出版者

「ディジタル図書館」編集委員会

巻号頁・発行日

1994

著者

池 昌男 永津 義隆 塚脇 篤也 上野 泰宏 蜂矢 祐司 河合 俊彦 向井 陽 河合 幹

雑誌

愛知学院大学歯学会誌 = The Aichi-Gakuin journal of dental science (ISSN:00446912)

巻号頁・発行日

vol.33, no.3, pp.639-644, 1995-09-30

参考文献数

16

被引用文献数

4

著者

石川 祐佑 鈴木 省三

出版者

仙台大学

雑誌

仙台大学大学院スポーツ科学研究科修士論文集 (ISSN:13486357)

巻号頁・発行日

vol.10, pp.69-77, 2009-03-31

著者

Emily Scida

出版者

Routledge

巻号頁・発行日

2004

著者

唐川 正典 胡田 光信 依藤 進 井口 松三

出版者

THE JAPANESE CIRCULATION SOCIETY

雑誌

日本循環器學誌 (ISSN:00471828)

巻号頁・発行日

vol.19, no.7, pp.321-325, 1955-10-20 (Released:2008-04-14)

参考文献数

8

---

The authors at first made formula from which assumed normal cardiac size could be calculated in reference to body-weight and length. Actual cardiac size/assumed normal cardiac size was called dilatation-gradient : actual cardiac size was measured by planimeter in its shadow in the direct postero-anterior projection of X-ray. Relatiohship between circulation time and dilatation-gradient was investigated in cases of congestive heart failure and non-congestive cardiac disease, and linear relationship was demonstrated between them. This does not mean that prolongation of real circulation time (decrease of blood velocity) is due to dilatation of heart. Because circulation-time, clinically used, shows not only the blood velocity but also the degree how much the drug injected is diluted by blood.

著者

杉山 尚 鈴木 桂伍

出版者

一般社団法人 日本温泉気候物理医学会

雑誌

日本温泉気候学会雑誌 (ISSN:03694240)

巻号頁・発行日

vol.19, no.4, pp.318-330, 1956-04-25 (Released:2010-08-06)

参考文献数

21

---

The authors have studied the effect of the single bathing in the hot spring on the time required for the blood circulation and its relation to the character of the spring and the age, the disease and the blood pressure of the patient, and obtained the following results:1) The circulation time in healthy persons is shortened immediately after the bathing both in the simple carbonate spring (37°C) and in “Unagi-yu” (alkaline sulphur spring, 44°C), but it is prolonged one hour after the bathing, being gradual in the simple carbonate spring bathing (37°C) and rapid in the alkaline spring bathing (44°C).2) As almost similar phenomena are seen in the case of fresh water bathing (37°C and 44°C), they seem to be due to the thermal action of the bathing water.3) Generally speaking, the bathing in the hot spring tends to lower both the maximal and the minimal blood pressures, and the fall keeps on going even one hour after the bathing. It is a characteristic feature of the hot spring bathing that the duration of the fall of the blood pressure is longer in the hot spring bathing than in the fresh water bathing.4) The fall in the blood pressure induced by the bathing in “Unagi-yu” (alkaline sulphur spring) is somewhat irregular and rapid, but that induced by the bathing in the simple carbonate spring is gradual.5) No changes are observed in the pulse after the bathing both in the simple carbonate spring and in the fresh water at 37°C, but a remarkable increase is observed immediately after the bathing in “Unagi-yu” end in the fresh water at 44°C. It returns to the normal pulse after one hour.6) The shortening of the circulation time induced by the hot spring bathing is more remarkably observed in persons with low blood pressure and in younger persons, and the fall in the blood pressure is more remarkable in persons with high blood pressure and in older persons.7) The shortening of the circulation time induced by the hot spring bathing is more remarkable in persons suffering from articular rheumatism than in healthy persons.The return to the normal circulation time is quickest in healthy persons, followed by those suffering from diseases of the stomach, and it is clearly slow in persons suffering from tuberculosis and from rheumatism.

