著者

松山 美和

出版者

公益社団法人 日本補綴歯科学会

雑誌

日本補綴歯科学会誌 (ISSN:18834426)

巻号頁・発行日

vol.7, no.2, pp.90-91, 2015 (Released:2015-04-18)

参考文献数

1

著者

中村 育子

出版者

公益社団法人 日本補綴歯科学会

雑誌

日本補綴歯科学会誌 (ISSN:18834426)

巻号頁・発行日

vol.7, no.2, pp.109-111, 2015 (Released:2015-04-18)

参考文献数

7

---

日本は高齢化が広がっており,要介護高齢者も増加している.サルコぺニアはたんぱく質の摂取不足と筋肉の減少量に関連があることが解明されており,サルコペニアの改善・予防にはたんぱく質の摂取量を増やすことが重要である.管理栄養士の在宅訪問栄養食事指導では,口腔内の問題が原因で摂取栄養量が低下した患者を栄養アセスメントから抽出し,この患者に歯科診療を導入,口腔内の問題を解決できれば,さまざまな食品を摂ることができる.歯科と管理栄養士の連携は在宅患者が食べたい物を食べることを可能にし,栄養状態の改善によりADLおよびQOLの向上に貢献することができると考えられる.

著者

飯島 勝矢

出版者

公益社団法人 日本補綴歯科学会

雑誌

日本補綴歯科学会誌 (ISSN:18834426)

巻号頁・発行日

vol.7, no.2, pp.92-101, 2015 (Released:2015-04-18)

被引用文献数

12

---

高齢期での自立生活の維持を考える上で,低栄養を背景とする虚弱及びその根底をなす筋肉減弱(サルコペニア)という大きな問題があり,高齢者における食の安定性を改めて再考する必要がある.我々は高齢者の『食力』に焦点を当て,食環境および口腔機能の悪化から始まる筋肉減少を経て最終的に生活機能障害に至る構造を新概念として構築している.早期の段階から軽微な口腔機能(=新概念「オーラル・フレイル」として提唱)や栄養状態の低下も認められ,さらに社会性の虚弱(social frailty)も深く関わっている.病態が顕在化するよりも早期の段階から介入すべきであるが,そのためには今まで以上に医科歯科協働を強め,「しっかり噛んで,しっかり食べ,しっかり動く,そして社会参加を」というメッセージを発信し,国民運動論に引っ張り上げることが求められている.

著者

Jeremy A. Gentles William G. Hornsby Howard S. Gray Jonathan A. Miller Andrew R. Dotterweich Charles A. Stuart Michael H. Stone

出版者

Active Aging Research Center

雑誌

Journal of Trainology (ISSN:21865264)

巻号頁・発行日

vol.4, no.1, pp.25-31, 2015-06-18 (Released:2015-07-06)

参考文献数

47

被引用文献数

3

---

Objectives: This study investigated chronic changes in cell free DNA (cf-DNA) throughout a collegiate soccer season. The relationship between cf-DNA, C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testoster one-cortisol ratio (T:C), body mass and body composition were also examined. Design: Longitudinal study design with repeated measures and group comparisons. Methods: Twenty three NCAA Division I male soccer players were divided into two groups. Starters were placed in Group 1 (G1) and non-starters were placed in Group 2 (G2). cf-DNA, CRP, CK, T, C, T:C, body mass and body composition were taken three times, corresponding to pre-season, approximately mid-season and immediately after the concluding the season. Results: In G1, cf-DNA, CRP, CK, cf-DNA %∆, CRP %∆ and, CK %∆ were all statistically higher at T2 and T3 than T1. In G2, CRP %∆ was statistically higher at T2 than T1. In G2, cf-DNA %∆, CRP %∆ and CK %∆ were higher at T2 and T3 than T1. Conclusions: This suggests that cf-DNA may be a useful marker that can reflect accumulated soccer training and competi tive stressors.

