著者

Yoshimune Nonomura Azusa Yamaguchi

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.151033, (Released:2015-12-16)

被引用文献数

1

---

The friction behavior of water and thickener aqueous solutions was evaluated between a contact probe with a striped rough surface and a substrate. When the probe surface is flat, the contact state is boundary lubrication and fluid film lubrication states for water and thickener aqueous solutions, respectively. In contrast, in the case of the contact probe with a striped rough surface, friction occurred under fluid lubrication state for both water and thickener solutions. These results indicate that the liquid in the depression on the striped rough surfaces change the regime of friction.

著者

松永 孜

出版者

一般社団法人 日本ゴム協会

雑誌

日本ゴム協会誌 (ISSN:0029022X)

巻号頁・発行日

vol.50, no.12, pp.769-781, 1977 (Released:2008-04-16)

参考文献数

5

著者

西 慎一

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.102, no.5, pp.1121-1127, 2013-05-10 (Released:2014-05-10)

参考文献数

10

---

膜性腎症は,糸球体基底膜に免疫複合体が沈着する糸球体腎炎で,原発性および続発性に発症する.近年,原発性膜性腎症の半数以上が内因性抗原であるphospholipase A2 receptor(PLA2R)に対するIgG4型抗体により発症することが解明された.抗PLA2R抗体が原発性,あるいは続発性の鑑別マーカーとしても利用されるようになってきた.「ネフローゼ症候群診療指針」が発表され,ステロイド薬が一次治療薬として推奨されている.寛解に至らない場合は免疫抑制薬の追加が考慮される.

著者

羽石 英里

出版者

日本音声言語医学会

雑誌

音声言語医学 (ISSN:00302813)

巻号頁・発行日

vol.53, no.3, pp.177-182, 2012 (Released:2012-10-09)

参考文献数

4

被引用文献数

1 3 1

---

職業歌手における音声障害の意味を知るために,オペラ,ミュージカル,ジャズ,ポピュラーを含むさまざまなジャンルの職業歌手9名を対象にインタビューを行った.インタビューでは,まず望ましい歌唱時の状態・身体感覚・筋感覚を言語化してもらい,次に望ましくない状態,すなわち音声障害の様子と,耳鼻咽喉科の受診等について語ってもらった.望ましい歌唱時には,呼吸の適切なコントロールにより,発声・共鳴も含めた歌うことのシステム全体が調整されていること,喉頭がリラックスした状態にあることなどが,歌手たちの言語表現から推察された.職業歌手は歌うためにさまざまな筋肉を使う「アスリート」であり,音声障害には,身体全体の調整不良が背景にある場合が考えられる.コンサートをキャンセルできない等の職業歌手に特有な「労働環境」,歌うことを職業とするがゆえの不安・ストレスへの理解も,職業歌手の音声障害への対処にあたって重要と思われる.

著者

丹羽 太左衞門

出版者

日本養豚学会

雑誌

日本養豚学会誌 (ISSN:0913882X)

巻号頁・発行日

vol.47, no.2, pp.61-69, 2010-06-25 (Released:2010-10-29)

参考文献数

6

被引用文献数

1

著者

Tatsuhito Matsuo Soichi Takeda Toshiro Oda Satoru Fujiwara

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.12, pp.145-158, 2015 (Released:2015-12-22)

