著者

村田 厚生 三宅 貴士 森若 誠

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.45, no.4, pp.226-235, 2009-08-15 (Released:2010-11-19)

参考文献数

19

被引用文献数

4 10

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本研究では視線入力装置を利用し,視線入力で快適にパソコンを扱えるブラウザを開発するための基礎的な研究として,高いポイント精度,速いポイント速度を保証する条件を同定する実験と視線移動方向の影響を明らかにする実験を実施した.その結果,ターゲットの横方向配置のほうが縦方向配置よりもポイント精度が高かった.両配置ともに,ポイント精度を高めるには,20ピクセル以上のターゲット間隔,40ピクセル以上のターゲットサイズにすべきであることが示された.また,両配置ともにポイント速度を速くするためには,ターゲットサイズをできるだけ大きくすべきで,ターゲット間隔はポイント速度にほとんど影響しないことが示された.また,マウスと視線入力のポイント速度の差は,若年者よりも高齢者のほうが大きくなり,視線入力システムは手指の運動機能の低下した高齢者には有効であることが示唆された.視線移動方向の影響に関しては,下方向のターゲットに対するポイント時間が他方向よりも長くなった.

著者

平野 敏明

出版者

特定非営利活動法人バードリサーチ

雑誌

Bird Research (ISSN:18801587)

巻号頁・発行日

vol.2, pp.A35-A46, 2006 (Released:2006-12-25)

参考文献数

14

被引用文献数

2

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2005年 5月中旬から 8月下旬,2006年 4月中旬から 8月下旬にかけて,栃木県藤岡町から小山市の渡良瀬遊水地で,カセットテープレコーダーから鳴声を再生してクイナとヒクイナの繁殖期における生息分布,個体数,生息環境の調査を行なった.2005年には110地点,2006年には140地点で鳴声再生を実施した結果,クイナおよびヒクイナの生息が2005年には20地点と 2地点,2006年には16地点と 2地点でそれぞれ確認された.しかし,同一個体の可能性のあるものを除くとクイナは2005年が12羽,2006年が10羽,ヒクイナは2005年,2006年とも 1羽と推定された.クイナおよびヒクイナが生息していた場所は,20cm以下の深さで地表に水があるヨシやスゲ類が繁茂する環境で,下層植物のない乾燥したヨシ原ではまったく記録されなかった.渡良瀬遊水地におけるこれら 2種の生息分布は,著しく限られていた.これは,渡良瀬遊水地の多くが,乾燥したヨシなどの高茎草原からなっていることが理由の 1つと考えられた.クイナ類など湿地性鳥類の良好な生息地を創出するために,人為的な掘削などによる湿地性環境の再生が必要と考えられる.

著者

Yusaku WATANABE Masatoshi FUJIHARA Jin SUZUKI Fumina SASAOKA Kazuya NAGAI Ryô HARASAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0096, (Released:2012-05-22)

被引用文献数

1 10 3

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Hemoplasma is a tribal name for epierythrocytic mycoplasmas including Mycoplasma suis and M. parvum which are currently recognized in pigs as causative of porcine hemoplasmosis. Here we report a real-time PCR assay for differential detection of these swine hemoplasma species by using allelic primers in the16S rRNA gene, and its application to survey for hemoplasma infections in pigs. Universal primers and species-specific primers were designed and evaluated by using swine blood samples positive in hemoplasmas. Mycoplasma suis and M. parvum infections were both confirmed by universal primers and mixed infections were clearly distinguished by species-specific primers. Further, we applied this real-time PCR assay to 120 swine blood specimens from clinically healthy pigs in eleven farms in Japan, and found six (5.0%) were positive for M. suis and 18 (15.0%) were positive for M. parvum, and three (2.5%) were mixed infection by both hemoplasma species.

著者

荒木 友希子

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.79, no.1, pp.9-17, 2008 (Released:2011-03-16)

参考文献数

20

被引用文献数

8 9 3

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The purpose of this study was to develop the Japanese Defensive Pessimism Inventory (JDPI), which measures defensive pessimism in an academic achievement situation for Japanese undergraduate students and differentiates between those who are realistically pessimistic and those who are defensively pessimistic. In Study 1, 695 undergraduates completed the JDPI. A factor analysis revealed that the 24 items of the JDPI comprised four factors: Pessimism, Past experience, Positive reflectivity, and Effort. In Study 2, 618 undergraduates completed the JDPI, the Test Coping Strategy Scale, and the State-Trait Anxiety Inventory. The JDPI had high internal consistency and test-retest reliability. Defensive pessimists and strategic optimists had higher scores on the active coping strategy and lower scores on the avoidant-thinking coping strategy than did realistic pessimists. Furthermore, defensive pessimists and realistic pessimists had higher scores on the state anxiety and lower scores on the optimistic-thinking coping strategy than did strategic optimists. The results indicate that the JDPI had high concurrent validity.

