著者

Toyoyuki Takada Toshihiko Shiroishi

出版者

公益社団法人 日本実験動物学会

雑誌

Experimental Animals (ISSN:13411357)

巻号頁・発行日

vol.61, no.4, pp.375-388, 2012 (Released:2012-07-26)

参考文献数

68

被引用文献数

4 6 4

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Mammalian quantitative traits that are observed at the whole-body level, such as body weight and length and blood biochemical parameters, are determined by the cooperative effects of multiple genetic and epigenetic factors as well as environmental factors. This complexity has hampered the genetic analysis of quantitative traits. To overcome this difficulty, we have established a full set of consomic mouse strains, also known as chromosome substitution strains, by replacing every chromosome of the classical inbred strain C57BL/6J with its counterpart from the Japanese wild-mouse-derived inbred strain MSM/Ms. The core components of the genomes of these two strains originated from different mouse subspecies. The inter-subspecific large-genome divergence and phenotypic differences between the two strains allowed the identification of genetic determinants for many quantitative traits by comprehensive phenotype screening. For some quantitative traits, the genetic determinants could be dissected into multiple chromosomes, thereby reflecting strain differences between C57BL/6J and MSM/Ms and their simple additive effects on the background of the consomic host strain. For other quantitative traits, the measured values of some consomic strains often far exceeded the range of the two parental strains, which suggests that nonadditive genetic interactions occur among multiple genes located on the substituted MSM/Ms chromosomes and the consomic host chromosomes. Thus, the inter-subspecific consomic strains are unique tools that can be used to identify both additive and nonadditive genetic effects on quantitative complex traits.

著者

Yasunori Niwa Shizukiyo Ishikawa Tadao Gotoh Kazunori Kayaba Yosikazu Nakamura Eiji Kajii

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.17, no.6, pp.203-209, 2007 (Released:2007-12-19)

参考文献数

28

被引用文献数

10 11 14

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BACKGROUND: Metabolic syndrome is known to increase morbidity and mortality of cardiovascular disease. The National Cholesterol Education Program Adult Treatment Expert Panel III in 2001 (revised in 2005) and the Japanese definition of metabolic syndrome were launched in 2005. No study regarding the association between metabolic syndrome by Japanese definition and mortality has been performed. The aim of this study was to clarify the prevalence of metabolic syndrome and its effects to mortality in a population-based cohort study.METHODS: A total of 2176 subjects who satisfied the necessary criteria for metabolic syndrome were examined between 1992 and 1995 as a part of Jichi Medical School Cohort Study by Japanese definition. Cox's proportional hazard models were used to analyze the association of metabolic syndrome with mortality.RESULTS: The prevalence of metabolic syndrome was 9.0% in males and 1.7% in females. There were 17 deaths (14 males), including 6 cardiovascular deaths (5 males), during a 12.5-year follow-up period among metabolic syndrome subjects. After adjusting for age, smoking status, and alcohol drinking status, the hazard ratio (95% confidence interval) for all-cause mortality was 1.13 (0.64-1.98) in males and 1.31 (0.41-4.18) in females, and HR for cardiovascular mortality was 1.84 (0.68-4.96) in males, and 1.31 (0.17-9.96) in females.CONCLUSION: No statistical significant relationship between metabolic syndrome by Japanese definition and all-cause mortality was observed in a population-based cohort study.J Epidemiol 2007; 17: 203-209.

著者

風間 健太郎 佐藤 雅彦

出版者

日本鳥学会

雑誌

日本鳥学会誌 (ISSN:0913400X)

巻号頁・発行日

vol.57, no.1, pp.30-32, 2008-05-01 (Released:2008-05-21)

参考文献数

9

被引用文献数

1

著者

塩田 研次 王村 維康 岡本 欣司 宮田 光男 志築 照和

出版者

Japanese Association for Oral Biology

雑誌

歯科基礎医学会雑誌 (ISSN:03850137)

巻号頁・発行日

vol.12, no.3, pp.185-197, 1970-10-31 (Released:2010-10-28)

参考文献数

16

著者

池島 厚 富山 文信 尾澤 光久 山本 浩嗣

出版者

特定非営利活動法人 日本歯科放射線学会

雑誌

歯科放射線 (ISSN:03899705)

巻号頁・発行日

vol.21, no.1, pp.47-48, 1981 (Released:2011-09-05)

著者

中谷内 一也

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.82, no.5, pp.467-472, 2011 (Released:2012-02-27)

参考文献数

28

被引用文献数

1 4

---

The present research investigated the relationship between public anxiety about a variety of risks and trust in the management of each risk. Adults (N = 2200) were selected from the residents' basic registers using a stratified two-step random sampling method. Of this sample, 1192 (54.2%) rated their anxiety toward 51 kinds of risks and their trust in the management of each risk. Six-point scales were utilized for their ratings. The results demonstrated that the more the risk management was trusted, the less the risk was of concern. The basic statistics for the trust ratings are provided for the discussion of societal risk governance. The implications and limitations of the present findings are discussed.