著者

髙石 鉄雄 對馬 明 児玉 泰 西井 匠 小林 培男 渡邊 航平 秋間 広

出版者

一般社団法人日本体力医学会

雑誌

体力科学 (ISSN:0039906X)

巻号頁・発行日

vol.62, no.4, pp.331-341, 2013-08-01 (Released:2013-08-29)

参考文献数

53

---

This study evaluated the exercise profile (heart rate, cycling speed and pedal cadence) during 25-30 km cycling and fitness and health level for adults (11 males: 69.6 ± 4.7 yrs; 6 females: 66.3 ± 4.9 yrs) with a recreational cycling habit (27.6 ± 14.8 km/week). Exercise intensity at a constant speed on a flat road during male and female cycling was 71.2 ± 11.5 and 66.8 ± 11.4% heart rate reserved (HRR), respectively. Exercise intensity over 60% HRR occupied 72% of cycling time. Peak intensity during male and female cycling was 89.2 ± 8.9 and 93.1 ± 6.1% HRR, respectively. VO2max and CS (chair stand)-30 test for male and female were 40.3 ± 4.3 and 37.7 ± 2.4 ml/kg/min, and 30.8 ± 3.1 and 30.1 ± 3.2 times, respectively. The muscle cross-sectional area of thigh extensor and flexor measured by MRI were 55.4 ± 6.5 and 58.3 ± 13.3 cm2 for male, and 45.5 ± 6.4 and 50.2 ± 5.7 cm2 for female, respectively. Blood profile for HDL-C (cholesterol), LDL-C and HbA1c (JDS) for male and female were 65.9 ± 8.2 and 67.9 ± 10.6 mg/dl, 112.3 ± 32.0 and 130.6 ± 12.3 mg/dl, and 4.8 ± 0.4 and 4.7 ± 0.1%, respectively. Fitness level and blood profile results were superior to those of the same aged adults. We concluded that the exercise intensity of cycling by middle and older adults with a recreational cycling habit is high and their fitness and health level are higher than average adults.

著者

平野 和久

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.50, no.8, pp.554-555, 2001-08-01 (Released:2011-10-14)

参考文献数

13

著者

荒木 浩

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.6, no.3, pp.134-136, 1970-06-15 (Released:2010-03-11)

著者

坂本 雄二 奥村 直毅 小泉 範子 山崎 健太 北野 絢嗣 沼田 諒平 駒田 孝文 星 信彦

出版者

比較眼科学会

雑誌

比較眼科研究 (ISSN:02867486)

巻号頁・発行日

vol.31, pp.3-11, 2012-12-27 (Released:2013-07-31)

参考文献数

22

---

角膜内皮は角膜の透明性を維持するために重要な役割を果たしている。我々は、角膜内皮研究のための新たな実験動物モデルを開発することを目的とし、フェレットの角膜内皮の形態学的特徴を調べ、実験動物として用いることができるか否かを評価した。さらに、フェレット角膜を組織学的に解析し、ウサギおよびカニクイザルの角膜と比較した。フェレット角膜組織のフラットマウント標本を用いた免疫組織学的検討の結果、フェレットの角膜内皮細胞は角膜内皮機能に関連するマーカーであるZO-1、N-カドヘリンおよびNa+/K+-ATPアーゼを発現していることが確認された。また、フェレット角膜において、臨床的に重要な角膜内皮細胞のパラメーターである角膜内皮密度、六角形細胞率および変動係数を、臨床診療で用いられている分析ソフトウェアを用いて解析することができた。フェレット角膜内皮細胞の初代培養も可能であり、初代培養された角膜内皮細胞は生体内の角膜内皮細胞にきわめて類似した六角形細胞からなる単層構造を示し、機能関連マーカーであるZO-1およびNa+/K+-ATPアーゼを発現していた。これらの結果より、フェレットは眼科領域、特に角膜内皮研究における有用な実験動物となる可能性が示唆された。

著者

中島 美紀

出版者

一般社団法人 日本不整脈心電学会

雑誌

心電図 (ISSN:02851660)

巻号頁・発行日

vol.26, no.3, pp.217-222, 2006-05-25 (Released:2010-09-09)

参考文献数

22

被引用文献数

1

---

ニコチンは喫煙によって肺から吸収された後, 肝臓においてコチニンへと代謝され薬理作用を失う.この代謝反応を触媒しているのはCYP2A6である.ニコチンの代謝能には非常に大きな個人差が認められており, CYP2A6の遺伝子多型との関連が明らかになった.日本人では遺伝子全欠損型であるCYP2A64や, アミノ酸変異を伴うsingle nucleotide polymorphism (SNP) を有するCYP2A67やCYP2A610, またプロモータ領域にSNPを有するCYP2A69の変異型の遺伝子頻度が高く (2~20%) , これらの遺伝子型を組み合わせて2つもつ時, ニコチン代謝のpoor metabolizer (PM) となる.このようにニコチン代謝能の個人差の大部分はCYP2A6の遺伝子多型で説明できる.PMではニコチンの消失半減期が顕著に延長し, 体内からの消失が遅延する.CYP2A6の遺伝子多型は喫煙量および喫煙に関連する疾患リスクにかかわる可能性が考えられる.