著者

山崎 和博 巻渕 有哉 申 富饒 長谷川 修

出版者

日本神経回路学会

雑誌

日本神経回路学会誌 (ISSN:1340766X)

巻号頁・発行日

vol.17, no.4, pp.187-196, 2010-12-05 (Released:2011-02-07)

参考文献数

19

被引用文献数

1

---

自己増殖型ニューラルネットワーク(SOINN)は,追加学習可能なオンライン教師なし学習手法であり,事前にネットワークの構造を決定する必要がないほか,高いノイズ耐性を有し,計算が軽いなどの特長がある.SOINN は特に実世界のデータ処理に有効であり,画像や音声などのパターンの学習·認識や,実環境でオンライン·リアルタイムに稼動する知能ロボットなどに効果的に活用できる.本稿では,SOINN のアルゴリズムを紹介した後,パラメータの調整に関する指針やソフトウェア実装の解説を行なう.

著者

寺岸 明彦 神原 嘉男 小野 浩

出版者

園芸学会

雑誌

園芸学会雑誌 (ISSN:00137626)

巻号頁・発行日

vol.67, no.3, pp.386-390, 1998-05-15

参考文献数

8

被引用文献数

5 2

---

1. 非循環閉鎖型養液栽培システムにおける1株当たりの吸液量は, 培養液の濃度がEC 1.2 dS/mの区で5月中旬からEC 1.8 dS/mの区よりも多くなり, 7月下旬には約1.8 liter/株/日に達した.2. 穂木の低温貯蔵の有無および貯蔵日数は挿し木苗の成苗率には影響を及ぼしたが, 定植後の新梢伸長および最下段着果節には影響を及ぼさなかった.3. 挿し木に用いる穂木径が太い方が下位節からの着果が認められた.4. EC 2.4 dS/mとして育苗し, 栽培中のECも2.4 dS/mとした区では約2節目から着果した.5. ファイトトロン内の明期を10時間または14時間として育苗し, 最下段着果節を比較しても差はなかった.

著者

Hye-Sook CHANG Hiroaki KAMISHINA Keijiro MIZUKAMI Yasuyuki MOMOI Masaaki KATAYAMA Mohammad Mahbubur RAHMAN Mohammad Mejbah UDDIN Akira YABUKI Moeko KOHYAMA Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.795-798, 2013 (Released:2013-07-01)

参考文献数

9

被引用文献数

9 26

---

Canine degenerative myelopathy is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds, particularly Pembroke Welsh Corgis. Recently, a degenerative myelopathy-associated mutation of the canine SOD1 gene was identified as c.118G>A (p.E40K). In the present study, genotyping assays using conventional and real-time PCR methods were developed, and a preliminary genotyping survey was performed on 122 randomly selected Pembroke Welsh Corgis without any degenerative myelopathy-related clinical signs to determine the current allele frequency in Japan. Both of the assays provided clear-cut genotyping. The survey demonstrated the frequencies of the G/G wild-type, G/A heterozygote and A/A homozygote to be 9.0, 42.6 and 48.4%, respectively, indicating that the prevalence of the mutant A allele (69.7%) in Pembroke Welsh Corgis is extremely high in Japan.

著者

Aki FUJIWARA-IGARASHI Yuko GOTO-KOSHINO Hiroyuki MOCHIZUKI Shingo MAEDA Yasuhito FUJINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.733-742, 2013 (Released:2013-07-01)

参考文献数

45

被引用文献数

6 11

---

The p16, p15 and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well analyzed on the aberrations of these genes. In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5’ and 3’ rapid amplification of cDNA ends methods. Based on the sequence data, primers specific for p16, p15 and p14 were designed. Using these primers, the expression of p16, p15 and p14 mRNAs could be individually evaluated by reverse transcriptase polymerase chain reaction. Genomic aberrations were also examined using genomic polymerase chain reaction. Two of the 6 canine lymphoid tumor cell lines did not express detectable levels of p16, p15 and p14 mRNAs, and wide-ranging deletions in the p15-p14-p16 genomic locus were suspected. Wide-ranging deletions were also speculated in 2 of 14 dogs with T-cell lymphoid tumors. On the other hand, similar failure of amplification suggesting wide-ranging deletions were not observed in any of the 14 dogs with B-cell lymphoma. Deletion of the p15-p14-p16 genomic locus could be one of the molecular aberrations in canine lymphoid tumor cells.

