著者

足立 壮一

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.134, no.4, pp.184-191, 2009 (Released:2009-10-14)

参考文献数

17

被引用文献数

1

---

癌治療において細胞死の機序を解明することは,新規治療法の開発や耐性化の克服などの治療成績の向上や,副作用の軽減など,患者治療に直結する重要な研究である.In vitroの培養系における各種白血病や癌細胞株の研究から,細胞死の1つであるアポトーシスについては機序の解明が進んでいる.しかしながら,生体内での細胞死の機序は不明のことが多く,また固形腫瘍における細胞死では,近年,アポトーシス以外の細胞死が注目されている.我々は,白血病,固形腫瘍いずれにおいても以下の系において,アポトーシス以外の細胞死の1つである,オートファジーの関与を証明した.(1)難治性白血病であるBcr-Abl陽性白血病(フィラデルフィア染色体陽性急性リンパ性白血病,慢性骨髄性白血病)に対して,従来から上記白血病の特効薬とされている,imatinib mesylateよりも有効な薬剤INNO-406によるin vitroにおける細胞死の機序にオートファジーが関与し,in vivoにおいても非アポトーシスの細胞死がみられること,(2)難治性固形腫瘍rhabdoid腫瘍におけるin vitroおよびin vivoでのHDAC阻害薬(depsipeptide)による細胞死の機序にオートファジーが関与し,AIFの核からミトコンドリアへの偏移がオートファジーに関与すること,の2点である.いずれの系においても,オートファジーを抑制すると細胞死が増強されたことから,オートファジーの抑制は難治性白血病,固形腫瘍の治療ターゲットとなりうる可能性が示唆され,オートファジーに関与する新薬の開発が望まれる.

著者

小林 訓史 田中 敦

出版者

日本複合材料学会

雑誌

日本複合材料学会誌 (ISSN:03852563)

巻号頁・発行日

vol.38, no.2, pp.51-57, 2012 (Released:2012-12-10)

参考文献数

8

被引用文献数

2 4

---

In order to fabricate composite components rapidly, a micro-braiding technique have been proposed and investigated. In the present study, a simple model is proposed to predict the resin impregnation process based on the Darcy's law and the continuity equation. Bending modulus was also modeled considering the difference between tensile and compressive moduli of a carbon fiber and resin impregnation. To confirm validity of the models, carbon fiber reinforced polypropylene composites were molded under various molding conditions. Cross-sectional observation results indicated the model proposed was possible to predict resin impregnation. Four-points bending tests were also conducted on the composites. It is confirmed that bending moduli were well-predicted based on the proposed model.

著者

小林 貞一

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.95, no.4, pp.225-240, 1986-08-25 (Released:2009-11-12)

参考文献数

30

被引用文献数

1

---

IV. Research in geology of Manchuria i.e. Northeast China was commenced with RICHTHOFEN's trip in its southern part in 1869. In 1895 AHNERT's life work on the geology of Central and North Manchuria was started, and KOCHIBE carried out a preliminary survey in South Manchuria. Since 1923 geological papers of Manchuria were published by Y. C. SUN and others in Bull. Geol. Soc. China from 1923. Geological survey founded in South Manchurian Railway Company published Geological Map of South Manchuria, 1918 and Geology and Mineral Resources of the region, 1929. There are many papers in the regional geology written by Japanese geologists and palaeontologists.Besides late Permian naiads Silurian-Permian marine fossils were discovered in Central and North Manchuria and the Manmo group was proposed for the whole sequence of the Palaeozoic rocks accumulated in the Mongolian geosyncline. It was strongly disturbed by the Permo-Triassic orogeny accompanied by the Mongolian granite with the result that the area was consolidated and united with South Manchuria. Small basins were later brought about there and the large Liao-Sungari basin was produced in the late Mesozoic age. Recent studies by Chinese geologists reveal that the Manmo group comprises Cambrian and Ordovician fossils in its lower part and that it is rich in volcanic materials of different ages. Permian plants and lower and middle Triassic non-marine animals were discovered at some places. Further it is known that sea entered into the eastern part of Heilongjiang province temporarily in the late Triassic, middle-upper Jurassic and Cretaceous ages.V. PUMPELLY's geological reconnaissance in 1863-65 was the first in China, followed by RICHTHOFEN and others including Japanese geologists. The Tokyo Geographic Society published Geological Maps of South and North China and then of Eastern Asia all in 1 by 2 mills, scale in 1920, 1922 and 1929 respectively.According to E. T. CHANG (1922) mining was started in China already in prehistoric age. Chinese classics on stone medicine and related knowledge were imported to Korea and Japan. Among Chinese geologists CHANG was first to write geology of Chekiang, 1911. The Central Geological Survey at Nanking, Department of Geology in the National University of Peking and the Geological Society of China were successively founded in 1916, 1920 and 1922. Since then her geology advanced considerably except for some years from 1966. The research activity, however, became quite explosive from about 1973. The Geological Map of China in scale of 1/4 mills. was compiled in 1976 by the Chinese Academy of Geological ScienceAn outline of Tectonic characteristics of China and the Tectonic Map of China were published by T. K. HUANG and his cooperators in 1977 and 1979 respectively.Supplementary notes are given on the Pentsao and world map (1) and the growth of Asia documented in the expansion of the non-marine facies in the continent (2).