著者

Hiroshi Fukasawa Madoka Nakagomi Naoko Yamagata Hiroshi Katsuki Kohichi Kawahara Kazuyoshi Kitaoka Takami Miki Koichi Shudo

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.8, pp.1206-1212, 2012-08-01 (Released:2012-08-01)

参考文献数

69

被引用文献数

17 75

---

Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. Am80 is considered to be a promising candidate drug for treatment of Alzheimer’s disease (AD) because of its transcriptional controls of multiple target genes involved in etiology and pathology of AD. In APP23 AD model mice, administration of Am80 decreased the deposition of insoluble amyloid-β(42). In senescence-accelerated mice (SAMP8), Am80 ameliorated the decrease of cortical acetylcholine, as well as reducing anxiety in behavioral tests and improving the sleep deficit. Am80 also effected a significant improvement of memory in the rat scopolamine-induced memory deficit model. Like other retinoids, Am80 also has an immunomodulatory effect and reduces secretion of proinflammatory cytokines and chemokines by astrocytes and microglia surrounding amyloid-β plaques. In a rat experimental autoimmune encephalomyelitis model, Am80 reduced inflammatory cytokines and showed significant efficacy. Retinoids also promote differentiation of neural stem cells, and Am80 improved the recovery of spinal cord-injured rats. Am80 may also improve vascular factors involved in onset and/or progression of AD. Am80 has been in clinical use for treatment of APL in Japan since 2005, and has been reported to have fewer side effects than other retinoids. We have recently started a clinical study to evaluate the efficacy and safety of Am80 for the treatment of Alzheimer’s disease.

著者

有光 興記

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.2, pp.53-59, 2015-01-01 (Released:2015-04-11)

参考文献数

13

---

The present study aimed to develop empirical definitions for the self-conscious emotions “zaiakukan,” “haji,” “shitto,” and “netami” in Japanese, and compare them with the definitions of the English equivalents of these terms, that is, “guilt,” “shame,” “embarrassment,” and “jealousy,” respectively. In the present study, 60 participants completed 556 statements that described emotional experiences. Based on their responses, the empirical definitions of each emotion were determined. The results indicated the following. (a) The experiences of “haji” were more physical than were those of the other emotions. Further, these experiences were considered more similar to “embarrassment” than “shame.” (b) The experiences of “zaiakukan” were considered more serious than “haji” and overlapped more with its English equivalent, “guilt.” (c) The experiences of “shitto” were more similar those of “netami” and “jealousy” than were other emotions, distinct because they shared feelings of resistance towards emotions and ruminative thoughts. These findings suggest that the terms used to indicate these self-conscious emotions need to be carefully translated because of the differences between these languages.

著者

内山 伊知郎 ジョセフ J. キャンポス

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.2, pp.70-74, 2015-01-01 (Released:2015-04-11)

参考文献数

27

---

Although most researchers state that emotion is a very difficult concept to define, what is now being called a functionalist approach to emotion proposes that emotion is very easy to define. Emotion occurs whenever an event is encountered which is significant to the person. There is no exception to this rule. What makes an event significant is the RELATION between an event and one of four fundamental axioms: 1) how the event relates to a person's goals, 2) how an event links up with the hedonic state of the person, 3) how an event relates to the social reactions of another person, and 4) how an event relates to the prior experiences of an individual, such as in the attachment relationship. In this article, we intend to propose cogently some the basic principles of a functionalist approach, how it differs from the orthodox approach to emotion, how it is relevant to the contemporary interest in emotion regulation, and how it can be illustrated in experiments in infancy.

