psychotropic cannabinoid of marijuana, cannabicyclohexanol (CCH, 3-[2-hydroxy-4-(2-methylnonan-2-yl)phenyl]cyclohexan-1-ol) and CP-47,497 (3-[2-hydroxy-4-(2-methyloctan-2-yl)phenyl]cyclohexan-1-ol), have been controlled as designated substances (Shitei-Yakubutsu) under the Pharmaceutical Affairs Law since November 2009. CCH was detected together with its trans-form (1-epimer) in many herbal products, and CCH and CP-47,497 have two chiral centers in the structures. However, the pharmaceutical activities of the isomers of CCH have not been reported. This study presents chiral separations of CCH, its trans-form and CP-47,497 in the products using LC-circular dichroism (CD) and LC-MS analyses. The enantiomeric pairs of CCH, its trans-form and CP-47,497 were separated, respectively. Subsequently, the analyses of the herbal products showed that CCH and its trans-form existed as mixtures of enantiomers and the relative ratios of CCH and the trans-form enantiomers ranged from 42/58% to 53/47% and from 33/67% to 52/48%, respectively.

著者

桜井 淑男 小幡 徹 堀口 徹 鳥海 和弘 鹿瀬 陽一 谷藤 泰正

出版者

The Japanese Society of Intensive Care Medicine

雑誌

日本集中治療医学会雑誌 (ISSN:13407988)

巻号頁・発行日

vol.11, no.2, pp.143-144, 2004-04-01 (Released:2009-03-27)

参考文献数

6

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We have developed a high sensitive method of measuring the serum endocannabinoids (anandamide, ABA and 2-arachidonyl-glycerol, 2-AG) by gas chromatography and mass spectrometry (GC/MS) with isotope dilution. We measured the serum endocannabinoids in 5 esophageal and 5 lung cancer patients perioperatively with GC/MS to clarify the relationship between perioperative inflammation and endocannabinoids. It was demonstrated that ABA didn' t significantly change perioperatively, although the pre and postoperative 2-AG concentrations in the cancer patients were significantly higher than the control value (P<0.05) and that AEA did not change perioperatively in significant manner. Therefore, 2-AG may play a pivotal role in perioperative inflammation.

著者

杉浦 隆之 和久 敬蔵

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.34, no.4, pp.334-338, 1998-04-01 (Released:2018-08-26)

参考文献数

17

著者

池田 慎哉 山口 翔大 竹本 光義

出版者

公益社団法人 日本化学会・情報化学部会

雑誌

ケモインフォマティクス討論会予稿集 第37回情報化学討論会 豊橋

巻号頁・発行日

pp.P15, 2014 (Released:2014-11-20)

参考文献数

1

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近年、危険薬物又はその類似物質が添加された危険ドラッグの使用による事件・事故が多発している。その対策として合成カンナビノイド類約800種類、カチノン類約500種類が包括指定という広範囲な規制をされた。これらの包括指定薬物の標準物質の多くは合成されていないため、標準物質との比較による同定が難しい。そこで密度汎関数法を用いてカンナビノイド類のMSスペクトルを予測する方法を考えた。この方法により予測したMSスペクトルをESI装置を備えたLC-MS/MSで測定した標準物質のMSスペクトルと比較した。

著者

辻川 健治

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.46, no.7, pp.693-694, 2010-07-01 (Released:2018-08-23)

参考文献数

4

著者

児玉 浩憲

出版者

一般社団法人 電気学会

雑誌

電気学会誌 (ISSN:13405551)

巻号頁・発行日

vol.134, no.11, pp.739, 2014 (Released:2014-11-01)

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吸って楽しむ危険な成分 児玉 浩憲

著者

渡辺 和人 山本 郁男

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.38, no.5, pp.385-396, 1992-10-31 (Released:2008-05-30)

参考文献数

133

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Marihuana is a complex mixture containing various biologically active compounds in which cannabinoids are major components. The drug interaction of marihuana with other drugs is a serious problem in some cases since marihuana is often taken with other centrally-acting drugs. Tetrahydrocannabinol (THC), which is a main component responsible for most of the psychomimetic effects of marihuana, can potentiate the effects of many depressants, such as alcohol, barbiturates, anesthetics, morphine and anticonvulsants, in the central nervous system. The drug interaction of THC with other drugs is a functional mechanism in the central nervous system. THC has biphasic effects (stimulant and depressant) depending on, maily, doses. THC, therefore, interacts with stimulants as cocaine and phencyclidine in a complicated manner. Cross-tolerance in some effects of the components of marihuana and of other drugs has been recognized. Cannabidiol (CBD), which is another major component in marihuana but lacks psychomimetic activity, potentiates the effects of some specified drugs that terminates their effects through metabolic inactivation. The interaction of CBD with other drugs is considered to be metabolic in origin since the cannabinoid can suppress the gepatic microsomal drugmetabolizing enzymes. Drug interaction can also occur among cannabinoids, indicating the complexity of the combined effect of marihuana and other drugs. These are additives, synergistic or antagonistic, depending on the conditions used. This review describes the interactions of marihuana components with centrally-acting drugs in relation to their pharmacological and toxicological significance.

著者

辻 由依

出版者

北海道医療大学

巻号頁・発行日

2021-03-20

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令和2年度

著者

朝倉 京子

出版者

東北医学会

雑誌

東北医学雑誌 (ISSN:00408700)

巻号頁・発行日

vol.121, no.2, pp.149-152, 2009-12

著者

塩田 拓哉 山添 雅彦 九鬼 孝夫

出版者

一般社団法人 映像情報メディア学会

雑誌

映像情報メディア学会誌 (ISSN:13426907)

巻号頁・発行日

vol.63, no.4, pp.428-432, 2009-04-01 (Released:2011-04-01)

参考文献数

6

著者

佐々木洋士 [著]

巻号頁・発行日

1991

著者

西原 宏史

出版者

日本微生物生態学会

雑誌

日本微生物生態学会誌 (ISSN:24241989)

巻号頁・発行日

vol.16, no.2, pp.32-39, 2001-09-29 (Released:2017-08-01)

参考文献数

33

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.56, no.2, pp.96-97, 2020 (Released:2020-02-01)

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ミニ特集:患者に寄り添った医療を考えるミニ特集にあたって:近年,薬剤師はあらゆる専門性を身に着け,医療チームの一員として活躍する姿が見られる.病棟や在宅などで患者と接していく中で,ある時ふと自分(薬剤師)の限界を感じた人もいるだろう.「私に何ができるだろう」と悩んだ時,「その患者にとって何が必要なのか」を考えられる薬剤師であってほしいと願っている.このミニ特集では患者に寄り添う医療の実際や,患者の声を聴くスキルについて紹介していただいた.患者に寄り添った医療の在り方と薬剤師の果たすべき役割を考える機会となれば幸いである.表紙の説明:大河ドラマ「麒麟がくる」が始まった.本能寺の変の主役,明智光秀が主人公だが,波乱万丈の生涯を送った光秀にふさわしい始まりだ.その光秀の家紋が桔梗紋である.光秀に大きな影響を与えた斉藤道三,一癖も二癖もありそうな足利義昭,人物として完成後に出会った織田信長,それらの人物と光秀の関係が,大河ドラマでどう描かれるか興味深い.また,意外な著名人も実は桔梗紋を使っていた.電子付録では,キキョウの花と共に桔梗紋の著名人を詳しく紹介したい.