著者

Teruyoshi Tanaka Hanjun Tang Kazuya Umehara Tatsuya Moriyama Yukio Kawamura

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-22-00103, (Released:2022-11-11)

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As the average longevity of humans increases, the number of patients with osteoporosis has also increased. Chemoprevention for osteoporosis, especially through food intake, may extend the healthy life expectancy. We previously reported that kudzu (Pueraria lobata) vine ethanol extract (PVEE) in the diet (20 mg/kg body weight/day) suppresses bone resorption and prevents bone loss in ovariectomized mice. However, experiments with lower PVEE concentrations are necessary to determine whether PVEE is a suitable functional food resource to improve osteoporosis. This study thus examined the effects of PVEE intake (2 or 5 mg/kg body weight/day, approximately 0.07 or 0.17 mg PVEE isoflavone/day/mouse) for 6 months. The dose was calculated on the basis of the recommended daily isoflavone allowance in Japan. Both 5 and 2 mg PVEE successfully prevented ovariectomy-induced bone loss in mice. These results indicated that PVEE was effective at these doses. Thus, PVEE has the potential to be a promising resource for osteoporosis-preventing functional foods.

著者

Motoi Tamura Hiroyuki Nakagawa Kazuhiro Hirayama

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

pp.FSTR-D-22-00117, (Released:2022-11-11)

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Isorhamnetin (3′-methylquercetin) is one of the major metabolites of quercetin. We hypothesized that Eubacterium limosum JCM6421 T transforms isorhamnetin back to quercetin and the type of sugar affects short-chain fatty acid production by E. limosum JCM6421T. Anaerobic broth (0.2 mL) containing this bacterium was added to the isorhamnetin solution and anaerobically incubated for 8 and 24 h. Additionally, E. limosum JCM6421T was anaerobically incubated with various 2 µL-sugar solutions for 24 h and short-chain fatty acid production by this bacterium was measured. Quercetin was produced by anaerobic incubation of isorhamnetin with E. limosum JCM6421T. Its production increased with an increase in incubation time from 8 to 24 h. Mannitol was the ideal sugar for butyric and acetic acid production by E. limosum JCM6421T among the investigated sugars. We discovered that E. limosum JCM6421T produces quercetin from isorhamnetin.

著者

中田 輝夫

出版者

The Japan Society for Oriental Medicine

雑誌

日本東洋医学雑誌 (ISSN:02874857)

巻号頁・発行日

vol.48, no.2, pp.205-210, 1997-09-20 (Released:2010-03-12)

参考文献数

11

被引用文献数

2 2

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主として中高年の, HRS得点で30点以下の軽うつ病の患者30例に対して, 加味帰脾湯の投与を試みたところ, 30例中76.6%が平均3.5週間の観察でやや有効以上の成績を得た。症例は虚証で, 自殺企図がない症例に限定し, 不眠, 不安, 食欲不振等の症状のある例にはその緩和のために Benzodiazepine 系の抗不安薬および十全大補湯の併用という条件であったが, 加味帰脾湯は有効であると考えられた。

著者

Wieland HEIM Aleksey ANTONOV Ilka BEERMANN Simeon LISOVSKI Martha Maria SANDER Steffen HAHN

出版者

The Ornithological Society of Japan

雑誌

ORNITHOLOGICAL SCIENCE (ISSN:13470558)

巻号頁・発行日

vol.21, no.1, pp.121-126, 2022 (Released:2022-01-31)

参考文献数

45

被引用文献数

6

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East Asian songbirds are known to migrate along two major corridors: from mainland Eurasia via China to South-East Asia, and from Japan and easternmost Russia through chains of islands in the Pacific to Indonesia and the Philippines. We successfully tracked the hitherto unknown migration of a Blue-and-white Flycatcher Cyanoptila cyanomelana breeding in the Russian Far East. The bird spent five months on Mindoro Island in the Philippines during the non-breeding season and migrated through Taiwan, the Chinese east coast, and the Korean peninsula. Thus, we provide the first direct evidence for songbird migration from mainland Russia to the Philippines.

著者

Vagata Daniela Shalom

出版者

イタリア学会

雑誌

イタリア学会誌 (ISSN:03872947)

巻号頁・発行日

vol.58, pp.197-203, 2008

著者

髙田 勝 田原 岳 天野 卓 野村 こう 高橋 幸水 古川 力 秋篠宮 文仁

出版者

日本養豚学会

雑誌

日本養豚学会誌 (ISSN:0913882X)

巻号頁・発行日

vol.55, no.1, pp.12-20, 2018-03-09 (Released:2018-06-30)