著者

高橋 誠 森本 哲介

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.2, pp.94-99, 2015-01-01 (Released:2015-04-11)

参考文献数

18

被引用文献数

1 4

---

The study of using strengths seems hampered by the lack of a validated measure in Japan. This study aimed to develop and validate Japanese version of Strength Use Scale (SUS: Govindji & Linley, 2007). Participants were 429 Japanese university students. The exploratory factor analysis showed one factor structure. SUS had adequate internal consistency and high test-retest reliability. The measure is associated with subjective well-being, self-esteem, characteristic self-efficacy, and feeling of depression. Japanese version of SUS showed an adequate reliability and validity, and may be considered as a promising tool for future research and practice of strengths in Japan.

著者

木村 昌紀 山本 恭子

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.Supplement, pp.17-17, 2014 (Released:2014-12-05)

著者

榊原 良太

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.22, no.Supplement, pp.22-22, 2014 (Released:2014-12-05)

著者

坂東 俊夫 小林 修

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会誌 (ISSN:00214663)

巻号頁・発行日

vol.31, no.349, pp.66-75, 1983-02-05 (Released:2009-05-25)

参考文献数

6

被引用文献数

1 2

著者

森田 光男 佐々木 誠 高沢 金吾 鳥崎 忠雄

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会誌 (ISSN:00214663)

巻号頁・発行日

vol.32, no.371, pp.731-739, 1984-12-05 (Released:2009-05-25)

参考文献数

12

著者

Barbara Marconi Ivan Bobyr Anna Campanati Elisa Molinelli Veronica Consales Valerio Brisigotti Marina Scarpelli Stefano Racchini Annamaria Offidani

出版者

バイオ&ソーシャル・サイエンス推進国際研究交流会

雑誌

Intractable & Rare Diseases Research (ISSN:21863644)

巻号頁・発行日

pp.2015.01014, (Released:2015-07-06)

参考文献数

94

被引用文献数

3 72

---

Pseudoxantoma elasticum (PXE), also known as Groenblad-Strandberg syndrome, is a rare heritable disease with an estimated prevalence of 1:50,000 in the general population. PXE is considered a prototype of multisystem ectopic mineralization disorders and it is characterized by aberrant mineralization of soft connective tissue with degeneration of the elastic fibers, involving primarily the eyes, the cardiovascular system, and the skin. Cutaneous lesions consist of small, asymptomatic, yellowish papules or larger coalescent plaques, typically located on the neck and the flexural areas. PXE is caused by mutations in the ABCC6 (ATP-binding cassette subfamily C member 6) gene that encodes a transmembrane ATP binding efflux transporter, normally expressed in the liver and the kidney; however, the exact mechanism of ectopic mineralization remains largely unknown. The histological examination of cutaneous lesions, revealing accumulation of pleomorphic elastic structures in middermis, is essential for the definitive diagnosis of PXE, excluding PXE-like conditions. PXE is currently an intractable disease; although the cutaneous findings primarily present a cosmetic problem, they signify the risk for development of ocular and cardiovascular complications associated with considerable morbidity and mortality. The purpose of this review is to present a comprehensive overview of this rare form of hereditary connective tissue disorders, focus on the pathogenesis, the clinical manifestation, and the differential diagnosis of PXE. Emphasis is also placed on the management of cutaneous lesions and treatment perspectives of PXE.

著者

香田 徹

出版者

一般社団法人 電子情報通信学会

雑誌

電子情報通信学会 基礎・境界ソサイエティ Fundamentals Review (ISSN:18820875)

巻号頁・発行日

vol.9, no.1, pp.71-72, 2015-07-01 (Released:2015-07-01)

著者

Jong-hwa Jeong Won-gyu Yoo

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.6, pp.1653-1654, 2015 (Released:2015-06-30)

参考文献数

10

被引用文献数

3

---

[Purpose] This study evaluated the effects of caregiver education on pulmonary rehabilitation of patients who have undergone lung resection for cancer. [Subjects] Patients were divided into experimental (n = 22) and control (n = 19) groups. [Methods] The caregivers of the experimental group patients received education on pulmonary rehabilitation, while the control group patients received general management advice for 4 weeks. [Results] Pulmonary muscle strength (maximum inspiratory pressure and maximum expiratory pressure) was increased significantly in the experimental group compared to the control group. Modified Borg scale scores were decreased significantly in the experimental vs. control group. [Conclusion] Providing caregivers with education pertaining to pulmonary rehabilitation was associated with improved pulmonary function in lung cancer patients following lung resection.