著者

岡崎 啓介

出版者

日本大腸肛門病学会

雑誌

日本大腸肛門病学会雑誌 (ISSN:00471801)

巻号頁・発行日

vol.63, no.6, pp.339-345, 2010 (Released:2010-05-31)

参考文献数

14

被引用文献数

2 2

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放射線不透過マーカーを用いて大腸通過時間を測定し,便秘の質的診断を試みた.健常成人ボランティア43名を対象とし,1,2,3日目に放射線不透過マーカー(Sitzmarks)を服用,4,7日目に腹部単純写真を撮影,Metcalfらの方法で全大腸通過時間,大腸各区域(右側,左側,S状結腸直腸)通過時間を測定した.質問アンケートと排便状況(回数,ブリストルスケール)について自記させた.通過時間は中央値で示した.男性(n=13)はすべて便秘(-)で,全大腸通過時間は7.2h,右側2.4h,左側3.6h,S状結腸直腸2.4h.女性で便秘(-)(n=24)は全大腸31.8h,右側4.2h,左側9.0h,S状結腸直腸11.4h.女性で便秘(+)(n=6)は全大腸110.4h,右側30.6h,左側36.6h,S状結腸直腸30.0hであった.大腸通過時間が40h超の延長例を類型化すると,左側通過時間を最長とするcolonic inertia型とS状結腸直腸通過時間を最長とするoutlet obstruction型に分類できた.この分類は排便回数やブリストルスケールでは判別できず,放射線不透過マーカーによる質的診断の有効性が示唆された.

著者

Atsushi YABUZOE Koji NISHIFUJI Maiko SEKIGUCHI Atsushi SHIMIZU Yasuyuki MOMOI Akira ISHIKO Toshiroh IWASAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.70, no.8, pp.807-812, 2008 (Released:2008-09-05)

参考文献数

19

被引用文献数

3 8

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Pemphigus foliaceus (PF) is an autoimmune blistering skin disease that affects certain mammals including dogs. In canine PF, neutrophils are infiltrated intensely into pustular lesions including acantholytic cells, although neutrophilic infiltration is not characterized in human PF. The roles of the neutrophils in the cutaneous lesions of canine PF have not yet been understood. The purpose of this study was to characterize the ultrastructural features underlying the acantholysis with pustule formation in canine PF. Four dogs diagnosed as PF on the basis of clinical signs, histopathological findings, and direct and indirect immunofluorescence examinations were performed. Electron microscopy revealed that the acantholytic cells were adjacent to multiple neutrophils in the pustules. At the contact points between neutrophils and acantholytic keratinocytes, half-desmosomes of acantholytic keratinocytes with intact attachment plaques were observed within invaginations of neutrophils. Furthermore, on the surface of acantholytic cells in the pustules, neutrophil granules seemed to be secreted to the surface of acantholytic cells and to degenerate the half-desmosome structures. Neutrophils were also observed within the epidermis adjacent to the pustule. At the intercellular gap between two dissociated keratinocytes, neutrophils inserted its pseudopodia into the gap between the two half-desmosomes of keratinocytes. These findings taken together suggested that, at least in the areas where we analyzed ultrastructurally, neutrophils contact desmosomal structures and seem to play some parts in separation of keratinocytes and degeneration of split-desmosomes in pustules of dogs with PF.

著者

Hiroki Yamaguchi

出版者

The Medical Association of Nippon Medical School

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.74, no.3, pp.202-209, 2007 (Released:2007-07-12)

参考文献数

35

被引用文献数

10 17

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Dyskeratosis congenita (DKC) is a bone marrow failure (BMF) with characteristic physical anomalies, and is typically diagnosed in childhood. Some forms of DKC are known to be caused by mutations occurring in DKC1, telomerase RNA component (TERC), and telomerase reverse transcriptase (TERT). These genes are the main constituents of the telomerase complex that plays a role in replicating telomeres and stabilizing them against shortening. Mutations in these genes could shorten telomeres and impair the proliferative capacity of hematopoietic stem cells, eventually causing DKC. Recently, mutations in TERC and TERT have been reported in some cases of aplastic anemia (AA) and myelodysplastic syndrome (MDS). These cases are considered to be atypical forms of DKC that develop slowly in adulthood without characteristic physical anomalies. Genetic tests are essential in diagnosing this late-presenting DKC and determining the appropriate treatment. This article reviews mutations in the telomerase complex and their connections with DKC and bone marrow failures.