著者

下沢 楯夫

出版者

公益社団法人 精密工学会

雑誌

精密機械 (ISSN:03743543)

巻号頁・発行日

vol.47, no.9, pp.1088-1095, 1981-09-05 (Released:2009-06-30)

参考文献数

28

著者

Masahiro Nishiyama Yusuke Suzuki Toshiyuki Katagi

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.35, no.4, pp.447-455, 2010-11-25 (Released:2010-11-24)

参考文献数

20

被引用文献数

5 7

---

Metofluthrin [I, 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl (EZ)-(1R,3R)-2,2-dimethyl-3-(prop-1-enyl)cyclopropanecarboxylate] was resistant to hydrolysis at pH 4 and 7 but moderately hydrolyzed with a half-life of 36.8 days at pH 9 and 25°C to form the corresponding acid and alcohol via ester cleavage. The activation energy was estimated to be 105 kJ mol−1 based on the hydrolysis rates at 25–50oC. By continuous exposure to light at >290 nm from a Xenon arc lamp at hydrolytically stable pH 4 and 25°C, I was rapidly photodegraded with half-lives of 1.1–3.4 days, mainly via ester cleavage and successive oxidation followed by mineralization to carbon dioxide. Spectroscopic analyses together with co-chromatography with authentic standards showed that the major degradates having an ester linkage were the aldehyde and carboxylic acid derivatives formed via oxidative cleavage of the prop-1-enyl group together with the diol formed possibly through an oxidative intermediate, such as an epoxide.

著者

為永 恵二郎

出版者

一般社団法人 映像情報メディア学会

雑誌

テレビジョン学会誌 (ISSN:03866831)

巻号頁・発行日

vol.34, no.1, pp.58-62, 1980-01-01 (Released:2011-03-14)

参考文献数

6

被引用文献数

1 1

---

特許, 実用新案などの工業所有権の国際化の進展に対処して, わが国の特許と実用新案の公告公報および公開公報の発行区分が, 昭和55年1月発行分から, 従来の「日本特許分類 (JPC) 」ベースから「国際特許分類 (IPC) 」をベースにした新しい発行区分に変更される.この国際特許分類のしくみ, 見方などを, テレビジョン学会に関連の深い分類を中心に紹介する.

著者

Mika SHIRASU Kouki FUJIOKA Satoshi KAKISHIMA Shunji NAGAI Yasuko TOMIZAWA Hirokazu TSUKAYA Jin MURATA Yoshinobu MANOME Kazushige TOUHARA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.74, no.12, pp.2550-2554, 2010-12-23 (Released:2010-12-23)

参考文献数

16

被引用文献数

31

---

The titan arum, Amorphophallus titanum, is a flowering plant with the largest inflorescence in the world. The flower emits a unique rotting animal-like odor that attracts insects for pollination. To determine the chemical identity of this characteristic odor, we performed gas chromatography-mass spectrometry-olfactometry analysis of volatiles derived from the inflorescence. The main odorant causing the smell during the flower-opening phase was identified as dimethyl trisulfide, a compound with a sulfury odor that has been found to be emitted from some vegetables, microorganisms, and cancerous wounds.

著者

鄭 顕志 中川 博之 川俣 洋次郎 吉岡 信和 深澤 良彰 本位田 真一

出版者

日本ソフトウェア科学会

雑誌

コンピュータ ソフトウェア (ISSN:02896540)

巻号頁・発行日

vol.25, no.4, pp.4_121-4_132, 2008-10-28 (Released:2008-11-30)

被引用文献数

1

---

ユビキタスコンピューティングにおけるアプリケーションは,実世界の状態を把握し,ユーザに対してより積極的なサポートを行わなければならない.このようなアプリケーションを効率良く開発するためには,従来とは異なる新たなアプリケーション開発手法が必要となり,数多くの研究が行われている.本論文では,ユビキタスコンピューティングにおける,アプリケーション開発手法に関する研究動向を調査し,傾向と問題点を整理する.

