著者
水野 繁 倉田 耕治
出版者
一般社団法人電子情報通信学会
雑誌
電子情報通信学会技術研究報告. NC, ニューロコンピューティング
巻号頁・発行日
vol.95, no.599, pp.185-192, 1996-03-19

網膜から外側膝状体への神経の投射の, 自己組織的な形成を説明する新しいモデルを提案する. Meisterらによる発達中の網膜に関する生理学的知見に基づき, 網膜を進行波を生じる左右2枚の神経場としてモデル化し, 外側膝枕体は, その3次元構造のうちの2次元は進行波を生じるような結合, それに垂直なもう1次元にはメキシカンハット型の競合結合を仮定し, 次に挙げるこの神経投射の2つの特徴の形成を説明する. 1つは, トポグラフィックな投射で, もう1つは外側膝状体はいくつかの層から成っており, 各々の層は眼優位性を有するということである.
著者
Shinya Endo Yasuyuki Toyoda Tatsuki Fukami Miki Nakajima Tsuyoshi Yokoi
出版者
日本薬物動態学会 会長/日本薬物動態学会 DMPK編集委員長
雑誌
Drug Metabolism and Pharmacokinetics (ISSN:13474367)
巻号頁・発行日
pp.DMPK-12-RG-019, (Released:2012-06-12)
参考文献数
44
被引用文献数
14

Drug-induced liver injury (DILI) is thought to be involved in the participation of drugs that either directly affect the cell viability or elicit an immune response. However, there is limited information about the immune responses induced by drugs, including those drugs that are metabolically activated. In this study, we constructed an in vitro assay system to assess the involvement of immune-related factors induced by metabolic activation of drugs. To investigate whether CYP3A4-mediated metabolism of 10 hepatotoxic drugs are associated with immune-related responses, human monocytic leukemia THP-1 cells were co-incubated with CYP3A4 Supersomes. Cluster of differentiation (CD) 86 and CD54 expression levels on THP-1 cells were upregulated by treatment with albendazole and amiodarone (AMD), respectively, in the presence of CYP3A4. Additionally, N-desethylamiodarone (DEA), a major metabolite of AMD, upregulated the CD54 expression of THP-1 cells with CYP3A4. The release of interleukin (IL) -8 and tumor necrosis factor (TNF) α from THP-1 cells was significantly increased by the treatment of AMD or DEA with CYP3A4. Similarly, IL-8 and TNFα were also upregulated by the treatment of AMD and DEA with human liver microsomes, but were inhibited by adding ketoconazole to the cell culture. In this study, we first report that albendazole, AMD and DEA activate immune reaction when metabolically activated.
著者
高岡 治子
出版者
一般社団法人 日本体育学会
雑誌
体育学研究 (ISSN:04846710)
巻号頁・発行日
vol.55, no.2, pp.525-538, 2010 (Released:2010-12-28)
参考文献数
25
被引用文献数
1

Japanese married women only began participating widely in sports after the Tokyo Olympic Games in 1964. It is often said that sports activities by housewives indicated their liberation from isolated domestic life, thereby promoting gender equality. However, close examination of the systemic characteristics of the ‘Mothers’ Volleyball’ movement (based on its ideology, competition rules and the nature of its routine activities) has shown that these activities possess both a recycling structure that releases housewives from their homes temporarily and reflects the participants’ ‘housewifeliness’, thereby reinforcing the separation of roles between the sexes. In order to clarify by whom and for what purpose this recycling structure was created, this paper focuses on the organizing bodies (sponsor organizations, supporting companies and other bodies that organized and ran the national championships, incorporating the systemic characteristics of Mothers’ Volleyball), analyzing the reasons for their involvement with the movement and the benefits they derived from it. The results show that the periodic reflection of housewifeliness, which housewives needed in order to continue in their role as housewives, was necessary for the economic and social benefit of all the organizations involved, and that this is why these organizations committed themselves to the movement. Participating in sports freed housewives from the routine of daily home life, and activities such as helping to organize competitions promoted their socialization and changed their image from that of ‘isolated housewife’ to ‘sporting housewife’ and further to ‘independent housewife’. The recycling structure mentioned earlier can therefore be thought of as being a directional spiral, and the organizing bodies that ran the national championships can be said to be its drivers. This spiral, which helped to reproduce ‘housewifeliness’, supplied society with good-quality labour for sustaining Japan's rapid economic growth, which was a political issue in the 1970s. The participation of housewives in sports as one of the activities of parent-teacher associations and women's associations can also be said to have contributed to local revitalization, another political topic at that time. Meanwhile, making sports one of their routine, repeated activities made housewives’ lives more satisfying, so that Mothers’ Volleyball acted as a medium for the formation of a conjugate relationship between housewives and society.
著者
鉄 拳
出版者
九州大学大学院人間環境学研究院
雑誌
九州大学心理学研究 (ISSN:13453904)
巻号頁・発行日
vol.12, pp.69-77, 2011