著者

Teruo ITOH Kazumi NIBE Atsuko KOJIMOTO Mayumi MIKAWA Kazuhiro MIKAWA Kazuyuki UCHIDA Hiroki SHII

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.68, no.8, pp.869-871, 2006 (Released:2006-09-05)

参考文献数

9

被引用文献数

7 15 13

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A 5-year-old female border collie presented with erythematous skin lesions at the axillae, groin, mucocutaneous junctions, and pinnae. Biopsy revealed lymphocytic interface dermatitis with hydropic degeneration of basal cells and keratinocyte apoptosis. Based on gross and histological features, diagnosis of erythema multiforme was made. The disease was resolved by treatment with azathioprine, prednisolone, and a hypoallergenic diet. Finally, the skin lesion was controlled without drug therapy but recurred easily every time commercial foods except the hypoallergenic diet were used, suggesting that food substances triggered this outbreak.

著者

Taro Shimizu Yasuharu Tokuda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.49, no.12, pp.1051-1057, 2010 (Released:2010-06-15)

参考文献数

80

被引用文献数

30 91

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Necrotizing fasciitis (NF) is a necrotizing soft tissue infection that can cause rapid local tissue destruction, necrosis and life-threatening severe sepsis. Predisposing conditions for NF include diabetes, malignancy, alcohol abuse, and chronic liver and kidney diseases. NF is classified into two categories (types 1 and 2) based on causative microorganisms. The initial clinical picture of NF mimics that of cellulitis or erysipelas, including fever, pain, tenderness, swelling and erythema. The cardinal manifestations of NF are severe pain at onset out of proportion to local findings, hemorrhagic bullae and/or vital sign abnormality. In such cases, NF should be strongly suspected and immediate surgical intervention should be considered, along with broad-spectrum antimicrobials and general supportive measures, regardless of the findings of imaging tests.

著者

津田 穣

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.19, no.2, pp.109-119, 1970-02-01 (Released:2011-09-21)

参考文献数

33

被引用文献数

1

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橋かけ型感光性樹脂は,光橋かけ剤と高分子化合物との混合組成物と感光性高分子化合物に大別できる.前者には,光橋かけ剤として重クロム酸塩,テトラゾニウム塩,ビスアジド化合物,アントラキノン誘導体などを含んだ組成物があり,後者にはポリ桂皮酸ビニル,ポリビニルベンゾフェノン,ポリフリルアクリル酸ビニル,ポリパラアジド安息香酸ビニル,ジアゾポリマーなどがある.このうち,テトラゾニウム塩とビスアジド化合物,ポリ桂皮酸ビニルについて,光の吸収(電子スペクトル)と光化学的反応性の問題を最近の研究に基いてやや詳しく論じた.最後に,ポリ桂皮酸ビニルのスペクトル増感を例にとり,増感過程において光化学的に重要な光の吸収,一重項⇔三重項間の分子内ならびに分子間エネルギー移動の問題を基礎的事項の平易な解説をかねて詳しく論じ,あわせて増感機構解明のプロセスと,増感機構を利用して新増感剤を開発した研究例を示した.また,重クロム酸系感光性樹脂についても簡単にふれた.

著者

田切 美智雄 森本 麻希 望月 涼子 横須賀 歩 Daniel J. DUNKLEY 足立 達朗

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.119, no.2, pp.245-256, 2010-04-25 (Released:2010-07-06)