著者

石田 弘明

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.75, no.3, pp.337-340, 2009-03-05 (Released:2010-11-30)

参考文献数

6

被引用文献数

1

著者

山県 登 岩島 清 永井 輝夫 渡利 一夫 飯沼 武

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.7, no.1, pp.29-46, 1966 (Released:2006-08-29)

参考文献数

13

被引用文献数

9 13

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Two single doses of coupled radioisotopes of 132Cs-86Rb and 132Cs-42K were orally administered to a human subject. Body retention, urinary and fecal excretions as well as the plasma and erythrocytes contents of radioisotopes were determined. The proportion of urinary to fecal excretion was found different in cesium and rubidium, the urinary excretion being 85.3% of the total in the former and only 68.1% in the latter. Loss of cesium in the sweat amounted to 1.5 and 3.5% of the total excretion for the first two days. Uptake by the plasma of oral dose was rapid and the whole blood content reached max. 11.4% of the dose of cesium at 1 hour, while 2.9 and 2.4% respectively of rubidium and potassium was reached. The levels in the erythrocytes seemed to grow at a slower rate in cesium than in the other alkali elements. The different feature of blood metabolism found in the alkali elements was interpreted by the slow rate of clearance of ingested cesium from blood. Daily fluctuations of fall-out 137Cs in blood and the errors involved in the assessment of the total body burden of 137Cs by blood analysis were also discussed.

著者

三谷 博

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.16, no.10, pp.10_40-10_43, 2011-10-01 (Released:2012-02-15)

参考文献数

6

著者

羽田 正

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.16, no.10, pp.10_28-10_30, 2011-10-01 (Released:2012-02-15)

著者

溝口 史高 上阪 等

出版者

日本臨床免疫学会

雑誌

日本臨床免疫学会会誌 (ISSN:09114300)

巻号頁・発行日

vol.35, no.1, pp.69-74, 2012 (Released:2012-02-28)

参考文献数

31

被引用文献数

1 1

---

近年様々な生理的・病的状態におけるmicroRNAの役割が明らかになってきている.特に免疫におけるmicroRNAの役割については詳細な検討が進められている.関節リウマチにおけるmicroRNAの報告は,免疫系における役割が報告されていたmiR-146とmiR-155が炎症性滑膜組織に発現することが報告されて以降,様々なmicroRNAの発現が病態に関与する可能性が報告されてきている.関節リウマチにおけるmicroRNAの役割についてはまだその一部が明らかとなったにすぎないが,今後さらに詳細な検討がなされることにより,新たな治療標的やバイオマーカーとしての役割が明らかとなることが期待される.

著者

瀬戸嶋 政勝 小林 靖幸 田中 宏明 栗林 善昭 井上 尚美

出版者

西日本整形・災害外科学会

雑誌

整形外科と災害外科 (ISSN:00371033)

巻号頁・発行日

vol.37, no.1, pp.229-233, 1988-10-25 (Released:2010-02-25)

参考文献数

6

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Since ankylosing spondylitis (A. S.) tends to be milder and less progressive in women that in men, there are great difficulties in early diagnosing A. S. in female patients. We report a case of A. S. in a woman. A 22-year-old woman with a 6-year history of A. S. was admitted to our hospital in Mar., 1987. The initial sign was gait disturbance due to severe left hip joint pain. Laboratory findings included an almost normal complete blood count, blood chemistry and urinalysis. The ESR at that time was 51mm/h, CRP was 2 puls, rheumatoid factor was negative and HLA B-27 antigen was detected.The plain roentgenogram revealed a narrowing of the joint space and an ankylosing change in the bilateral hip and sacroiliac joints. Routine X-ray examination of the spine showed an almost normal view. An open biopsy of the hip joint showed histopathologically nonspecific chronic inflammatory findings. A Tc-99m scintigram on Feb. 9, 1982 showed an increased activity area in the bilateral hips and sternoclavicular joints, in the sacroiliac joints especially in the iliac sides, and in a part of the cervical spine. This activity began in the early stage of A. S. However, a plain roentgenogram of these joints at that time showed normal findings.If history, clinical and laboratory findings lead to a suspicion of A. S., and there is little significant change by roentgenographic studies, the whole body scintigraphy is useful for the early diagnosis of A. S. in female patients.

