著者

先崎 理之

出版者

日本鳥学会

雑誌

日本鳥学会誌 (ISSN:0913400X)

巻号頁・発行日

vol.62, no.1, pp.64-67, 2013 (Released:2013-05-28)

参考文献数

20

著者

溝口 昌弘

出版者

日本脳神経外科コングレス

雑誌

脳神経外科ジャーナル (ISSN:0917950X)

巻号頁・発行日

vol.24, no.6, pp.366-377, 2015 (Released:2015-06-25)

参考文献数

93

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TCGAに代表される大規模癌ゲノム解析により, 体系的かつ包括的なゲノム解析が推進され, グリオーマにおいて新たな知見が続々と報告されている. ゲノム, トランスクリプトーム, エピゲノムといった複層的な解析により, その全体像が明らかとなりつつある. 次世代シークエンサーに代表される, 近年の技術開発に伴い, その解析速度は飛躍的に向上し, 大量のゲノムデータが公開されるとともに, その複雑さも明らかとなった. 本稿では膠芽腫を中心に, これまで明らかとなった知見を総括し. 現時点での問題点と今後の課題について考察した.

著者

酒井 利信

出版者

日本武道学会

雑誌

武道学研究 (ISSN:02879700)

巻号頁・発行日

vol.23, no.2, pp.61-62, 1990-11-30 (Released:2012-11-27)

著者

Hiroto FUNABASHI Kazuki MURATA Seiya TSUJIMURA

出版者

公益社団法人 電気化学会

雑誌

Electrochemistry (ISSN:13443542)

巻号頁・発行日

vol.83, no.5, pp.372-375, 2015-05-05 (Released:2015-05-05)

参考文献数

26

被引用文献数

8 40

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MgO-templated porous carbon (MgOC) was developed for D-fructose dehydrogenase (FDH) electrodes. MgOCs with an average pore diameter ranging from 10 to 100 nm were used in this study. FDH adsorbed on a MgOC electrode exhibited significant catalytic currents for D-fructose-oxidation without a redox mediator. When the pore size of MgOC was much larger than the size of FDH, a sufficient amount of FDH was adsorbed in the mesopore on and even inside the MgOC structure. In contrast, when the pore size of MgOC was comparable to the size of FDH, the catalytic current depended only on the amount of enzyme adsorbed in mesopores formed at the surface of the carbon particles; however, an enhanced thermal stability of FDH was observed. Thus, FDH was stabilized through encaging in carbon mesopores with a size comparable to that of the enzyme.

著者

Megumi Miyakawa

出版者

日本小児内分泌学会

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.23, no.3, pp.73-82, 2014 (Released:2014-08-06)

参考文献数

18

被引用文献数

2 8

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It has been more than three years since the unprecedentedly massive earthquake and tsunami struck eastern Japan on March 11, 2011, and the large accident occurred at the Fukushima Daiichi Nuclear Power Plant. To investigate the influence of radiation exposure, thyroid ultrasonography has been provided preliminarily for 360,000 children who lived in Fukushima Prefecture at the time of the accident. As of September 2013, 59 children had been diagnosed with thyroid cancer by fine-needle aspiration cytology, and 34 children had been treated surgically and ultimately diagnosed with papillary thyroid cancer. Here, I would like to describe the characteristics of pediatric thyroid cancer and typical thyroid images obtained by ultrasonography.

著者

Radan Dzodic Marko Buta Ivan Markovic Dusica Gavrilovic Milovan Matovic Igor Djurisic Zorka Milovanovic Gordana Pupic Slobodan Tasic Nikola Besic

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.61, no.11, pp.1079-1086, 2014 (Released:2014-11-28)

参考文献数

42

被引用文献数

2 11

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Well-differentiated thyroid carcinoma in children and adolescents is rare but demonstrates aggressive behavior. Gross lymph node metastases and distant metastases are common upon first clinical presentation. During a 33-year period (1981-2014) at the Institute of Oncology and Radiology of Serbia, 62 children and adolescents underwent surgery due to well-differentiated thyroid carcinoma. Mean age was 16.7 (range 7-21) years. At the time of diagnosis 6% of patients had lung metastases. Total thyroidectomy or completion thyroidectomy was performed for all patients followed by central neck dissection and frozen section examination of jugular-carotid compartments. Median follow-up was 10.9 (range 0.69-33.05) years and median tumor size was 20 (range 2-60) mm. Papillary carcinoma was found in 96%, and follicular and Hürthle cell carcinoma in 2% of patients. Multifocal tumors were found in 50% and capsular invasion in 60% of patients. Lymphonodal metastases in either central or lateral neck compartments were found in 73% of patients. Multifocality and capsular invasion were significantly more frequent in patients less than 16 years of age (both p<0.01). Median disease-free interval had not been reached and overall survival rate was 100%. Well-differentiated thyroid carcinoma in children and adolescents is characterized by a high rate of loco-regional aggressiveness, multifocality, capsular invasion, lymph node metastases and distant metastases at the time of diagnosis. Adequate surgical approaches should be performed for both primary and recurrent disease in young patients with well-differentiated thyroid carcinoma in order to achieve loco-regional disease control and longer disease-free survival.