著者

工藤 彰 村井 源 徃住 彰文

出版者

情報知識学会

雑誌

情報知識学会誌 (ISSN:09171436)

巻号頁・発行日

vol.22, no.3, pp.187-202, 2012-10-10 (Released:2012-11-30)

参考文献数

21

---

本論文の目的は,物語の推移に伴った単語の布置と変化から,並行形式小説がどのような構造を持っているのかを明らかにすることである.対象としたデータは,村上春樹の小説『1Q84』とし,二人の主人公である青豆と天吾のそれぞれの章に対して,語彙頻度を測度とした因子分析と変化率分析を行った.その結果,因子分析からはお互いのBOOK2までの特徴がBOOK3で相手の側に現れ,未消化だった二人の再会の物語を完結させるためにBOOK3が書かれたことが明確になった.変化率分析からは,物語進行に従って対称的に登場する二人の人物が発見された.また文芸批評との比較も行い,本研究の分析手法が物語の理解に有効であることを確認した.

著者

Takakazu Kawase Keitaro Matsuo Akio Hiraki Takeshi Suzuki Miki Watanabe Hiroji Iwata Hideo Tanaka Kazuo Tajima

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.19, no.5, pp.244-250, 2009-09-05 (Released:2009-09-05)

参考文献数

35

被引用文献数

16 30

---

Background: Epidemiological studies consistently indicate that alcoholic beverages are an independent risk factor for female breast cancer. Although the mechanism underlying this effect remains unknown, the predominant hypothesis implicates mutagenesis via the ethanol metabolite acetaldehyde, whose impact on the carcinogenesis of several types of cancer has been shown in both experimental models and molecular epidemiological studies. Many of the epidemiological studies have investigated genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) His48Arg and aldehyde dehydrogenase-2 (ALDH2) Glu504Lys, because of the strong impact these polymorphisms have on exposure to and accumulation of acetaldehyde. With regard to breast cancer, however, evidence is scarce.Methods: To clarify the impact on female breast cancer risk of the interaction of the effects of alcohol consumption and polymorphisms in the alcohol-metabolizing enzymes ADH1B and ALDH2, we conducted a case–control study of 456 newly and histologically diagnosed breast cancer cases and 912 age- and menopausal status-matched noncancer controls. Gene–gene and gene–environment interactions between individual and combined ADH1B and ALDH2 gene polymorphisms and alcohol consumption were evaluated.Results: Despite sufficient statistical power, there was no significant impact of ADH1B and ALDH2 on the risk of breast cancer. Neither was there any significant gene–environment interactions between alcohol drinking and polymorphisms in ADH1B and ALDH2.Conclusions: Our findings do not support the hypothesis that acetaldehyde is the main contributor to the carcinogenesis of alcohol-induced breast cancer.

著者

黒子 正人

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.56, no.5, pp.310-317, 2013-08-01 (Released:2013-08-01)

参考文献数

1

著者

清水 暢子

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.56, no.5, pp.276-283, 2013-08-01 (Released:2013-08-01)

---

国際医学情報センター(IMIC)は,製薬企業や医師,薬剤師からの依頼を受け,医薬文献の検索など,医薬情報にかかわるさまざまな業務を受託している。本稿ではIMICが財団全体で取り組んでいる調査担当者育成のプログラムを紹介した。はじめにIMICが受託する医薬情報の調査に関連する業務と,その業務の遂行に必要な知識・スキルについて述べた。次に,知識・スキル習得のための教育プログラムをステップごとに詳述し(医薬雑誌ハンドサーチ,外部研修,内部研修,検索演題の実施,継続教育),今後,医薬関連の調査担当者に求められる役割についても述べた。

著者

佐野 知子 原田 雅史 菅原 隆光 伊坂 直紀 増岡 昭生 三上 昭廣 島森 美光 黒澤 菜穂子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.8, pp.897-903, 2013 (Released:2013-08-01)