著者

Katsuhito SONE Hideo AKIYOSHI Junichiro SHIMIZU Zheng CAO Yijyun LI Toshiyuki TANAKA Akiyoshi HAYASHI Shunji SUGII Fumihito OHASHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.685-691, 2013 (Released:2013-07-01)

参考文献数

29

被引用文献数

1 6

---

Pulmonary surfactant protein A (SP-A) is used as a biomarker to understand the clinical features of pulmonary diseases and associated prognostic indices in human medicine. This study was conducted to investigate whether or not serum SP-A concentration can be used as a biomarker for identifying pulmonary parenchymal diseases in dogs. Thirty-two dogs with pulmonary parenchymal diseases, 34 with nonrespiratory diseases and 57 healthy dogs were included. Serum SP-A concentration was measured in all dogs using sandwich enzyme linked immunosorbent assay with an anti-dog SP-A polyclonal antibody. Median serum SP-A concentration in healthy dogs was ng/ml, whereas that in dogs with aspiration pneumonia (n=11), primary lung tumors (n=9) and blunt traumatic lung injury (BTLI; n=12) was 3.1, 7.2 and 2.6 ng/ml, respectively; these values were significantly higher than those in healthy dogs. The serum SP-A concentration in dogs with nonrespiratory diseases was comparable with that in healthy dogs. No correlation was observed between the serum SP-A and plasma C-reactive protein concentrations in dogs with aspiration pneumonia and BTLI. There was a significant correlation between the serum SP-A concentration and thoracic radiographic changes in dogs with BTLI. These findings suggest that the serum SP-A concentration may be a useful clinical biomarker of alveolar damage that can be used for differential diagnosis of pulmonary parenchymal diseases and nonrespiratory diseases in dogs.

著者

Sungjin CHOI Jongil LEE Kazuyo IGAWA I-Li LIU Muneki HONNAMI Shigeki SUZUKI Ryohei NISHIMURA Ung-Il CHUNG Nobuo SASAKI Manabu MOCHIZUKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.721-726, 2013 (Released:2013-07-01)

参考文献数

29

被引用文献数

1 2

---

In this study, we aimed to determine the effect of trehalose coating and the optimal dose of basic fibroblast growth factor (bFGF), an osteoinductive protein, loaded onto tailor-made bone implants for implant-induced bone formation in vivo. We fabricated tailor-made α-tricalcium phosphate bone implants (11 mm diameter with 2 parallel cylindrical holes). bFGF 0, 1, 10, 100 or 200 μg/implant was incorporated into implants with and without a trehalose coating, and these were subsequently implanted into dogs to correct temporal bone defects of the same size and shape. Four weeks after implantation, we analyzed the bone implants and surrounding tissues by using micro-computed tomography imaging and histological analyses, as well as gross evaluation. No significant difference in new bone formation was observed between implants with and without a trehalose coating at any of the bFGF doses. Bone implants with 100 and 200 μg bFGF showed significantly more new bone formation at the implant site and within the cylindrical holes of the implants than those without bFGF (Pin vivo, probably due to the presence of blood proteins and electrolytes at the implant site.

著者

Yasushi KATAOKA Chieko ITO Aya KAWASHIMA Miki ISHII Satoko YAMASHIRO Kazuki HARADA Hiroki OCHI Takuo SAWADA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.749-753, 2013 (Released:2013-07-01)

参考文献数

32

被引用文献数

3 14

---

The purpose of the present study was to determine the prevalence of antibiotic-resistant enterococci in dogs and cats subjected to differing antibiotic pressures, and the prevalence of vancomycin resistance genes in isolates from these animals. Enterococci were isolated from fecal samples of 65 healthy dogs and 29 healthy cats brought to animal hospitals, from rectal swabs of 73 puppies and 15 kittens from five breeders and two pet shops, and from fecal samples of 20 dogs and 9 cats that were treated with antibiotics in Nippon Veterinary and Life Science University Animal Medical Center. The rates of resistance to ampicillin among isolates from the kitten–puppy group and healthy dog–cat group were 6.8 and 4.3%, respectively. In contrast, the rates of resistance to ampicillin in enterococci from the treatment group under antibiotic pressure were 37.5%. There was a significant difference between the antibiotic-treated group and the untreated group (PPvanA or vanB were not detected in any groups. Therefore, contamination of VRE in dogs and cats is still considered to be minimal in Japan.