著者

郷倉 久徳 根本 正之 川原 淳

出版者

一般社団法人 環境情報科学センター

雑誌

環境情報科学論文集 Vol.20(第20回環境研究発表会)

巻号頁・発行日

pp.111-116, 2006 (Released:2008-12-02)

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公園内の生物資源を保護し利活用するためには、画一的な管理では不十分で、立地条件に基づいたきめ細かな管理が必要となる。本研究では国営昭和記念公園で保護の対象となっている野生のネジバナが自生する、管理手法の異なる草地で植生調査を行い、管理が草本群落の構造に及ぼす影響を明らかにした。次に景観上から有用植物とされるネジバナの生活史を調査し、ネジバナの栄養成長期にみられる周辺植生が、光を透過しやすいイネ科雑草であること、また草刈り後の刈草を除去することがネジバナを生育域内で保全する上で重要であることを指摘した。

著者

篠田 晃

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.57, no.3, pp.198-202, 2015-06-30 (Released:2015-07-01)

参考文献数

5

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X-ray crystallography is an important technique for structure-based drug discovery, mainly because it is the only technique that can reveal whether a ligand binds to the target protein as well as where and how it binds. However, ligand screening by X-ray crystallography involves a crystal soaking experiment, which is usually performed manual. Thus, the throughput is not satisfactory for screening large numbers of candidate ligands. In this study, we developed a technique to anchor protein crystals to mounting loops by using gel and inkjet technology; the method allows soaking of the mounted crystals in ligand-containing solution. This new technique may assist in designing a fully automated drug screening pipeline.

著者

Seiji Hokimoto Satoshi Yasuda Daisuke Sueta Kenichi Tsujita Kenji Sakamoto Megumi Yamamuro Yasuhiro Izumiya Yuichiro Arima Hiroki Usuku Yoko Sumida Sunao Kojima Koichi Kaikita Hisanori Kanazawa Hiroshige Yamabe Hisao Ogawa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-0675, (Released:2015-07-03)

参考文献数

8

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The 79thAnnual Scientific Meeting of the Japanese Circulation Society was held in Osaka on April 24–26, 2015. The main theme was “Late-breaking Cardiovascular Medicine from Japan”. Recently, optimal medical treatment has been guided by evidence-based medicine. We aim to emphasize the research findings and advances in cardiology from Japan, in the hope that Japan will become one of the leaders in the field worldwide. Unlike previous meetings, this annual scientific meeting was held in late April. Approximately 18,000 people, including medical doctors, healthcare professionals, and management staff, attended. The meeting was successfully completed, and included discussions on state-of-the art medicine.

著者

Hiroshi SHIMIZU Takayuki HOSHI Kenji NAKAMURA Jai-Eok PARK

出版者

日本生物環境工学会

雑誌

Environmental Control in Biology (ISSN:1880554X)

巻号頁・発行日

vol.53, no.2, pp.85-88, 2015 (Released:2015-06-17)

参考文献数

9

被引用文献数

4

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An ultrasonic pollination device was developed to achieve effective artificial pollination of strawberries in artificial light type plant factories. A phase array of hundreds of ultrasonic transducers was appropriately controlled and focused on one point in space, and it is possible to generate a force at any position in space. The force was modulated at 30 Hz which is the characteristic frequency of strawberry flower. The pollination experiment was conducted using the strawberry variety F1 Elan (Fragaria×ananassa). The total weight of the strawberries harvested over 22 days was 1.22 kg, and the average weights of individual strawberry fruits were 9.1 g.

著者

岩崎 礼次郎 荒木 健治

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第19回全国大会(2005)

巻号頁・発行日

pp.65, 2005 (Released:2006-10-26)

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コールセンターにおいて、毎日の営業日報作成といった作業は非常に手間のかかる作業である。そこで、コールセンターの対話データから自動的に営業日報を生成するために、対話データの特徴を元に営業日報にするべき内容の重要文の抽出を行った

著者

Yoshitaka Maeda Shuzo Shintani

出版者

(社)日本農村医学会

雑誌

Journal of Rural Medicine (ISSN:1880487X)

巻号頁・発行日

vol.10, no.1, pp.29-33, 2015 (Released:2015-06-19)