参考文献数

12

被引用文献数

5 6

---

As hospitalized patients in psychiatry departments are often prescribed multiple psychotropics depending on their psychiatric symptoms, psychotropics are considered as important factors potentially associated with a high risk of falls. In this study, we attempted to investigate, from the aspect of drug prescription, to what degree the number and doses of psychotropics must be adjusted in order to reduce risk of falls in hospitalized psychiatric patients. The subjects were 526 patients, consisting of a fall group of 313 patients, who had experienced 1 to 5 falls (510 events) and a control group of 213 patients who had never experienced falls. Multiple logistic regression analysis was performed to determine the correlations between the occurrence of falls and the number and doses of psychotropics. The results showed that the risk of falls increased with increasing number of antipsychotics and anxiolytics/hypnotics prescribed, with the risk increasing, by 3.75-fold with the increase in the dose of chlorpromazine (CP)-equivalents to more than 600 mg, by 2.08-fold when the dose of diazepam (DAP)-equivalents to more than 15 mg, and by 7.80-fold with increase in CP-equivalents to more than 600 mg concomitantly with an increase in DAP-equivalents to more than 15 mg. In addition, a tendency towards increase in the frequency of falls was observed when more than 5 psychotropics were prescribed concomitantly. The above results suggested that the risk of falls may be reduced by appropriately adjusting the number of drugs and the doses of psychotropics used in the treatment of psychiatric disorders.

著者

奥澤 保 塚原 弘昭

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.53, no.3, pp.241-253, 2001-03-25 (Released:2010-03-11)

参考文献数

31

被引用文献数

5

---

Many small earthquakes occurred in the Matsushiro area in a period from 1965 to 1967. This is called “Matsushiro Earthquake Swarm”. The swarm earthquakes are interpreted as a result of deep ground water intrusion into the focal area. At the hardest time of the crustal movement, water flow from pre-existing springs increased, and many new springs appeared along a hidden fault zone formed by the swarm earthquakes. Some of springs are still alive and have peculiar chemical compositions. The deep ground water must have caused the earthquake swarm. We show the characteristics of the deep ground water through analyzing chemical composition. Our measured data and many published data show that the deep ground water obtains Ca2+ from rocks and loses Na+ during its upwelling migration through the fault zone of Matsushiro Swarm Earthquakes. The data also show that the major components of Cl- and (Na++Ca2+) have a liner relation in concentrations, although every spring water has different concentrations of Cl- and (Na++Ca2+). It is interpreted in terms of mixing deep ground water with shallow ground water at defferent ratios. The concentrations of the major ions of the deep ground water are estimated from both of our measured data and compiled data using the liner relation, e. g., Na+: 310meq/l, Cl-: 330meq/l. Analysis of our measured data also reveals that the small temporal variation in the concentration of Ca2+ in a short period such as several months is attributable to the reaction between the ground water with CO2 and surrounding rocks.

著者

桑江 豊 三好 寿顕 関根 正樹 辻 美和 藤元 登四郎 田村 俊世

出版者

公益社団法人 日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.50, no.6, pp.535-542, 2012-12-10 (Released:2013-07-31)

参考文献数

17

---

This study was performed to examine the effects of weekly exercise in subjects classified as support_1 according to the Japanese health care insurance system. We evaluated the ability of eight elderly subjects to walk using wireless inertia sensors with an embedded triaxial accelerometer and angular velocity sensor. The subjects participated in training once a week and were evaluated once a month over a study period of 3 months. Wearable motion sensors were attached to the lower back and both thighs of each subject. The subjects performed high-performance walking over a distance of 10 m. The speed, cadence, gait cycle, thigh pitch angle, and autocorrelation function on the lower back were determined. The subjects attained high-performance walking sooner after 3 months. Although most of the subjects showed an improvement in walking ability, there were no significant improvements in the cadence gait cycle or autocorrelation function. Exercise once a week can significantly improve the ability of elderly subjects to walk. Thus, home exercise is recommended to improve walking ability in the elderly.

著者

Katsumi SHIBATA Tsutomu FUKUWATARI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.59, no.2, pp.87-92, 2013 (Released:2013-05-31)

参考文献数

18

被引用文献数

2 5

---

It is thought that increasing energy expenditure increases consumption of vitamin B1, leading to an increase in the requirement of vitamin B1. However, evidence supporting this hypothesis is lacking. To examine the hypothesis, initially, we determined the minimum requirement of vitamin B1 for weaning rats. We found that the minimum requirement of vitamin B1 for optimum growth of weaning rats was around 0.786 mg thiamin/kg diet. Next, rats fed a diet containing the minimum requirement of vitamin B1 were forced to swim until exhaustion. Concentrations of vitamin B1 in the blood and liver as well as urinary excretion of swimming rats decreased significantly compared with those of non-swimming rats (p<0.05), while in rats fed the diet containing a sufficient amount of vitamin B1 (4.720 mg thiamin/kg diet), vitamin B1 amounts in the blood, liver and urine were not affected by swimming. We clearly and firstly showed the reduction of body vitamin B1 following increases in energy expenditure.