参考文献数

29

被引用文献数

14 20

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Hitachi metamorphic rocks located in the southern part of the Abukuma Mountains, Northeast Japan, distinctively contain meta-volcanic rocks and meta/sheared granitoids. The igneous ages of meta-granite and meta-porphyry from the Hitachi metamorphic rocks were determined by the SHRIMP zircon method. In this paper, we describe occurrence, petrography, and petrochemical characteristics of these studied rocks. Meta-porphyry, with an igneous age of 506 Ma, intrudes into the meta-volcanic rocks of the Akazawa Formation of the Hitachi metamorphic rocks and has a micrographic texture and a spherulitic texture of an igneous origin. Previous studies have already reported an igneous age of 491 Ma for meta/sheared granitoids using the SHRIMP zircon method. Cambrian meta/sheared granitoid samples occur widely as a granitic body in the northeastern part of the Hitachi metamorphic rocks. (A) Meta-granite of the same age (498 Ma) as the sample used for the above dating is found as boulders in meta-conglomerates. The meta-conglomerate, which is found in the Daioin Formation of the Hitachi metamorphic rocks, lies unconformably on a Cambrian meta-granite body. Both meta-volcanic rocks and meta/sheared granitoids have chemical characteristics commonly associated with island arc volcanism. As such, the Akazawa Formation is likely to have originated in the Cambrian era, although we have no SHRIMP age for meta-volcanic rocks of the Akazawa Formation.

著者

A. Prysyazhnyuk A. Romanenko N. Gudzenko M. Fuzik Z. Fedorenko

出版者

CODATA

雑誌

Data Science Journal (ISSN:16831470)

巻号頁・発行日

vol.8, pp.BR6-BR12, 2009-09-24 (Released:2009-09-24)

参考文献数

17

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The study goal was to investigate thyroid cancer morbidity in population groups affected by the Chernobyl catastrophe. The study period comprised 1994-2006 for clean-up workers and 1990-2006 for Chernobyl evacuees and residents of contaminated territories. A significant increase of thyroid cancer incidence was registered in all observed population groups. The most significant excess over the national level was identified in clean-up workers. This amounted to a factor of 5.9, while it was 5.5 for the evacuees and 1.7 for the residents. The highest thyroid cancer risk was observed in persons exposed to radioiodine in childhood and adolescence.

著者

辻野 泰之

出版者

一般社団法人 日本地質学会

雑誌

地質学雑誌 (ISSN:00167630)

巻号頁・発行日

vol.115, no.3, pp.122-129, 2009-03-15 (Released:2009-08-07)

参考文献数

33

被引用文献数

1 1

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北海道古丹別地域に分布する蝦夷層群最上部を函淵層に帰属させた.この層準は砂岩優勢の砂岩泥岩互層で構成され,ハンモック状斜交層理が発達する.本研究では,古丹別地域の函淵層からいくつかのアンモノイド類やイノセラムス類を産出したものの,時代決定に有効な大型化石は得られなかった.しかしながら,古丹別および羽幌地域の羽幌川層最上部からは,下部カンパニアン中部-上部を示すSphenoceramus orientalisやS. schmidtiが報告されており,古丹別地域の函淵層はS. orientalis−S. schmidti帯の最下部に対応すると考えられる.さらに函淵層が,古丹別地域で確認されたこと,また羽幌地域や達布地域の羽幌川層最上部においても,すでに上方粗粒化の傾向が見られることは,羽幌-古丹別-達布地域の広域において函淵層が堆積していた可能性を示す.

著者

豊岡 伸一 高野 利実 高坂 貴行 堀田 勝幸 松尾 恵太郎 市原 周治 藤原 義朗 宗 淳一 大谷 弘樹 木浦 勝行 青江 啓介 谷田部 恭 大江 裕一郎 光冨 徹哉 伊達 洋至

出版者

特定非営利活動法人 日本肺癌学会

雑誌

肺癌 (ISSN:03869628)

巻号頁・発行日

vol.49, no.4, pp.409-415, 2009 (Released:2009-10-08)

参考文献数

20

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目的.ゲフィチニブ投与患者では上皮成長因子受容体(EGFR)変異例で予後が良いことが報告されている.一方,喫煙,性差はEGFR変異に影響し,さらに,肺癌の予後因子であることが示唆されている.本研究では,EGFR変異,性差,喫煙が,ゲフィチニブ治療を受けた肺腺癌患者の生存期間に与える影響を検討した.対象と方法.ゲフィチニブにより治療された肺腺癌患者362例において,EGFR変異,性差,喫煙が全生存期間(OS)および無増悪生存期間(PFS)に及ぼす影響を評価した.結果.EGFR変異は169例(46.7%)に認めた.多変量解析では,変異例で野生型例に比べOSおよびPFSが有意に長かった(P<0.001).EGFR変異の有無による群別で性差,喫煙量は,OSおよびPFSの延長とは関連がなかった.一方,性別,および,喫煙により分類した群別での解析では,EGFR変異は,OS,PFSの延長と有意な関連を認めた(P<0.001).結論.本検討から,ゲフィチニブ投与を行う患者を選択する際,EGFR変異は重要な指標であると考えられる.