参考文献数

59

被引用文献数

10

---

Troponin (Tn), consisting of three subunits, TnC, TnI, and TnT, is a protein in the thin filaments in muscle, and, together with another thin-filament protein tropomyosin (Tm), plays a major role in regulation of muscle contraction. Various mutations of Tn cause familial hypertrophic cardiomyopathy. These mutations are directly related to aberrations in this regulatory mechanism. Here we focus on the mutations E244D and K247R of TnT, which reside in the middle of the pathway of the Ca2+-binding signal from TnC to Tm. These mutations induce an increase in the maximum tension of cardiac muscle without changes in Ca2+-sensitivity. As a first step toward elucidating the molecular mechanism underlying this functional aberration, we carried out small-angle X-ray scattering experiments on the Tn core domain containing the wild type subunits and those containing the mutant TnT in the absence and presence of Ca2+. Changes in the overall shape induced by the mutations were detected for the first time by the changes in the radius of gyration and the maximum dimension between the wild type and the mutants. Analysis of the scattering curves by model calculations shows that TnC adopts a dumbbell structure regardless of the mutations, and that the mutations change the distributions of the conformational ensembles so that the flexible N- and C-terminal regions of TnT become close to the center of the whole moelcule. This suggests, since these regions are related to the Tn-Tm interactions, that alteration of the Tn-Tm interactions induced by the mutations causes the functional aberration.

著者

Daichi Yamada Tatsuya Iwata Junpei Yamamoto Kenichi Hitomi Takeshi Todo Shigenori Iwai Elizabeth D. Getzoff Hideki Kandori

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.12, pp.139-144, 2015 (Released:2015-12-22)

参考文献数

34

被引用文献数

1 8

---

Photolyases (PHRs) are DNA repair enzymes that revert UV-induced photoproducts, either cyclobutane pyrimidine dimers (CPD) or (6-4) photoproducts (PPs), into normal bases to maintain genetic integrity. (6-4) PHR must catalyze not only covalent bond cleavage, but also hydroxyl or amino group transfer, yielding a more complex mechanism than that postulated for CPD PHR. Previous mutation analysis revealed the importance of two histidines in the active center, H354 and H358 for Xenopus (6-4) PHR, whose mutations significantly lowered the enzymatic activity. Based upon highly sensitive FTIR analysis of the repair function, here we report that both H354A and H358A mutants of Xenopus (6-4) PHR still maintain their repair activity, although the efficiency is much lower than that of the wild type. Similar difference FTIR spectra between the wild type and mutant proteins suggest a common mechanism of repair in which (6-4) PP binds to the active center of each mutant, and is released after repair, as occurs in the wild type. Similar FTIR spectra also suggest that a decrease in volume by the H-to-A mutation is possibly compensated by the addition of water molecule(s). Such a modified environment is sufficient for the repair function that is probably controlled by proton-coupled electron transfer between the enzyme and substrate. On the other hand, two histidines must work in a concerted manner in the active center of the wild-type enzyme, which significantly raises the repair efficiency.

著者

Saki Aoto Kei Yura

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.12, pp.103-116, 2015 (Released:2015-12-02)

参考文献数

69

被引用文献数

2

---

We addressed the evolutionary trace of hetero-oligomer interfaces by comparing the structures of paralogous proteins; one of them is a monomer or homo-oligomer and the other is a hetero-oligomer. We found different trends in amino acid conservation pattern and hydrophobicity between homo-oligomer and hetero-oligomer. The degree of amino acid conservation in the interface of homo-oligomer has no obvious difference from that in the surface, whereas the degree of conservation is much higher in the interface of hetero-oligomer. The interface of homo-oligomer has a few very conserved residue positions, whereas the residue conservation in the interface of hetero-oligomer tends to be higher. In addition, the interface of hetero-oligomer has a tendency of being more hydrophobic compared with the one in homo-oligomer. We conjecture that these differences are related to the inherent symmetry in homo-oligomers that cannot exist in hetero-oligomers. Paucity of the structural data precludes statistical tests of these tendencies, yet the trend can be applied to the prediction of the interface of hetero-oligomer. We obtained putative interfaces of the subunits in CPSF (cleavage and polyadenylation specificity factor), one of the human pre-mRNA 3’-processing complexes. The locations of predicted interface residues were consistent with the known experimental data.