著者

Ko KOJIMA Yasuhito FUJINO Yuko GOTO-KOSHINO Koichi OHNO Hajime TSUJIMOTO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.727-731, 2013 (Released:2013-07-01)

参考文献数

21

被引用文献数

4 8

---

Lymphoid malignancies, such as leukemia, and many types of lymphoma are common and severe disorders in dogs. Since shortening remission duration caused by resistance to chemotherapy often becomes clinically critical problems, development of novel and effective therapy should be required. The present study investigated the status of NF-κB and effect of its inhibitor, bortezomib, in six canine neoplastic lymphoid cell lines. NF-κB p65 and p50 were detected in the nuclear fraction of GL-1, CLBL-1 and CL-1, suggesting that NF-κB was constitutively activated in the cells. NF-κB p65 was detected in the cytoplasmic fraction of UL-1 and Ema. After incubation with bortezomib, NF-κB p50 and p65 became undetectable in the nuclear fraction of GL-1, CLBL-1 and CL-1, and CLBL-1, respectively, and p65 was clearly degraded in the cytoplasmic fraction of CLBL-1 and CL-1. Bortezomib inhibited the proliferation of all cell lines except Nody-1 in a concentration-dependent manner. The results indicated that constitutive activation of NF-κB could contribute to the proliferation of canine neoplastic lymphoid cells, and bortezomib would have suppressive effects on the NF-κB activation and the proliferation of neoplastic lymphoid cells in dogs.

著者

Ayumi FUJIMOTO Sakurako NEO Chinatsu ISHIZUKA Takashi KATO Kazuhito SEGAWA Shinpei KAWARAI Kikumi OGIHARA Masaharu HISASUE Ryo TSUCHIYA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.6, pp.831-835, 2013 (Released:2013-07-01)

参考文献数

22

被引用文献数

1 7

---

The characteristics of surface antigens in canine hepatocellular carcinoma (cHCC) have not been clarified. The objective of this study was to investigate surface antigens, which are considered as stem/progenitor or cancer cell markers, in cHCC cell lines. Expression of various antigens including CD29, CD34, CD44, CD90, CD133 and Dlk-1 was assessed in four cHCC cell lines by flow cytometry. CD44, CD133 and Dlk-1 expression was detectable in all cell lines, and three cell lines expressed CD29. These results indicate that CD29, CD44, CD133 and Dlk-1 have potential as suitable markers in cHCC identification, suggesting that these findings will contribute to the establishment of an early diagnostic tool for the identification of hepatocellular maturation processes.

出版者

ジエムコ出版

巻号頁・発行日

1992

著者

北村 強 静野 隆之 岡部 稔哉

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. NS, ネットワークシステム (ISSN:09135685)

巻号頁・発行日

vol.105, no.470, pp.13-16, 2005-12-08

参考文献数

4

被引用文献数

12

---

帯域制御装置やファイアウォール装置では, ヘッダ情報やペイロード情報を用いてフローを識別し, シェーピングやフィルタリング処理を行うが, ポート番号詐称フロー及び暗号化フローに対してはこの手法が適用できない. そこで筆者らは, ヘッダやペイロード情報に依存しないパケット長やパケット到着間隔といったフロー挙動の分析に基づくアプリケーション識別手法を開発した. 提案手法を用いてアプリケーション識別評価を実施した結果, HTTPポートを使用する音声アプリケーションを識別できることから, ポート番号を詐称するフローに対応できることを示す. また, 暗号化フローに対してもアプリケーション識別が可能であることを示す.

著者

富永 枝里香

出版者

アメリカ学会

雑誌

アメリカ研究 (ISSN:03872815)

巻号頁・発行日

no.46, pp.89-108, 2012

著者

北住 炯一

出版者

名古屋大学

雑誌

名古屋大學法政論集 (ISSN:04395905)

巻号頁・発行日

vol.246, pp.1-57, 2012-09-25

著者

能勢 和宏

出版者

史学研究会

雑誌

史林 (ISSN:03869369)

巻号頁・発行日

vol.95, no.3, pp.457-490, 2012-05