参考文献数

8

被引用文献数

9

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Objective: Living wills, written types of advanced directives, are now widespread in western countries, but in Japan, their recognition still remains restricted to a small part of the population. As an initial step to introduction of such patient-oriented medicine, we surveyed present recognition and acceptance patterns concerning living wills in a main regional hospital located in a suburban area of Tokyo.Methods: Without any preceding guidance on living wills, the questionnaire on living wills was distributed to all the staff working at JA Toride Medical Center in September 2013, and their responses were collected for analysis within one month.Results: Questionnaires were distributed to all hospital staff, 843 in total, and 674 responses (80.0% of distributed) were obtained. The term of living will was known by 304 (45.1%) of the respondents, and introduction of living wills to patients was accepted in 373 (55.3%) of the respondents, meanwhile, 286 (42.4%) respondents did not indicate their attitude toward living wills. As to styles of document form, 332 respondents (49.3%) supported selection of wanted or unwanted medical treatments and care from a prepared list, and 102 respondents (15.1%) supported description of living wills in free form. As preferred treatment options that should be provided as a checklist, cardiac massage (chest compression) and a ventilator were selected by more than half of the respondents. Based on their responses, we developed an original type of living wills available to patients visiting the hospital.Conclusions: Although not all the respondents were aware of living wills even in this main regional hospital, introduction of living wills to patients was accepted by many of the hospital staff. Awareness programs or information campaigns are needed to introduce living wills to support patient-centered medicine.

著者

Hirotoshi MIZUKAMI Tsuyoshi SUZUKI Yasuo NAMBO Mutsuki ISHIMARU Hiroshi NAITO Kenji KOROSUE Kentaro AKIYAMA Kenji MIYATA Akira YAMANOBE Kentaro NAGAOKA Gen WATANABE Kazuyoshi TAYA

出版者

日本ウマ科学会

雑誌

Journal of Equine Science (ISSN:13403516)

巻号頁・発行日

vol.26, no.2, pp.49-56, 2015 (Released:2015-07-02)

参考文献数

14

被引用文献数

4 11

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Development and endocrine changes in Thoroughbreds colts and fillies were compared between those reared at two facilities of the Japan Racing Association, the Hidaka Training and Research Center (Hidaka) and Miyazaki Yearling Training Farm (Miyazaki). Thoroughbred colts and fillies born in Japan between 2003 and 2010 were used. Each colt group and filly group was divided into 2 groups, respectively, and raised in Hidaka or Miyazaki for 7 months from September at 1 year old to April at 2 years old. For the growth parameters, the body weight, height at withers, and girth and cannon circumferences were measured once a month. For parameters of endocrine function, circulating prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), insulin-like growth factor-1 (IGF-1), testosterone, progesterone, and estradiol-17β levels were measured. Regarding growth, the rate of increase over the 7-month period was significantly higher in both colts and fillies raised in Miyazaki than in Hidaka in all 4 parameters: body weight, height at withers, and girth and cannon circumferences. The endocrine changes of the colts and fillies born in 2007 were as follows. In colts, although circulating prolactin tended to be higher in colts reared in Hidaka from October to April, circulating LH, FSH, testosterone, estradiol-17β and IGF-1 tended to be higher in colts reared in Miyazaki than in Hidaka, suggesting that the gonadotropin-releasing hormone-LH/FSH system and the growth hormone-IGF-1 system were more active in colts reared in Miyazaki as compared with those reared in Hidaka. In fillies, circulating prolactin tended to be higher in fillies reared in Hidaka in February and March, but no significant difference was noted in the serum LH, FSH, IGF-1, or progesterone level between the 2 groups. Circulating estradiol-17β tended to be higher in fillies reared in Miyazaki than in Hidaka in October and November. Regarding ovarian function, the initial ovulation occurred by the end of March in 2 (16.7%) of 12 fillies reared in Hidaka and 7 (38.9%) of 18 fillies reared in Miyazaki, suggesting that the ovarian function was more active in fillies reared in Miyazaki as compared with those reared in Hidaka. Based on these findings, it was clarified that development of the body and gonads was faster in Miyazaki compared with Hidaka in both colts and fillies.

著者

君塚 直隆

出版者

一般財団法人 日本国際政治学会

雑誌

国際政治 (ISSN:04542215)

巻号頁・発行日

vol.2013, no.173, pp.173_155-173_169, 2013-06-25 (Released:2015-06-09)