著者

Tetsuichi Wazawa Nobuyuki Morimoto Takeharu Nagai Makoto Suzuki

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.12, pp.87-102, 2015 (Released:2015-12-02)

参考文献数

57

被引用文献数

1

---

Investigation of the rotational motion of a fluorescent probe tethered to a protein helps to elucidate the local properties of the solvent and protein near the conjugation site of the probe. In this study, we have developed an instrument for frequency-domain fluorescence (FDF) anisotropy measurements, and studied how the local properties around a protein, actin, can be elucidated from the rotational motion of a dye tethered to actin. Rhodamine 6G (R6G) was attached to Cys-374 using newly-synthesized R6G-maleimide with three different oligo(ethylene glycol) (OEG) linker lengths. The time-resolved anisotropy decay of R6G tethered to G-actin was revealed to be a combination of the two modes of the wobbling motion of R6G and the tumbling motion of G-actin. The rotational diffusion coefficient (RDC) of R6G wobbling was ~0.1 ns–1 at 20°C and increased with OEG linker length. The use of the three R6G-actin conjugates of different linker lengths was useful to not only figure out the linker length dependence of the rotational motion of R6G but also validate the analyses. In the presence of a cosolvent of glycerol, although the tumbling motion of G-actin was retarded in response to the bulk viscosity, the wobbling motion of R6G tethered to actin exhibited an increase of RDC as glycerol concentration increased. This finding suggests an intricate relationship between the fluid properties of the bulk solvent and the local environment around actin.

著者

門口 直仁 田中 聡 宮本 典文 山本 創一 喜多村 泰輔

出版者

一般社団法人 日本臨床救急医学会

雑誌

日本臨床救急医学会雑誌 (ISSN:13450581)

巻号頁・発行日

vol.18, no.6, pp.715-719, 2015-12-28 (Released:2015-12-28)

参考文献数

9

---

目的:ICUにおいて,プロポフォール注射液は鎮静薬として繁用されているが,その投与による静脈炎の発生が臨床上問題となる。そこで,プロポフォール注射液投与による静脈炎の発生状況を調査した。方法:2012年9月から12月までに救命救急センターにおいてプロポフォール注射液が末梢静脈から2日間以上持続投与された症例を対象とした。結果:調査期間中の対象患者は41名で,静脈炎が発生した患者は19名(46.3%)であった。投与時間と平均投与速度が静脈炎発現の有意な因子であり,投与時間77時間以上,投与速度3.44mg/kg/hr以上で静脈炎が高頻度に発現していた。考察:プロポフォール注射液による静脈炎は添付文書上では頻度不明とされているが,今回の調査では46.3%と高頻度に発生していた。静脈炎の発生および重症化を防ぐため,投与時間,投与速度の確認と頻回な穿刺部位モニタリングの必要性が示唆された。

著者

Yingjie Zhong Ye Wang Jun Guo Haifeng Chu Yong Gao Limin Pang

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.237, no.3, pp.183-191, 2015 (Released:2015-10-17)

参考文献数

55

被引用文献数

1 14

---

Juvenile idiopathic arthritis (JIA) is the most common arthritis in the adolescents under the age of 16. Etanercept, an inhibitor of tumor necrosis factor, is often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered as a primary treatment. We aimed to explore the efficacy and safety of combination therapy of blueberry and etanercept for JIA. Two hundred and one JIA patients were selected, and randomly and evenly assigned to three groups: ETA (50 mg of etanercept twice weekly), ETABJ (matched etanercept and 50 ml blueberry juice daily) and ETAPJ (matched etanercept and placebo juice). The severity of JIA was measured using American College of Rheumatology scales (ACR) 20, 50 and 70. The levels of pro-inflammatory cytokines, interleukin-1 (IL1) alpha and IL1 beta, and interleukin-1 receptor antagonist (IL1RA) were measured by qRT-PCR and ELISA. After a 6-month follow-up, the ACR20, ACR50 and ACR70 in an ETABJ group were higher than those in other two groups (P < 0.05), suggesting clinically meaningful improvement in JIA. Meanwhile, the symptoms and side effects were reduced significantly or absent in an ETABJ group, including mental diseases, retrobulbar optic neuritis, gaining weight, infection, cutaneous vasculitis, diarrhea, uveitis and pancytopenia. Blueberries reduced the levels of IL1 alpha and beta, and increased the level of IL1RA. Thus, a combination therapy of blueberry and etanercept can reduce the severity of JIA and should be developed as a new method for JIA therapy.