参考文献数

28

被引用文献数

1 1

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琉球豚は中国豚由来であり,黒色を有するアグーと白斑を有するアヨーがある。アグーはバークシャー種との交雑により改良されたと報告されているが,西洋系豚や中国系豚との分子遺伝学的類縁関係は明らかでない。そこで,アグー系とアヨー系を系統内交配により維持している今帰仁アグー集団の繁殖豚AG (B),AG (R),AG (W) とその交雑集団AG (O) およびこれらの祖先集団AG06,AY06,さらに西洋系豚,中国系豚について,マイクロサテライト30座位の遺伝子型を解析することにより,琉球豚の遺伝的多様性とともに西洋系豚,中国系豚との類縁関係および遺伝的構造を明らかにすることを目的とした。有効対立遺伝子数,アレリックリッチネス,多型情報量などの遺伝的多様性の指標値は,いずれもAG (W) が最も小さくAG (O) が最も大きく,AG (O) の多様性は西洋系と同程度であった。今帰仁アグー各系統は西洋系品種に比べてヘテロ接合度の観測値が期待値よりも大きい傾向にあり,FIS は負の値を示して,近親交配を避けた交配が行われていたことが示唆された。品種·系統間の遺伝的関係では,主座標分析から,琉球豚,中国系,西洋系が二次元上にそれぞれのクラスターを形成することが明らかとなった。遺伝的距離にもとづく系統樹からは,AG (B) はAG06と近縁であり,AG (W) はAY06と近縁であることが示され,これらを含む琉球豚は中国系とクラスターを形成した。遺伝的構造の解析からも,琉球豚は中国豚と共通する祖先に由来することが示されたが,AG (B) とAG (R) はバークシャー種と共通する祖先集団由来の遺伝子を有すると推察された。この結果はこれまでの琉球豚の由来の記述を裏付けるものであった。

著者

つくばね書房

出版者

つくばね書房

巻号頁・発行日

no.7, 1949-12

著者

下平 高次郎 広島 勉

出版者

一般社団法人 日本鉱物科学会

雑誌

鉱物学雜誌 (ISSN:04541146)

巻号頁・発行日

vol.14, no.Special2, pp.96-108, 1980-03-10 (Released:2009-08-11)

参考文献数

11

被引用文献数

1 1

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The Synthesis of Opalin Materials Takajiro Shimohira, Tsutomu Hiroshima: National Institute for Researches in Inorganic Materials, Sakura-mura, Niiharigun, Ibaraki Opalin materials which show some of the characteristics of natural precious opal have been synthesized. The process of making the materials was as follows;1) Monodispersed suspensions of spherical silica particles of colloidal size were produced by means of hydrolysis of ethyl silicate.2) An ordered close-packed array of hydrated silica particles has been achieved by sedimentation over a period of several months.3) Sintering and impregnation method were used to harden the arrays of stacked spheres.

著者

杉江 雅彦 Masahiko Sugie

出版者

同志社大学商学会

雑誌

同志社商学 = Doshisha Shogaku (The Doshisha Business Review) (ISSN:03872858)

巻号頁・発行日

vol.56, no.2-3-4, pp.107-125, 2004-12-20

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研究

著者

田中清 編

出版者

田中清

巻号頁・発行日

1933

著者

遠藤 操

出版者

一般社団法人 エネルギー・資源学会

雑誌

エネルギー・資源学会論文誌 (ISSN:24330531)

巻号頁・発行日

vol.41, no.6, pp.233-242, 2020 (Released:2020-11-10)

参考文献数

28

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The purpose of this paper is to evaluate the swing option price written on the underlying asset of JEPX spot price. The swing option price is calculated by following three steps; (i) modeling JEPX spot price process taking into account the features of mean-reverting, seasonality and spikes, (ii) deriving risk-neutral measure from TOCOM electricity forward curve, and (iii) executing Least-squares Monte Carlo simulation. The calculation result is shown in several graphs which focus on the combination of swing type, number of swing rights and option exercise price. Moreover, this paper analyzes the sensitivity of swing option price to the spot price trend, volatility and spike frequency. Swing option has already been introduced in power purchase agreements between power generating companies and power retail companies in Japan. Therefore, it is considered important for these companies to find a suitable reference price for negotiation. This paper will show a theoretical way to calculate the reference price.

著者

Jun-ichi KIRA Shozo TOBIMATSU Ikuo GOTO

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.33, no.2, pp.82-86, 1994 (Released:2006-03-27)

参考文献数

37

被引用文献数

35 45

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Serum vitamin B12 levels and unsaturated vitamin B12 binding capacities were measured in 24 patients with multiple sclerosis (MS), 73 patients with other neurological disorders and 21 healthy subjects. There was no decrease in the vitamin B12 levels, however, a significant decrease in the unsaturated vitamin B12 binding capacities was observed in patients with MS when compared with other groups. A massive dose of methyl vitamin B12 (60 mg every day for 6 months) was administered to 6 patients with chronic progressive MS, a disease which usually had a morbid prognosis and widespread demyelination in the central nervous system. Although the motor disability did not improve clinically, the abnormalities in both the visual and brainstem auditory evoked potentials improved more frequently during the therapy than in the pre-treatment period. We therefore consider that a massive dose methyl vitamin B12 therapy may be useful as an adjunct to immunosuppressive treatment for chronic progressive MS.(Internal Medicine 33: 82-86, 1994)

著者

Fabiana Mallone Luca Lucchino Federica Franzone Marco Marenco Sandra Cinzia Carlesimo Antonietta Moramarco