参考文献数

44

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Queen Elizabeth II has played an important part in British foreign policy after the Second World War during her extreme long reign of sixty years. The Queen has undertaken 92 State visits and gone around Commonwealth countries all over the world. Moreover, she has hosted more than hundred Heads of States at the Buckingham Palace or Windsor Castle since her accession of 1952. Elizabeth has supported twelve Prime Ministers from Winston Churchill to David Cameron when they promoted their own foreign policies among the ‘Three Circles’: United States, Europe and Commonwealth for sixty years. However, the Queen also has promoted her own diplomacy towards foreign royal sovereigns during the same period, in particular when she determined to confer them the highest order of the United Kingdom, the Most Noble Order of the Garter. Since the establishment of the Order of the Garter in 1348, it had only been given to Christian monarchs except for a few Sultans and Shahs from the later Nineteenth Century to the beginning of Twentieth Century. After 1906, the British monarchs have conferred this honour only upon Japanese Emperors as their valuable partners of the Anglo-Japanese Alliance, but the honour of Emperor Hirohito was withdrawn when Japan entered the Second World War in December 1941. Since then, there was no Non-Christian extra Knight of the Garter in the world. Thirty years after, in October 1971, Hirohito visited Britain, and the Queen instructed that the name of the Emperor be formally restored to the list of members of the Garter Knights. It was possible to imagine that she desired the Anglo-Japanese reconciliation and also she has respected a precedent of former British monarchs who created only Japanese Emperors as extra Knights of that Order from 1906. It also means that she has no mind to confer this honour upon any other Non-Christian sovereigns even though their own power and positions in international politics have been strengthened during the Cold War. Actually the Queen never created the Shah of Iran or the King of Thailand as extra Knights of the Garter although they earnestly desired to become knights, because there was no precedent. Elizabeth II has given support to successive UK governments in order to protect British national interests on the one hand, but has gone her own way against policies of governments on the other. It is also a fine example of originality and diversity of British foreign policy after the Second World War.

著者

岸田 元美

出版者

一般社団法人 日本教育心理学会

雑誌

教育心理学研究 (ISSN:00215015)

巻号頁・発行日

vol.7, no.2, pp.1-12,61, 1969-10-15 (Released:2013-02-19)

参考文献数

7

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This study is the 2nd report by the author concerning the study on the human relationship between pupil and teacher. The 1st report was an analysis of pupils' attitude toward their teachers. In order to confirm the points which had been proposed in the 1st report, the author took six teachers as subjects and investigated their personality traits and the educational attitude toward their pupils which had caused the differences in the pupils' attitude toward them.As personality traits, sex, age, intro-extro vert, the term of teaching experience and final schooling were adopted. In order to investigate the patterns of teachers' educational attitude toword the pupils, a questionnaire was made, asking the teachers their daily attitude toward the pupils. The questionnaire consisted of five investigation sheets (1) affectionate indifferent (2) authoritathe laissez-faire (3) strict liberal (4) devoted neglectful (5) qualified unqualified.The pupils' attitude toward their teaehers was then compared with the teachers' personality traits and educational attitude toward the pupils.The main results of the investigation were as follow; The teachers' sex and age scarecely influenced upon the pupils' attitude toward them but their educational attitude toward the pupils much influenced upon it. Those teachers who had more desirable human relations to their pupils were identified as qualified, devoted, liberal and affectionate.

著者

甲斐 倫明

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.35, no.1, pp.101-103, 2000 (Released:2010-02-25)

著者

吉野 邦俊

出版者

一般社団法人 日本耳鼻咽喉科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.116, no.8, pp.986-987, 2013-08-20 (Released:2013-10-09)

参考文献数

3

被引用文献数

1

著者

依田 新

出版者

一般社団法人 日本教育学会

雑誌

教育学研究 (ISSN:03873161)

巻号頁・発行日

vol.10, no.7, pp.699-708, 1941 (Released:2009-01-13)

著者

坂本 雅樹 林 祐一 今藤 裕之 高山 悟 可児 久典 大橋 純子

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.10, no.2, pp.531-534, 2015 (Released:2015-06-22)

参考文献数

20

被引用文献数

1

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消化器がん患者では黄疸による皮膚掻痒感を訴える例が多く,さまざまな治療・ケアが提供されるが,症状緩和に難渋することも多い.進行がんによる黄疸が原因の皮膚掻痒症に対して,牛車腎気丸が有効と考えられた 2例を経験した.【症例1】68歳男性,胆管細胞がん.閉塞性黄疸による掻痒感が持続し,内視鏡的経鼻胆管ドレナージ(endoscopic nasobiliarydrainage; ENBD)にて減黄しても掻痒感は軽減せず,種々の対症療法も無効であった.牛車腎気丸 7.5g分 3を投与開始し,睡眠が改善した.【症例 2】81歳男性,C型肝硬変,肝細胞がん.黄疸の進行により皮膚掻痒感が出現し,種々の治療は無効であった.牛車腎気丸を 5.0 g分 2で開始し,掻痒感 NRSが 10→3に減少した.黄疸による皮膚掻痒感に牛車腎気丸が有効であり,同様の症例に対して試してみてよい治療法と考えられた.

著者

藤原 喜悦

出版者

一般社団法人 日本教育心理学会

雑誌

教育心理学年報 (ISSN:04529650)

巻号頁・発行日

vol.27, pp.30-34, 1988-03-30 (Released:2012-12-11)