This paper examined regional characteristic of stress in junior high school students from Okinawa and Fukuoka. The results showed that the frequency and strength of stressor in Fukuoka is higher than Okinawa. And stress response for students in Fukuoka is higher than for those in Okinawa. It was showed a higher stress reacton in Fukuoka, and students of this population seem to receive more social support. It is thought that it is because they have more experience receiving stressors. There is no difference in the factor concerning to "Relation between parents" in both regions, but Fukuoka shows a higher level in the factors related to "friends", "teacher", and "studies". There was no difference in the support from "teacher" and "friend" in both regions. Finally, in Fukuoka it was found higher the level of the "support from parents", and there was no difference in the support from "teacher" and "friends".
著者
崔 勝旭 黒川 隆志 仰木 孝治 胡 泰志
出版者
広島大学教科教育学会
雑誌
教科教育学研究 (ISSN:13402900)
巻号頁・発行日
no.10, pp.53-62, 1995-03-31
被引用文献数
2

軽装時の児童の水辺事故防止の観点から, Tシャツだけ及びTシャツ+長ズボンを着用した着衣泳と水着泳の間で, 泳速, ストローク頻度とストローク長, 及び心拍数を比較検討した。10名の児童を対象に, クロール, 平泳及び背泳の3泳法で25mを全力で泳がせた。その結果, 次の結論を得た。①クロールは水着の場合3泳法中最も速い0.69m/秒の泳速を示した。水着泳に対する着衣泳の泳速はTシャツ泳で12.2%(P<0.05), Tシャツ+長ズボン泳で26.7%(P<0.01)低下した。②背泳は水着の場合3泳法中最も遅い0.49m/秒の泳速を示した。水着泳に対する着衣泳の泳速はTシャツ泳で2.3%, Tシャツ+長ズボン泳で24.5%(P<0.001)低下した。③平泳は水着の場合3泳法中第2位の0.58m/秒の泳速を示した。水着泳に対する着衣泳の泳速はTシャツ泳で5.9%, Tシャツ+長ズボン泳で12.7%(P<0.01)低下した。④Tシャツ泳の泳速はクロール, 平泳, 背泳の順に高かった。Tシャツ+長ズボン泳の泳速はクロールと平泳の間に差はなかったが, 背泳はこれらより遅かった。⑤着衣泳の泳速の低下はクロールではストローク頻度の影響が大きく, 平泳ではストローク長の影響が大きく, 背泳では両者が影響した。⑥生理的運動強度としての心拍数はどの泳法においても150拍/分前後であり, 着衣泳と水着泳の間に差はなかった。The comparison of the effect of swimming in swimming wear and swimming in T-shirts or in T-shirts and pants to the swimming speed, frequency and length of strokes, and heart rate was made with a view to preventing children from drowning accidents. Ten children were allowed to devote all their energy to swim a span of 25m with the front crawl stroke, the breast stroke and the back crawl stroke. The results were as follows:(1) The front crawl stroke in swimming wear showed the fastest swimming speed of 0.69 m/s among the three swimming strokes. The swimming speed in T-shirts and in T-shirts and pants were 12.2% (p<0.05) and 26.7% (p<0.01) lower than that in swimming wear, respectively.(2) The back crawl stroke in swimming wear showed the slowest swimming speed of 0.49 m/s among the three swimming strokes. The swimming speed in T-shirts and in T-shirts and pants were 2.3% and 24.5% (p<0.001) lower than that in swimming wear, respectively.(3) The breast stroke in swimming wear showed the second swimming speed of 0.58 m/s among the three swimming strokes. The swimming speed in T-shirts and in T-shirts and pants were 5.9% and 12.7% (p<0.01) lower than that in the swimming wear, respectively.(4) In T-shirts, the descending order of the swimming speed were from the front crawl stroke to the breast stroke and the back crawl stroke. In swimming speed in T-shirts and pants, there was no difference between the front crawl stroke and the breast stroke, but the back crawl stroke was lower than those two strokes.(5) The declining tendency of swimming speed in clothes was remarkably affected by the frequency of stroke in the front crawl stroke, by the length of stroke in the breast stroke, and by both factors in the back crawl stroke.(6) The heart rate registered around 150 beats/min in any stroke. No major difference was noticed between swimming in clothes and swimming in swimming wear.
著者
岩本 順二郎
出版者
一般社団法人日本機械学会
雑誌
日本機械学会論文集 B編 (ISSN:03875016)
巻号頁・発行日
vol.52, no.482, pp.p3422-3427, 1986-10