著者

横澤 公道 粟田 輝 増田 のぞみ 新宅 純二郎 樋沢 洋司

出版者

特定非営利活動法人 グローバルビジネスリサーチセンター

雑誌

赤門マネジメント・レビュー (ISSN:13485504)

巻号頁・発行日

vol.13, no.12, pp.507-524, 2014-12-25 (Released:2015-12-26)

著者

山根 淳平

出版者

特定非営利活動法人 グローバルビジネスリサーチセンター

雑誌

赤門マネジメント・レビュー (ISSN:13485504)

巻号頁・発行日

vol.13, no.12, pp.499-506, 2014-12-25 (Released:2015-12-26)

被引用文献数

1

---

ハッカソンとは、hack とmarathon を合成した造語であり、アメリカ発の、多様な人々が課題に取り組み、解決ができるサービスを開発するイベントである。ハッカソンはアメリカでは非常に普及しているが、日本ではまだ課題が多い。本稿では、ハッカソンが、イノベーションを生み続ける仕組みとして定着するための、課題と取り組みについて紹介する。

著者

Divya BAJPAI V.K. TYAGI

出版者

公益社団法人 日本油化学会

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

vol.55, no.7, pp.319-329, 2006 (Released:2006-06-13)

参考文献数

50

被引用文献数

18 49 39

---

Imidazoline surfactants belong to the category of cationic surfactants. Cationic surfactants are often quaternary nitrogen salts and are widely used both in non aqueous systems and in applications such as textile softeners, dispersants and emulsifiers. In the class of imidazoline compounds there is a presence of a pendant group, an imidazoline head group and a hydrocarbon tail. This paper reviews the imidazoline and its salts as an emerging class of cationic surfactants. It deals with the synthesis, various properties that prove its use in laundry detergent applications like good detergency, resiliency, foaming property, softening property, rewettability, good storage stability and less irritating property. In addition the film forming and corrosion inhibition properties tend them to varied and numerous industrial applications.

著者

寺田 久仁子 岩本 佳代子 小林 睦 辻野 政司 寺岡 文雄 荒川 行生 恩田 光子 前田 頼伸

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.35, no.2, pp.96-102, 2009 (Released:2010-02-07)

参考文献数

21

---

Bone cements have been widely used to fill the dead space of bone tissues in orthopaedic surgeries.Loaded with antibiotics,these materials are also administered for the prevention and treatment of infections,infectious osteomyelitis for example.We made polymethylmethacrylate cement preparations of five commercial vancomycin (VCM) products and compared the in vitro dissolution profiles of the VCM in them and mechanical strengths of the cements.When immersed in phosphate buffer (PB) for 30 days,dissolved amounts of VCM ranged between just 5 and 19% of the calculated contents and after immersion in PB for 40 days mechanical strengths were significantly decreased (50-75% of the control without VCM).Further,on testing a cement preparation containing pharmaceutical additives as well as VCM,the amount of antibiotic released was significantly larger than that for other preparations and the release was more rapid as well.This cement preparation also had the lowest strength among those studied.By doing this,we showed that pharmaceutical additives could have marked effect on the dissolution of the antibiotic and mechanical strength for antibiotic-laden bone cements for the first time,though these were in vitro findings.The present study clearly demonstrated that the antibiotic products used can cause functional differences in antibioticladen bone cements and also suggested that pharmaceutical additives influence cement functions.It is therefore necessary to pay attention to both the antibiotic content of commercial VCM products and types of pharmaceutical additive in the preparation of such cements.