著者

中西 剛

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.3, pp.491-500, 2007 (Released:2007-03-01)

参考文献数

38

被引用文献数

2 8

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Rodent models have great utility for evaluating the potential of environmental chemicals to alter human reproductive development. However, animal studies have some problems of species differences in extrapolating to human developmental toxicity induced by xenobiotics, because the placental endocrine functions in particular vary considerably among different species. For example, estrogen biosynthesis during pregnancy in humans is much different from that in rodents. In humans, ovarian function gradually declines after fertilization, as the placenta becomes the primary site of estrogen biosynthesis during pregnancy. In contrast to the process in humans, the ovary (not the placenta) is the main source of estrogen during pregnancy in rodents, because the placenta of rodents does not express the catalytic enzymes for estrogen biosynthesis, such as aromatase. The regulation of estrogen biosynthesis in the placenta is very important for human embryos because altering placental function can cause permanent effects on embryos. It has been suggested that rodents are therefore unsuitable for evaluating the potential effects of xenobiotics on the human reproductive system and developmental toxicity induced by the alteration of placental endocrine functions. Consequently, there is an urgent need to establish effective tools to evaluate the in vivo reproductive and developmental toxicity of environmental contaminants that disrupt the placental endocrine functions, including maintenance of local estrogen concentrations in the placenta. To resolve the problems, in this review we propose using transgenic mice, in which the transgene is controlled by placental-specific promoters, and local transgene systems into the placenta using viral vectors.

著者

中野 眞汎 中野 真子

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.33, no.1, pp.201S-202S, 2002-01-31 (Released:2010-06-28)

被引用文献数

1 1

出版者

公益社団法人 日本心理学会

雑誌

心理研究 (ISSN:18841066)

巻号頁・発行日

vol.28, no.162, pp.61-67, 1925-07-01 (Released:2010-07-16)

著者

白岩 一彦

出版者

一般社団法人 日本オリエント学会

雑誌

オリエント (ISSN:00305219)

巻号頁・発行日

vol.34, no.1, pp.17-31, 1991-09-30 (Released:2010-03-12)

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The Paris Manuscript of the Jami' al-tavarikh of Rashid al-Din (Bibliothèque Nationale, Supplément persan 1113), adorned with 109 miniatures, is one of the best manuscripts of this work. É. Blochet put this manuscript in high esteem, considering it to have been completed in 1304-1318. However, B. Gray and other art historians opposed this, stating that the manuscript in question is of later date, namely of Timurid period. The close examinations of this manuscript both in text and miniatures in comparison with other contemporary manuscripts (Revan 1518, Hazine 1654, etc.) reveal to us the fact that this manuscript actually belongs to the earliest manuscripts of the Jami' al-tavarikh, and that it was completed most probably in 1304-1318 as was originally maintained by É. Blochet.

著者

白岩 一彦

出版者

一般社団法人 日本オリエント学会

雑誌

オリエント (ISSN:00305219)

巻号頁・発行日

vol.36, no.1, pp.55-70, 1993-09-30 (Released:2010-03-12)

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The Tehran Manuscript of the Jami' al-tavarikh (Kitabkhanah-i Majlis-i Shuray-i Milli, MS no. 2294) has so far been neglected in the scholarly world in general save in Japan where some scholars used the facsimile edition of this manuscript in their scholarly articles. This manuscript was, however, only partially utilized in them, and the true value of it remains unknown to the world.This article intends to bring to light the unique features of this manuscript in comparison with other manuscripts such as Istanbul Manuscript (Revan Köškü 1518) and Paris Manuscript (Supplément persan 1113) and to prove that it is actually older and much more accurate manuscript of the Jami' al-tavarikh than the Istanbul Manuscript which has so far been considered to be the best and oldest manuscript of the same work.

著者

岡島 康友

出版者

社団法人 日本リハビリテーション医学会

雑誌

リハビリテーション医学 (ISSN:0034351X)

巻号頁・発行日

vol.31, no.10, pp.725-728, 1994-10-18 (Released:2009-10-28)

参考文献数

9