著者

Yasunori SATO Shunsuke SHIMAMURA Tadahisa MASHITA Saori KOBAYASHI Yasuhiko OKAMURA Masaaki KATAYAMA Hiroaki KAMISHINA Reeko SATO Yuji UZUKA Jun YASUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.7, pp.949-953, 2013 (Released:2013-07-31)

参考文献数

17

被引用文献数

5 22

---

In humans, increased levels of GFAP in the CSF and blood have been reported with various neural diseases. However, there has been no study describing the usefulness of GFAP in the blood for disease of the spinal cord in dogs. The aim of this study was to describe the utility of GFAP in serum for a diagnosis of progressive myelomalacia. Fifty-six dogs with acute thoracolumbar IVDD diagnosed by computed tomography with myelography or MRI were included. Serum specimens were collected at initial presentation from all cases and at follow-up examinations from some cases. Serum samples were assayed for GFAP concentrations using a commercially available GFAP ELISA Kit. Progressive myelomalacia was the final diagnosis in 8/51 cases (15.6%). Eight dogs had clinical signs suggestive of progressive myelomalacia, of which 6 were positive and 2 were negative by GFAP. Seven dogs had a detectable level of serum GFAP, of which 6 had the onset of progressive myelomalacia. The sensitivity and specificity of the GFAP to progressive myelomalacia were 75% and 97.7%, respectively. The results suggest the utility of GFAP in serum in the diagnosis of progressive myelomalacia.

著者

Matteo CERQUETELLA Fulvio LAUS Emanuele PAGGI Tamara ZUCCARI Andrea SPATERNA Beniamino TESEI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.7, pp.959-962, 2013 (Released:2013-07-31)

参考文献数

13

被引用文献数

2 15

---

In the present work, a retrospective study on the localization of vegetal foreign bodies (VFBs) inside the tracheobronchial tree of 41 dogs is reported. In total, 47 grass awns were found, and only three dogs presented more than one foreign body. Most VFBs were found inside right bronchial ramifications (76.6%, no. 36), while 23.4% (no. 11) were found inside the ventrocaudal branch of the left cranial lobar bronchus. The impossibility of predicting the location and the concomitant presence of more than one foreign body in a single patient are conditions that impose the need for careful evaluation of the whole bronchial tree in all cases.

著者

Hiroki OKANISHI Jun MATSUMOTO Sadao NOGAMI Yumiko KAGAWA Toshihiro WATARI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.7, pp.991-994, 2013 (Released:2013-07-31)

参考文献数

20

被引用文献数

1

---

An 8-year-old male Shiba dog presented with chronic vomiting and diarrhea. Upper gastrointestinal endoscopy revealed severe enteritis and infection of the duodenal mucosa with Echinostoma hortense. We performed therapy for parasites and enteritis. The therapy was successful for deworming and temporarily improved the symptoms, but the dog died soon thereafter. To the authors’ knowledge, this is the first case report of an antemortem diagnosis of E. hortense infection in a dog.

著者

Takashi KATO Masaharu HISASUE Kazuhito SEGAWA Ayumi FUJIMOTO Eri MAKIISHI Sakurako NEO Kyohei YASUNO Ryosuke KOBAYASHI Ryo TSUCHIYA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.7, pp.847-855, 2013 (Released:2013-07-31)

参考文献数

29

被引用文献数

1 1

---

Bone marrow cell infusion (BMI) has recently been suggested as an effective therapy for refractory liver disease; however, the efficiency of BMI using canine bone marrow cells (cBMCs) has not been reported. We evaluated the accumulation potential of cBMCs in a mouse model of acute liver failure. Acute hepatitis was induced by carbon tetrachloride (CCl4) treatment in NOD/SCID/γcnull(NOG) mice and wild-type (WT) C57BL mice, and the characteristics of liver dysfunction and the degree of hepatic injury and regeneration were compared between the two mouse models. Next, female CCl4-treated NOG mice were xenotransplanted with male PKH26-labeled cBMCs, and the potential of cBMCs to accumulate in injured liver tissue compartments was examined. Fluorescence microscopy was performed to histologically detect the infused cBMCs, and DNA polymerase chain reaction was performed for detection of the male Y chromosome (SRY gene) in the recipient female NOG mice. The number of PKH26-positive cBMCs transplanted in the liver tissue gradually increased in the NOG mice. The infused cBMCs were located in the necrotic area of the liver at an early stage after transplantation, and most had accumulated a week after transplantation. However, the therapeutic efficacy of the xenotransplantation remained unclear, because no significant differences were observed concerning the extent liver injury and regeneration between the cBMC-transplanted and saline control mice. These results suggest that cBMCs will specifically accumulate in injured liver tissue and that BMC transplantation may have the potential to repair liver deficiency.