著者

山本 浩充 小林 万里 芳賀 吏那子 伊東 奈保美 小川 法子 田口 真穂 高橋 千里 礒部 隆史 埴岡 伸光 村田 実希郎 岡田 賢二 重山 昌人

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.75, no.4, pp.264-270, 2015 (Released:2015-07-01)

参考文献数

9

被引用文献数

5

---

Mohs paste is using for chemosurgery to treat local recurrence of breast cancer tumors and other tumors. However, physicochemical properties of Mohs paste such as hardness, viscosity, stickiness, and spreadability, change signifi cantly during storage after preparation. We investigated the mechanism of change in these physicochemical properties and reformulated Mohs paste. Mohs paste was very hard immediately after preparation and then gradually became soft and sticky during storage. We found that starch particles in the formulation caused the change in physicochemical properties. The initial hardening of the paste was caused by water adsorption and swelling of starch granules. The ensuing softening and tackifying were caused by gelatinization of the starch. The change in physicochemical properties could be restricted by reduction of free water in the formulation by adding a sugar alcohol. Sorbitol was the most effective material among additives because sorbitol can interact strongly with hydration water.

著者

岡本 正行

出版者

公益社団法人 日本工学教育協会

雑誌

工学教育 (ISSN:13412167)

巻号頁・発行日

vol.57, no.5, pp.5_2-5_2, 2009 (Released:2009-10-05)

被引用文献数

2 2

著者

林 亮子 水関 博志

出版者

公益社団法人 日本化学会・情報化学部会

雑誌

ケモインフォマティクス討論会予稿集 第37回情報化学討論会 豊橋

巻号頁・発行日

pp.P21, 2014 (Released:2014-11-20)

参考文献数

6

---

我々は決定木を用いて,簡単な例題について分子構造の自動分類を試みた.使用したデータはGaussian09を用いた構造最適化結果から原子間距離行列の一部を抜き出したものである.その結果,おおむね妥当と考えられる分類規則を自動的に得ることができた.

著者

津村 徳道

出版者

公益社団法人 応用物理学会

雑誌

応用物理 (ISSN:03698009)

巻号頁・発行日

vol.70, no.6, pp.699-701, 2001-06-10 (Released:2009-02-05)

参考文献数

19

著者

工藤 信樹 清水 孝一 松本 伍良

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.23, no.3, pp.194-198, 1985-06-30 (Released:2011-10-14)

参考文献数

12

被引用文献数

3

---

A new method of biotelemetry is proposed, which realizes nonrestrained acquisition of biological signals using the infrared light diffused out from animal skin. This technique is fundamentally different from conventional telemetry techniques which use radio-frequency electromagnetic waves.An optical transmitter which consists of some LED's is implanted beneath the skin. Biological information such as ECG signal is collected in vivo and the light emitted from the LED's is modulated by the signal. The light transmitted through the skin is strongly diffused and spread out in a wide angle. The light is collected by the remotely located optical receivers and the biological information is obtained by demodulating the signal. Thus, the biological information in vivo is obtained without restraining the object with cables or optical fibers.In order to verify the possibility of the above technique, a system, which obtains an ECG from laboratory animals, has been developed. An infrared light was chosen due to its invisibility and high transmittance through the skin. Considering the stability of the communication link and the power consumption of the implanted transmitter, PFM (Pulse Frequency Modulation) technique was used. Using the system, the transcutaneous ECG telemetry was performed successfully.In the experiment, the indirect light reflected and scattered by the walls, the ceiling and the floor was shown to be useful in the optical telemetry. Light transmission patterns through the skin of a mouse were measured. The results suggest the possibility of telemetry even from the deep part of the body cavity.It is concluded that recent progress of optical and electronic technologies have reached the point, where transcutaneous optical telemetry of biological signals has become practically possible.