著者

Chen-Long Wu Shih-Bin Su Jin-Luh Chen Hung-Jung Lin How-Ran Guo

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.50, no.2, pp.99-102, 2008 (Released:2008-04-10)

参考文献数

14

被引用文献数

16 35

著者

太田 暢人

出版者

社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.15, no.3, pp.121-128, 1957 (Released:2010-10-20)

参考文献数

25

著者

吉村 忍 小林 敬 秋葉 博 鈴木 智 荻野 正雄

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会和文論文誌 (ISSN:13472879)

巻号頁・発行日

vol.11, no.3, pp.203-221, 2012 (Released:2012-08-15)

参考文献数

17

被引用文献数

3 7

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In this paper, we present the three-dimensional finite element seismic response analysis of the full-scale boiling water reactor BWR5 at the Kashiwazaki-Kariwa Nuclear Power Plant subjected to the Niigata-ken Chuetsu-Oki (NCO) earthquake that occurred on 16th July 2007. During the earthquake, the automatic shutdown of the reactors was performed successfully. Although the monitored seismic acceleration significantly exceeded the design level, it was found through in-depth investigation that there was no significant damage of the reactor cores or other important systems, structures and components (SSCs). In the seismic design commonly used in Japan, a lumped mass model is employed to evaluate the seismic response of SSCs. Although the lumped mass model has worked well so far for a seismic proof design, more precise methods should be developed to understand response behaviors visually. In the present study, we propose the three-dimensional finite element seismic response analysis of the full-scale and precise BWR model in order to directly visualize the dynamic behaviors of this model. Through the comparison of the analysis results, we discuss the characteristics of both models. The stress values were also found to be generally under the design value.

著者

柳 千裕 村瀬 道雄 吉田 至孝 楠木 貴世志

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会和文論文誌 (ISSN:13472879)

巻号頁・発行日

vol.11, no.3, pp.193-202, 2012 (Released:2012-08-15)

参考文献数

12

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A prediction method for water temperature in a spent fuel pit of a PWR has been developed to calculate the increase in water temperature during the shutdown of cooling systems. In this study, the prediction method was extended to calculate the water level in a spent fuel pit during loss of all AC powers, and predicted results were compared with data of spent fuel pools in the Fukushima Daiichi Nuclear Power Station. The calculations gave reasonable results, but overestimated the decreasing rate of the water level and water temperature. This result indicated that decay heat was overestimated and evaporation heat transfer from the water surface was underestimated. Results of calculations with 80% decay heat and 155% (No. 4 pool) or 230% (No. 2 pool) evaporation heat flux were in good agreement with data. The data-fitted evaporation heat fluxes agreed rather well with the evaporation heat transfer correlation proposed by Fujii et al.

著者

金田 章裕

出版者

一般社団法人 人文地理学会

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.48, no.5, pp.424-426, 1996-10-28 (Released:2009-04-28)

出版者

公益社団法人 日本地理学会

雑誌

地理学評論 Ser. A (ISSN:00167444)

巻号頁・発行日

vol.69, no.11, pp.907-910,916_1, 1996-11-01 (Released:2008-12-25)

著者

Hairihan

出版者

日本建築学会(AIJ)、大韓建築学会(AIK)、中国建築学会(ASC) 編集事務局:AIJ jaabe(at)aij.or.jp

雑誌

Journal of Asian Architecture and Building Engineering (ISSN:13467581)

巻号頁・発行日

vol.1, no.2, pp.2_227-231, 2002 (Released:2003-06-17)

参考文献数

6

被引用文献数

1 1

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Because many people are acquiring settled dwellings in Inner Mongolia, they now no longer live in Yurts only. This article probes the extension of the traditional culture of Yurts by analyzing and studying the distribution and orientation of the earth brick house and cave dwellings compared with Yurts.

著者

東亞合成化学工業株式会社ポリマー事業部

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.14, no.2, pp.271-272, 1989-05-20 (Released:2010-08-05)

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各種毒性試験を実施し, ポリアクリル酸ナトリウムの安全性評価を行なった.ポリアクリル酸ナトリウムのマウスに対する急性経口LD50値は10,000mg/kg以上であり, きわめて低毒性の化合物と判断された. ラットの亜急性および慢性毒性試験においては, 高用量群で若干の体重増加抑制の結果も得られたが, 蓄積的毒性ならびに癌化, 前癌的変化などの特異的影響は見られなかった.以上から, ポリアクリル酸ナトリウムは, 食品添加物にも指定されているように, 非常に安全性の高い化合物といえる. また, 魚貝類に対しても通常の使用では問題もなく, 魚毒性はA類に該当している.なお, ポリアクリル酸ナトリウムを含有するアロンAは安全性の高い薬剤である上, 空中液剤散布における補助剤として噴霧粒子中の主剤のドリフト防止効果およびそれにより主剤の病害虫防除効果を向上させうることから, 農業資材としてきわめて有用であると考えられる.