The results of experiments on the thermal effect for tubes of different tapers are presented, and the effects of the tapering of the tube on the internal flow are shown. The results are summarized as follows: (1) With a tapered tube a higher temperature is obtained with smaller intervals of nozzle-tube spacings compared with the cylindrical tube. (2) With a tapered tube a higher frequency of flow oscillations and a shorter penetration length of contact surfaces which are considered to cause a higher temperature in the tube, together with stronger shock, are obtained (3) The velocity history at the open end is different for tubes with different tapers. When the taper is small, the amplitude of the velocity change becomes very small. (4) The pressure amplitude at the closed end becomes large for tubes with large tapers.
著者
梶内 俊夫 白神 直弘 畑山 実
出版者
The Society of Chemical Engineers, Japan
雑誌
化学工学論文集 (ISSN:0386216X)
巻号頁・発行日
vol.11, no.4, pp.450-455, 1985

層流領域においてビンガム流体のテーパー管拡大流れと縮小流れによる圧力差を実験的に検討した.<BR>テーパー部に積分形エネルギー収支式を適用してビンガム流体のテーパー管による圧力差の推算式を得た.運動エネルギーに対する補正係数と広義レイノルズ数を導入することによって, 無次元化圧力差はニュートン流体に対する式と相似な形で表すことができた.圧力差を予測する計算手順を示した.<BR>これらの式からの予測値は実験結果と良好に一致した.
著者
早瀬 敏幸 Hayase Toshiyuki
巻号頁・発行日
1987-01-29 (Released:2009-12-24)
著者
末松 良一 伊藤 思哉 早瀬 敏幸
出版者
一般社団法人日本機械学会
雑誌
日本機械学會論文集. B編 (ISSN:03875016)
巻号頁・発行日
vol.52, no.476, pp.1626-1635, 1986-04-25

It is known that a swirling flow in a diverging pipe breaks down more easily than a flow in a converging one. In this report, experiments are made using diverging, converging and straight pipes, in order to clarify the relation between the shape of pipes and the occurrence of the breakdown. Swirling flow fields, that are realized by rotation of pipes, are measured by a Laser-Doppler-Velocimeter. When each pipe rotates faster than a certain critical value, a stationary internal wave occurs. The vortex breakdown phenomenon is due to the internal waves in swirling flows, as pointed out in preceding reports. In the diverging pipe, the amplitude of the wave is rather smaller than that in the converging pipe ; but the mean axial flow near the axial is fairly retarded, so that the flow reverses at the trough of the superposed wave component, and bubble type breakdown appears. A mathematical model is also presented to give a qualitative explanation of the effect of a sectional area variation.