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

vol.14, no.3, pp.122-128, 2020-06-30 (Released:2020-07-15)

参考文献数

51

被引用文献数

3 7

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The aim of this study is to investigate the potential neuroprotective effect of high-doses vitamins B1, B6 and B12 in patients with relapsing-remitting multiple sclerosis (RRMS) and persistent visual loss after acute optic neuritis (AON). Sixteen patients (20 eyes) diagnosed with RRMS and visual permanent disability following AON were enrolled for the present open, pilot study. Each patient was treated with oral high-doses 300 mg of vitamin B1, 450 mg of vitamin B6 and 1,500 mcg of vitamin B12, as add-on treatment to concomitant disease-modifying therapies (DMTs) for consecutive 90 days. Outcome measures were to determine changes from baseline to month three in visual acuity (VA) and visual field (VF) testing, with correlations with clinical parameters. Logistical regression was performed to evaluate predictors of final VA. A statistically significant improvement was registered in visual acuity (p = 0.002) and foveal sensitivity threshold (FT) (p = 0.006) at follow-up compared to baseline. A similar trend was demonstrated for mean deviation (MD) (p < 0.0001), and pattern standard deviation (PSD) (p < 0.0001). Age at the time of inclusion was positively correlated with latency time (rho = 0.47, p = 0.03), while showing a negative correlation with visual acuity (rho = – 0.45, p = 0.04) and foveal sensitivity threshold (rho = – 0.6, p = 0.005) at follow up. A statistically significant correlation was demonstrated between foveal sensitivity threshold and visual acuity at baseline (rho = 0.79, p < 0.0001). In a linear regression model, the main predictor of visual acuity at follow up was the foveal sensitivity threshold (B = 1.39; p < 0.0001). Supplemental high-dose vitamins B1, B6 and B12 resulted as effective therapy to improve visual function parameters in MS-related visual persistent disability.

著者

中堀 正洋 Масахиро Накахори

出版者

創価大学ロシア・スラヴ学会

雑誌

創価大学ロシア・スラヴ論集 (ISSN:18827403)

巻号頁・発行日

no.13, pp.63-64, 2021-03-31

著者

日本電信電話公社施設局 編

出版者

電気通信協会

巻号頁・発行日

vol.26, no.6, 1974-06

著者

山本 雅博

出版者

公益社団法人 電気化学会

雑誌

Electrochemistry (ISSN:13443542)

巻号頁・発行日

vol.80, no.11, pp.925-931, 2012-11-05 (Released:2012-11-05)

参考文献数

22

被引用文献数

1

著者

日本電信電話公社施設局 編

出版者

電気通信協会

巻号頁・発行日

vol.26, no.4, 1974-04

著者

山田 恵太

出版者

法と心理学会

雑誌

法と心理 (ISSN:13468669)

巻号頁・発行日

vol.18, pp.3-5, 2020 (Released:2020-04-05)

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近年、障害のある人、特に知的障害、発達障害、精神障害等のある人が、刑事手続における被疑 者・被告人になっている事案について、注目が集まっている。刑務所に障害のある人や高齢の人が 多くいるという問題が明らかとなったことを発端として、そのような人たちを刑事裁判の段階から 支える「入口支援」にも目が向けられているのである。そして、その 1 つとして、弁護士と社会福祉 士等のソーシャルワーカーが連携し、ソーシャルワーカーに「更生支援計画」と呼ばれる支援計画を 作成してもらった上で、これを捜査や公判の場面で被疑者・被告人に有利な証拠として扱う活動が 行われている。本報告では、このような更生支援計画を作成する活動の紹介に加え、実際に更生支 援計画を作成してもらい、公判において立証し、これが量刑上有利に斟酌された事例について報告 した。あわせて、福祉的支援を考える上で、身体拘束中の被疑者被告人に対する意思決定支援のあ り方の問題が存在することなど、今後の課題についても報告した。

著者

内堀 朝子 松岡 和美 南田 政浩 矢野 羽衣子

出版者

日本手話学会

雑誌

手話学研究 (ISSN:18843204)

巻号頁・発行日

vol.20, pp.67-88, 2011-12-19 (Released:2012-12-20)

参考文献数

33

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Since Japanese Sign Language(JSL) is a human language, as clearly shown by previous studies, it should be possible for JSL to have a hierarchical structure that can be generated as a result of the application of syntactic operations. This paper deals with one such case, i.e. embedding a clause into a verb complement position, and is aimed at developing a solid basis for the syntactic analysis of JSL. In order to confirm that JSL actually has a complement structure, clauses selected by a verb of saying and thinking were compared with direct quotation clauses. The differences examined in this paper concern word order, the possibility of topicalization, and the possibility of WH-question formation. The basic word order of a sentence with a complement clause is SOV, whereas that with a direct quotation is OSV. A sentence with a complement clause allows topicalization and WH-question formation, while one with a direct quotation does not allow either of them. The difference in the grammatical acceptability of topicalization and WH-question formation suggests that a sentence with a complement clause can undergo syntactic operations such as Move (or Internal Merge), Whereas one with a direct quotation clause cannot